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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HSP90B1-MDM2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HSP90B1-MDM2
FusionPDB ID: 37826
FusionGDB2.0 ID: 37826
HgeneTgene
Gene symbol

HSP90B1

MDM2

Gene ID

7184

4193

Gene nameheat shock protein 90 beta family member 1MDM2 proto-oncogene
SynonymsECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1ACTFS|HDMX|LSKB|hdm2
Cytomap

12q23.3

12q15

Type of geneprotein-codingprotein-coding
Descriptionendoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1heaE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum
Modification date2020032020200329
UniProtAcc

P14625

Q00987

Ensembl transtripts involved in fusion geneENST idsENST00000299767, ENST00000258148, 
ENST00000299252, ENST00000348801, 
ENST00000350057, ENST00000360430, 
ENST00000393410, ENST00000393412, 
ENST00000393413, ENST00000478070, 
ENST00000517852, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000258149, ENST00000356290, 
ENST00000428863, ENST00000462284, 
ENST00000540827, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 19 X 10=361012 X 10 X 6=720
# samples 2512
** MAII scorelog2(25/3610*10)=-3.85199883711245
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HSP90B1 [Title/Abstract] AND MDM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HSP90B1(104341208)-MDM2(69229609), # samples:1
Anticipated loss of major functional domain due to fusion event.HSP90B1-MDM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HSP90B1-MDM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HSP90B1-MDM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HSP90B1-MDM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90B1

GO:0001666

response to hypoxia

15620698

HgeneHSP90B1

GO:0031247

actin rod assembly

19000834

HgeneHSP90B1

GO:0043666

regulation of phosphoprotein phosphatase activity

19000834

HgeneHSP90B1

GO:0071318

cellular response to ATP

19000834

TgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

TgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

TgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

TgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

TgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

TgeneMDM2

GO:0034504

protein localization to nucleus

10360174

TgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

TgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

TgeneMDM2

GO:0045184

establishment of protein localization

10360174

TgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

TgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

TgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

TgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

TgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

TgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across HSP90B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MDM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-PC-A5DN-01AHSP90B1chr12

104341208

+MDM2chr12

69229609

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000299767HSP90B1chr12104341208+ENST00000462284MDM2chr1269229609+8959256418233731063
ENST00000299767HSP90B1chr12104341208+ENST00000356290MDM2chr1269229609+8956256418233731063
ENST00000299767HSP90B1chr12104341208+ENST00000540827MDM2chr1269229609+8956256418233731063
ENST00000299767HSP90B1chr12104341208+ENST00000258149MDM2chr1269229609+8956256418233731063
ENST00000299767HSP90B1chr12104341208+ENST00000428863MDM2chr1269229609+8878256418232951037

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299767ENST00000462284HSP90B1chr12104341208+MDM2chr1269229609+8.97E-050.99991024
ENST00000299767ENST00000356290HSP90B1chr12104341208+MDM2chr1269229609+8.93E-050.9999106
ENST00000299767ENST00000540827HSP90B1chr12104341208+MDM2chr1269229609+8.93E-050.9999106
ENST00000299767ENST00000258149HSP90B1chr12104341208+MDM2chr1269229609+8.93E-050.9999106
ENST00000299767ENST00000428863HSP90B1chr12104341208+MDM2chr1269229609+0.0001012050.9998988

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37826_37826_1_HSP90B1-MDM2_HSP90B1_chr12_104341208_ENST00000299767_MDM2_chr12_69229609_ENST00000258149_length(amino acids)=1063AA_BP=794
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKDLDAGVSEHSGDWLDQ
DSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALREN
WLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREE

--------------------------------------------------------------

>37826_37826_2_HSP90B1-MDM2_HSP90B1_chr12_104341208_ENST00000299767_MDM2_chr12_69229609_ENST00000356290_length(amino acids)=1063AA_BP=794
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKDLDAGVSEHSGDWLDQ
DSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALREN
WLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREE

--------------------------------------------------------------

>37826_37826_3_HSP90B1-MDM2_HSP90B1_chr12_104341208_ENST00000299767_MDM2_chr12_69229609_ENST00000428863_length(amino acids)=1037AA_BP=794
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKDLDAGVSEHSGDWLDQ
DSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEDYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGR

--------------------------------------------------------------

>37826_37826_4_HSP90B1-MDM2_HSP90B1_chr12_104341208_ENST00000299767_MDM2_chr12_69229609_ENST00000462284_length(amino acids)=1063AA_BP=794
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKDLDAGVSEHSGDWLDQ
DSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALREN
WLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREE

--------------------------------------------------------------

>37826_37826_5_HSP90B1-MDM2_HSP90B1_chr12_104341208_ENST00000299767_MDM2_chr12_69229609_ENST00000540827_length(amino acids)=1063AA_BP=794
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLII
NSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKK
YSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRET
LQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKDLDAGVSEHSGDWLDQ
DSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALREN
WLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:104341208/chr12:69229609)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90B1

P14625

MDM2

Q00987

FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000250|UniProtKB:P08113, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:32272059}.FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:30879903}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959210_215167.0437.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959243_301167.0437.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215210_21552.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215243_30152.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103210_21522.0266.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103243_30122.0266.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026210_21552.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026243_30152.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004210_21527.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203210_2150219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302210_2150.0219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302243_3010.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314210_21527.0271.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314243_30127.0271.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711243_301228.0498.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715210_21527.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:104341208chr12:69229609ENST000003488010326_10922.0266.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST000003604300426_10927.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST000003934120326_1090219.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST000003934130226_1090.0219.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST000004288631426_10927.0271.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST000005408271526_10927.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959179_185167.0437.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959190_202167.0437.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959466_473167.0437.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215179_18552.0322.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215190_20252.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215466_47352.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103179_18522.0266.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103190_20222.0266.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103466_47322.0266.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026179_18552.0322.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026190_20252.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026466_47352.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004179_18527.0297.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004190_20227.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004466_47327.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203179_1850219.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203190_2020219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203466_4730219.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302179_1850.0219.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302190_2020.0219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302466_4730.0219.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314179_18527.0271.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314190_20227.0271.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314466_47327.0271.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711466_473228.0498.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715179_18527.0297.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715190_20227.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715466_47327.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959210_304167.0437.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959242_331167.0437.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215210_30452.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215242_33152.0322.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103210_30422.0266.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103242_33122.0266.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026210_30452.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026242_33152.0322.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004210_30427.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004242_33127.0297.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST00000393412031_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203210_3040219.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203242_3310219.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST00000393413021_1010.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302210_3040.0219.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302242_3310.0219.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314210_30427.0271.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314242_33127.0271.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711242_331228.0498.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715210_30427.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715242_33127.0297.0RegionNote=Region II
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959299_328167.0437.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959438_479167.0437.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215299_32852.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000029925215438_47952.0322.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103299_32822.0266.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000034880103438_47922.0266.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026299_32852.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000035629026438_47952.0322.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004299_32827.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000036043004438_47927.0297.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203299_3280219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341203438_4790219.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302299_3280.0219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000039341302438_4790.0219.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314299_32827.0271.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000042886314438_47927.0271.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711299_328228.0498.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711438_479228.0498.0Zinc fingerRING-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715299_32827.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:104341208chr12:69229609ENST0000054082715438_47927.0297.0Zinc fingerRING-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSP90B1chr12:104341208chr12:69229609ENST00000299767+1718800_803794.0804.0MotifNote=Prevents secretion from ER
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711210_215228.0498.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:104341208chr12:69229609ENST000002581495926_109167.0437.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST000002992521526_10952.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST000003562902626_10952.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST0000046228471126_109228.0498.0DomainSWIB/MDM2
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711179_185228.0498.0MotifNuclear localization signal
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711190_202228.0498.0MotifNote=Nuclear export signal
TgeneMDM2chr12:104341208chr12:69229609ENST00000258149591_101167.0437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST00000299252151_10152.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST00000348801031_10122.0266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST00000356290261_10152.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST00000360430041_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST00000428863141_10127.0271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST000004622847111_101228.0498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711210_304228.0498.0RegionNote=ARF-binding
TgeneMDM2chr12:104341208chr12:69229609ENST00000540827151_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HSP90B1
MDM2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711170_306228.0498.0MTBP
TgeneMDM2chr12:104341208chr12:69229609ENST0000025814959150_230167.0437.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711150_230228.0498.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:104341208chr12:69229609ENST00000462284711223_232228.0498.0USP7


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Related Drugs to HSP90B1-MDM2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HSP90B1-MDM2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource