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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:IGDCC3-GLDN

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: IGDCC3-GLDN
	FusionPDB ID: 38464
	FusionGDB2.0 ID: 38464
		Hgene	Tgene
	Gene symbol	IGDCC3	GLDN
	Gene ID	9543	342035
	Gene name	immunoglobulin superfamily DCC subclass member 3	gliomedin
	Synonyms	HsT18880\|PUNC	CLOM\|COLM\|CRG-L2\|CRGL2\|LCCS11\|UNC-112\|UNC-122
	Cytomap	15q22.31	15q21.2
	Type of gene	protein-coding	protein-coding
	Description	immunoglobulin superfamily DCC subclass member 3putative neuronal cell adhesion molecule	gliomedincollomincolmedin
	Modification date	20200313	20200313
	UniProtAcc	Q8IVU1	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000327987, ENST00000559231,	ENST00000335449, ENST00000396399,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 3=48	5 X 5 X 4=100
	# samples	5	6
	** MAII score	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: IGDCC3 [Title/Abstract] AND GLDN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	IGDCC3(65667435)-GLDN(51675982), # samples:3
Anticipated loss of major functional domain due to fusion event.	IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across IGDCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GLDN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DB-5277-01A	IGDCC3	chr15	65667435	-	GLDN	chr15	51675982	+
ChimerDB4	LGG	TCGA-DB-5277	IGDCC3	chr15	65667434	-	GLDN	chr15	51675981	+
ChimerDB4	LGG	TCGA-DB-5277	IGDCC3	chr15	65667435	-	GLDN	chr15	51675982	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000327987	IGDCC3	chr15	65667435	-	ENST00000335449	GLDN	chr15	51675982	+	5143	661	237	1883	548
ENST00000327987	IGDCC3	chr15	65667435	-	ENST00000396399	GLDN	chr15	51675982	+	5135	661	237	1883	548
ENST00000327987	IGDCC3	chr15	65667434	-	ENST00000335449	GLDN	chr15	51675981	+	5143	661	237	1883	548
ENST00000327987	IGDCC3	chr15	65667434	-	ENST00000396399	GLDN	chr15	51675981	+	5135	661	237	1883	548

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000327987	ENST00000335449	IGDCC3	chr15	65667435	-	GLDN	chr15	51675982	+	0.000652547	0.9993474
ENST00000327987	ENST00000396399	IGDCC3	chr15	65667435	-	GLDN	chr15	51675982	+	0.000655844	0.99934417
ENST00000327987	ENST00000335449	IGDCC3	chr15	65667434	-	GLDN	chr15	51675981	+	0.000652547	0.9993474
ENST00000327987	ENST00000396399	IGDCC3	chr15	65667434	-	GLDN	chr15	51675981	+	0.000655844	0.99934417

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>38464_38464_1_IGDCC3-GLDN_IGDCC3_chr15_65667434_ENST00000327987_GLDN_chr15_51675981_ENST00000335449_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ

--------------------------------------------------------------

>38464_38464_2_IGDCC3-GLDN_IGDCC3_chr15_65667434_ENST00000327987_GLDN_chr15_51675981_ENST00000396399_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ

--------------------------------------------------------------

>38464_38464_3_IGDCC3-GLDN_IGDCC3_chr15_65667435_ENST00000327987_GLDN_chr15_51675982_ENST00000335449_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ

--------------------------------------------------------------

>38464_38464_4_IGDCC3-GLDN_IGDCC3_chr15_65667435_ENST00000327987_GLDN_chr15_51675982_ENST00000396399_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:65667435/chr15:51675982)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IGDCC3 Q8IVU1	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

36_139

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 1

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

36_139

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 1

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000335449

237_264

144.33333333333334

552.0

Compositional bias

Note=Pro-rich

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000396399

237_264

20.333333333333332

428.0

Compositional bias

Note=Pro-rich

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000335449

237_264

144.33333333333334

552.0

Compositional bias

Note=Pro-rich

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000396399

237_264

20.333333333333332

428.0

Compositional bias

Note=Pro-rich

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000335449

196_222

144.33333333333334

552.0

Domain

Note=Collagen-like 2

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000335449

299_546

144.33333333333334

552.0

Domain

Olfactomedin-like

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000396399

137_195

20.333333333333332

428.0

Domain

Note=Collagen-like 1

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000396399

196_222

20.333333333333332

428.0

Domain

Note=Collagen-like 2

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000396399

299_546

20.333333333333332

428.0

Domain

Olfactomedin-like

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000335449

196_222

144.33333333333334

552.0

Domain

Note=Collagen-like 2

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000335449

299_546

144.33333333333334

552.0

Domain

Olfactomedin-like

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000396399

137_195

20.333333333333332

428.0

Domain

Note=Collagen-like 1

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000396399

196_222

20.333333333333332

428.0

Domain

Note=Collagen-like 2

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000396399

299_546

20.333333333333332

428.0

Domain

Olfactomedin-like

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000396399

40_551

20.333333333333332

428.0

Topological domain

Extracellular

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000396399

40_551

20.333333333333332

428.0

Topological domain

Extracellular

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000396399

18_39

20.333333333333332

428.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000396399

18_39

20.333333333333332

428.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

783_786

136.33333333333334

815.0

Compositional bias

Note=Poly-Pro

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

783_786

136.33333333333334

815.0

Compositional bias

Note=Poly-Pro

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

140_220

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 2

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

238_321

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 3

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

329_416

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 4

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

426_520

136.33333333333334

815.0

Domain

Fibronectin type-III 1

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

523_618

136.33333333333334

815.0

Domain

Fibronectin type-III 2

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

140_220

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 2

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

238_321

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 3

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

329_416

136.33333333333334

815.0

Domain

Note=Ig-like C2-type 4

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

426_520

136.33333333333334

815.0

Domain

Fibronectin type-III 1

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

523_618

136.33333333333334

815.0

Domain

Fibronectin type-III 2

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

36_640

136.33333333333334

815.0

Topological domain

Extracellular

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

662_814

136.33333333333334

815.0

Topological domain

Cytoplasmic

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

36_640

136.33333333333334

815.0

Topological domain

Extracellular

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

662_814

136.33333333333334

815.0

Topological domain

Cytoplasmic

Hgene

IGDCC3

chr15:65667434

chr15:51675981

ENST00000327987

641_661

136.33333333333334

815.0

Transmembrane

Helical

Hgene

IGDCC3

chr15:65667435

chr15:51675982

ENST00000327987

641_661

136.33333333333334

815.0

Transmembrane

Helical

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000335449

137_195

144.33333333333334

552.0

Domain

Note=Collagen-like 1

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000335449

137_195

144.33333333333334

552.0

Domain

Note=Collagen-like 1

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000335449

1_17

144.33333333333334

552.0

Topological domain

Cytoplasmic

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000335449

40_551

144.33333333333334

552.0

Topological domain

Extracellular

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000396399

1_17

20.333333333333332

428.0

Topological domain

Cytoplasmic

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000335449

1_17

144.33333333333334

552.0

Topological domain

Cytoplasmic

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000335449

40_551

144.33333333333334

552.0

Topological domain

Extracellular

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000396399

1_17

20.333333333333332

428.0

Topological domain

Cytoplasmic

Tgene

GLDN

chr15:65667434

chr15:51675981

ENST00000335449

18_39

144.33333333333334

552.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

GLDN

chr15:65667435

chr15:51675982

ENST00000335449

18_39

144.33333333333334

552.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1172_IGDCC3_65667435_GLDN_51675982_1172_IGDCC3_65667435_GLDN_51675982_ranked_0.pdb	IGDCC3	65667434	65667435	ENST00000396399	GLDN	chr15	51675982	+	MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ	548

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

IGDCC3_pLDDT.png

GLDN_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
IGDCC3
GLDN

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to IGDCC3-GLDN

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to IGDCC3-GLDN

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source