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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HNRNPUL1-CYP2S1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HNRNPUL1-CYP2S1
	FusionPDB ID: 37309
	FusionGDB2.0 ID: 37309
		Hgene	Tgene
	Gene symbol	HNRNPUL1	CYP2S1
	Gene ID	11100	29785
	Gene name	heterogeneous nuclear ribonucleoprotein U like 1	cytochrome P450 family 2 subfamily S member 1
	Synonyms	E1B-AP5\|E1BAP5\|HNRPUL1	CYPIIS1
	Cytomap	19q13.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	heterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5	cytochrome P450 2S1cytochrome P450, family 2, subfamily S, polypeptide 1cytochrome P540, subfamily IIS, polypeptide 1hydroperoxy icosatetraenoate dehydratasethromboxane-A synthase
	Modification date	20200327	20200313
	UniProtAcc	Q9BUJ2	Q96SQ9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000378215, ENST00000392006, ENST00000602130, ENST00000263367, ENST00000352456, ENST00000593587, ENST00000595018, ENST00000594207,	ENST00000542619, ENST00000310054,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 14 X 12=3024	6 X 6 X 5=180
	# samples	20	7
	** MAII score	log2(20/3024*10)=-3.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HNRNPUL1 [Title/Abstract] AND CYP2S1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HNRNPUL1(41770597)-CYP2S1(41700449), # samples:1 HNRNPUL1(41770703)-CYP2S1(41700449), # samples:1 HNRNPUL1(41807609)-CYP2S1(41703684), # samples:1
Anticipated loss of major functional domain due to fusion event.	HNRNPUL1-CYP2S1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HNRNPUL1-CYP2S1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HNRNPUL1-CYP2S1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HNRNPUL1-CYP2S1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HNRNPUL1-CYP2S1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. HNRNPUL1-CYP2S1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CYP2S1	GO:0006690	icosanoid metabolic process	21068195
Tgene	CYP2S1	GO:0006693	prostaglandin metabolic process	21068195
Tgene	CYP2S1	GO:0042573	retinoic acid metabolic process	12711469

Fusion gene breakpoints across HNRNPUL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CYP2S1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-3561-01A	HNRNPUL1	chr19	41770597	+	CYP2S1	chr19	41700449	+
ChimerDB4	COAD	TCGA-AA-3561-01A	HNRNPUL1	chr19	41770703	+	CYP2S1	chr19	41700449	+
ChimerDB4	OV	TCGA-30-1718-01A	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000352456	HNRNPUL1	chr19	41807609	+	ENST00000310054	CYP2S1	chr19	41703684	+	3702	1479	11	2650	879
ENST00000595018	HNRNPUL1	chr19	41807609	+	ENST00000310054	CYP2S1	chr19	41703684	+	3679	1456	45	2627	860
ENST00000392006	HNRNPUL1	chr19	41807609	+	ENST00000310054	CYP2S1	chr19	41703684	+	4083	1860	44	3031	995
ENST00000378215	HNRNPUL1	chr19	41807609	+	ENST00000310054	CYP2S1	chr19	41703684	+	3700	1477	3	2648	881
ENST00000602130	HNRNPUL1	chr19	41807609	+	ENST00000310054	CYP2S1	chr19	41703684	+	3963	1740	53	2911	952
ENST00000593587	HNRNPUL1	chr19	41807609	+	ENST00000310054	CYP2S1	chr19	41703684	+	3704	1481	94	2652	852
ENST00000263367	HNRNPUL1	chr19	41807609	+	ENST00000310054	CYP2S1	chr19	41703684	+	3837	1614	161	2785	874

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000352456	ENST00000310054	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+	0.001778999	0.998221
ENST00000595018	ENST00000310054	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+	0.001864225	0.9981358
ENST00000392006	ENST00000310054	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+	0.003919193	0.9960808
ENST00000378215	ENST00000310054	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+	0.00480531	0.9951946
ENST00000602130	ENST00000310054	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+	0.00409883	0.99590117
ENST00000593587	ENST00000310054	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+	0.00200262	0.99799734
ENST00000263367	ENST00000310054	HNRNPUL1	chr19	41807609	+	CYP2S1	chr19	41703684	+	0.001519226	0.99848074

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37309_37309_1_HNRNPUL1-CYP2S1_HNRNPUL1_chr19_41807609_ENST00000263367_CYP2S1_chr19_41703684_ENST00000310054_length(amino acids)=874AA_BP=484
MRKEDPGICRWMRSWAFSYLDAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQF
QSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVC
FEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKN
GKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWA
IKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKA
IVICPTDEDLKDRTIKRTDEEGKDVPDHAVLEMKGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDP
SLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLD
ASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRL
PYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVC

--------------------------------------------------------------

>37309_37309_2_HNRNPUL1-CYP2S1_HNRNPUL1_chr19_41807609_ENST00000352456_CYP2S1_chr19_41703684_ENST00000310054_length(amino acids)=879AA_BP=489
MGGERERGSRTWARGGVSGLEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKP
DRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVR
RGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVEL
SFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAG
KTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEG
FQRKAIVICPTDEDLKDRTIKRTDEEGKDVPDHAVLEMKGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEG
RPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQH
QGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLG
DRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSL

--------------------------------------------------------------

>37309_37309_3_HNRNPUL1-CYP2S1_HNRNPUL1_chr19_41807609_ENST00000378215_CYP2S1_chr19_41703684_ENST00000310054_length(amino acids)=881AA_BP=491
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKDFECGNDV
ELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPA
AGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPF
EGFQRKAIVICPTDEDLKDRTIKRTDEEGKDVPDHAVLEMKGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGT
EGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQ
QHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS
LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPF

--------------------------------------------------------------

>37309_37309_4_HNRNPUL1-CYP2S1_HNRNPUL1_chr19_41807609_ENST00000392006_CYP2S1_chr19_41703684_ENST00000310054_length(amino acids)=995AA_BP=605
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERE
LDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAY
RPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARD
RSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFE
NYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSE
RIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAAR
KKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDEEGKDVPDHAVLEMKGVFFSNGERWRQLRKFTMLALRDLG
MGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRP
LPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLM
KYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHP
EEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHS

--------------------------------------------------------------

>37309_37309_5_HNRNPUL1-CYP2S1_HNRNPUL1_chr19_41807609_ENST00000593587_CYP2S1_chr19_41703684_ENST00000310054_length(amino acids)=852AA_BP=462
MDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDR
RGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPH
VVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYP
HVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMD
KMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDEEG
KDVPDHAVLEMKGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFS
YEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQN
PGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIP
RTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS

--------------------------------------------------------------

>37309_37309_6_HNRNPUL1-CYP2S1_HNRNPUL1_chr19_41807609_ENST00000595018_CYP2S1_chr19_41703684_ENST00000310054_length(amino acids)=860AA_BP=470
MEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRG
YFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHL
PSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEA
LGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNI
LGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRT
IKRTDEEGKDVPDHAVLEMKGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCS
LLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLL
KMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLL
ALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFF

--------------------------------------------------------------

>37309_37309_7_HNRNPUL1-CYP2S1_HNRNPUL1_chr19_41807609_ENST00000602130_CYP2S1_chr19_41703684_ENST00000310054_length(amino acids)=952AA_BP=562
MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVK
HLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQK
EALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKY
NILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKD
RTIKRTDEEGKDVPDHAVLEMKGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVV
CSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAF
LLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQR
LLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:41770597/chr19:41700449)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HNRNPUL1 Q9BUJ2	CYP2S1 Q96SQ9
FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269\|PubMed:12489984, ECO:0000269\|PubMed:9733834}.	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195). {ECO:0000269\|PubMed:12711469, ECO:0000269\|PubMed:21068195}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

191_388

448.3333333333333

753.0

Domain

B30.2/SPRY

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

3_37

448.3333333333333

753.0

Domain

SAP

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

191_388

562.3333333333334

857.0

Domain

B30.2/SPRY

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

3_37

562.3333333333334

857.0

Domain

SAP

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

191_388

462.3333333333333

757.0

Domain

B30.2/SPRY

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

3_37

462.3333333333333

757.0

Domain

SAP

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

191_388

462.3333333333333

757.0

Domain

B30.2/SPRY

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

3_37

462.3333333333333

757.0

Domain

SAP

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

191_388

562.3333333333334

805.0

Domain

B30.2/SPRY

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

3_37

562.3333333333334

805.0

Domain

SAP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

613_666

448.3333333333333

753.0

Compositional bias

Note=Gly-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

670_689

448.3333333333333

753.0

Compositional bias

Note=Asn-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

692_811

448.3333333333333

753.0

Compositional bias

Note=Pro-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

757_845

448.3333333333333

753.0

Compositional bias

Note=Tyr-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

806_832

448.3333333333333

753.0

Compositional bias

Note=Gln-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

613_666

562.3333333333334

857.0

Compositional bias

Note=Gly-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

670_689

562.3333333333334

857.0

Compositional bias

Note=Asn-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

692_811

562.3333333333334

857.0

Compositional bias

Note=Pro-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

757_845

562.3333333333334

857.0

Compositional bias

Note=Tyr-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

806_832

562.3333333333334

857.0

Compositional bias

Note=Gln-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

613_666

462.3333333333333

757.0

Compositional bias

Note=Gly-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

670_689

462.3333333333333

757.0

Compositional bias

Note=Asn-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

692_811

462.3333333333333

757.0

Compositional bias

Note=Pro-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

757_845

462.3333333333333

757.0

Compositional bias

Note=Tyr-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

806_832

462.3333333333333

757.0

Compositional bias

Note=Gln-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

613_666

462.3333333333333

757.0

Compositional bias

Note=Gly-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

670_689

462.3333333333333

757.0

Compositional bias

Note=Asn-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

692_811

462.3333333333333

757.0

Compositional bias

Note=Pro-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

757_845

462.3333333333333

757.0

Compositional bias

Note=Tyr-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

806_832

462.3333333333333

757.0

Compositional bias

Note=Gln-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

613_666

562.3333333333334

805.0

Compositional bias

Note=Gly-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

670_689

562.3333333333334

805.0

Compositional bias

Note=Asn-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

692_811

562.3333333333334

805.0

Compositional bias

Note=Pro-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

757_845

562.3333333333334

805.0

Compositional bias

Note=Tyr-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

806_832

562.3333333333334

805.0

Compositional bias

Note=Gln-rich

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

612_658

448.3333333333333

753.0

Region

Note=Necessary for transcription repression

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

612_658

562.3333333333334

857.0

Region

Note=Necessary for transcription repression

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

612_658

462.3333333333333

757.0

Region

Note=Necessary for transcription repression

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

612_658

462.3333333333333

757.0

Region

Note=Necessary for transcription repression

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

612_658

562.3333333333334

805.0

Region

Note=Necessary for transcription repression

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

612_614

448.3333333333333

753.0

Repeat

Note=1-1

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

620_622

448.3333333333333

753.0

Repeat

Note=1-2

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

639_641

448.3333333333333

753.0

Repeat

Note=1-3

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

645_647

448.3333333333333

753.0

Repeat

Note=1-4

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000378215

656_658

448.3333333333333

753.0

Repeat

Note=1-5

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

612_614

562.3333333333334

857.0

Repeat

Note=1-1

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

620_622

562.3333333333334

857.0

Repeat

Note=1-2

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

639_641

562.3333333333334

857.0

Repeat

Note=1-3

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

645_647

562.3333333333334

857.0

Repeat

Note=1-4

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000392006

656_658

562.3333333333334

857.0

Repeat

Note=1-5

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

612_614

462.3333333333333

757.0

Repeat

Note=1-1

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

620_622

462.3333333333333

757.0

Repeat

Note=1-2

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

639_641

462.3333333333333

757.0

Repeat

Note=1-3

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

645_647

462.3333333333333

757.0

Repeat

Note=1-4

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000593587

656_658

462.3333333333333

757.0

Repeat

Note=1-5

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

612_614

462.3333333333333

757.0

Repeat

Note=1-1

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

620_622

462.3333333333333

757.0

Repeat

Note=1-2

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

639_641

462.3333333333333

757.0

Repeat

Note=1-3

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

645_647

462.3333333333333

757.0

Repeat

Note=1-4

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000595018

656_658

462.3333333333333

757.0

Repeat

Note=1-5

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

612_614

562.3333333333334

805.0

Repeat

Note=1-1

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

620_622

562.3333333333334

805.0

Repeat

Note=1-2

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

639_641

562.3333333333334

805.0

Repeat

Note=1-3

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

645_647

562.3333333333334

805.0

Repeat

Note=1-4

Hgene

HNRNPUL1

chr19:41807609

chr19:41703684

ENST00000602130

656_658

562.3333333333334

805.0

Repeat

Note=1-5

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HNRNPUL1
CYP2S1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to HNRNPUL1-CYP2S1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to HNRNPUL1-CYP2S1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source