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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HSP90B1-ACVR1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HSP90B1-ACVR1B
FusionPDB ID: 37817
FusionGDB2.0 ID: 37817
HgeneTgene
Gene symbol

HSP90B1

ACVR1B

Gene ID

7184

91

Gene nameheat shock protein 90 beta family member 1activin A receptor type 1B
SynonymsECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1ACTRIB|ACVRLK4|ALK4|SKR2
Cytomap

12q23.3

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionendoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1heaactivin receptor type-1Bactivin A receptor, type IBactivin A receptor, type II-like kinase 4activin receptor-like kinase 4serine/threonine-protein kinase receptor R2
Modification date2020032020200313
UniProtAcc

P14625

P36896

Ensembl transtripts involved in fusion geneENST idsENST00000299767, ENST00000563121, 
ENST00000415850, ENST00000257963, 
ENST00000426655, ENST00000541224, 
ENST00000542485, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 19 X 10=36106 X 5 X 6=180
# samples 256
** MAII scorelog2(25/3610*10)=-3.85199883711245
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HSP90B1 [Title/Abstract] AND ACVR1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HSP90B1(104337652)-ACVR1B(52380602), # samples:1
Anticipated loss of major functional domain due to fusion event.HSP90B1-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HSP90B1-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HSP90B1-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HSP90B1-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HSP90B1-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
HSP90B1-ACVR1B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HSP90B1-ACVR1B seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90B1

GO:0001666

response to hypoxia

15620698

HgeneHSP90B1

GO:0031247

actin rod assembly

19000834

HgeneHSP90B1

GO:0043666

regulation of phosphoprotein phosphatase activity

19000834

HgeneHSP90B1

GO:0071318

cellular response to ATP

19000834

TgeneACVR1B

GO:0000082

G1/S transition of mitotic cell cycle

11117535

TgeneACVR1B

GO:0006355

regulation of transcription, DNA-templated

8622651|12665502

TgeneACVR1B

GO:0006468

protein phosphorylation

12065756

TgeneACVR1B

GO:0007165

signal transduction

8622651|12665502

TgeneACVR1B

GO:0018107

peptidyl-threonine phosphorylation

18039968

TgeneACVR1B

GO:0030308

negative regulation of cell growth

11117535

TgeneACVR1B

GO:0032924

activin receptor signaling pathway

9892009

TgeneACVR1B

GO:0032927

positive regulation of activin receptor signaling pathway

16720724

TgeneACVR1B

GO:0045648

positive regulation of erythrocyte differentiation

9032295

TgeneACVR1B

GO:0046777

protein autophosphorylation

18039968

TgeneACVR1B

GO:1901165

positive regulation of trophoblast cell migration

21356369


check buttonFusion gene breakpoints across HSP90B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACVR1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8531-01AHSP90B1chr12

104337652

+ACVR1Bchr12

52380602

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000299767HSP90B1chr12104337652+ENST00000257963ACVR1Bchr1252380602+555922091822590802
ENST00000299767HSP90B1chr12104337652+ENST00000541224ACVR1Bchr1252380602+269822091822590802
ENST00000299767HSP90B1chr12104337652+ENST00000426655ACVR1Bchr1252380602+281322091822503773
ENST00000299767HSP90B1chr12104337652+ENST00000542485ACVR1Bchr1252380602+340622091822590802

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299767ENST00000257963HSP90B1chr12104337652+ACVR1Bchr1252380602+0.0002363470.99976367
ENST00000299767ENST00000541224HSP90B1chr12104337652+ACVR1Bchr1252380602+0.0006423920.99935764
ENST00000299767ENST00000426655HSP90B1chr12104337652+ACVR1Bchr1252380602+0.0003626280.99963737
ENST00000299767ENST00000542485HSP90B1chr12104337652+ACVR1Bchr1252380602+0.0004804010.9995196

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37817_37817_1_HSP90B1-ACVR1B_HSP90B1_chr12_104337652_ENST00000299767_ACVR1B_chr12_52380602_ENST00000257963_length(amino acids)=802AA_BP=676
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTKYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVH

--------------------------------------------------------------

>37817_37817_2_HSP90B1-ACVR1B_HSP90B1_chr12_104337652_ENST00000299767_ACVR1B_chr12_52380602_ENST00000426655_length(amino acids)=773AA_BP=676
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTKYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVH

--------------------------------------------------------------

>37817_37817_3_HSP90B1-ACVR1B_HSP90B1_chr12_104337652_ENST00000299767_ACVR1B_chr12_52380602_ENST00000541224_length(amino acids)=802AA_BP=676
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTKYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVH

--------------------------------------------------------------

>37817_37817_4_HSP90B1-ACVR1B_HSP90B1_chr12_104337652_ENST00000299767_ACVR1B_chr12_52380602_ENST00000542485_length(amino acids)=802AA_BP=676
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTKYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVH

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:104337652/chr12:52380602)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90B1

P14625

ACVR1B

P36896

FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000250|UniProtKB:P08113, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:32272059}.FUNCTION: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. {ECO:0000269|PubMed:12364468, ECO:0000269|PubMed:12639945, ECO:0000269|PubMed:18039968, ECO:0000269|PubMed:20226172, ECO:0000269|PubMed:8196624, ECO:0000269|PubMed:9032295, ECO:0000269|PubMed:9892009}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSP90B1chr12:104337652chr12:52380602ENST00000299767+1418800_803675.6666666666666804.0MotifNote=Prevents secretion from ER
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000025796359177_206378.6666666666667506.0DomainGS
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000025796359207_497378.6666666666667506.0DomainProtein kinase
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000041585057177_206378.6666666666667488.0DomainGS
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000041585057207_497378.6666666666667488.0DomainProtein kinase
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000042665558177_206378.6666666666667477.0DomainGS
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000042665558207_497378.6666666666667477.0DomainProtein kinase
TgeneACVR1Bchr12:104337652chr12:52380602ENST00000541224610177_206419.6666666666667547.0DomainGS
TgeneACVR1Bchr12:104337652chr12:52380602ENST00000541224610207_497419.6666666666667547.0DomainProtein kinase
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000054248559177_206326.6666666666667454.0DomainGS
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000054248559207_497326.6666666666667454.0DomainProtein kinase
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000025796359213_221378.6666666666667506.0Nucleotide bindingATP
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000041585057213_221378.6666666666667488.0Nucleotide bindingATP
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000042665558213_221378.6666666666667477.0Nucleotide bindingATP
TgeneACVR1Bchr12:104337652chr12:52380602ENST00000541224610213_221419.6666666666667547.0Nucleotide bindingATP
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000054248559213_221326.6666666666667454.0Nucleotide bindingATP
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000025796359150_505378.6666666666667506.0Topological domainCytoplasmic
TgeneACVR1Bchr12:104337652chr12:52380602ENST000002579635924_126378.6666666666667506.0Topological domainExtracellular
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000041585057150_505378.6666666666667488.0Topological domainCytoplasmic
TgeneACVR1Bchr12:104337652chr12:52380602ENST000004158505724_126378.6666666666667488.0Topological domainExtracellular
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000042665558150_505378.6666666666667477.0Topological domainCytoplasmic
TgeneACVR1Bchr12:104337652chr12:52380602ENST000004266555824_126378.6666666666667477.0Topological domainExtracellular
TgeneACVR1Bchr12:104337652chr12:52380602ENST00000541224610150_505419.6666666666667547.0Topological domainCytoplasmic
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000054122461024_126419.6666666666667547.0Topological domainExtracellular
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000054248559150_505326.6666666666667454.0Topological domainCytoplasmic
TgeneACVR1Bchr12:104337652chr12:52380602ENST000005424855924_126326.6666666666667454.0Topological domainExtracellular
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000025796359127_149378.6666666666667506.0TransmembraneHelical
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000041585057127_149378.6666666666667488.0TransmembraneHelical
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000042665558127_149378.6666666666667477.0TransmembraneHelical
TgeneACVR1Bchr12:104337652chr12:52380602ENST00000541224610127_149419.6666666666667547.0TransmembraneHelical
TgeneACVR1Bchr12:104337652chr12:52380602ENST0000054248559127_149326.6666666666667454.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HSP90B1
ACVR1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HSP90B1-ACVR1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HSP90B1-ACVR1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource