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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ALDH3A2-PITPNM2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ALDH3A2-PITPNM2
	FusionPDB ID: 3902
	FusionGDB2.0 ID: 3902
		Hgene	Tgene
	Gene symbol	ALDH3A2	PITPNM2
	Gene ID	224	57605
	Gene name	aldehyde dehydrogenase 3 family member A2	phosphatidylinositol transfer protein membrane associated 2
	Synonyms	ALDH10\|FALDH\|SLS	NIR-3\|NIR3\|RDGB2\|RDGBA2
	Cytomap	17p11.2	12q24.31
	Type of gene	protein-coding	protein-coding
	Description	aldehyde dehydrogenase family 3 member A2aldehyde dehydrogenase 10fatty aldehyde dehydrogenasemicrosomal aldehyde dehydrogenase	membrane-associated phosphatidylinositol transfer protein 2PYK2 N-terminal domain-interacting receptor 3retinal degeneration B alpha 2
	Modification date	20200315	20200313
	UniProtAcc	P51648	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000176643, ENST00000339618, ENST00000395575, ENST00000571163, ENST00000579855, ENST00000581518, ENST00000574597,	ENST00000451868, ENST00000546049, ENST00000280562, ENST00000320201, ENST00000392428, ENST00000542749,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 5 X 5=150	7 X 6 X 6=252
	# samples	6	7
	** MAII score	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ALDH3A2 [Title/Abstract] AND PITPNM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ALDH3A2(19568360)-PITPNM2(123477216), # samples:5
Anticipated loss of major functional domain due to fusion event.	ALDH3A2-PITPNM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALDH3A2-PITPNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ALDH3A2	GO:0006081	cellular aldehyde metabolic process	9133646
Hgene	ALDH3A2	GO:0046458	hexadecanal metabolic process	25047030
Hgene	ALDH3A2	GO:0055114	oxidation-reduction process	9133646
Tgene	PITPNM2	GO:0048015	phosphatidylinositol-mediated signaling	10022914

Fusion gene breakpoints across ALDH3A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PITPNM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-G9-6494-01A	ALDH3A2	chr17	19568360	-	PITPNM2	chr12	123477216	-
ChimerDB4	PRAD	TCGA-G9-6494-01A	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-
ChimerDB4	PRAD	TCGA-G9-6494	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000176643	ALDH3A2	chr17	19568360	+	ENST00000320201	PITPNM2	chr12	123477216	-	6017	1653	212	3469	1085
ENST00000176643	ALDH3A2	chr17	19568360	+	ENST00000392428	PITPNM2	chr12	123477216	-	6017	1653	212	3469	1085
ENST00000176643	ALDH3A2	chr17	19568360	+	ENST00000280562	PITPNM2	chr12	123477216	-	5999	1653	212	3451	1079
ENST00000176643	ALDH3A2	chr17	19568360	+	ENST00000542749	PITPNM2	chr12	123477216	-	6016	1653	212	3469	1085
ENST00000581518	ALDH3A2	chr17	19568360	+	ENST00000320201	PITPNM2	chr12	123477216	-	5820	1456	15	3272	1085
ENST00000581518	ALDH3A2	chr17	19568360	+	ENST00000392428	PITPNM2	chr12	123477216	-	5820	1456	15	3272	1085
ENST00000581518	ALDH3A2	chr17	19568360	+	ENST00000280562	PITPNM2	chr12	123477216	-	5802	1456	15	3254	1079
ENST00000581518	ALDH3A2	chr17	19568360	+	ENST00000542749	PITPNM2	chr12	123477216	-	5819	1456	15	3272	1085
ENST00000395575	ALDH3A2	chr17	19568360	+	ENST00000320201	PITPNM2	chr12	123477216	-	5729	1365	113	3181	1022
ENST00000395575	ALDH3A2	chr17	19568360	+	ENST00000392428	PITPNM2	chr12	123477216	-	5729	1365	113	3181	1022
ENST00000395575	ALDH3A2	chr17	19568360	+	ENST00000280562	PITPNM2	chr12	123477216	-	5711	1365	113	3163	1016
ENST00000395575	ALDH3A2	chr17	19568360	+	ENST00000542749	PITPNM2	chr12	123477216	-	5728	1365	113	3181	1022
ENST00000339618	ALDH3A2	chr17	19568360	+	ENST00000320201	PITPNM2	chr12	123477216	-	5792	1428	98	3244	1048
ENST00000339618	ALDH3A2	chr17	19568360	+	ENST00000392428	PITPNM2	chr12	123477216	-	5792	1428	98	3244	1048
ENST00000339618	ALDH3A2	chr17	19568360	+	ENST00000280562	PITPNM2	chr12	123477216	-	5774	1428	98	3226	1042
ENST00000339618	ALDH3A2	chr17	19568360	+	ENST00000542749	PITPNM2	chr12	123477216	-	5791	1428	98	3244	1048
ENST00000579855	ALDH3A2	chr17	19568360	+	ENST00000320201	PITPNM2	chr12	123477216	-	5670	1306	57	3122	1021
ENST00000579855	ALDH3A2	chr17	19568360	+	ENST00000392428	PITPNM2	chr12	123477216	-	5670	1306	57	3122	1021
ENST00000579855	ALDH3A2	chr17	19568360	+	ENST00000280562	PITPNM2	chr12	123477216	-	5652	1306	57	3104	1015
ENST00000579855	ALDH3A2	chr17	19568360	+	ENST00000542749	PITPNM2	chr12	123477216	-	5669	1306	57	3122	1021
ENST00000571163	ALDH3A2	chr17	19568360	+	ENST00000320201	PITPNM2	chr12	123477216	-	4590	226	0	2042	680
ENST00000571163	ALDH3A2	chr17	19568360	+	ENST00000392428	PITPNM2	chr12	123477216	-	4590	226	0	2042	680
ENST00000571163	ALDH3A2	chr17	19568360	+	ENST00000280562	PITPNM2	chr12	123477216	-	4572	226	0	2024	674
ENST00000571163	ALDH3A2	chr17	19568360	+	ENST00000542749	PITPNM2	chr12	123477216	-	4589	226	0	2042	680

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000176643	ENST00000320201	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000817414	0.9991825
ENST00000176643	ENST00000392428	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000817414	0.9991825
ENST00000176643	ENST00000280562	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.001058135	0.99894184
ENST00000176643	ENST00000542749	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000817895	0.99918205
ENST00000581518	ENST00000320201	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000649723	0.99935025
ENST00000581518	ENST00000392428	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000649723	0.99935025
ENST00000581518	ENST00000280562	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000837687	0.9991623
ENST00000581518	ENST00000542749	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000650015	0.99935
ENST00000395575	ENST00000320201	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000621573	0.99937844
ENST00000395575	ENST00000392428	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000621573	0.99937844
ENST00000395575	ENST00000280562	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000805888	0.9991941
ENST00000395575	ENST00000542749	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.00062218	0.99937785
ENST00000339618	ENST00000320201	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000642633	0.9993574
ENST00000339618	ENST00000392428	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000642633	0.9993574
ENST00000339618	ENST00000280562	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000831853	0.99916816
ENST00000339618	ENST00000542749	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000642828	0.99935716
ENST00000579855	ENST00000320201	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000598332	0.9994017
ENST00000579855	ENST00000392428	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000598332	0.9994017
ENST00000579855	ENST00000280562	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000774292	0.99922574
ENST00000579855	ENST00000542749	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.000598926	0.9994011
ENST00000571163	ENST00000320201	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.012563163	0.9874369
ENST00000571163	ENST00000392428	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.012563163	0.9874369
ENST00000571163	ENST00000280562	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.008825626	0.99117434
ENST00000571163	ENST00000542749	ALDH3A2	chr17	19568360	+	PITPNM2	chr12	123477216	-	0.012588908	0.9874111

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3902_3902_1_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000176643_PITPNM2_chr12_123477216_ENST00000280562_length(amino acids)=1079AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLVET
VQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQDGPRPGCAESDVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMA
ESYTASSIAQIAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQ
RKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGV
YPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNF
PHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHR

--------------------------------------------------------------

>3902_3902_2_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000176643_PITPNM2_chr12_123477216_ENST00000320201_length(amino acids)=1085AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADV
LQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKAS
PGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSK
PREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESH
RLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAW
LAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQ
LKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGA

--------------------------------------------------------------

>3902_3902_3_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000176643_PITPNM2_chr12_123477216_ENST00000392428_length(amino acids)=1085AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADV
LQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKAS
PGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSK
PREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESH
RLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAW
LAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQ
LKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGA

--------------------------------------------------------------

>3902_3902_4_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000176643_PITPNM2_chr12_123477216_ENST00000542749_length(amino acids)=1085AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADV
LQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKAS
PGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSK
PREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESH
RLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAW
LAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQ
LKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGA

--------------------------------------------------------------

>3902_3902_5_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000339618_PITPNM2_chr12_123477216_ENST00000280562_length(amino acids)=1042AA_BP=443
MTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADL
CKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSEL
SENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRI
TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLT
DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPA
CQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLVETVQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQD
GPRPGCAESDVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQIAAKWWGQKRIDYALYCPDALTAFPTV
ALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYG
PLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFA
ASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAA
YGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTI

--------------------------------------------------------------

>3902_3902_6_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000339618_PITPNM2_chr12_123477216_ENST00000320201_length(amino acids)=1048AA_BP=443
MTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADL
CKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSEL
SENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRI
TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLT
DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPA
CQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQ
VSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDAL
TAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLT
GRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFS
IDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELH
LRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRN

--------------------------------------------------------------

>3902_3902_7_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000339618_PITPNM2_chr12_123477216_ENST00000392428_length(amino acids)=1048AA_BP=443
MTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADL
CKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSEL
SENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRI
TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLT
DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPA
CQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQ
VSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDAL
TAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLT
GRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFS
IDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELH
LRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRN

--------------------------------------------------------------

>3902_3902_8_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000339618_PITPNM2_chr12_123477216_ENST00000542749_length(amino acids)=1048AA_BP=443
MTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADL
CKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSEL
SENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRI
TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLT
DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPA
CQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQ
VSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDAL
TAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLT
GRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFS
IDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELH
LRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRN

--------------------------------------------------------------

>3902_3902_9_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000395575_PITPNM2_chr12_123477216_ENST00000280562_length(amino acids)=1016AA_BP=417
MWLAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENL
PEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVING
GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN
QIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV
DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRF
HALPPFSVPRYQRYPLGDGCSTLLVETVQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQDGPRPGCAESDVLQTHNAAFQEHGAPS
SPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQIAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMR
HDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWL
YLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDL
GYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRP
TKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQR

--------------------------------------------------------------

>3902_3902_10_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000395575_PITPNM2_chr12_123477216_ENST00000320201_length(amino acids)=1022AA_BP=417
MWLAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENL
PEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVING
GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN
QIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV
DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRF
HALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPS
VRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFL
LRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQP
PSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVV
RHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQI
YIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADG

--------------------------------------------------------------

>3902_3902_11_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000395575_PITPNM2_chr12_123477216_ENST00000392428_length(amino acids)=1022AA_BP=417
MWLAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENL
PEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVING
GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN
QIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV
DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRF
HALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPS
VRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFL
LRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQP
PSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVV
RHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQI
YIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADG

--------------------------------------------------------------

>3902_3902_12_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000395575_PITPNM2_chr12_123477216_ENST00000542749_length(amino acids)=1022AA_BP=417
MWLAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENL
PEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVING
GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN
QIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV
DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRF
HALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPS
VRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFL
LRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQP
PSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVV
RHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQI
YIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADG

--------------------------------------------------------------

>3902_3902_13_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000571163_PITPNM2_chr12_123477216_ENST00000280562_length(amino acids)=674AA_BP=75
MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLF
HPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLVETVQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQDGPRPGCAE
SDVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQIAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHA
SYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLT
GEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGS
DPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVA
VYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPS

--------------------------------------------------------------

>3902_3902_14_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000571163_PITPNM2_chr12_123477216_ENST00000320201_length(amino acids)=680AA_BP=75
MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLF
HPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESY
TASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVAL
PHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPL
DMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAAS
VSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYG
STKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISA

--------------------------------------------------------------

>3902_3902_15_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000571163_PITPNM2_chr12_123477216_ENST00000392428_length(amino acids)=680AA_BP=75
MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLF
HPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESY
TASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVAL
PHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPL
DMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAAS
VSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYG
STKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISA

--------------------------------------------------------------

>3902_3902_16_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000571163_PITPNM2_chr12_123477216_ENST00000542749_length(amino acids)=680AA_BP=75
MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLF
HPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESY
TASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVAL
PHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPL
DMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAAS
VSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYG
STKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISA

--------------------------------------------------------------

>3902_3902_17_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000579855_PITPNM2_chr12_123477216_ENST00000280562_length(amino acids)=1015AA_BP=416
MSERALGDSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLP
EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGG
VEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQ
IVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD
EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFH
ALPPFSVPRYQRYPLGDGCSTLLVETVQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQDGPRPGCAESDVLQTHNAAFQEHGAPSS
PGTAPASRGFRRASEISIASQVSGMAESYTASSIAQIAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRH
DNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLY
LDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLG
YLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPT
KKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRS

--------------------------------------------------------------

>3902_3902_18_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000579855_PITPNM2_chr12_123477216_ENST00000320201_length(amino acids)=1021AA_BP=416
MSERALGDSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLP
EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGG
VEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQ
IVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD
EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFH
ALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSV
RRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLL
RQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPP
SGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVR
HWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIY
IVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGE

--------------------------------------------------------------

>3902_3902_19_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000579855_PITPNM2_chr12_123477216_ENST00000392428_length(amino acids)=1021AA_BP=416
MSERALGDSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLP
EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGG
VEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQ
IVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD
EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFH
ALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSV
RRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLL
RQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPP
SGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVR
HWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIY
IVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGE

--------------------------------------------------------------

>3902_3902_20_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000579855_PITPNM2_chr12_123477216_ENST00000542749_length(amino acids)=1021AA_BP=416
MSERALGDSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLP
EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGG
VEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQ
IVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD
EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFH
ALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSV
RRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLL
RQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPP
SGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVR
HWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIY
IVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGE

--------------------------------------------------------------

>3902_3902_21_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000581518_PITPNM2_chr12_123477216_ENST00000280562_length(amino acids)=1079AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLVET
VQRNPELVLEGGPLAPLPHGDGFLETSMPVPAPTWQDGPRPGCAESDVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMA
ESYTASSIAQIAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQ
RKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGV
YPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNF
PHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHR

--------------------------------------------------------------

>3902_3902_22_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000581518_PITPNM2_chr12_123477216_ENST00000320201_length(amino acids)=1085AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADV
LQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKAS
PGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSK
PREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESH
RLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAW
LAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQ
LKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGA

--------------------------------------------------------------

>3902_3902_23_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000581518_PITPNM2_chr12_123477216_ENST00000392428_length(amino acids)=1085AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADV
LQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKAS
PGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSK
PREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESH
RLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAW
LAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQ
LKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGA

--------------------------------------------------------------

>3902_3902_24_ALDH3A2-PITPNM2_ALDH3A2_chr17_19568360_ENST00000581518_PITPNM2_chr12_123477216_ENST00000542749_length(amino acids)=1085AA_BP=480
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADV
LQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKAS
PGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSK
PREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESH
RLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAW
LAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQ
LKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:19568360/chr12:123477216)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ALDH3A2 P51648	.
FUNCTION: Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). {ECO:0000269\|PubMed:18035827, ECO:0000269\|PubMed:18182499, ECO:0000269\|PubMed:22633490, ECO:0000269\|PubMed:25047030, ECO:0000269\|PubMed:9133646, ECO:0000269\|PubMed:9662422}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000176643

185_190

402.3333333333333

486.0

Nucleotide binding

NAD

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000339618

185_190

402.3333333333333

1064.0

Nucleotide binding

NAD

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000395575

185_190

402.3333333333333

486.0

Nucleotide binding

NAD

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000579855

185_190

402.3333333333333

486.0

Nucleotide binding

NAD

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000581518

185_190

402.3333333333333

620.3333333333334

Nucleotide binding

NAD

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000176643

1_463

402.3333333333333

486.0

Topological domain

Note=Cytoplasmic

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000339618

1_463

402.3333333333333

1064.0

Topological domain

Note=Cytoplasmic

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000395575

1_463

402.3333333333333

486.0

Topological domain

Note=Cytoplasmic

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000579855

1_463

402.3333333333333

486.0

Topological domain

Note=Cytoplasmic

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000581518

1_463

402.3333333333333

620.3333333333334

Topological domain

Note=Cytoplasmic

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000176643

464_484

402.3333333333333

486.0

Transmembrane

Helical

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000339618

464_484

402.3333333333333

1064.0

Transmembrane

Helical

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000395575

464_484

402.3333333333333

486.0

Transmembrane

Helical

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000579855

464_484

402.3333333333333

486.0

Transmembrane

Helical

Hgene

ALDH3A2

chr17:19568360

chr12:123477216

ENST00000581518

464_484

402.3333333333333

620.3333333333334

Transmembrane

Helical

Tgene

PITPNM2

chr17:19568360

chr12:123477216

ENST00000280562

612_632

744.3333333333334

1344.0

Compositional bias

Note=Gly-rich

Tgene

PITPNM2

chr17:19568360

chr12:123477216

ENST00000320201

612_632

744.3333333333334

1350.0

Compositional bias

Note=Gly-rich

Tgene

PITPNM2

chr17:19568360

chr12:123477216

ENST00000542749

612_632

744.3333333333334

1350.0

Compositional bias

Note=Gly-rich

Tgene

PITPNM2

chr17:19568360

chr12:123477216

ENST00000280562

715_963

744.3333333333334

1344.0

Domain

DDHD

Tgene

PITPNM2

chr17:19568360

chr12:123477216

ENST00000320201

715_963

744.3333333333334

1350.0

Domain

DDHD

Tgene

PITPNM2

chr17:19568360

chr12:123477216

ENST00000542749

715_963

744.3333333333334

1350.0

Domain

DDHD

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1855_ALDH3A2_19568360_PITPNM2_123477216_ranked_0.pdb	ALDH3A2	19568360	19568360	ENST00000542749	PITPNM2	chr12	123477216	-	MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK RMIDETSSGGVTGNDVIMHFTLNSFPFGGVVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADV LQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKAS PGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSK PREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESH RLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAW LAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQ LKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGA	1085

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ALDH3A2_pLDDT.png

PITPNM2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ALDH3A2
PITPNM2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ALDH3A2-PITPNM2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ALDH3A2-PITPNM2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source