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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IGSF3-KDM2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IGSF3-KDM2A
FusionPDB ID: 39319
FusionGDB2.0 ID: 39319
HgeneTgene
Gene symbol

IGSF3

KDM2A

Gene ID

3321

22992

Gene nameimmunoglobulin superfamily member 3lysine demethylase 2A
SynonymsEWI-3|LCDD|V8CXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINA
Cytomap

1p13.1

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionimmunoglobulin superfamily member 3glu-Trp-Ile EWI motif-containing protein 3immunoglobin superfamily, member 3lysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing h
Modification date2020031320200320
UniProtAcc

O75054

Q9Y2K7

Ensembl transtripts involved in fusion geneENST idsENST00000318837, ENST00000369483, 
ENST00000369486, 		ENST00000308783, 
ENST00000526258, ENST00000530342, 
ENST00000398645, ENST00000529006, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 7 X 6=42028 X 27 X 8=6048
# samples 1132
** MAII scorelog2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/6048*10)=-4.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IGSF3 [Title/Abstract] AND KDM2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IGSF3(117208906)-KDM2A(66947550), # samples:3
Anticipated loss of major functional domain due to fusion event.IGSF3-KDM2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGSF3-KDM2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGSF3-KDM2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGSF3-KDM2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IGSF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDM2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0W3-01AIGSF3chr1

117208906

-KDM2Achr11

66947550

+
ChimerDB4BRCATCGA-BH-A0W3IGSF3chr1

117208905

-KDM2Achr11

66947549

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369483IGSF3chr1117208906-ENST00000398645KDM2Achr1166947550+63537487393054771
ENST00000369483IGSF3chr1117208906-ENST00000529006KDM2Achr1166947550+722774873941941151
ENST00000369486IGSF3chr1117208906-ENST00000398645KDM2Achr1166947550+64148098003115771
ENST00000369486IGSF3chr1117208906-ENST00000529006KDM2Achr1166947550+728880980042551151
ENST00000318837IGSF3chr1117208906-ENST00000398645KDM2Achr1166947550+57531481392454771
ENST00000318837IGSF3chr1117208906-ENST00000529006KDM2Achr1166947550+662714813935941151
ENST00000369483IGSF3chr1117208905-ENST00000398645KDM2Achr1166947549+63537487393054771
ENST00000369483IGSF3chr1117208905-ENST00000529006KDM2Achr1166947549+722774873941941151
ENST00000369486IGSF3chr1117208905-ENST00000398645KDM2Achr1166947549+64148098003115771
ENST00000369486IGSF3chr1117208905-ENST00000529006KDM2Achr1166947549+728880980042551151
ENST00000318837IGSF3chr1117208905-ENST00000398645KDM2Achr1166947549+57531481392454771
ENST00000318837IGSF3chr1117208905-ENST00000529006KDM2Achr1166947549+662714813935941151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369483ENST00000398645IGSF3chr1117208906-KDM2Achr1166947550+0.0014390550.99856097
ENST00000369483ENST00000529006IGSF3chr1117208906-KDM2Achr1166947550+0.0005787180.99942136
ENST00000369486ENST00000398645IGSF3chr1117208906-KDM2Achr1166947550+0.0014951210.9985049
ENST00000369486ENST00000529006IGSF3chr1117208906-KDM2Achr1166947550+0.0006463320.9993537
ENST00000318837ENST00000398645IGSF3chr1117208906-KDM2Achr1166947550+0.0015282440.9984718
ENST00000318837ENST00000529006IGSF3chr1117208906-KDM2Achr1166947550+0.0003009160.9996991
ENST00000369483ENST00000398645IGSF3chr1117208905-KDM2Achr1166947549+0.0014390550.99856097
ENST00000369483ENST00000529006IGSF3chr1117208905-KDM2Achr1166947549+0.0005787180.99942136
ENST00000369486ENST00000398645IGSF3chr1117208905-KDM2Achr1166947549+0.0014951210.9985049
ENST00000369486ENST00000529006IGSF3chr1117208905-KDM2Achr1166947549+0.0006463320.9993537
ENST00000318837ENST00000398645IGSF3chr1117208905-KDM2Achr1166947549+0.0015282440.9984718
ENST00000318837ENST00000529006IGSF3chr1117208905-KDM2Achr1166947549+0.0003009160.9996991

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39319_39319_1_IGSF3-KDM2A_IGSF3_chr1_117208905_ENST00000318837_KDM2A_chr11_66947549_ENST00000398645_length(amino acids)=771AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS

--------------------------------------------------------------

>39319_39319_2_IGSF3-KDM2A_IGSF3_chr1_117208905_ENST00000318837_KDM2A_chr11_66947549_ENST00000529006_length(amino acids)=1151AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS
PRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQA
ITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELC
ECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCP
LLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSS

--------------------------------------------------------------

>39319_39319_3_IGSF3-KDM2A_IGSF3_chr1_117208905_ENST00000369483_KDM2A_chr11_66947549_ENST00000398645_length(amino acids)=771AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS

--------------------------------------------------------------

>39319_39319_4_IGSF3-KDM2A_IGSF3_chr1_117208905_ENST00000369483_KDM2A_chr11_66947549_ENST00000529006_length(amino acids)=1151AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS
PRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQA
ITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELC
ECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCP
LLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSS

--------------------------------------------------------------

>39319_39319_5_IGSF3-KDM2A_IGSF3_chr1_117208905_ENST00000369486_KDM2A_chr11_66947549_ENST00000398645_length(amino acids)=771AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS

--------------------------------------------------------------

>39319_39319_6_IGSF3-KDM2A_IGSF3_chr1_117208905_ENST00000369486_KDM2A_chr11_66947549_ENST00000529006_length(amino acids)=1151AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS
PRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQA
ITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELC
ECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCP
LLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSS

--------------------------------------------------------------

>39319_39319_7_IGSF3-KDM2A_IGSF3_chr1_117208906_ENST00000318837_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=771AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS

--------------------------------------------------------------

>39319_39319_8_IGSF3-KDM2A_IGSF3_chr1_117208906_ENST00000318837_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1151AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS
PRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQA
ITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELC
ECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCP
LLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSS

--------------------------------------------------------------

>39319_39319_9_IGSF3-KDM2A_IGSF3_chr1_117208906_ENST00000369483_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=771AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS

--------------------------------------------------------------

>39319_39319_10_IGSF3-KDM2A_IGSF3_chr1_117208906_ENST00000369483_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1151AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS
PRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQA
ITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELC
ECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCP
LLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSS

--------------------------------------------------------------

>39319_39319_11_IGSF3-KDM2A_IGSF3_chr1_117208906_ENST00000369486_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=771AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS

--------------------------------------------------------------

>39319_39319_12_IGSF3-KDM2A_IGSF3_chr1_117208906_ENST00000369486_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1151AA_BP=3
MCWRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMC
VGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEM
QYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSG
WIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESG
NGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGL
RCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTP
VRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLME
CCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVS
PRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQA
ITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELC
ECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCP
LLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:117208906/chr11:66947550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGSF3

O75054

KDM2A

Q9Y2K7

FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKDM2Achr1:117208905chr11:66947549ENST00000308783010148_3160621.0DomainJmjC
TgeneKDM2Achr1:117208905chr11:66947549ENST00000308783010889_9360621.0DomainNote=F-box
TgeneKDM2Achr1:117208905chr11:66947549ENST00000398645121148_31614.01490.3333333333333DomainJmjC
TgeneKDM2Achr1:117208905chr11:66947549ENST00000398645121889_93614.01490.3333333333333DomainNote=F-box
TgeneKDM2Achr1:117208905chr11:66947549ENST00000529006121148_31614.01163.0DomainJmjC
TgeneKDM2Achr1:117208905chr11:66947549ENST00000529006121889_93614.01163.0DomainNote=F-box
TgeneKDM2Achr1:117208905chr11:66947549ENST00000530342010148_3160724.0DomainJmjC
TgeneKDM2Achr1:117208905chr11:66947549ENST00000530342010889_9360724.0DomainNote=F-box
TgeneKDM2Achr1:117208906chr11:66947550ENST00000308783010148_3160621.0DomainJmjC
TgeneKDM2Achr1:117208906chr11:66947550ENST00000308783010889_9360621.0DomainNote=F-box
TgeneKDM2Achr1:117208906chr11:66947550ENST00000398645121148_31614.01490.3333333333333DomainJmjC
TgeneKDM2Achr1:117208906chr11:66947550ENST00000398645121889_93614.01490.3333333333333DomainNote=F-box
TgeneKDM2Achr1:117208906chr11:66947550ENST00000529006121148_31614.01163.0DomainJmjC
TgeneKDM2Achr1:117208906chr11:66947550ENST00000529006121889_93614.01163.0DomainNote=F-box
TgeneKDM2Achr1:117208906chr11:66947550ENST00000530342010148_3160724.0DomainJmjC
TgeneKDM2Achr1:117208906chr11:66947550ENST00000530342010889_9360724.0DomainNote=F-box
TgeneKDM2Achr1:117208905chr11:66947549ENST000003087830101048_10730621.0RepeatNote=LRR 3
TgeneKDM2Achr1:117208905chr11:66947549ENST000003087830101074_11030621.0RepeatNote=LRR 4
TgeneKDM2Achr1:117208905chr11:66947549ENST000003087830101104_11280621.0RepeatNote=LRR 5
TgeneKDM2Achr1:117208905chr11:66947549ENST000003087830101129_11560621.0RepeatNote=LRR 6
TgeneKDM2Achr1:117208905chr11:66947549ENST00000308783010961_9820621.0RepeatNote=LRR 1
TgeneKDM2Achr1:117208905chr11:66947549ENST00000308783010984_10100621.0RepeatNote=LRR 2
TgeneKDM2Achr1:117208905chr11:66947549ENST000003986451211048_107314.01490.3333333333333RepeatNote=LRR 3
TgeneKDM2Achr1:117208905chr11:66947549ENST000003986451211074_110314.01490.3333333333333RepeatNote=LRR 4
TgeneKDM2Achr1:117208905chr11:66947549ENST000003986451211104_112814.01490.3333333333333RepeatNote=LRR 5
TgeneKDM2Achr1:117208905chr11:66947549ENST000003986451211129_115614.01490.3333333333333RepeatNote=LRR 6
TgeneKDM2Achr1:117208905chr11:66947549ENST00000398645121961_98214.01490.3333333333333RepeatNote=LRR 1
TgeneKDM2Achr1:117208905chr11:66947549ENST00000398645121984_101014.01490.3333333333333RepeatNote=LRR 2
TgeneKDM2Achr1:117208905chr11:66947549ENST000005290061211048_107314.01163.0RepeatNote=LRR 3
TgeneKDM2Achr1:117208905chr11:66947549ENST000005290061211074_110314.01163.0RepeatNote=LRR 4
TgeneKDM2Achr1:117208905chr11:66947549ENST000005290061211104_112814.01163.0RepeatNote=LRR 5
TgeneKDM2Achr1:117208905chr11:66947549ENST000005290061211129_115614.01163.0RepeatNote=LRR 6
TgeneKDM2Achr1:117208905chr11:66947549ENST00000529006121961_98214.01163.0RepeatNote=LRR 1
TgeneKDM2Achr1:117208905chr11:66947549ENST00000529006121984_101014.01163.0RepeatNote=LRR 2
TgeneKDM2Achr1:117208905chr11:66947549ENST000005303420101048_10730724.0RepeatNote=LRR 3
TgeneKDM2Achr1:117208905chr11:66947549ENST000005303420101074_11030724.0RepeatNote=LRR 4
TgeneKDM2Achr1:117208905chr11:66947549ENST000005303420101104_11280724.0RepeatNote=LRR 5
TgeneKDM2Achr1:117208905chr11:66947549ENST000005303420101129_11560724.0RepeatNote=LRR 6
TgeneKDM2Achr1:117208905chr11:66947549ENST00000530342010961_9820724.0RepeatNote=LRR 1
TgeneKDM2Achr1:117208905chr11:66947549ENST00000530342010984_10100724.0RepeatNote=LRR 2
TgeneKDM2Achr1:117208906chr11:66947550ENST000003087830101048_10730621.0RepeatNote=LRR 3
TgeneKDM2Achr1:117208906chr11:66947550ENST000003087830101074_11030621.0RepeatNote=LRR 4
TgeneKDM2Achr1:117208906chr11:66947550ENST000003087830101104_11280621.0RepeatNote=LRR 5
TgeneKDM2Achr1:117208906chr11:66947550ENST000003087830101129_11560621.0RepeatNote=LRR 6
TgeneKDM2Achr1:117208906chr11:66947550ENST00000308783010961_9820621.0RepeatNote=LRR 1
TgeneKDM2Achr1:117208906chr11:66947550ENST00000308783010984_10100621.0RepeatNote=LRR 2
TgeneKDM2Achr1:117208906chr11:66947550ENST000003986451211048_107314.01490.3333333333333RepeatNote=LRR 3
TgeneKDM2Achr1:117208906chr11:66947550ENST000003986451211074_110314.01490.3333333333333RepeatNote=LRR 4
TgeneKDM2Achr1:117208906chr11:66947550ENST000003986451211104_112814.01490.3333333333333RepeatNote=LRR 5
TgeneKDM2Achr1:117208906chr11:66947550ENST000003986451211129_115614.01490.3333333333333RepeatNote=LRR 6
TgeneKDM2Achr1:117208906chr11:66947550ENST00000398645121961_98214.01490.3333333333333RepeatNote=LRR 1
TgeneKDM2Achr1:117208906chr11:66947550ENST00000398645121984_101014.01490.3333333333333RepeatNote=LRR 2
TgeneKDM2Achr1:117208906chr11:66947550ENST000005290061211048_107314.01163.0RepeatNote=LRR 3
TgeneKDM2Achr1:117208906chr11:66947550ENST000005290061211074_110314.01163.0RepeatNote=LRR 4
TgeneKDM2Achr1:117208906chr11:66947550ENST000005290061211104_112814.01163.0RepeatNote=LRR 5
TgeneKDM2Achr1:117208906chr11:66947550ENST000005290061211129_115614.01163.0RepeatNote=LRR 6
TgeneKDM2Achr1:117208906chr11:66947550ENST00000529006121961_98214.01163.0RepeatNote=LRR 1
TgeneKDM2Achr1:117208906chr11:66947550ENST00000529006121984_101014.01163.0RepeatNote=LRR 2
TgeneKDM2Achr1:117208906chr11:66947550ENST000005303420101048_10730724.0RepeatNote=LRR 3
TgeneKDM2Achr1:117208906chr11:66947550ENST000005303420101074_11030724.0RepeatNote=LRR 4
TgeneKDM2Achr1:117208906chr11:66947550ENST000005303420101104_11280724.0RepeatNote=LRR 5
TgeneKDM2Achr1:117208906chr11:66947550ENST000005303420101129_11560724.0RepeatNote=LRR 6
TgeneKDM2Achr1:117208906chr11:66947550ENST00000530342010961_9820724.0RepeatNote=LRR 1
TgeneKDM2Achr1:117208906chr11:66947550ENST00000530342010984_10100724.0RepeatNote=LRR 2
TgeneKDM2Achr1:117208905chr11:66947549ENST00000308783010564_6100621.0Zinc fingerCXXC-type
TgeneKDM2Achr1:117208905chr11:66947549ENST00000308783010617_6780621.0Zinc fingerPHD-type
TgeneKDM2Achr1:117208905chr11:66947549ENST00000398645121564_61014.01490.3333333333333Zinc fingerCXXC-type
TgeneKDM2Achr1:117208905chr11:66947549ENST00000398645121617_67814.01490.3333333333333Zinc fingerPHD-type
TgeneKDM2Achr1:117208905chr11:66947549ENST00000529006121564_61014.01163.0Zinc fingerCXXC-type
TgeneKDM2Achr1:117208905chr11:66947549ENST00000529006121617_67814.01163.0Zinc fingerPHD-type
TgeneKDM2Achr1:117208905chr11:66947549ENST00000530342010564_6100724.0Zinc fingerCXXC-type
TgeneKDM2Achr1:117208905chr11:66947549ENST00000530342010617_6780724.0Zinc fingerPHD-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000308783010564_6100621.0Zinc fingerCXXC-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000308783010617_6780621.0Zinc fingerPHD-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000398645121564_61014.01490.3333333333333Zinc fingerCXXC-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000398645121617_67814.01490.3333333333333Zinc fingerPHD-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000529006121564_61014.01163.0Zinc fingerCXXC-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000529006121617_67814.01163.0Zinc fingerPHD-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000530342010564_6100724.0Zinc fingerCXXC-type
TgeneKDM2Achr1:117208906chr11:66947550ENST00000530342010617_6780724.0Zinc fingerPHD-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111143_26214.3333333333333341215.0DomainNote=Ig-like C2-type 2
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-11120_13814.3333333333333341215.0DomainNote=Ig-like C2-type 1
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111276_38614.3333333333333341215.0DomainNote=Ig-like C2-type 3
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111401_53914.3333333333333341215.0DomainNote=Ig-like C2-type 4
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111545_66114.3333333333333341215.0DomainNote=Ig-like C2-type 5
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111676_80314.3333333333333341215.0DomainNote=Ig-like C2-type 6
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111813_94514.3333333333333341215.0DomainNote=Ig-like C2-type 7
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111949_109714.3333333333333341215.0DomainNote=Ig-like C2-type 8
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212143_26214.3333333333333341215.0DomainNote=Ig-like C2-type 2
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-21220_13814.3333333333333341215.0DomainNote=Ig-like C2-type 1
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212276_38614.3333333333333341215.0DomainNote=Ig-like C2-type 3
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212401_53914.3333333333333341215.0DomainNote=Ig-like C2-type 4
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212545_66114.3333333333333341215.0DomainNote=Ig-like C2-type 5
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212676_80314.3333333333333341215.0DomainNote=Ig-like C2-type 6
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212813_94514.3333333333333341215.0DomainNote=Ig-like C2-type 7
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212949_109714.3333333333333341215.0DomainNote=Ig-like C2-type 8
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211143_26214.3333333333333341195.0DomainNote=Ig-like C2-type 2
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-21120_13814.3333333333333341195.0DomainNote=Ig-like C2-type 1
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211276_38614.3333333333333341195.0DomainNote=Ig-like C2-type 3
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211401_53914.3333333333333341195.0DomainNote=Ig-like C2-type 4
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211545_66114.3333333333333341195.0DomainNote=Ig-like C2-type 5
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211676_80314.3333333333333341195.0DomainNote=Ig-like C2-type 6
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211813_94514.3333333333333341195.0DomainNote=Ig-like C2-type 7
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211949_109714.3333333333333341195.0DomainNote=Ig-like C2-type 8
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111143_26214.3333333333333341215.0DomainNote=Ig-like C2-type 2
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-11120_13814.3333333333333341215.0DomainNote=Ig-like C2-type 1
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111276_38614.3333333333333341215.0DomainNote=Ig-like C2-type 3
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111401_53914.3333333333333341215.0DomainNote=Ig-like C2-type 4
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111545_66114.3333333333333341215.0DomainNote=Ig-like C2-type 5
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111676_80314.3333333333333341215.0DomainNote=Ig-like C2-type 6
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111813_94514.3333333333333341215.0DomainNote=Ig-like C2-type 7
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111949_109714.3333333333333341215.0DomainNote=Ig-like C2-type 8
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212143_26214.3333333333333341215.0DomainNote=Ig-like C2-type 2
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-21220_13814.3333333333333341215.0DomainNote=Ig-like C2-type 1
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212276_38614.3333333333333341215.0DomainNote=Ig-like C2-type 3
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212401_53914.3333333333333341215.0DomainNote=Ig-like C2-type 4
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212545_66114.3333333333333341215.0DomainNote=Ig-like C2-type 5
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212676_80314.3333333333333341215.0DomainNote=Ig-like C2-type 6
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212813_94514.3333333333333341215.0DomainNote=Ig-like C2-type 7
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212949_109714.3333333333333341215.0DomainNote=Ig-like C2-type 8
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211143_26214.3333333333333341195.0DomainNote=Ig-like C2-type 2
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-21120_13814.3333333333333341195.0DomainNote=Ig-like C2-type 1
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211276_38614.3333333333333341195.0DomainNote=Ig-like C2-type 3
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211401_53914.3333333333333341195.0DomainNote=Ig-like C2-type 4
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211545_66114.3333333333333341195.0DomainNote=Ig-like C2-type 5
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211676_80314.3333333333333341195.0DomainNote=Ig-like C2-type 6
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211813_94514.3333333333333341195.0DomainNote=Ig-like C2-type 7
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211949_109714.3333333333333341195.0DomainNote=Ig-like C2-type 8
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-111250_25214.3333333333333341215.0MotifNote=EWI motif
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-212250_25214.3333333333333341215.0MotifNote=EWI motif
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-211250_25214.3333333333333341195.0MotifNote=EWI motif
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-111250_25214.3333333333333341215.0MotifNote=EWI motif
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-212250_25214.3333333333333341215.0MotifNote=EWI motif
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-211250_25214.3333333333333341195.0MotifNote=EWI motif
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-1111146_119414.3333333333333341215.0Topological domainCytoplasmic
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-11120_112414.3333333333333341215.0Topological domainExtracellular
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-2121146_119414.3333333333333341215.0Topological domainCytoplasmic
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-21220_112414.3333333333333341215.0Topological domainExtracellular
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-2111146_119414.3333333333333341195.0Topological domainCytoplasmic
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-21120_112414.3333333333333341195.0Topological domainExtracellular
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-1111146_119414.3333333333333341215.0Topological domainCytoplasmic
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-11120_112414.3333333333333341215.0Topological domainExtracellular
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-2121146_119414.3333333333333341215.0Topological domainCytoplasmic
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-21220_112414.3333333333333341215.0Topological domainExtracellular
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-2111146_119414.3333333333333341195.0Topological domainCytoplasmic
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-21120_112414.3333333333333341195.0Topological domainExtracellular
HgeneIGSF3chr1:117208905chr11:66947549ENST00000318837-1111125_114514.3333333333333341215.0TransmembraneHelical
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369483-2121125_114514.3333333333333341215.0TransmembraneHelical
HgeneIGSF3chr1:117208905chr11:66947549ENST00000369486-2111125_114514.3333333333333341195.0TransmembraneHelical
HgeneIGSF3chr1:117208906chr11:66947550ENST00000318837-1111125_114514.3333333333333341215.0TransmembraneHelical
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369483-2121125_114514.3333333333333341215.0TransmembraneHelical
HgeneIGSF3chr1:117208906chr11:66947550ENST00000369486-2111125_114514.3333333333333341195.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IGSF3
KDM2A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to IGSF3-KDM2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IGSF3-KDM2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource