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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ALDH1A2-ADAM10

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ALDH1A2-ADAM10
	FusionPDB ID: 3847
	FusionGDB2.0 ID: 3847
		Hgene	Tgene
	Gene symbol	ALDH1A2	ADAM10
	Gene ID	8854	102
	Gene name	aldehyde dehydrogenase 1 family member A2	ADAM metallopeptidase domain 10
	Synonyms	RALDH(II)\|RALDH2\|RALDH2-T	AD10\|AD18\|CD156c\|CDw156\|HsT18717\|MADM\|RAK\|kuz
	Cytomap	15q21.3	15q21.3
	Type of gene	protein-coding	protein-coding
	Description	retinal dehydrogenase 2RALDH 2retinaldehyde-specific dehydrogenase type 2	disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease
	Modification date	20200313	20200329
	UniProtAcc	O94788	O14672
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000249750, ENST00000347587, ENST00000537372, ENST00000558231, ENST00000559517, ENST00000559579,	ENST00000558733, ENST00000396140, ENST00000402627, ENST00000561288, ENST00000260408,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 3 X 3=18	12 X 10 X 8=960
	# samples	3	13
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/960*10)=-2.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ALDH1A2 [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ADAM10(59041679)-ALDH1A2(58712304), # samples:1 ALDH1A2(58302847)-ADAM10(59009926), # samples:1 ALDH1A2(58623378)-ADAM10(58891923), # samples:1
Anticipated loss of major functional domain due to fusion event.	ALDH1A2-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH1A2-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ALDH1A2	GO:0002138	retinoic acid biosynthetic process	29240402
Hgene	ALDH1A2	GO:0008285	negative regulation of cell proliferation	16166285
Hgene	ALDH1A2	GO:0034097	response to cytokine	18495959
Hgene	ALDH1A2	GO:0051289	protein homotetramerization	29240402
Tgene	ADAM10	GO:0006509	membrane protein ectodomain proteolysis	12714508\|17557115\|18355449\|18419754\|18676862\|19114711
Tgene	ADAM10	GO:0007162	negative regulation of cell adhesion	12714508
Tgene	ADAM10	GO:0034612	response to tumor necrosis factor	11831872
Tgene	ADAM10	GO:0051089	constitutive protein ectodomain proteolysis	12714508

Fusion gene breakpoints across ALDH1A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-1736-01B	ALDH1A2	chr15	58302847	-	ADAM10	chr15	59009926	-
ChimerDB4	SKCM	TCGA-ER-A19C-06A	ALDH1A2	chr15	58623378	-	ADAM10	chr15	58891923	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000249750	ALDH1A2	chr15	58302847	-	ENST00000260408	ADAM10	chr15	59009926	-	5796	1261	672	3452	926
ENST00000347587	ALDH1A2	chr15	58302847	-	ENST00000260408	ADAM10	chr15	59009926	-	5116	581	88	2772	894
ENST00000537372	ALDH1A2	chr15	58302847	-	ENST00000260408	ADAM10	chr15	59009926	-	5143	608	178	2799	873
ENST00000558231	ALDH1A2	chr15	58302847	-	ENST00000260408	ADAM10	chr15	59009926	-	5001	466	18	2657	879
ENST00000559517	ALDH1A2	chr15	58302847	-	ENST00000260408	ADAM10	chr15	59009926	-	4909	374	136	2565	809

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000249750	ENST00000260408	ALDH1A2	chr15	58302847	-	ADAM10	chr15	59009926	-	0.000209873	0.99979013
ENST00000347587	ENST00000260408	ALDH1A2	chr15	58302847	-	ADAM10	chr15	59009926	-	0.000191041	0.99980897
ENST00000537372	ENST00000260408	ALDH1A2	chr15	58302847	-	ADAM10	chr15	59009926	-	7.32E-05	0.9999268
ENST00000558231	ENST00000260408	ALDH1A2	chr15	58302847	-	ADAM10	chr15	59009926	-	0.000114643	0.9998853
ENST00000559517	ENST00000260408	ALDH1A2	chr15	58302847	-	ADAM10	chr15	59009926	-	0.0001933	0.9998067

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3847_3847_1_ALDH1A2-ADAM10_ALDH1A2_chr15_58302847_ENST00000249750_ADAM10_chr15_59009926_ENST00000260408_length(amino acids)=926AA_BP=196
MPIYRRARPRAADRAHSPHCPTPRARDTRPATMTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVY
NPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFR
YYAGWADKIHGMTIPVGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSN
KVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERM
RKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMV
KRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGI
ITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCF
VESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTAL
CPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPC
NDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKR

--------------------------------------------------------------

>3847_3847_2_ALDH1A2-ADAM10_ALDH1A2_chr15_58302847_ENST00000347587_ADAM10_chr15_59009926_ENST00000260408_length(amino acids)=894AA_BP=164
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSL
GSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVGQYGNPLNKYIRHYEG
LSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRF
EGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRT
TSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELN
SEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHD
SGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECC
FDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEK
YGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSP

--------------------------------------------------------------

>3847_3847_3_ALDH1A2-ADAM10_ALDH1A2_chr15_58302847_ENST00000537372_ADAM10_chr15_59009926_ENST00000260408_length(amino acids)=873AA_BP=143
MKNQCETVWLKSPIKLKLIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLAD
LVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSH
EDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIK
DRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKY
YGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDD
GVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNY
IMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSP
SQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCH
VCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMG

--------------------------------------------------------------

>3847_3847_4_ALDH1A2-ADAM10_ALDH1A2_chr15_58302847_ENST00000558231_ADAM10_chr15_59009926_ENST00000260408_length(amino acids)=879AA_BP=149
MVSGCLWSCTYSFFMKGRNWKTTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRL
LDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRA
KRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEP
AERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTD
HLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFT
DRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQ
KENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKP
GKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKD
DKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWW

--------------------------------------------------------------

>3847_3847_5_ALDH1A2-ADAM10_ALDH1A2_chr15_58302847_ENST00000559517_ADAM10_chr15_59009926_ENST00000260408_length(amino acids)=809AA_BP=79
MAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVGQYGNPLNKYI
RHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSV
IDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELL
RKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEK
FLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNF
GSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQC
KDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAG
SICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:59041679/chr15:58712304)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ALDH1A2 O94788	ADAM10 O14672
FUNCTION: Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity). {ECO:0000250\|UniProtKB:Q63639, ECO:0000269\|PubMed:29240402}.	FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-\|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905, PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). {ECO:0000250\|UniProtKB:O35598, ECO:0000269\|PubMed:11477090, ECO:0000269\|PubMed:11786905, ECO:0000269\|PubMed:12475894, ECO:0000269\|PubMed:16239146, ECO:0000269\|PubMed:17557115, ECO:0000269\|PubMed:19114711, ECO:0000269\|PubMed:20592283, ECO:0000269\|PubMed:21288900, ECO:0000269\|PubMed:24990881, ECO:0000269\|PubMed:26686862, ECO:0000269\|PubMed:26876177, ECO:0000269\|PubMed:29224781}.; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. {ECO:0000269\|PubMed:20624979, ECO:0000269\|PubMed:30463011}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

555_673

18.333333333333332

749.0

Compositional bias

Cys-rich

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

220_456

18.333333333333332

749.0

Domain

Peptidase M12B

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

457_551

18.333333333333332

749.0

Domain

Disintegrin

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

171_178

18.333333333333332

749.0

Motif

Cysteine switch

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

708_715

18.333333333333332

749.0

Motif

SH3-binding

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

722_728

18.333333333333332

749.0

Motif

SH3-binding

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

20_672

18.333333333333332

749.0

Topological domain

Extracellular

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

694_748

18.333333333333332

749.0

Topological domain

Cytoplasmic

Tgene

ADAM10

chr15:58302847

chr15:59009926

ENST00000260408

673_693

18.333333333333332

749.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000249750

184_186

164.33333333333334

519.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000249750

210_213

164.33333333333334

519.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000249750

264_266

164.33333333333334

519.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000249750

366_370

164.33333333333334

519.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000347587

184_186

164.33333333333334

481.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000347587

210_213

164.33333333333334

481.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000347587

264_266

164.33333333333334

481.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000347587

366_370

164.33333333333334

481.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000537372

184_186

143.33333333333334

498.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000537372

210_213

143.33333333333334

498.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000537372

264_266

143.33333333333334

498.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000537372

366_370

143.33333333333334

498.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000559517

184_186

68.33333333333333

423.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000559517

210_213

68.33333333333333

423.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000559517

264_266

68.33333333333333

423.0

Nucleotide binding

NAD

Hgene

ALDH1A2

chr15:58302847

chr15:59009926

ENST00000559517

366_370

68.33333333333333

423.0

Nucleotide binding

NAD

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ALDH1A2
ADAM10

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ALDH1A2-ADAM10

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ALDH1A2-ADAM10

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source