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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IL17RE-SLC3A2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IL17RE-SLC3A2
FusionPDB ID: 39454
FusionGDB2.0 ID: 39454
HgeneTgene
Gene symbol

IL17RE

SLC3A2

Gene ID

132014

6520

Gene nameinterleukin 17 receptor Esolute carrier family 3 member 2
Synonyms-4F2|4F2HC|4T2HC|CD98|CD98HC|MDU1|NACAE
Cytomap

3p25.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-17 receptor EIL-17 receptor E4F2 cell-surface antigen heavy chainCD98 heavy chainantigen defined by monoclonal antibody 4F2, heavy chainantigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43lymphocyte activation antigen 4F2 large subunitmonoclonal antibody 44D7
Modification date2020031320200313
UniProtAcc

Q6ZVW7

.
Ensembl transtripts involved in fusion geneENST idsENST00000295980, ENST00000383814, 
ENST00000421412, ENST00000454190, 
ENST00000538682, ENST00000536981, 
ENST00000338663, ENST00000377889, 
ENST00000377890, ENST00000377891, 
ENST00000377892, ENST00000535296, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=110 X 11 X 7=770
# samples 113
** MAII scorelog2(1/1*10)=3.32192809488736log2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IL17RE [Title/Abstract] AND SLC3A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IL17RE(9950967)-SLC3A2(62650380), # samples:1
Anticipated loss of major functional domain due to fusion event.IL17RE-SLC3A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IL17RE-SLC3A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IL17RE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC3A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8216-01AIL17REchr3

9950967

+SLC3A2chr11

62650380

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000421412IL17REchr39950967+ENST00000377892SLC3A2chr1162650380+2098919151910631
ENST00000421412IL17REchr39950967+ENST00000377890SLC3A2chr1162650380+2011919151910631
ENST00000421412IL17REchr39950967+ENST00000377891SLC3A2chr1162650380+2078919151910631
ENST00000421412IL17REchr39950967+ENST00000377889SLC3A2chr1162650380+2071919151910631
ENST00000421412IL17REchr39950967+ENST00000535296SLC3A2chr1162650380+2093919151910631
ENST00000421412IL17REchr39950967+ENST00000338663SLC3A2chr1162650380+2073919151910631
ENST00000295980IL17REchr39950967+ENST00000377892SLC3A2chr1162650380+2098919151910631
ENST00000295980IL17REchr39950967+ENST00000377890SLC3A2chr1162650380+2011919151910631
ENST00000295980IL17REchr39950967+ENST00000377891SLC3A2chr1162650380+2078919151910631
ENST00000295980IL17REchr39950967+ENST00000377889SLC3A2chr1162650380+2071919151910631
ENST00000295980IL17REchr39950967+ENST00000535296SLC3A2chr1162650380+2093919151910631
ENST00000295980IL17REchr39950967+ENST00000338663SLC3A2chr1162650380+2073919151910631
ENST00000383814IL17REchr39950967+ENST00000377892SLC3A2chr1162650380+208690791898629
ENST00000383814IL17REchr39950967+ENST00000377890SLC3A2chr1162650380+199990791898629
ENST00000383814IL17REchr39950967+ENST00000377891SLC3A2chr1162650380+206690791898629
ENST00000383814IL17REchr39950967+ENST00000377889SLC3A2chr1162650380+205990791898629
ENST00000383814IL17REchr39950967+ENST00000535296SLC3A2chr1162650380+208190791898629
ENST00000383814IL17REchr39950967+ENST00000338663SLC3A2chr1162650380+206190791898629
ENST00000454190IL17REchr39950967+ENST00000377892SLC3A2chr1162650380+206688771878623
ENST00000454190IL17REchr39950967+ENST00000377890SLC3A2chr1162650380+197988771878623
ENST00000454190IL17REchr39950967+ENST00000377891SLC3A2chr1162650380+204688771878623
ENST00000454190IL17REchr39950967+ENST00000377889SLC3A2chr1162650380+203988771878623
ENST00000454190IL17REchr39950967+ENST00000535296SLC3A2chr1162650380+206188771878623
ENST00000454190IL17REchr39950967+ENST00000338663SLC3A2chr1162650380+204188771878623

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000421412ENST00000377892IL17REchr39950967+SLC3A2chr1162650380+0.058370890.94162905
ENST00000421412ENST00000377890IL17REchr39950967+SLC3A2chr1162650380+0.0644070660.93559295
ENST00000421412ENST00000377891IL17REchr39950967+SLC3A2chr1162650380+0.058441670.94155836
ENST00000421412ENST00000377889IL17REchr39950967+SLC3A2chr1162650380+0.0584444930.9415555
ENST00000421412ENST00000535296IL17REchr39950967+SLC3A2chr1162650380+0.057909730.9420903
ENST00000421412ENST00000338663IL17REchr39950967+SLC3A2chr1162650380+0.059405040.940595
ENST00000295980ENST00000377892IL17REchr39950967+SLC3A2chr1162650380+0.058370890.94162905
ENST00000295980ENST00000377890IL17REchr39950967+SLC3A2chr1162650380+0.0644070660.93559295
ENST00000295980ENST00000377891IL17REchr39950967+SLC3A2chr1162650380+0.058441670.94155836
ENST00000295980ENST00000377889IL17REchr39950967+SLC3A2chr1162650380+0.0584444930.9415555
ENST00000295980ENST00000535296IL17REchr39950967+SLC3A2chr1162650380+0.057909730.9420903
ENST00000295980ENST00000338663IL17REchr39950967+SLC3A2chr1162650380+0.059405040.940595
ENST00000383814ENST00000377892IL17REchr39950967+SLC3A2chr1162650380+0.0499820930.9500179
ENST00000383814ENST00000377890IL17REchr39950967+SLC3A2chr1162650380+0.056394620.9436053
ENST00000383814ENST00000377891IL17REchr39950967+SLC3A2chr1162650380+0.050024650.9499753
ENST00000383814ENST00000377889IL17REchr39950967+SLC3A2chr1162650380+0.0500159970.949984
ENST00000383814ENST00000535296IL17REchr39950967+SLC3A2chr1162650380+0.049434370.9505657
ENST00000383814ENST00000338663IL17REchr39950967+SLC3A2chr1162650380+0.050904120.9490959
ENST00000454190ENST00000377892IL17REchr39950967+SLC3A2chr1162650380+0.053480010.94652
ENST00000454190ENST00000377890IL17REchr39950967+SLC3A2chr1162650380+0.0605896450.9394104
ENST00000454190ENST00000377891IL17REchr39950967+SLC3A2chr1162650380+0.053653970.94634604
ENST00000454190ENST00000377889IL17REchr39950967+SLC3A2chr1162650380+0.0537121040.9462879
ENST00000454190ENST00000535296IL17REchr39950967+SLC3A2chr1162650380+0.0528996140.94710034
ENST00000454190ENST00000338663IL17REchr39950967+SLC3A2chr1162650380+0.0545640180.945436

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39454_39454_1_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000295980_SLC3A2_chr11_62650380_ENST00000338663_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_2_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000295980_SLC3A2_chr11_62650380_ENST00000377889_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_3_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000295980_SLC3A2_chr11_62650380_ENST00000377890_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_4_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000295980_SLC3A2_chr11_62650380_ENST00000377891_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_5_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000295980_SLC3A2_chr11_62650380_ENST00000377892_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_6_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000295980_SLC3A2_chr11_62650380_ENST00000535296_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_7_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000383814_SLC3A2_chr11_62650380_ENST00000338663_length(amino acids)=629AA_BP=300
MLVLCSLLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCR
TWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHK
GLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFL
LPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLA
EWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLR
LYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDF

--------------------------------------------------------------

>39454_39454_8_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000383814_SLC3A2_chr11_62650380_ENST00000377889_length(amino acids)=629AA_BP=300
MLVLCSLLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCR
TWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHK
GLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFL
LPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLA
EWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLR
LYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDF

--------------------------------------------------------------

>39454_39454_9_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000383814_SLC3A2_chr11_62650380_ENST00000377890_length(amino acids)=629AA_BP=300
MLVLCSLLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCR
TWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHK
GLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFL
LPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLA
EWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLR
LYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDF

--------------------------------------------------------------

>39454_39454_10_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000383814_SLC3A2_chr11_62650380_ENST00000377891_length(amino acids)=629AA_BP=300
MLVLCSLLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCR
TWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHK
GLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFL
LPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLA
EWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLR
LYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDF

--------------------------------------------------------------

>39454_39454_11_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000383814_SLC3A2_chr11_62650380_ENST00000377892_length(amino acids)=629AA_BP=300
MLVLCSLLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCR
TWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHK
GLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFL
LPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLA
EWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLR
LYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDF

--------------------------------------------------------------

>39454_39454_12_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000383814_SLC3A2_chr11_62650380_ENST00000535296_length(amino acids)=629AA_BP=300
MLVLCSLLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCR
TWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHK
GLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFL
LPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLA
EWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLR
LYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDF

--------------------------------------------------------------

>39454_39454_13_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000421412_SLC3A2_chr11_62650380_ENST00000338663_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_14_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000421412_SLC3A2_chr11_62650380_ENST00000377889_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_15_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000421412_SLC3A2_chr11_62650380_ENST00000377890_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_16_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000421412_SLC3A2_chr11_62650380_ENST00000377891_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_17_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000421412_SLC3A2_chr11_62650380_ENST00000377892_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_18_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000421412_SLC3A2_chr11_62650380_ENST00000535296_length(amino acids)=631AA_BP=302
MMLAPFLLLLTHSRSPLSFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIP
CRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDIS
HKGLRSKRTQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYE
FLLPCLCIEASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSF
LAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG
DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYA

--------------------------------------------------------------

>39454_39454_19_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000454190_SLC3A2_chr11_62650380_ENST00000338663_length(amino acids)=623AA_BP=294
MLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALF
STKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKR
TQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCI
EASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNIT
KGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLML
FTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAG

--------------------------------------------------------------

>39454_39454_20_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000454190_SLC3A2_chr11_62650380_ENST00000377889_length(amino acids)=623AA_BP=294
MLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALF
STKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKR
TQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCI
EASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNIT
KGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLML
FTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAG

--------------------------------------------------------------

>39454_39454_21_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000454190_SLC3A2_chr11_62650380_ENST00000377890_length(amino acids)=623AA_BP=294
MLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALF
STKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKR
TQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCI
EASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNIT
KGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLML
FTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAG

--------------------------------------------------------------

>39454_39454_22_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000454190_SLC3A2_chr11_62650380_ENST00000377891_length(amino acids)=623AA_BP=294
MLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALF
STKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKR
TQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCI
EASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNIT
KGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLML
FTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAG

--------------------------------------------------------------

>39454_39454_23_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000454190_SLC3A2_chr11_62650380_ENST00000377892_length(amino acids)=623AA_BP=294
MLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALF
STKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKR
TQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCI
EASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNIT
KGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLML
FTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAG

--------------------------------------------------------------

>39454_39454_24_IL17RE-SLC3A2_IL17RE_chr3_9950967_ENST00000454190_SLC3A2_chr11_62650380_ENST00000535296_length(amino acids)=623AA_BP=294
MLHSKALPPTFRPCSHVPGALIAQKPMGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHTDDSFTGSSAYIPCRTWWALF
STKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQKSKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKR
TQPSDPETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSPYDVQKIVSGGHTVELPYEFLLPCLCI
EASYLQEDTVRRKKCPFQSWPEACIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNIT
KGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLML
FTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:9950967/chr11:62650380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL17RE

Q6ZVW7

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC3A2chr3:9950967chr11:62650380ENST0000033866319206_630199.33333333333334530.0Topological domainExtracellular

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL17REchr3:9950967chr11:62650380ENST00000295980+917487_624267.3333333333333668.0DomainSEFIR
HgeneIL17REchr3:9950967chr11:62650380ENST00000383814+816487_624267.3333333333333668.0DomainSEFIR
HgeneIL17REchr3:9950967chr11:62650380ENST00000454190+816487_624267.3333333333333534.0DomainSEFIR
HgeneIL17REchr3:9950967chr11:62650380ENST00000295980+91724_454267.3333333333333668.0Topological domainExtracellular
HgeneIL17REchr3:9950967chr11:62650380ENST00000295980+917476_667267.3333333333333668.0Topological domainCytoplasmic
HgeneIL17REchr3:9950967chr11:62650380ENST00000383814+81624_454267.3333333333333668.0Topological domainExtracellular
HgeneIL17REchr3:9950967chr11:62650380ENST00000383814+816476_667267.3333333333333668.0Topological domainCytoplasmic
HgeneIL17REchr3:9950967chr11:62650380ENST00000454190+81624_454267.3333333333333534.0Topological domainExtracellular
HgeneIL17REchr3:9950967chr11:62650380ENST00000454190+816476_667267.3333333333333534.0Topological domainCytoplasmic
HgeneIL17REchr3:9950967chr11:62650380ENST00000295980+917455_475267.3333333333333668.0TransmembraneHelical
HgeneIL17REchr3:9950967chr11:62650380ENST00000383814+816455_475267.3333333333333668.0TransmembraneHelical
HgeneIL17REchr3:9950967chr11:62650380ENST00000454190+816455_475267.3333333333333534.0TransmembraneHelical
TgeneSLC3A2chr3:9950967chr11:62650380ENST0000033866319102_184199.33333333333334530.0Topological domainCytoplasmic
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377889210102_184238.33333333333334569.0Topological domainCytoplasmic
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377889210206_630238.33333333333334569.0Topological domainExtracellular
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377890412102_184300.3333333333333631.0Topological domainCytoplasmic
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377890412206_630300.3333333333333631.0Topological domainExtracellular
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377892513102_184331.3333333333333662.0Topological domainCytoplasmic
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377892513206_630331.3333333333333662.0Topological domainExtracellular
TgeneSLC3A2chr3:9950967chr11:62650380ENST0000033866319185_205199.33333333333334530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377889210185_205238.33333333333334569.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377890412185_205300.3333333333333631.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr3:9950967chr11:62650380ENST00000377892513185_205331.3333333333333662.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IL17RE
SLC3A2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to IL17RE-SLC3A2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IL17RE-SLC3A2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource