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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IGFBP3-ZDHHC8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IGFBP3-ZDHHC8
FusionPDB ID: 38579
FusionGDB2.0 ID: 38579
HgeneTgene
Gene symbol

IGFBP3

ZDHHC8

Gene ID

3486

29801

Gene nameinsulin like growth factor binding protein 3zinc finger DHHC-type palmitoyltransferase 8
SynonymsBP-53|IBP3DHHC8|ZDHHCL1|ZNF378
Cytomap

7p12.3

22q11.21

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding proteinprobable palmitoyltransferase ZDHHC8membrane-associated DHHC8 zinc finger proteinzinc finger DHHC-type containing 8zinc finger protein 378zinc finger, DHHC domain like containing 1
Modification date2020031520200313
UniProtAcc

P17936

.
Ensembl transtripts involved in fusion geneENST idsENST00000275521, ENST00000381083, 
ENST00000381086, ENST00000465642, 
ENST00000468112, ENST00000320602, 
ENST00000334554, ENST00000405930, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 4=3242 X 3 X 2=12
# samples 93
** MAII scorelog2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IGFBP3 [Title/Abstract] AND ZDHHC8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IGFBP3(45956812)-ZDHHC8(20128140), # samples:1
Anticipated loss of major functional domain due to fusion event.IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
IGFBP3-ZDHHC8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGFBP3

GO:0001933

negative regulation of protein phosphorylation

17591901

HgeneIGFBP3

GO:0006468

protein phosphorylation

17434920

HgeneIGFBP3

GO:0014912

negative regulation of smooth muscle cell migration

10766744

HgeneIGFBP3

GO:0045663

positive regulation of myoblast differentiation

12599210

HgeneIGFBP3

GO:0048662

negative regulation of smooth muscle cell proliferation

10766744

TgeneZDHHC8

GO:0018345

protein palmitoylation

23034182


check buttonFusion gene breakpoints across IGFBP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZDHHC8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5730-11AIGFBP3chr7

45956812

-ZDHHC8chr22

20128140

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000275521IGFBP3chr745956812-ENST00000334554ZDHHC8chr2220128140+5009764262401791
ENST00000275521IGFBP3chr745956812-ENST00000320602ZDHHC8chr2220128140+3452764262401791
ENST00000275521IGFBP3chr745956812-ENST00000405930ZDHHC8chr2220128140+3216764262440804
ENST00000381083IGFBP3chr745956812-ENST00000334554ZDHHC8chr2220128140+500475932396797
ENST00000381083IGFBP3chr745956812-ENST00000320602ZDHHC8chr2220128140+344775932396797
ENST00000381083IGFBP3chr745956812-ENST00000405930ZDHHC8chr2220128140+321175932435810

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000275521ENST00000334554IGFBP3chr745956812-ZDHHC8chr2220128140+0.0302456780.96975434
ENST00000275521ENST00000320602IGFBP3chr745956812-ZDHHC8chr2220128140+0.04473340.95526665
ENST00000275521ENST00000405930IGFBP3chr745956812-ZDHHC8chr2220128140+0.0599887150.94001126
ENST00000381083ENST00000334554IGFBP3chr745956812-ZDHHC8chr2220128140+0.0330355540.9669644
ENST00000381083ENST00000320602IGFBP3chr745956812-ZDHHC8chr2220128140+0.049211910.950788
ENST00000381083ENST00000405930IGFBP3chr745956812-ZDHHC8chr2220128140+0.067203710.9327963

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>38579_38579_1_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000320602_length(amino acids)=791AA_BP=246
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDR
SAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCGNVEHVL
CSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPR
PGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASD
AFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGAT
GDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRY
GSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFI

--------------------------------------------------------------

>38579_38579_2_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000334554_length(amino acids)=791AA_BP=246
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDR
SAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCGNVEHVL
CSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPR
PGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASD
AFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGAT
GDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRY
GSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFI

--------------------------------------------------------------

>38579_38579_3_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000405930_length(amino acids)=804AA_BP=246
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDR
SAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCGNVEHVL
CSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPR
PGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASD
AFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGAT
GDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRY
GSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFI

--------------------------------------------------------------

>38579_38579_4_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000320602_length(amino acids)=797AA_BP=252
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNAS
ESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCG
NVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSS
DLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSP
PLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPY
LHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPR
GPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGP

--------------------------------------------------------------

>38579_38579_5_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000334554_length(amino acids)=797AA_BP=252
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNAS
ESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCG
NVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSS
DLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSP
PLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPY
LHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPR
GPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGP

--------------------------------------------------------------

>38579_38579_6_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000405930_length(amino acids)=810AA_BP=252
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNAS
ESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCG
NVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSS
DLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSP
PLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPY
LHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPR
GPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGP
KAVAFIHTDLPEPPPSLTVQRGRIGTCTRGWGRRGQPWVPPGLHLCHLGRPEDRPPLRAPWSQAAGAPPRGAMCRLHLAASSLFPSLSGP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:45956812/chr22:20128140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP3

P17936

.
FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000275521-25138_161210.0496.6666666666667Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000275521-25192_208210.0496.6666666666667Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000381083-25138_161216.0102.0Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000381083-25192_208216.0102.0Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000275521-2536_117210.0496.6666666666667DomainIGFBP N-terminal
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000381083-25210_285216.0102.0DomainThyroglobulin type-1
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000381083-2536_117216.0102.0DomainIGFBP N-terminal
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000275521-2528_134210.0496.6666666666667RegionIGF-binding
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000381083-2528_134216.0102.0RegionIGF-binding
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000032060229170_190128.0674.0Topological domainLumenal
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000032060229212_765128.0674.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000032060229149_169128.0674.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000032060229191_211128.0674.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGFBP3chr7:45956812chr22:20128140ENST00000275521-25210_285210.0496.6666666666667DomainThyroglobulin type-1
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000032060229104_154128.0674.0DomainDHHC
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000334554411104_154220.0766.0DomainDHHC
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000405930411104_154220.0779.0DomainDHHC
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000320602291_13128.0674.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST000003206022935_52128.0674.0Topological domainLumenal
TgeneZDHHC8chr7:45956812chr22:20128140ENST000003206022974_148128.0674.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000334554411170_190220.0766.0Topological domainLumenal
TgeneZDHHC8chr7:45956812chr22:20128140ENST000003345544111_13220.0766.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000334554411212_765220.0766.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000033455441135_52220.0766.0Topological domainLumenal
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000033455441174_148220.0766.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000405930411170_190220.0779.0Topological domainLumenal
TgeneZDHHC8chr7:45956812chr22:20128140ENST000004059304111_13220.0779.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000405930411212_765220.0779.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000040593041135_52220.0779.0Topological domainLumenal
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000040593041174_148220.0779.0Topological domainCytoplasmic
TgeneZDHHC8chr7:45956812chr22:20128140ENST000003206022914_34128.0674.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST000003206022953_73128.0674.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000334554411149_169220.0766.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000033455441114_34220.0766.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000334554411191_211220.0766.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000033455441153_73220.0766.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000405930411149_169220.0779.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000040593041114_34220.0779.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST00000405930411191_211220.0779.0TransmembraneHelical
TgeneZDHHC8chr7:45956812chr22:20128140ENST0000040593041153_73220.0779.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IGFBP3
ZDHHC8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to IGFBP3-ZDHHC8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IGFBP3-ZDHHC8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource