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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IGSF1-LRPPRC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IGSF1-LRPPRC
FusionPDB ID: 39310
FusionGDB2.0 ID: 39310
HgeneTgene
Gene symbol

IGSF1

LRPPRC

Gene ID

3547

10128

Gene nameimmunoglobulin superfamily member 1leucine rich pentatricopeptide repeat containing
SynonymsCHTE|IGCD1|IGDC1|INHBP|PGSF2|p120CLONE-23970|GP130|LRP130|LSFC
Cytomap

Xq26.1

2p21

Type of geneprotein-codingprotein-coding
Descriptionimmunoglobulin superfamily member 1immunoglobulin-like domain-containing protein 1inhibin-binding proteinpituitary gland-specific factor 2leucine-rich PPR motif-containing protein, mitochondrial130 kDa leucine-rich proteinLRP 130leucine-rich PPR-motif containingmitochondrial leucine-rich PPR motif-containing protein
Modification date2020031320200329
UniProtAcc

Q5DX21

P42704

Ensembl transtripts involved in fusion geneENST idsENST00000361420, ENST00000370900, 
ENST00000370901, ENST00000370903, 
ENST00000370904, ENST00000370910, 
ENST00000467244, 		ENST00000409659, 
ENST00000409946, ENST00000260665, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 4=16813 X 13 X 4=676
# samples 613
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/676*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IGSF1 [Title/Abstract] AND LRPPRC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IGSF1(130420578)-LRPPRC(44139697), # samples:3
Anticipated loss of major functional domain due to fusion event.IGSF1-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGSF1-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGSF1-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGSF1-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGSF1-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IGSF1-LRPPRC seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGSF1

GO:0006355

regulation of transcription, DNA-templated

11266516

HgeneIGSF1

GO:0032926

negative regulation of activin receptor signaling pathway

11266516


check buttonFusion gene breakpoints across IGSF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRPPRC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-V5-AASWIGSF1chrX

130420578

-LRPPRCchr2

44139697

-
ChimerDB4STADTCGA-BR-6452IGSF1chrX

130420578

-LRPPRCchr2

44139697

-
ChimerDB4STADTCGA-VQ-A91NIGSF1chrX

130420578

-LRPPRCchr2

44139697

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370910IGSF1chrX130420578-ENST00000260665LRPPRCchr244139697-3331202751238387
ENST00000361420IGSF1chrX130420578-ENST00000260665LRPPRCchr244139697-3279150231186387
ENST00000370903IGSF1chrX130420578-ENST00000260665LRPPRCchr244139697-3482353611389442
ENST00000370900IGSF1chrX130420578-ENST00000260665LRPPRCchr244139697-3305176311212393
ENST00000370901IGSF1chrX130420578-ENST00000260665LRPPRCchr244139697-3339210831246387

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370910ENST00000260665IGSF1chrX130420578-LRPPRCchr244139697-0.0003129930.9996871
ENST00000361420ENST00000260665IGSF1chrX130420578-LRPPRCchr244139697-0.000295180.9997048
ENST00000370903ENST00000260665IGSF1chrX130420578-LRPPRCchr244139697-0.0003649580.999635
ENST00000370900ENST00000260665IGSF1chrX130420578-LRPPRCchr244139697-0.0002980620.9997019
ENST00000370901ENST00000260665IGSF1chrX130420578-LRPPRCchr244139697-0.0003139570.9996861

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39310_39310_1_IGSF1-LRPPRC_IGSF1_chrX_130420578_ENST00000361420_LRPPRC_chr2_44139697_ENST00000260665_length(amino acids)=387AA_BP=41
MLRRKILQDSEHTASTRGPMTLDRPGEGATMLKTFTVLLFCIRAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHI
KGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQ
IKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRC
GAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAG

--------------------------------------------------------------

>39310_39310_2_IGSF1-LRPPRC_IGSF1_chrX_130420578_ENST00000370900_LRPPRC_chr2_44139697_ENST00000260665_length(amino acids)=393AA_BP=47
MPRSHHLLRRKILQDSEHTASTRGPMTLDRPGEGATMLKTFTVLLFCIRAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKA
FAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFIN
NIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDAR
ALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYAS

--------------------------------------------------------------

>39310_39310_3_IGSF1-LRPPRC_IGSF1_chrX_130420578_ENST00000370901_LRPPRC_chr2_44139697_ENST00000260665_length(amino acids)=387AA_BP=41
MLRRKILQDSEHTASTRGPMTLDRPGEGATMLKTFTVLLFCIRAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHI
KGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQ
IKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRC
GAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAG

--------------------------------------------------------------

>39310_39310_4_IGSF1-LRPPRC_IGSF1_chrX_130420578_ENST00000370903_LRPPRC_chr2_44139697_ENST00000260665_length(amino acids)=442AA_BP=96
MGRAGRRAGERGRRGSEPKRLSLDSSSHAGQFAASGGAHWRISNIGAGLQLPSHHLLRRKILQDSEHTASTRGPMTLDRPGEGATMLKTF
TVLLFCIRAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLD
QQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLF
RKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIP

--------------------------------------------------------------

>39310_39310_5_IGSF1-LRPPRC_IGSF1_chrX_130420578_ENST00000370910_LRPPRC_chr2_44139697_ENST00000260665_length(amino acids)=387AA_BP=41
MLRRKILQDSEHTASTRGPMTLDRPGEGATMLKTFTVLLFCIRAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHI
KGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQ
IKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRC
GAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:130420578/chr2:44139697)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGSF1

Q5DX21

LRPPRC

P42704

FUNCTION: Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth. {ECO:0000269|PubMed:15795899, ECO:0000269|PubMed:16108831}.FUNCTION: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRPPRCchrX:130420578chr2:44139697ENST0000026066528381121_13941049.33333333333331395.0RegionNote=RNA-binding
TgeneLRPPRCchrX:130420578chr2:44139697ENST000004099460141121_13940532.0RegionNote=RNA-binding
TgeneLRPPRCchrX:130420578chr2:44139697ENST0000026066528381066_11021049.33333333333331395.0RepeatNote=PPR 16
TgeneLRPPRCchrX:130420578chr2:44139697ENST0000026066528381103_11371049.33333333333331395.0RepeatNote=PPR 17
TgeneLRPPRCchrX:130420578chr2:44139697ENST0000026066528381138_11751049.33333333333331395.0RepeatNote=PPR 18
TgeneLRPPRCchrX:130420578chr2:44139697ENST0000026066528381176_12101049.33333333333331395.0RepeatNote=PPR 19
TgeneLRPPRCchrX:130420578chr2:44139697ENST0000026066528381317_13511049.33333333333331395.0RepeatNote=PPR 20
TgeneLRPPRCchrX:130420578chr2:44139697ENST000004099460141031_10650532.0RepeatNote=PPR 15
TgeneLRPPRCchrX:130420578chr2:44139697ENST000004099460141066_11020532.0RepeatNote=PPR 16
TgeneLRPPRCchrX:130420578chr2:44139697ENST000004099460141103_11370532.0RepeatNote=PPR 17
TgeneLRPPRCchrX:130420578chr2:44139697ENST000004099460141138_11750532.0RepeatNote=PPR 18
TgeneLRPPRCchrX:130420578chr2:44139697ENST000004099460141176_12100532.0RepeatNote=PPR 19
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014126_1600532.0RepeatNote=PPR 1
TgeneLRPPRCchrX:130420578chr2:44139697ENST000004099460141317_13510532.0RepeatNote=PPR 20
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014161_1950532.0RepeatNote=PPR 2
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014196_2300532.0RepeatNote=PPR 3
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014231_2650532.0RepeatNote=PPR 4
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014266_3000532.0RepeatNote=PPR 5
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014301_3350532.0RepeatNote=PPR 6
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014403_4370532.0RepeatNote=PPR 7
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014438_4720532.0RepeatNote=PPR 8
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014678_7090532.0RepeatNote=PPR 9
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014710_7460532.0RepeatNote=PPR 10
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014747_7840532.0RepeatNote=PPR 11
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014785_8200532.0RepeatNote=PPR 12
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014821_8560532.0RepeatNote=PPR 13
TgeneLRPPRCchrX:130420578chr2:44139697ENST00000409946014954_9880532.0RepeatNote=PPR 14

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-2201065_115023.3333333333333321337.0DomainNote=Ig-like C2-type 11
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-2201161_124223.3333333333333321337.0DomainNote=Ig-like C2-type 12
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220137_22223.3333333333333321337.0DomainNote=Ig-like C2-type 2
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220226_31223.3333333333333321337.0DomainNote=Ig-like C2-type 3
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220321_40823.3333333333333321337.0DomainNote=Ig-like C2-type 4
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-22038_12223.3333333333333321337.0DomainNote=Ig-like C2-type 1
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220419_50023.3333333333333321337.0DomainNote=Ig-like C2-type 5
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220589_67723.3333333333333321337.0DomainNote=Ig-like C2-type 6
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220686_76023.3333333333333321337.0DomainNote=Ig-like C2-type 7
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220777_86923.3333333333333321337.0DomainNote=Ig-like C2-type 8
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220873_95823.3333333333333321337.0DomainNote=Ig-like C2-type 9
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220965_106023.3333333333333321337.0DomainNote=Ig-like C2-type 10
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-251065_115023.333333333333332243.0DomainNote=Ig-like C2-type 11
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-251161_124223.333333333333332243.0DomainNote=Ig-like C2-type 12
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25137_22223.333333333333332243.0DomainNote=Ig-like C2-type 2
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25226_31223.333333333333332243.0DomainNote=Ig-like C2-type 3
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25321_40823.333333333333332243.0DomainNote=Ig-like C2-type 4
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-2538_12223.333333333333332243.0DomainNote=Ig-like C2-type 1
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25419_50023.333333333333332243.0DomainNote=Ig-like C2-type 5
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25589_67723.333333333333332243.0DomainNote=Ig-like C2-type 6
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25686_76023.333333333333332243.0DomainNote=Ig-like C2-type 7
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25777_86923.333333333333332243.0DomainNote=Ig-like C2-type 8
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25873_95823.333333333333332243.0DomainNote=Ig-like C2-type 9
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25965_106023.333333333333332243.0DomainNote=Ig-like C2-type 10
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-251065_115023.333333333333332243.0DomainNote=Ig-like C2-type 11
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-251161_124223.333333333333332243.0DomainNote=Ig-like C2-type 12
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25137_22223.333333333333332243.0DomainNote=Ig-like C2-type 2
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25226_31223.333333333333332243.0DomainNote=Ig-like C2-type 3
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25321_40823.333333333333332243.0DomainNote=Ig-like C2-type 4
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-2538_12223.333333333333332243.0DomainNote=Ig-like C2-type 1
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25419_50023.333333333333332243.0DomainNote=Ig-like C2-type 5
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25589_67723.333333333333332243.0DomainNote=Ig-like C2-type 6
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25686_76023.333333333333332243.0DomainNote=Ig-like C2-type 7
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25777_86923.333333333333332243.0DomainNote=Ig-like C2-type 8
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25873_95823.333333333333332243.0DomainNote=Ig-like C2-type 9
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25965_106023.333333333333332243.0DomainNote=Ig-like C2-type 10
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-2201065_115023.3333333333333321342.0DomainNote=Ig-like C2-type 11
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-2201161_124223.3333333333333321342.0DomainNote=Ig-like C2-type 12
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220137_22223.3333333333333321342.0DomainNote=Ig-like C2-type 2
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220226_31223.3333333333333321342.0DomainNote=Ig-like C2-type 3
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220321_40823.3333333333333321342.0DomainNote=Ig-like C2-type 4
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-22038_12223.3333333333333321342.0DomainNote=Ig-like C2-type 1
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220419_50023.3333333333333321342.0DomainNote=Ig-like C2-type 5
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220589_67723.3333333333333321342.0DomainNote=Ig-like C2-type 6
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220686_76023.3333333333333321342.0DomainNote=Ig-like C2-type 7
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220777_86923.3333333333333321342.0DomainNote=Ig-like C2-type 8
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220873_95823.3333333333333321342.0DomainNote=Ig-like C2-type 9
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220965_106023.3333333333333321342.0DomainNote=Ig-like C2-type 10
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-9261065_115023.3333333333333321328.0DomainNote=Ig-like C2-type 11
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-9261161_124223.3333333333333321328.0DomainNote=Ig-like C2-type 12
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926137_22223.3333333333333321328.0DomainNote=Ig-like C2-type 2
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926226_31223.3333333333333321328.0DomainNote=Ig-like C2-type 3
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926321_40823.3333333333333321328.0DomainNote=Ig-like C2-type 4
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-92638_12223.3333333333333321328.0DomainNote=Ig-like C2-type 1
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926419_50023.3333333333333321328.0DomainNote=Ig-like C2-type 5
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926589_67723.3333333333333321328.0DomainNote=Ig-like C2-type 6
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926686_76023.3333333333333321328.0DomainNote=Ig-like C2-type 7
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926777_86923.3333333333333321328.0DomainNote=Ig-like C2-type 8
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926873_95823.3333333333333321328.0DomainNote=Ig-like C2-type 9
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926965_106023.3333333333333321328.0DomainNote=Ig-like C2-type 10
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-2191065_115023.3333333333333321328.0DomainNote=Ig-like C2-type 11
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-2191161_124223.3333333333333321328.0DomainNote=Ig-like C2-type 12
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219137_22223.3333333333333321328.0DomainNote=Ig-like C2-type 2
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219226_31223.3333333333333321328.0DomainNote=Ig-like C2-type 3
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219321_40823.3333333333333321328.0DomainNote=Ig-like C2-type 4
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-21938_12223.3333333333333321328.0DomainNote=Ig-like C2-type 1
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219419_50023.3333333333333321328.0DomainNote=Ig-like C2-type 5
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219589_67723.3333333333333321328.0DomainNote=Ig-like C2-type 6
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219686_76023.3333333333333321328.0DomainNote=Ig-like C2-type 7
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219777_86923.3333333333333321328.0DomainNote=Ig-like C2-type 8
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219873_95823.3333333333333321328.0DomainNote=Ig-like C2-type 9
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219965_106023.3333333333333321328.0DomainNote=Ig-like C2-type 10
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-22029_51823.3333333333333321337.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220540_55923.3333333333333321337.0Topological domainCytoplasmic
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220581_133623.3333333333333321337.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-2529_51823.333333333333332243.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25540_55923.333333333333332243.0Topological domainCytoplasmic
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25581_133623.333333333333332243.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-2529_51823.333333333333332243.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25540_55923.333333333333332243.0Topological domainCytoplasmic
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25581_133623.333333333333332243.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-22029_51823.3333333333333321342.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220540_55923.3333333333333321342.0Topological domainCytoplasmic
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220581_133623.3333333333333321342.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-92629_51823.3333333333333321328.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926540_55923.3333333333333321328.0Topological domainCytoplasmic
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926581_133623.3333333333333321328.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-21929_51823.3333333333333321328.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219540_55923.3333333333333321328.0Topological domainCytoplasmic
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219581_133623.3333333333333321328.0Topological domainExtracellular
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220519_53923.3333333333333321337.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000361420-220560_58023.3333333333333321337.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25519_53923.333333333333332243.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370900-25560_58023.333333333333332243.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25519_53923.333333333333332243.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370901-25560_58023.333333333333332243.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220519_53923.3333333333333321342.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370903-220560_58023.3333333333333321342.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926519_53923.3333333333333321328.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370904-926560_58023.3333333333333321328.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219519_53923.3333333333333321328.0TransmembraneHelical
HgeneIGSF1chrX:130420578chr2:44139697ENST00000370910-219560_58023.3333333333333321328.0TransmembraneHelical
TgeneLRPPRCchrX:130420578chr2:44139697ENST0000026066528381031_10651049.33333333333331395.0RepeatNote=PPR 15
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838126_1601049.33333333333331395.0RepeatNote=PPR 1
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838161_1951049.33333333333331395.0RepeatNote=PPR 2
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838196_2301049.33333333333331395.0RepeatNote=PPR 3
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838231_2651049.33333333333331395.0RepeatNote=PPR 4
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838266_3001049.33333333333331395.0RepeatNote=PPR 5
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838301_3351049.33333333333331395.0RepeatNote=PPR 6
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838403_4371049.33333333333331395.0RepeatNote=PPR 7
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838438_4721049.33333333333331395.0RepeatNote=PPR 8
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838678_7091049.33333333333331395.0RepeatNote=PPR 9
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838710_7461049.33333333333331395.0RepeatNote=PPR 10
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838747_7841049.33333333333331395.0RepeatNote=PPR 11
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838785_8201049.33333333333331395.0RepeatNote=PPR 12
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838821_8561049.33333333333331395.0RepeatNote=PPR 13
TgeneLRPPRCchrX:130420578chr2:44139697ENST000002606652838954_9881049.33333333333331395.0RepeatNote=PPR 14


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>926_IGSF1_130420578_LRPPRC_44139697_926_IGSF1_130420578_LRPPRC_44139697_ranked_0.pdbIGSF1130420578130420578ENST00000260665LRPPRCchr244139697-
MGRAGRRAGERGRRGSEPKRLSLDSSSHAGQFAASGGAHWRISNIGAGLQLPSHHLLRRKILQDSEHTASTRGPMTLDRPGEGATMLKTF
TVLLFCIRAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLD
QQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLF
RKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIP
442


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
IGSF1_pLDDT.png
all structure
all structure
LRPPRC_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IGSF1
LRPPRC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to IGSF1-LRPPRC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IGSF1-LRPPRC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource