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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HNRNPK-NR6A1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HNRNPK-NR6A1
FusionPDB ID: 37224
FusionGDB2.0 ID: 37224
HgeneTgene
Gene symbol

HNRNPK

NR6A1

Gene ID

3190

2649

Gene nameheterogeneous nuclear ribonucleoprotein Knuclear receptor subfamily 6 group A member 1
SynonymsAUKS|CSBP|HNRPK|TUNPCT150|GCNF|GCNF1|NR61|RTR|hGCNF|hRTR
Cytomap

9q21.32

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein KdC-stretch binding proteintransformation upregulated nuclear proteinnuclear receptor subfamily 6 group A member 1germ cell nuclear factor variant 1retinoic acid receptor-related testis-associated receptorretinoid receptor-related testis-specific receptor
Modification date2020032920200313
UniProtAcc

P61978

Q15406

Ensembl transtripts involved in fusion geneENST idsENST00000351839, ENST00000360384, 
ENST00000376263, ENST00000376264, 
ENST00000376281, 		ENST00000344523, 
ENST00000373584, ENST00000416460, 
ENST00000487099, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 18 X 8=230414 X 13 X 6=1092
# samples 1714
** MAII scorelog2(17/2304*10)=-3.76053406530461
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1092*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HNRNPK [Title/Abstract] AND NR6A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HNRNPK(86592604)-NR6A1(127316849), # samples:2
Anticipated loss of major functional domain due to fusion event.HNRNPK-NR6A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPK-NR6A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPK-NR6A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPK-NR6A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPK-NR6A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HNRNPK-NR6A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HNRNPK-NR6A1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HNRNPK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NR6A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KZ-01AHNRNPKchr9

86592604

-NR6A1chr9

127316849

-
ChimerDB4SARCTCGA-RN-AAAQ-01AHNRNPKchr9

86592604

-NR6A1chr9

127316849

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376263HNRNPKchr986592604-ENST00000487099NR6A1chr9127316849-71113804451680411
ENST00000360384HNRNPKchr986592604-ENST00000487099NR6A1chr9127316849-70923614261661411

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376263ENST00000487099HNRNPKchr986592604-NR6A1chr9127316849-0.0011071110.99889296
ENST00000360384ENST00000487099HNRNPKchr986592604-NR6A1chr9127316849-0.001114930.9988851

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37224_37224_1_HNRNPK-NR6A1_HNRNPK_chr9_86592604_ENST00000360384_NR6A1_chr9_127316849_ENST00000487099_length(amino acids)=411AA_BP=
MHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSG
QEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLPQQARSLDPQ
SYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQ
IFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYK

--------------------------------------------------------------

>37224_37224_2_HNRNPK-NR6A1_HNRNPK_chr9_86592604_ENST00000376263_NR6A1_chr9_127316849_ENST00000487099_length(amino acids)=411AA_BP=
MHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSG
QEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLPQQARSLDPQ
SYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQ
IFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:86592604/chr9:127316849)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPK

P61978

NR6A1

Q15406

FUNCTION: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850}.FUNCTION: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNR6A1chr9:86592604chr9:127316849ENST0000034452311057_13247.333333333333336480.0DNA bindingNuclear receptor
TgeneNR6A1chr9:86592604chr9:127316849ENST0000037358401057_1320477.0DNA bindingNuclear receptor
TgeneNR6A1chr9:86592604chr9:127316849ENST0000041646001057_1320476.0DNA bindingNuclear receptor
TgeneNR6A1chr9:86592604chr9:127316849ENST0000048709911057_13247.333333333333336481.0DNA bindingNuclear receptor
TgeneNR6A1chr9:86592604chr9:127316849ENST00000344523110249_48047.333333333333336480.0DomainNR LBD
TgeneNR6A1chr9:86592604chr9:127316849ENST00000373584010249_4800477.0DomainNR LBD
TgeneNR6A1chr9:86592604chr9:127316849ENST00000416460010249_4800476.0DomainNR LBD
TgeneNR6A1chr9:86592604chr9:127316849ENST00000487099110249_48047.333333333333336481.0DomainNR LBD
TgeneNR6A1chr9:86592604chr9:127316849ENST0000034452311060_8047.333333333333336480.0Zinc fingerNR C4-type
TgeneNR6A1chr9:86592604chr9:127316849ENST0000034452311096_12047.333333333333336480.0Zinc fingerNR C4-type
TgeneNR6A1chr9:86592604chr9:127316849ENST0000037358401060_800477.0Zinc fingerNR C4-type
TgeneNR6A1chr9:86592604chr9:127316849ENST0000037358401096_1200477.0Zinc fingerNR C4-type
TgeneNR6A1chr9:86592604chr9:127316849ENST0000041646001060_800476.0Zinc fingerNR C4-type
TgeneNR6A1chr9:86592604chr9:127316849ENST0000041646001096_1200476.0Zinc fingerNR C4-type
TgeneNR6A1chr9:86592604chr9:127316849ENST0000048709911060_8047.333333333333336481.0Zinc fingerNR C4-type
TgeneNR6A1chr9:86592604chr9:127316849ENST0000048709911096_12047.333333333333336481.0Zinc fingerNR C4-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316289_29452.0464.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316310_31552.0464.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417289_29452.0464.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417310_31552.0464.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417289_29452.0465.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417310_31552.0465.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417289_29452.0464.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417310_31552.0464.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417289_29452.0465.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417310_31552.0465.0Compositional biasNote=Poly-Pro
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316144_20952.0464.0DomainKH 2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316387_45152.0464.0DomainKH 3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-31642_10452.0464.0DomainKH 1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417144_20952.0464.0DomainKH 2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417387_45152.0464.0DomainKH 3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-41742_10452.0464.0DomainKH 1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417144_20952.0465.0DomainKH 2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417387_45152.0465.0DomainKH 3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-41742_10452.0465.0DomainKH 1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417144_20952.0464.0DomainKH 2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417387_45152.0464.0DomainKH 3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-41742_10452.0464.0DomainKH 1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417144_20952.0465.0DomainKH 2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417387_45152.0465.0DomainKH 3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-41742_10452.0465.0DomainKH 1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316236_27352.0464.0RegionNote=RNA-binding RGG-box
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316245_32952.0464.0RegionNote=2 X 6 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-31654_42152.0464.0RegionNote=2 X 22 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-31659_40752.0464.0RegionNote=5 X 4 AA repeats of G-X-G-G
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417236_27352.0464.0RegionNote=RNA-binding RGG-box
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417245_32952.0464.0RegionNote=2 X 6 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-41754_42152.0464.0RegionNote=2 X 22 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-41759_40752.0464.0RegionNote=5 X 4 AA repeats of G-X-G-G
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417236_27352.0465.0RegionNote=RNA-binding RGG-box
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417245_32952.0465.0RegionNote=2 X 6 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-41754_42152.0465.0RegionNote=2 X 22 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-41759_40752.0465.0RegionNote=5 X 4 AA repeats of G-X-G-G
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417236_27352.0464.0RegionNote=RNA-binding RGG-box
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417245_32952.0464.0RegionNote=2 X 6 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-41754_42152.0464.0RegionNote=2 X 22 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-41759_40752.0464.0RegionNote=5 X 4 AA repeats of G-X-G-G
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417236_27352.0465.0RegionNote=RNA-binding RGG-box
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417245_32952.0465.0RegionNote=2 X 6 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-41754_42152.0465.0RegionNote=2 X 22 AA approximate repeats
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-41759_40752.0465.0RegionNote=5 X 4 AA repeats of G-X-G-G
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316245_25052.0464.0RepeatNote=2-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316257_26052.0464.0RepeatNote=3-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316267_27052.0464.0RepeatNote=3-3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316295_29852.0464.0RepeatNote=3-4
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316324_32952.0464.0RepeatNote=2-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316399_42152.0464.0RepeatNote=1-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316404_40752.0464.0RepeatNote=3-5
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-31654_7652.0464.0RepeatNote=1-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-31659_6252.0464.0RepeatNote=3-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417245_25052.0464.0RepeatNote=2-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417257_26052.0464.0RepeatNote=3-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417267_27052.0464.0RepeatNote=3-3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417295_29852.0464.0RepeatNote=3-4
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417324_32952.0464.0RepeatNote=2-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417399_42152.0464.0RepeatNote=1-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417404_40752.0464.0RepeatNote=3-5
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-41754_7652.0464.0RepeatNote=1-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-41759_6252.0464.0RepeatNote=3-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417245_25052.0465.0RepeatNote=2-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417257_26052.0465.0RepeatNote=3-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417267_27052.0465.0RepeatNote=3-3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417295_29852.0465.0RepeatNote=3-4
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417324_32952.0465.0RepeatNote=2-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417399_42152.0465.0RepeatNote=1-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417404_40752.0465.0RepeatNote=3-5
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-41754_7652.0465.0RepeatNote=1-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-41759_6252.0465.0RepeatNote=3-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417245_25052.0464.0RepeatNote=2-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417257_26052.0464.0RepeatNote=3-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417267_27052.0464.0RepeatNote=3-3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417295_29852.0464.0RepeatNote=3-4
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417324_32952.0464.0RepeatNote=2-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417399_42152.0464.0RepeatNote=1-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417404_40752.0464.0RepeatNote=3-5
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-41754_7652.0464.0RepeatNote=1-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-41759_6252.0464.0RepeatNote=3-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417245_25052.0465.0RepeatNote=2-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417257_26052.0465.0RepeatNote=3-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417267_27052.0465.0RepeatNote=3-3
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417295_29852.0465.0RepeatNote=3-4
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417324_32952.0465.0RepeatNote=2-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417399_42152.0465.0RepeatNote=1-2
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417404_40752.0465.0RepeatNote=3-5
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-41754_7652.0465.0RepeatNote=1-1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-41759_6252.0465.0RepeatNote=3-1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>839_HNRNPK_86592604_NR6A1_127316849_839_HNRNPK_86592604_NR6A1_127316849_ranked_0.pdbHNRNPK8659260486592604ENST00000487099NR6A1chr9127316849-
MHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSG
QEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLPQQARSLDPQ
SYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQ
IFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYK
411


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HNRNPK_pLDDT.png
all structure
all structure
NR6A1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HNRNPK
NR6A1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-31635_19752.0464.0ASFV p30
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-41735_19752.0464.0ASFV p30
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-41735_19752.0465.0ASFV p30
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-41735_19752.0464.0ASFV p30
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-41735_19752.0465.0ASFV p30
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000351839-316209_33752.0464.0ZIK1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000360384-417209_33752.0464.0ZIK1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376263-417209_33752.0465.0ZIK1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376264-417209_33752.0464.0ZIK1
HgeneHNRNPKchr9:86592604chr9:127316849ENST00000376281-417209_33752.0465.0ZIK1


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Related Drugs to HNRNPK-NR6A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HNRNPK-NR6A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource