UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:HNRNPUL1-SLC8A2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HNRNPUL1-SLC8A2
FusionPDB ID: 37318
FusionGDB2.0 ID: 37318
HgeneTgene
Gene symbol

HNRNPUL1

SLC8A2

Gene ID

11100

6543

Gene nameheterogeneous nuclear ribonucleoprotein U like 1solute carrier family 8 member A2
SynonymsE1B-AP5|E1BAP5|HNRPUL1NCX2
Cytomap

19q13.2

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5sodium/calcium exchanger 2Na(+)/Ca(2+)-exchange protein 2Na+/Ca2+-exchanging protein Nac2solute carrier family 8 (sodium/calcium exchanger), member 2solute carrier family 8 member 2
Modification date2020032720200313
UniProtAcc

Q9BUJ2

.
Ensembl transtripts involved in fusion geneENST idsENST00000263367, ENST00000352456, 
ENST00000392006, ENST00000593587, 
ENST00000595018, ENST00000602130, 
ENST00000378215, ENST00000594207, 
ENST00000542837, ENST00000539381, 
ENST00000601757, ENST00000236877, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 14 X 12=30242 X 2 X 2=8
# samples 202
** MAII scorelog2(20/3024*10)=-3.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: HNRNPUL1 [Title/Abstract] AND SLC8A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HNRNPUL1(41787180)-SLC8A2(47960851), # samples:4
Anticipated loss of major functional domain due to fusion event.HNRNPUL1-SLC8A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-SLC8A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-SLC8A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-SLC8A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HNRNPUL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC8A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5518-01AHNRNPUL1chr19

41787180

-SLC8A2chr19

47960851

-
ChimerDB4PRADTCGA-EJ-5518-01AHNRNPUL1chr19

41787180

+SLC8A2chr19

47960851

-
ChimerDB4PRADTCGA-EJ-5518HNRNPUL1chr19

41787180

+SLC8A2chr19

47960851

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000352456HNRNPUL1chr1941787180+ENST00000236877SLC8A2chr1947960851-4954791112881956
ENST00000595018HNRNPUL1chr1941787180+ENST00000236877SLC8A2chr1947960851-4931768452858937
ENST00000392006HNRNPUL1chr1941787180+ENST00000236877SLC8A2chr1947960851-533511724432621072
ENST00000602130HNRNPUL1chr1941787180+ENST00000236877SLC8A2chr1947960851-521510525331421029
ENST00000593587HNRNPUL1chr1941787180+ENST00000236877SLC8A2chr1947960851-4956793942883929
ENST00000263367HNRNPUL1chr1941787180+ENST00000236877SLC8A2chr1947960851-50899261613016951

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000352456ENST00000236877HNRNPUL1chr1941787180+SLC8A2chr1947960851-0.0009578150.9990422
ENST00000595018ENST00000236877HNRNPUL1chr1941787180+SLC8A2chr1947960851-0.0009718240.9990282
ENST00000392006ENST00000236877HNRNPUL1chr1941787180+SLC8A2chr1947960851-0.0017571440.99824286
ENST00000602130ENST00000236877HNRNPUL1chr1941787180+SLC8A2chr1947960851-0.0015869730.99841297
ENST00000593587ENST00000236877HNRNPUL1chr1941787180+SLC8A2chr1947960851-0.0010499260.99895006
ENST00000263367ENST00000236877HNRNPUL1chr1941787180+SLC8A2chr1947960851-0.0011105970.9988894

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37318_37318_1_HNRNPUL1-SLC8A2_HNRNPUL1_chr19_41787180_ENST00000263367_SLC8A2_chr19_47960851_ENST00000236877_length(amino acids)=951AA_BP=255
MRKEDPGICRWMRSWAFSYLDAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQF
QSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVC
FEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAVWEALLTLVFFPVCV
VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKD
LEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG
GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPL
LATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHS
WREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK
DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGI

--------------------------------------------------------------

>37318_37318_2_HNRNPUL1-SLC8A2_HNRNPUL1_chr19_41787180_ENST00000352456_SLC8A2_chr19_47960851_ENST00000236877_length(amino acids)=956AA_BP=260
MGGERERGSRTWARGGVSGLEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKP
DRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVR
RGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAVWEALLTLVF
FPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQK
HPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLS
VTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGR
LVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKI
VDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALV
IGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGC
TVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVF

--------------------------------------------------------------

>37318_37318_3_HNRNPUL1-SLC8A2_HNRNPUL1_chr19_41787180_ENST00000392006_SLC8A2_chr19_47960851_ENST00000236877_length(amino acids)=1072AA_BP=376
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERE
LDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAY
RPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARD
RSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFE
NYGDKFAENDVIGCFAVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLG
PGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE
DDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFF
VRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGG
GVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRL
EVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW
ACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAV

--------------------------------------------------------------

>37318_37318_4_HNRNPUL1-SLC8A2_HNRNPUL1_chr19_41787180_ENST00000593587_SLC8A2_chr19_47960851_ENST00000236877_length(amino acids)=929AA_BP=233
MDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDR
RGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPH
VVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRT
DPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAF
YRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGS
DYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLL
HVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS
ALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDG
SREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASK
VAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPK

--------------------------------------------------------------

>37318_37318_5_HNRNPUL1-SLC8A2_HNRNPUL1_chr19_41787180_ENST00000595018_SLC8A2_chr19_47960851_ENST00000236877_length(amino acids)=937AA_BP=241
MEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRG
YFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHL
PSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAVWEALLTLVFFPVCVVFAWMADKRLLFYK
YVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALL
HQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTE
DGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGI
FSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP
QWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAG
DEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTS
IPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGE

--------------------------------------------------------------

>37318_37318_6_HNRNPUL1-SLC8A2_HNRNPUL1_chr19_41787180_ENST00000602130_SLC8A2_chr19_47960851_ENST00000236877_length(amino acids)=1029AA_BP=333
MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVK
HLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAVWEALLTLVFFPVCVVFAWMADKRLLF
YKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYA
LLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYR
TEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHA
GIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELG
QPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVS
AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALG
TSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:41787180/chr19:47960851)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPUL1

Q9BUJ2

.
FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+7153_37333.0857.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+7153_37233.0757.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+7153_37233.0757.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+7153_37333.0805.0DomainSAP
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110638_641225.0922.0Compositional biasNote=Poly-Glu
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110384_483225.0922.0DomainNote=Calx-beta 1
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110512_612225.0922.0DomainNote=Calx-beta 2
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110248_267225.0922.0RegionPutative calmodulin-binding region
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110790_826225.0922.0RepeatNote=Alpha-2
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110247_720225.0922.0Topological domainCytoplasmic
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110741_747225.0922.0Topological domainExtracellular
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110771_772225.0922.0Topological domainCytoplasmic
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110792_822225.0922.0Topological domainExtracellular
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110844_854225.0922.0Topological domainCytoplasmic
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110876_892225.0922.0Topological domainExtracellular
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110910_921225.0922.0Topological domainCytoplasmic
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110223_246225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110721_740225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110748_770225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110773_791225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110823_843225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110855_875225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110893_909225.0922.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114613_6660753.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114670_6890753.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114692_8110753.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114757_8450753.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114806_8320753.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715613_666333.0857.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715670_689333.0857.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715692_811333.0857.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715757_845333.0857.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715806_832333.0857.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715613_666233.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715670_689233.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715692_811233.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715757_845233.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715806_832233.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715613_666233.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715670_689233.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715692_811233.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715757_845233.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715806_832233.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715613_666333.0805.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715670_689333.0805.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715692_811333.0805.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715757_845333.0805.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715806_832333.0805.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114191_3880753.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+1143_370753.0DomainSAP
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715191_388333.0857.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715191_388233.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715191_388233.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715191_388333.0805.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114612_6580753.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715612_658333.0857.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715612_658233.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715612_658233.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715612_658333.0805.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114612_6140753.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114620_6220753.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114639_6410753.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114645_6470753.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000378215+114656_6580753.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715612_614333.0857.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715620_622333.0857.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715639_641333.0857.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715645_647333.0857.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000392006+715656_658333.0857.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715612_614233.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715620_622233.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715639_641233.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715645_647233.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000593587+715656_658233.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715612_614233.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715620_622233.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715639_641233.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715645_647233.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000595018+715656_658233.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715612_614333.0805.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715620_622333.0805.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715639_641333.0805.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715645_647333.0805.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41787180chr19:47960851ENST00000602130+715656_658333.0805.0RepeatNote=1-5
TgeneSLC8A2chr19:41787180chr19:47960851ENST0000023687711029_32225.0922.0Compositional biasNote=Poly-Pro
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110135_175225.0922.0RepeatNote=Alpha-1
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110153_164225.0922.0Topological domainExtracellular
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110186_196225.0922.0Topological domainCytoplasmic
TgeneSLC8A2chr19:41787180chr19:47960851ENST0000023687711021_68225.0922.0Topological domainExtracellular
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110220_222225.0922.0Topological domainExtracellular
TgeneSLC8A2chr19:41787180chr19:47960851ENST0000023687711091_130225.0922.0Topological domainCytoplasmic
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110131_152225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110165_185225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST00000236877110197_219225.0922.0TransmembraneHelical
TgeneSLC8A2chr19:41787180chr19:47960851ENST0000023687711069_90225.0922.0TransmembraneHelical


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1845_HNRNPUL1_41787180_SLC8A2_47960851_ranked_0.pdbHNRNPUL14178718041787180ENST00000236877SLC8A2chr1947960851-
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERE
LDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAY
RPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARD
RSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFE
NYGDKFAENDVIGCFAVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLG
PGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE
DDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFF
VRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGG
GVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRL
EVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW
ACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAV
1072


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HNRNPUL1_pLDDT.png
all structure
all structure
SLC8A2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HNRNPUL1
SLC8A2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to HNRNPUL1-SLC8A2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to HNRNPUL1-SLC8A2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource