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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HSP90AB1-PGD

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HSP90AB1-PGD
	FusionPDB ID: 37807
	FusionGDB2.0 ID: 37807
		Hgene	Tgene
	Gene symbol	HSP90AB1	PGD
	Gene ID	3326	26227
	Gene name	heat shock protein 90 alpha family class B member 1	phosphoglycerate dehydrogenase
	Synonyms	D6S182\|HSP84\|HSP90B\|HSPC2\|HSPCB	3-PGDH\|3PGDH\|HEL-S-113\|NLS\|NLS1\|PDG\|PGAD\|PGD\|PGDH\|PHGDHD\|SERA
	Cytomap	6p21.1	1p12
	Type of gene	protein-coding	protein-coding
	Description	heat shock protein HSP 90-betaHSP90-betaheat shock 84 kDaheat shock 90kD protein 1, betaheat shock protein 90 kDaheat shock protein 90kDa alpha (cytosolic), class B member 1heat shock protein 90kDa alpha family class B member 1	D-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenase
	Modification date	20200327	20200320
	UniProtAcc	P08238	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000353801, ENST00000371554, ENST00000371646,	ENST00000498356, ENST00000270776, ENST00000538557, ENST00000541529,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 20 X 7=2800	9 X 7 X 8=504
	# samples	22	10
	** MAII score	log2(22/2800*10)=-3.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/504*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HSP90AB1 [Title/Abstract] AND PGD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HSP90AB1(44218135)-PGD(10471475), # samples:1
Anticipated loss of major functional domain due to fusion event.	HSP90AB1-PGD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSP90AB1-PGD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HSP90AB1-PGD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HSP90AB1-PGD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HSP90AB1	GO:0007004	telomere maintenance via telomerase	10197982
Hgene	HSP90AB1	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	24613385
Hgene	HSP90AB1	GO:0031396	regulation of protein ubiquitination	16809764
Hgene	HSP90AB1	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	24613385
Hgene	HSP90AB1	GO:0032516	positive regulation of phosphoprotein phosphatase activity	26593036
Hgene	HSP90AB1	GO:0051131	chaperone-mediated protein complex assembly	10811660
Hgene	HSP90AB1	GO:0051973	positive regulation of telomerase activity	10197982
Hgene	HSP90AB1	GO:1901389	negative regulation of transforming growth factor beta activation	20599762
Hgene	HSP90AB1	GO:1905323	telomerase holoenzyme complex assembly	10197982
Hgene	HSP90AB1	GO:2000010	positive regulation of protein localization to cell surface	23431407

Fusion gene breakpoints across HSP90AB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PGD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-5577-01A	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000353801	HSP90AB1	chr6	44218135	+	ENST00000541529	PGD	chr1	10471475	+	1943	971	122	1903	593
ENST00000353801	HSP90AB1	chr6	44218135	+	ENST00000270776	PGD	chr1	10471475	+	2299	971	122	1903	593
ENST00000353801	HSP90AB1	chr6	44218135	+	ENST00000538557	PGD	chr1	10471475	+	2206	971	122	1903	593
ENST00000371646	HSP90AB1	chr6	44218135	+	ENST00000541529	PGD	chr1	10471475	+	1930	958	73	1890	605
ENST00000371646	HSP90AB1	chr6	44218135	+	ENST00000270776	PGD	chr1	10471475	+	2286	958	73	1890	605
ENST00000371646	HSP90AB1	chr6	44218135	+	ENST00000538557	PGD	chr1	10471475	+	2193	958	73	1890	605
ENST00000371554	HSP90AB1	chr6	44218135	+	ENST00000541529	PGD	chr1	10471475	+	2035	1063	214	1995	593
ENST00000371554	HSP90AB1	chr6	44218135	+	ENST00000270776	PGD	chr1	10471475	+	2391	1063	214	1995	593
ENST00000371554	HSP90AB1	chr6	44218135	+	ENST00000538557	PGD	chr1	10471475	+	2298	1063	214	1995	593

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000353801	ENST00000541529	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.002644081	0.99735594
ENST00000353801	ENST00000270776	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.00212151	0.99787855
ENST00000353801	ENST00000538557	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.002220675	0.9977793
ENST00000371646	ENST00000541529	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.002754729	0.9972453
ENST00000371646	ENST00000270776	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.002159331	0.99784064
ENST00000371646	ENST00000538557	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.002246479	0.99775356
ENST00000371554	ENST00000541529	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.001701868	0.9982981
ENST00000371554	ENST00000270776	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.001517301	0.99848276
ENST00000371554	ENST00000538557	HSP90AB1	chr6	44218135	+	PGD	chr1	10471475	+	0.001510984	0.998489

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37807_37807_1_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000353801_PGD_chr1_10471475_ENST00000270776_length(amino acids)=593AA_BP=283
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYK
SLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHL
LPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFM
LLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFY

--------------------------------------------------------------

>37807_37807_2_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000353801_PGD_chr1_10471475_ENST00000538557_length(amino acids)=593AA_BP=283
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYK
SLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHL
LPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFM
LLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFY

--------------------------------------------------------------

>37807_37807_3_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000353801_PGD_chr1_10471475_ENST00000541529_length(amino acids)=593AA_BP=283
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYK
SLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHL
LPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFM
LLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFY

--------------------------------------------------------------

>37807_37807_4_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000371554_PGD_chr1_10471475_ENST00000270776_length(amino acids)=593AA_BP=283
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYK
SLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHL
LPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFM
LLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFY

--------------------------------------------------------------

>37807_37807_5_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000371554_PGD_chr1_10471475_ENST00000538557_length(amino acids)=593AA_BP=283
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYK
SLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHL
LPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFM
LLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFY

--------------------------------------------------------------

>37807_37807_6_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000371554_PGD_chr1_10471475_ENST00000541529_length(amino acids)=593AA_BP=283
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTG
IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYK
SLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHL
LPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFM
LLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFY

--------------------------------------------------------------

>37807_37807_7_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000371646_PGD_chr1_10471475_ENST00000270776_length(amino acids)=605AA_BP=295
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPD
DITQEEYGEFYKSLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITAN
ILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALY
ASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGI

--------------------------------------------------------------

>37807_37807_8_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000371646_PGD_chr1_10471475_ENST00000538557_length(amino acids)=605AA_BP=295
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPD
DITQEEYGEFYKSLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITAN
ILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALY
ASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGI

--------------------------------------------------------------

>37807_37807_9_HSP90AB1-PGD_HSP90AB1_chr6_44218135_ENST00000371646_PGD_chr1_10471475_ENST00000541529_length(amino acids)=605AA_BP=295
MLTITYNPFLFKMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPD
DITQEEYGEFYKSLTNDWEDHLAVKVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITAN
ILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALY
ASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:44218135/chr1:10471475)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HSP90AB1 P08238	.
FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269\|PubMed:16478993, ECO:0000269\|PubMed:18239673, ECO:0000269\|PubMed:19696785, ECO:0000269\|PubMed:20353823, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:32272059, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PGD

chr6:44218135

chr1:10471475

ENST00000270776

478_481

173.0

484.0

Nucleotide binding

NADP%3B shared with dimeric partner

Tgene

PGD

chr6:44218135

chr1:10471475

ENST00000270776

187_188

173.0

484.0

Region

Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HSP90AB1

chr6:44218135

chr1:10471475

ENST00000353801

720_724

725.0

Motif

Note=TPR repeat-binding

Hgene

HSP90AB1

chr6:44218135

chr1:10471475

ENST00000371554

720_724

725.0

Motif

Note=TPR repeat-binding

Hgene

HSP90AB1

chr6:44218135

chr1:10471475

ENST00000371646

720_724

725.0

Motif

Note=TPR repeat-binding

Tgene

PGD

chr6:44218135

chr1:10471475

ENST00000270776

10_15

173.0

484.0

Nucleotide binding

NADP

Tgene

PGD

chr6:44218135

chr1:10471475

ENST00000270776

33_35

173.0

484.0

Nucleotide binding

NADP

Tgene

PGD

chr6:44218135

chr1:10471475

ENST00000270776

75_77

173.0

484.0

Nucleotide binding

NADP

Tgene

PGD

chr6:44218135

chr1:10471475

ENST00000270776

129_131

173.0

484.0

Region

Substrate binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HSP90AB1
PGD

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000353801	+	1	12	215_552	0	725.0	AHSA1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371554	+	1	12	215_552	0	725.0	AHSA1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371646	+	1	12	215_552	0	725.0	AHSA1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000353801	+	1	12	2_214	0	725.0	BIRC2
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371554	+	1	12	2_214	0	725.0	BIRC2
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371646	+	1	12	2_214	0	725.0	BIRC2
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000353801	+	1	12	620_723	0	725.0	NR1D1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371554	+	1	12	620_723	0	725.0	NR1D1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371646	+	1	12	620_723	0	725.0	NR1D1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000353801	+	1	12	264_608	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000353801	+	1	12	9_231	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371554	+	1	12	264_608	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371554	+	1	12	9_231	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371646	+	1	12	264_608	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371646	+	1	12	9_231	0	725.0	NR3C1
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000353801	+	1	12	2_527	0	725.0	TP53
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371554	+	1	12	2_527	0	725.0	TP53
Hgene	HSP90AB1	chr6:44218135	chr1:10471475	ENST00000371646	+	1	12	2_527	0	725.0	TP53

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Related Drugs to HSP90AB1-PGD

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HSP90AB1-PGD

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source