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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HP-CFB

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HP-CFB
	FusionPDB ID: 37494
	FusionGDB2.0 ID: 37494
		Hgene	Tgene
	Gene symbol	HP	CFB
	Gene ID	10395	629
	Gene name	DLC1 Rho GTPase activating protein	complement factor B
	Synonyms	ARHGAP7\|HP\|STARD12\|p122-RhoGAP	AHUS4\|ARMD14\|BF\|BFD\|CFAB\|CFBD\|FB\|FBI12\|GBG\|H2-Bf\|PBF2
	Cytomap	8p22	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia	complement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
	Modification date	20200313	20200327
	UniProtAcc	P02790	P00751
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000355906, ENST00000357763, ENST00000398131, ENST00000562526, ENST00000569639, ENST00000570083, ENST00000565574,	ENST00000375455, ENST00000399981, ENST00000417261, ENST00000419411, ENST00000419920, ENST00000424727, ENST00000426239, ENST00000427888, ENST00000433503, ENST00000436692, ENST00000455591, ENST00000459734, ENST00000460958, ENST00000465211, ENST00000473139, ENST00000474621, ENST00000489605, ENST00000497841, ENST00000425368, ENST00000456570, ENST00000477310, ENST00000556679,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 11 X 3=297	17 X 11 X 9=1683
	# samples	10	20
	** MAII score	log2(10/297*10)=-1.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1683*10)=-3.07296327155522 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HP [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HP(72093066)-CFB(31918944), # samples:1
Anticipated loss of major functional domain due to fusion event.	HP-CFB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HP-CFB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HP-CFB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HP-CFB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HP	GO:0006915	apoptotic process	17292327
Hgene	HP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	17888903
Hgene	HP	GO:0008285	negative regulation of cell proliferation	12545165\|17932950
Hgene	HP	GO:0030336	negative regulation of cell migration	17932950\|19158340
Hgene	HP	GO:0035307	positive regulation of protein dephosphorylation	17292327
Hgene	HP	GO:0051497	negative regulation of stress fiber assembly	17932950
Hgene	HP	GO:0051895	negative regulation of focal adhesion assembly	19158340
Hgene	HP	GO:1900119	positive regulation of execution phase of apoptosis	17888903

Fusion gene breakpoints across HP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CFB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BC007464	HP	chr16	72093066	+	CFB	chr6	31918944	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000570083	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	706	272	19	687	222
ENST00000570083	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	706	272	19	687	222
ENST00000570083	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	688	272	19	687	223
ENST00000570083	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	742	272	19	687	222
ENST00000355906	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	880	446	16	861	281
ENST00000355906	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	880	446	16	861	281
ENST00000355906	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	862	446	16	861	282
ENST00000355906	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	916	446	16	861	281
ENST00000398131	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	689	255	2	670	222
ENST00000398131	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	689	255	2	670	222
ENST00000398131	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	671	255	2	670	223
ENST00000398131	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	725	255	2	670	222
ENST00000569639	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	948	514	525	929	134
ENST00000569639	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	948	514	525	929	134
ENST00000569639	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	930	514	525	929	134
ENST00000569639	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	984	514	525	929	134
ENST00000357763	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	957	523	27	938	303
ENST00000357763	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	957	523	27	938	303
ENST00000357763	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	939	523	27	938	303
ENST00000357763	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	993	523	27	938	303
ENST00000562526	HP	chr16	72093066	+	ENST00000556679	CFB	chr6	31918944	+	672	238	27	653	208
ENST00000562526	HP	chr16	72093066	+	ENST00000456570	CFB	chr6	31918944	+	672	238	27	653	208
ENST00000562526	HP	chr16	72093066	+	ENST00000477310	CFB	chr6	31918944	+	654	238	27	653	208
ENST00000562526	HP	chr16	72093066	+	ENST00000425368	CFB	chr6	31918944	+	708	238	27	653	208

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000570083	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005928626	0.9940713
ENST00000570083	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005928626	0.9940713
ENST00000570083	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.00612938	0.9938706
ENST00000570083	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.00604317	0.9939568
ENST00000355906	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005954868	0.99404514
ENST00000355906	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005954868	0.99404514
ENST00000355906	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006346113	0.9936539
ENST00000355906	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005616536	0.99438345
ENST00000398131	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006201833	0.9937982
ENST00000398131	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006201833	0.9937982
ENST00000398131	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.006546828	0.99345315
ENST00000398131	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005950078	0.9940499
ENST00000569639	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.15452811	0.84547186
ENST00000569639	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.15452811	0.84547186
ENST00000569639	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.15270771	0.8472923
ENST00000569639	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.16190442	0.8380956
ENST00000357763	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.003077754	0.9969222
ENST00000357763	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.003077754	0.9969222
ENST00000357763	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.003192858	0.9968072
ENST00000357763	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.002920458	0.9970796
ENST00000562526	ENST00000556679	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005132796	0.9948672
ENST00000562526	ENST00000456570	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005132796	0.9948672
ENST00000562526	ENST00000477310	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.005287633	0.99471235
ENST00000562526	ENST00000425368	HP	chr16	72093066	+	CFB	chr6	31918944	+	0.004720376	0.99527967

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37494_37494_1_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000425368_length(amino acids)=281AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------

>37494_37494_2_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000456570_length(amino acids)=281AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------

>37494_37494_3_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000477310_length(amino acids)=282AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------

>37494_37494_4_HP-CFB_HP_chr16_72093066_ENST00000355906_CFB_chr6_31918944_ENST00000556679_length(amino acids)=281AA_BP=143
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWIN
KAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYA
PGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLK

--------------------------------------------------------------

>37494_37494_5_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000425368_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------

>37494_37494_6_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000456570_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------

>37494_37494_7_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000477310_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------

>37494_37494_8_HP-CFB_HP_chr16_72093066_ENST00000357763_CFB_chr6_31918944_ENST00000556679_length(amino acids)=303AA_BP=165
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADD
GCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPKLPECEADIKALFVSEEEKKLT
RKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQ

--------------------------------------------------------------

>37494_37494_9_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000425368_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

>37494_37494_10_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000456570_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

>37494_37494_11_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000477310_length(amino acids)=223AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

>37494_37494_12_HP-CFB_HP_chr16_72093066_ENST00000398131_CFB_chr6_31918944_ENST00000556679_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

>37494_37494_13_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000425368_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------

>37494_37494_14_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000456570_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------

>37494_37494_15_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000477310_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------

>37494_37494_16_HP-CFB_HP_chr16_72093066_ENST00000562526_CFB_chr6_31918944_ENST00000556679_length(amino acids)=208AA_BP=70
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALFVSEEEKKLTRKEVY
IKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPA

--------------------------------------------------------------

>37494_37494_17_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000425368_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------

>37494_37494_18_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000456570_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------

>37494_37494_19_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000477310_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------

>37494_37494_20_HP-CFB_HP_chr16_72093066_ENST00000569639_CFB_chr6_31918944_ENST00000556679_length(amino acids)=134AA_BP=
MFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG

--------------------------------------------------------------

>37494_37494_21_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000425368_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

>37494_37494_22_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000456570_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

>37494_37494_23_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000477310_length(amino acids)=223AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

>37494_37494_24_HP-CFB_HP_chr16_72093066_ENST00000570083_CFB_chr6_31918944_ENST00000556679_length(amino acids)=222AA_BP=84
MPHSTALPEARPTKMSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDELPECEADIKALF
VSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:72093066/chr6:31918944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HP P02790	CFB P00751
FUNCTION: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000399981

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000417261

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419411

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000419920

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000424727

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000425368

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000426239

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000427888

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000433503

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000436692

477_757

765.0

Domain

Peptidase S1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

101_160

765.0

Domain

Sushi 2

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

163_220

765.0

Domain

Sushi 3

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

270_469

765.0

Domain

VWFA

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

35_100

765.0

Domain

Sushi 1

Tgene

CFB

chr16:72093066

chr6:31918944

ENST00000455591

477_757

765.0

Domain

Peptidase S1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

chr16:72093066

chr6:31918944

ENST00000355906

162_404

407.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000355906

31_88

407.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000355906

90_147

407.0

Domain

Sushi 2

Hgene

chr16:72093066

chr6:31918944

ENST00000398131

162_404

348.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000398131

31_88

348.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000398131

90_147

348.0

Domain

Sushi 2

Hgene

chr16:72093066

chr6:31918944

ENST00000565574

162_404

348.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000565574

31_88

348.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000565574

90_147

348.0

Domain

Sushi 2

Hgene

chr16:72093066

chr6:31918944

ENST00000570083

162_404

348.0

Domain

Peptidase S1

Hgene

chr16:72093066

chr6:31918944

ENST00000570083

31_88

348.0

Domain

Sushi 1

Hgene

chr16:72093066

chr6:31918944

ENST00000570083

90_147

348.0

Domain

Sushi 2

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HP
CFB

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000355906	+	1	7	318_323	0	407.0	CD163
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000398131	+	1	5	318_323	0	348.0	CD163
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000565574	+	1	5	318_323	0	348.0	CD163
Hgene	HP	chr16:72093066	chr6:31918944	ENST00000570083	+	1	5	318_323	0	348.0	CD163

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Related Drugs to HP-CFB

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HP-CFB

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source