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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:IL1RAPL1-DMD

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IL1RAPL1-DMD
FusionPDB ID: 39469
FusionGDB2.0 ID: 39469
HgeneTgene
Gene symbol

IL1RAPL1

DMD

Gene ID

11141

1756

Gene nameinterleukin 1 receptor accessory protein like 1dystrophin
SynonymsIL-1-RAPL-1|IL-1RAPL-1|IL1R8|IL1RAPL|IL1RAPL-1|MRX10|MRX21|MRX34|OPHN4|TIGIRR-2BMD|CMD3B|DXS142|DXS164|DXS206|DXS230|DXS239|DXS268|DXS269|DXS270|DXS272|MRX85
Cytomap

Xp21.3-p21.2

Xp21.2-p21.1

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-1 receptor accessory protein-like 1X-linked interleukin-1 receptor accessory protein-like 1interleukin 1 receptor-8mental retardation, X-linked 10oligophrenin-4three immunoglobulin domain-containing IL-1 receptor-related 2dystrophin
Modification date2020031320200329
UniProtAcc

Q9NZN1

P11532

Ensembl transtripts involved in fusion geneENST idsENST00000302196, ENST00000378993, 
ENST00000288447, ENST00000361471, 
ENST00000378680, ENST00000378702, 
ENST00000378723, ENST00000445312, 
ENST00000343523, ENST00000357033, 
ENST00000359836, ENST00000378677, 
ENST00000378707, ENST00000474231, 
ENST00000541735, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 4=52835 X 39 X 12=16380
# samples 1241
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/16380*10)=-5.32016763702292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IL1RAPL1 [Title/Abstract] AND DMD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IL1RAPL1(29417425)-DMD(31697705), # samples:1
Anticipated loss of major functional domain due to fusion event.IL1RAPL1-DMD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IL1RAPL1-DMD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IL1RAPL1-DMD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IL1RAPL1-DMD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL1RAPL1

GO:0045920

negative regulation of exocytosis

12783849

HgeneIL1RAPL1

GO:0099175

regulation of postsynapse organization

21926414

HgeneIL1RAPL1

GO:0099545

trans-synaptic signaling by trans-synaptic complex

21926414

HgeneIL1RAPL1

GO:1905606

regulation of presynapse assembly

21926414

TgeneDMD

GO:0043043

peptide biosynthetic process

16000376


check buttonFusion gene breakpoints across IL1RAPL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DMD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..IL1RAPL1chrX

29327346

+DMDchrX

31607424

-
ChiTaRS5.0N/AAF533682IL1RAPL1chrX

29417425

+DMDchrX

31697705

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378993IL1RAPL1chrX29417425+ENST00000378707DMDchrX31697705-7465137664047731377
ENST00000378993IL1RAPL1chrX29417425+ENST00000359836DMDchrX31697705-7394137664047881382
ENST00000378993IL1RAPL1chrX29417425+ENST00000541735DMDchrX31697705-7135137664044431267
ENST00000378993IL1RAPL1chrX29417425+ENST00000343523DMDchrX31697705-7103137664044971285
ENST00000378993IL1RAPL1chrX29417425+ENST00000378677DMDchrX31697705-7465137664047731377
ENST00000378993IL1RAPL1chrX29417425+ENST00000357033DMDchrX31697705-7465137664047731377
ENST00000378993IL1RAPL1chrX29417425+ENST00000474231DMDchrX31697705-5264137664048271395
ENST00000302196IL1RAPL1chrX29417425+ENST00000378707DMDchrX31697705-6792703041001366
ENST00000302196IL1RAPL1chrX29417425+ENST00000359836DMDchrX31697705-6721703041151371
ENST00000302196IL1RAPL1chrX29417425+ENST00000541735DMDchrX31697705-6462703037701256
ENST00000302196IL1RAPL1chrX29417425+ENST00000343523DMDchrX31697705-6430703038241274
ENST00000302196IL1RAPL1chrX29417425+ENST00000378677DMDchrX31697705-6792703041001366
ENST00000302196IL1RAPL1chrX29417425+ENST00000357033DMDchrX31697705-6792703041001366
ENST00000302196IL1RAPL1chrX29417425+ENST00000474231DMDchrX31697705-4591703041541384

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378993ENST00000378707IL1RAPL1chrX29417425+DMDchrX31697705-0.0004874320.99951255
ENST00000378993ENST00000359836IL1RAPL1chrX29417425+DMDchrX31697705-0.0003066740.9996934
ENST00000378993ENST00000541735IL1RAPL1chrX29417425+DMDchrX31697705-0.000432560.99956745
ENST00000378993ENST00000343523IL1RAPL1chrX29417425+DMDchrX31697705-0.0004696840.9995303
ENST00000378993ENST00000378677IL1RAPL1chrX29417425+DMDchrX31697705-0.0004874320.99951255
ENST00000378993ENST00000357033IL1RAPL1chrX29417425+DMDchrX31697705-0.0004874320.99951255
ENST00000378993ENST00000474231IL1RAPL1chrX29417425+DMDchrX31697705-0.002440360.99755967
ENST00000302196ENST00000378707IL1RAPL1chrX29417425+DMDchrX31697705-0.0002587730.99974126
ENST00000302196ENST00000359836IL1RAPL1chrX29417425+DMDchrX31697705-0.0001663130.9998337
ENST00000302196ENST00000541735IL1RAPL1chrX29417425+DMDchrX31697705-0.0002191870.99978083
ENST00000302196ENST00000343523IL1RAPL1chrX29417425+DMDchrX31697705-0.0002403690.9997596
ENST00000302196ENST00000378677IL1RAPL1chrX29417425+DMDchrX31697705-0.0002587730.99974126
ENST00000302196ENST00000357033IL1RAPL1chrX29417425+DMDchrX31697705-0.0002587730.99974126
ENST00000302196ENST00000474231IL1RAPL1chrX29417425+DMDchrX31697705-0.001564590.99843544

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39469_39469_1_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000302196_DMD_chrX_31697705_ENST00000343523_length(amino acids)=1274AA_BP=234
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIA
FDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL
WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK
EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE
REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS
DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE
PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLK
LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLH
EAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAA
CDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLF
KQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH
QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQT
VLEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQ
PQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAM

--------------------------------------------------------------

>39469_39469_2_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000302196_DMD_chrX_31697705_ENST00000357033_length(amino acids)=1366AA_BP=234
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIA
FDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL
WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK
EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE
REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS
DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE
PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLK
LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLH
EAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAA
CDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLF
KQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH
QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQT
VLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPR
SPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQIL
EDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPS

--------------------------------------------------------------

>39469_39469_3_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000302196_DMD_chrX_31697705_ENST00000359836_length(amino acids)=1371AA_BP=234
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIA
FDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL
WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK
EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE
REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS
DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE
PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLK
LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLH
EAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAA
CDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLF
KQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH
QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQT
VLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE
RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHR
LRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMA

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>39469_39469_4_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000302196_DMD_chrX_31697705_ENST00000378677_length(amino acids)=1366AA_BP=234
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIA
FDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL
WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK
EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE
REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS
DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE
PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLK
LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLH
EAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAA
CDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLF
KQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH
QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQT
VLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPR
SPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQIL
EDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPS

--------------------------------------------------------------

>39469_39469_5_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000302196_DMD_chrX_31697705_ENST00000378707_length(amino acids)=1366AA_BP=234
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIA
FDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL
WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK
EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE
REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS
DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE
PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLK
LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLH
EAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAA
CDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLF
KQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH
QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQT
VLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPR
SPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQIL
EDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPS

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>39469_39469_6_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000302196_DMD_chrX_31697705_ENST00000474231_length(amino acids)=1384AA_BP=234
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIA
FDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL
WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK
EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE
REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS
DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE
PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLK
LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLH
EAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAA
CDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLF
KQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH
QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQT
VLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPR
SPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQIL
EDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPS

--------------------------------------------------------------

>39469_39469_7_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000302196_DMD_chrX_31697705_ENST00000541735_length(amino acids)=1256AA_BP=234
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIA
FDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL
WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK
EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE
REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS
DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE
PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLK
LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLH
EAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAA
CDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLF
KQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH
QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQT
VLEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQ

--------------------------------------------------------------

>39469_39469_8_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000378993_DMD_chrX_31697705_ENST00000343523_length(amino acids)=1285AA_BP=245
MLWGTAFKSWKMKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKS
SGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIED
FLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEM
LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA
SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN
SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH
RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRE
LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQ
VAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK
AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVL
HRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK
HPRMGYLPVQTVLEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLES
QLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSL

--------------------------------------------------------------

>39469_39469_9_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000378993_DMD_chrX_31697705_ENST00000357033_length(amino acids)=1377AA_BP=245
MLWGTAFKSWKMKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKS
SGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIED
FLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEM
LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA
SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN
SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH
RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRE
LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQ
VAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK
AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVL
HRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK
HPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQS
LNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQH
KGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEE

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>39469_39469_10_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000378993_DMD_chrX_31697705_ENST00000359836_length(amino acids)=1382AA_BP=245
MLWGTAFKSWKMKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKS
SGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIED
FLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEM
LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA
SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN
SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH
RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRE
LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQ
VAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK
AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVL
HRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK
HPRMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP
AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILED
HNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR

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>39469_39469_11_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000378993_DMD_chrX_31697705_ENST00000378677_length(amino acids)=1377AA_BP=245
MLWGTAFKSWKMKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKS
SGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIED
FLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEM
LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA
SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN
SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH
RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRE
LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQ
VAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK
AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVL
HRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK
HPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQS
LNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQH
KGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEE

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>39469_39469_12_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000378993_DMD_chrX_31697705_ENST00000378707_length(amino acids)=1377AA_BP=245
MLWGTAFKSWKMKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKS
SGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIED
FLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEM
LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA
SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN
SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH
RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRE
LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQ
VAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK
AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVL
HRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK
HPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQS
LNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQH
KGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEE

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>39469_39469_13_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000378993_DMD_chrX_31697705_ENST00000474231_length(amino acids)=1395AA_BP=245
MLWGTAFKSWKMKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKS
SGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIED
FLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEM
LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA
SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN
SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH
RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRE
LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQ
VAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK
AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVL
HRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK
HPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQS
LNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQH
KGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEE

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>39469_39469_14_IL1RAPL1-DMD_IL1RAPL1_chrX_29417425_ENST00000378993_DMD_chrX_31697705_ENST00000541735_length(amino acids)=1267AA_BP=245
MLWGTAFKSWKMKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKS
SGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIED
FLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTVERIQNQWDEVQEHLQNRRQQLNEM
LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINA
SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN
SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH
RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRE
LQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQ
VAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCK
AHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVL
HRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAK
HPRMGYLPVQTVLEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLES
QLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:29417425/chrX:31697705)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL1RAPL1

Q9NZN1

DMD

P11532

FUNCTION: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). {ECO:0000250|UniProtKB:P59823, ECO:0000250|UniProtKB:P59824, ECO:0000269|PubMed:12783849, ECO:0000269|PubMed:15123616}.FUNCTION: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+410143_232234.33333333333334697.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+41019_134234.33333333333334697.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+511143_232234.33333333333334697.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+51119_134234.33333333333334697.0DomainNote=Ig-like C2-type 1
TgeneDMDchrX:29417425chrX:31697705ENST00000361471016134_2400623.0DomainCalponin-homology (CH) 2
TgeneDMDchrX:29417425chrX:31697705ENST0000036147101615_1190623.0DomainCalponin-homology (CH) 1
TgeneDMDchrX:29417425chrX:31697705ENST000003614710163055_30880623.0DomainWW
TgeneDMDchrX:29417425chrX:31697705ENST00000378680013134_2400526.0DomainCalponin-homology (CH) 2
TgeneDMDchrX:29417425chrX:31697705ENST0000037868001315_1190526.0DomainCalponin-homology (CH) 1
TgeneDMDchrX:29417425chrX:31697705ENST000003786800133055_30880526.0DomainWW
TgeneDMDchrX:29417425chrX:31697705ENST00000378702018134_2400618.0DomainCalponin-homology (CH) 2
TgeneDMDchrX:29417425chrX:31697705ENST0000037870201815_1190618.0DomainCalponin-homology (CH) 1
TgeneDMDchrX:29417425chrX:31697705ENST000003787020183055_30880618.0DomainWW
TgeneDMDchrX:29417425chrX:31697705ENST00000378723017134_2400636.0DomainCalponin-homology (CH) 2
TgeneDMDchrX:29417425chrX:31697705ENST0000037872301715_1190636.0DomainCalponin-homology (CH) 1
TgeneDMDchrX:29417425chrX:31697705ENST000003787230173055_30880636.0DomainWW
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161_2400623.0RegionNote=Actin-binding
TgeneDMDchrX:29417425chrX:31697705ENST000003614710163466_35180623.0RegionNote=Binds to SNTB1
TgeneDMDchrX:29417425chrX:31697705ENST0000036147101663_720623.0RegionANK2- and ANK-3 binding
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131_2400526.0RegionNote=Actin-binding
TgeneDMDchrX:29417425chrX:31697705ENST000003786800133466_35180526.0RegionNote=Binds to SNTB1
TgeneDMDchrX:29417425chrX:31697705ENST0000037868001363_720526.0RegionANK2- and ANK-3 binding
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181_2400618.0RegionNote=Actin-binding
TgeneDMDchrX:29417425chrX:31697705ENST000003787020183466_35180618.0RegionNote=Binds to SNTB1
TgeneDMDchrX:29417425chrX:31697705ENST0000037870201863_720618.0RegionANK2- and ANK-3 binding
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171_2400636.0RegionNote=Actin-binding
TgeneDMDchrX:29417425chrX:31697705ENST000003787230173466_35180636.0RegionNote=Binds to SNTB1
TgeneDMDchrX:29417425chrX:31697705ENST0000037872301763_720636.0RegionANK2- and ANK-3 binding
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161048_11540623.0RepeatNote=Spectrin 7
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161157_12630623.0RepeatNote=Spectrin 8
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161266_13670623.0RepeatNote=Spectrin 9
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161368_14630623.0RepeatNote=Spectrin 10
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161468_15680623.0RepeatNote=Spectrin 11
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161571_16760623.0RepeatNote=Spectrin 12
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161679_17780623.0RepeatNote=Spectrin 13
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161779_18740623.0RepeatNote=Spectrin 14
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161877_19790623.0RepeatNote=Spectrin 15
TgeneDMDchrX:29417425chrX:31697705ENST000003614710161992_21010623.0RepeatNote=Spectrin 16
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162104_22080623.0RepeatNote=Spectrin 17
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162211_23180623.0RepeatNote=Spectrin 18
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162319_24230623.0RepeatNote=Spectrin 19
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162475_25770623.0RepeatNote=Spectrin 20
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162580_26860623.0RepeatNote=Spectrin 21
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162689_28020623.0RepeatNote=Spectrin 22
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162808_29300623.0RepeatNote=Spectrin 23
TgeneDMDchrX:29417425chrX:31697705ENST000003614710162935_30400623.0RepeatNote=Spectrin 24
TgeneDMDchrX:29417425chrX:31697705ENST00000361471016339_4470623.0RepeatNote=Spectrin 1
TgeneDMDchrX:29417425chrX:31697705ENST00000361471016448_5560623.0RepeatNote=Spectrin 2
TgeneDMDchrX:29417425chrX:31697705ENST00000361471016559_6670623.0RepeatNote=Spectrin 3
TgeneDMDchrX:29417425chrX:31697705ENST00000361471016719_8280623.0RepeatNote=Spectrin 4
TgeneDMDchrX:29417425chrX:31697705ENST00000361471016830_9340623.0RepeatNote=Spectrin 5
TgeneDMDchrX:29417425chrX:31697705ENST00000361471016943_10450623.0RepeatNote=Spectrin 6
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131048_11540526.0RepeatNote=Spectrin 7
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131157_12630526.0RepeatNote=Spectrin 8
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131266_13670526.0RepeatNote=Spectrin 9
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131368_14630526.0RepeatNote=Spectrin 10
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131468_15680526.0RepeatNote=Spectrin 11
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131571_16760526.0RepeatNote=Spectrin 12
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131679_17780526.0RepeatNote=Spectrin 13
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131779_18740526.0RepeatNote=Spectrin 14
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131877_19790526.0RepeatNote=Spectrin 15
TgeneDMDchrX:29417425chrX:31697705ENST000003786800131992_21010526.0RepeatNote=Spectrin 16
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132104_22080526.0RepeatNote=Spectrin 17
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132211_23180526.0RepeatNote=Spectrin 18
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132319_24230526.0RepeatNote=Spectrin 19
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132475_25770526.0RepeatNote=Spectrin 20
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132580_26860526.0RepeatNote=Spectrin 21
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132689_28020526.0RepeatNote=Spectrin 22
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132808_29300526.0RepeatNote=Spectrin 23
TgeneDMDchrX:29417425chrX:31697705ENST000003786800132935_30400526.0RepeatNote=Spectrin 24
TgeneDMDchrX:29417425chrX:31697705ENST00000378680013339_4470526.0RepeatNote=Spectrin 1
TgeneDMDchrX:29417425chrX:31697705ENST00000378680013448_5560526.0RepeatNote=Spectrin 2
TgeneDMDchrX:29417425chrX:31697705ENST00000378680013559_6670526.0RepeatNote=Spectrin 3
TgeneDMDchrX:29417425chrX:31697705ENST00000378680013719_8280526.0RepeatNote=Spectrin 4
TgeneDMDchrX:29417425chrX:31697705ENST00000378680013830_9340526.0RepeatNote=Spectrin 5
TgeneDMDchrX:29417425chrX:31697705ENST00000378680013943_10450526.0RepeatNote=Spectrin 6
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181048_11540618.0RepeatNote=Spectrin 7
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181157_12630618.0RepeatNote=Spectrin 8
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181266_13670618.0RepeatNote=Spectrin 9
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181368_14630618.0RepeatNote=Spectrin 10
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181468_15680618.0RepeatNote=Spectrin 11
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181571_16760618.0RepeatNote=Spectrin 12
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181679_17780618.0RepeatNote=Spectrin 13
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181779_18740618.0RepeatNote=Spectrin 14
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181877_19790618.0RepeatNote=Spectrin 15
TgeneDMDchrX:29417425chrX:31697705ENST000003787020181992_21010618.0RepeatNote=Spectrin 16
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182104_22080618.0RepeatNote=Spectrin 17
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182211_23180618.0RepeatNote=Spectrin 18
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182319_24230618.0RepeatNote=Spectrin 19
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182475_25770618.0RepeatNote=Spectrin 20
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182580_26860618.0RepeatNote=Spectrin 21
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182689_28020618.0RepeatNote=Spectrin 22
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182808_29300618.0RepeatNote=Spectrin 23
TgeneDMDchrX:29417425chrX:31697705ENST000003787020182935_30400618.0RepeatNote=Spectrin 24
TgeneDMDchrX:29417425chrX:31697705ENST00000378702018339_4470618.0RepeatNote=Spectrin 1
TgeneDMDchrX:29417425chrX:31697705ENST00000378702018448_5560618.0RepeatNote=Spectrin 2
TgeneDMDchrX:29417425chrX:31697705ENST00000378702018559_6670618.0RepeatNote=Spectrin 3
TgeneDMDchrX:29417425chrX:31697705ENST00000378702018719_8280618.0RepeatNote=Spectrin 4
TgeneDMDchrX:29417425chrX:31697705ENST00000378702018830_9340618.0RepeatNote=Spectrin 5
TgeneDMDchrX:29417425chrX:31697705ENST00000378702018943_10450618.0RepeatNote=Spectrin 6
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171048_11540636.0RepeatNote=Spectrin 7
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171157_12630636.0RepeatNote=Spectrin 8
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171266_13670636.0RepeatNote=Spectrin 9
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171368_14630636.0RepeatNote=Spectrin 10
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171468_15680636.0RepeatNote=Spectrin 11
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171571_16760636.0RepeatNote=Spectrin 12
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171679_17780636.0RepeatNote=Spectrin 13
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171779_18740636.0RepeatNote=Spectrin 14
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171877_19790636.0RepeatNote=Spectrin 15
TgeneDMDchrX:29417425chrX:31697705ENST000003787230171992_21010636.0RepeatNote=Spectrin 16
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172104_22080636.0RepeatNote=Spectrin 17
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172211_23180636.0RepeatNote=Spectrin 18
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172319_24230636.0RepeatNote=Spectrin 19
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172475_25770636.0RepeatNote=Spectrin 20
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172580_26860636.0RepeatNote=Spectrin 21
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172689_28020636.0RepeatNote=Spectrin 22
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172808_29300636.0RepeatNote=Spectrin 23
TgeneDMDchrX:29417425chrX:31697705ENST000003787230172935_30400636.0RepeatNote=Spectrin 24
TgeneDMDchrX:29417425chrX:31697705ENST00000378723017339_4470636.0RepeatNote=Spectrin 1
TgeneDMDchrX:29417425chrX:31697705ENST00000378723017448_5560636.0RepeatNote=Spectrin 2
TgeneDMDchrX:29417425chrX:31697705ENST00000378723017559_6670636.0RepeatNote=Spectrin 3
TgeneDMDchrX:29417425chrX:31697705ENST00000378723017719_8280636.0RepeatNote=Spectrin 4
TgeneDMDchrX:29417425chrX:31697705ENST00000378723017830_9340636.0RepeatNote=Spectrin 5
TgeneDMDchrX:29417425chrX:31697705ENST00000378723017943_10450636.0RepeatNote=Spectrin 6
TgeneDMDchrX:29417425chrX:31697705ENST000003614710163307_33540623.0Zinc fingerZZ-type
TgeneDMDchrX:29417425chrX:31697705ENST000003786800133307_33540526.0Zinc fingerZZ-type
TgeneDMDchrX:29417425chrX:31697705ENST000003787020183307_33540618.0Zinc fingerZZ-type
TgeneDMDchrX:29417425chrX:31697705ENST000003787230173307_33540636.0Zinc fingerZZ-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+410242_350234.33333333333334697.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+410403_559234.33333333333334697.0DomainTIR
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+511242_350234.33333333333334697.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+511403_559234.33333333333334697.0DomainTIR
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+41019_357234.33333333333334697.0Topological domainExtracellular
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+410379_696234.33333333333334697.0Topological domainCytoplasmic
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+51119_357234.33333333333334697.0Topological domainExtracellular
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+511379_696234.33333333333334697.0Topological domainCytoplasmic
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+410358_378234.33333333333334697.0TransmembraneHelical
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+511358_378234.33333333333334697.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IL1RAPL1
DMD


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000302196+410549_644234.33333333333334697.0NCS1
HgeneIL1RAPL1chrX:29417425chrX:31697705ENST00000378993+511549_644234.33333333333334697.0NCS1


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Related Drugs to IL1RAPL1-DMD


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to IL1RAPL1-DMD


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource