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Fusion Protein:IL4R-RBBP6 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: IL4R-RBBP6 | FusionPDB ID: 39565 | FusionGDB2.0 ID: 39565 | Hgene | Tgene | Gene symbol | IL4R | RBBP6 | Gene ID | 3566 | 5930 |
| Gene name | interleukin 4 receptor | RB binding protein 6, ubiquitin ligase | |
| Synonyms | CD124|IL-4RA|IL4RA | MY038|P2P-R|PACT|RBQ-1|SNAMA | |
| Cytomap | 16p12.1 | 16p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interleukin-4 receptor subunit alphaIL-4 receptor subunit alphaIL4R nirs variant 1interleukin 13 receptorinterleukin-4 receptor alpha chain | E3 ubiquitin-protein ligase RBBP6RB-binding Q-protein 1RING-type E3 ubiquitin transferase RBBP6p53-associated cellular protein of testisproliferation potential-related proteinprotein P2P-Rretinoblastoma binding protein 6retinoblastoma-binding Q pro | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | P24394 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000380922, ENST00000170630, ENST00000395762, ENST00000449195, ENST00000543915, ENST00000565915, | ENST00000319715, ENST00000348022, ENST00000381039, ENST00000452655, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 8 X 5=360 | 6 X 6 X 5=180 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: IL4R [Title/Abstract] AND RBBP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | IL4R(27351594)-RBBP6(24557483), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | IL4R-RBBP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IL4R-RBBP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. IL4R-RBBP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. IL4R-RBBP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RBBP6 | GO:0006511 | ubiquitin-dependent protein catabolic process | 18851979 |
| Fusion gene breakpoints across IL4R (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RBBP6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CN-A6V1 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000395762 | IL4R | chr16 | 27351594 | + | ENST00000319715 | RBBP6 | chr16 | 24557483 | + | 5960 | 329 | 238 | 5541 | 1767 |
| ENST00000395762 | IL4R | chr16 | 27351594 | + | ENST00000452655 | RBBP6 | chr16 | 24557483 | + | 886 | 329 | 238 | 519 | 93 |
| ENST00000395762 | IL4R | chr16 | 27351594 | + | ENST00000381039 | RBBP6 | chr16 | 24557483 | + | 3440 | 329 | 238 | 3021 | 927 |
| ENST00000395762 | IL4R | chr16 | 27351594 | + | ENST00000348022 | RBBP6 | chr16 | 24557483 | + | 5858 | 329 | 238 | 5439 | 1733 |
| ENST00000543915 | IL4R | chr16 | 27351594 | + | ENST00000319715 | RBBP6 | chr16 | 24557483 | + | 5814 | 183 | 113 | 5395 | 1760 |
| ENST00000543915 | IL4R | chr16 | 27351594 | + | ENST00000452655 | RBBP6 | chr16 | 24557483 | + | 740 | 183 | 270 | 1 | 90 |
| ENST00000543915 | IL4R | chr16 | 27351594 | + | ENST00000381039 | RBBP6 | chr16 | 24557483 | + | 3294 | 183 | 113 | 2875 | 920 |
| ENST00000543915 | IL4R | chr16 | 27351594 | + | ENST00000348022 | RBBP6 | chr16 | 24557483 | + | 5712 | 183 | 113 | 5293 | 1726 |
| ENST00000449195 | IL4R | chr16 | 27351594 | + | ENST00000319715 | RBBP6 | chr16 | 24557483 | + | 5943 | 312 | 221 | 5524 | 1767 |
| ENST00000449195 | IL4R | chr16 | 27351594 | + | ENST00000452655 | RBBP6 | chr16 | 24557483 | + | 869 | 312 | 221 | 502 | 93 |
| ENST00000449195 | IL4R | chr16 | 27351594 | + | ENST00000381039 | RBBP6 | chr16 | 24557483 | + | 3423 | 312 | 221 | 3004 | 927 |
| ENST00000449195 | IL4R | chr16 | 27351594 | + | ENST00000348022 | RBBP6 | chr16 | 24557483 | + | 5841 | 312 | 221 | 5422 | 1733 |
| ENST00000170630 | IL4R | chr16 | 27351594 | + | ENST00000319715 | RBBP6 | chr16 | 24557483 | + | 5722 | 91 | 21 | 5303 | 1760 |
| ENST00000170630 | IL4R | chr16 | 27351594 | + | ENST00000452655 | RBBP6 | chr16 | 24557483 | + | 648 | 91 | 21 | 281 | 86 |
| ENST00000170630 | IL4R | chr16 | 27351594 | + | ENST00000381039 | RBBP6 | chr16 | 24557483 | + | 3202 | 91 | 21 | 2783 | 920 |
| ENST00000170630 | IL4R | chr16 | 27351594 | + | ENST00000348022 | RBBP6 | chr16 | 24557483 | + | 5620 | 91 | 21 | 5201 | 1726 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000395762 | ENST00000319715 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000405838 | 0.99959415 |
| ENST00000395762 | ENST00000452655 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.30368245 | 0.69631755 |
| ENST00000395762 | ENST00000381039 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000357222 | 0.9996427 |
| ENST00000395762 | ENST00000348022 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.00040593 | 0.99959403 |
| ENST00000543915 | ENST00000319715 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000350743 | 0.9996493 |
| ENST00000543915 | ENST00000452655 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.22422813 | 0.7757719 |
| ENST00000543915 | ENST00000381039 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000365668 | 0.99963427 |
| ENST00000543915 | ENST00000348022 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000349356 | 0.9996506 |
| ENST00000449195 | ENST00000319715 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000398872 | 0.9996012 |
| ENST00000449195 | ENST00000452655 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.46997914 | 0.5300209 |
| ENST00000449195 | ENST00000381039 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000357793 | 0.99964225 |
| ENST00000449195 | ENST00000348022 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000399051 | 0.99960095 |
| ENST00000170630 | ENST00000319715 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000333485 | 0.9996666 |
| ENST00000170630 | ENST00000452655 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.26726127 | 0.7327387 |
| ENST00000170630 | ENST00000381039 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.000402489 | 0.9995975 |
| ENST00000170630 | ENST00000348022 | IL4R | chr16 | 27351594 | + | RBBP6 | chr16 | 24557483 | + | 0.00032674 | 0.99967325 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >39565_39565_1_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000170630_RBBP6_chr16_24557483_ENST00000319715_length(amino acids)=1760AA_BP=1691 MGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAE ANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAML TNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQN DVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQS SLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHG QLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTL PLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFT NDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHG YHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYY KGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNK HKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRK NDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKK DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL SAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTV IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH EIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRD KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVD KNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSV KEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHK -------------------------------------------------------------- >39565_39565_2_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000170630_RBBP6_chr16_24557483_ENST00000348022_length(amino acids)=1726AA_BP=1657 MGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAE ANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAML TNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQN DVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQS SLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHG QLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTL PLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEESKSPYSGSSYS RSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNV PQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFT RGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGV EENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSE PPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK RKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLE STSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDF ESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENP EKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKD SASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPET QVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVG ISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDK -------------------------------------------------------------- >39565_39565_3_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000170630_RBBP6_chr16_24557483_ENST00000381039_length(amino acids)=920AA_BP=851 MGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAE ANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAML TNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQN DVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQS SLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWD KDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLE KENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS RNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILN PPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAV VQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKK -------------------------------------------------------------- >39565_39565_4_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000170630_RBBP6_chr16_24557483_ENST00000452655_length(amino acids)=86AA_BP=11 -------------------------------------------------------------- >39565_39565_5_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000395762_RBBP6_chr16_24557483_ENST00000319715_length(amino acids)=1767AA_BP=1698 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLT KTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDP NMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHT CPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSIS SLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLL GQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLY PPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKK SKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYR SRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYR EWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAP GDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPV KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTP EKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEK TDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQK FTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNK DFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPN EETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESD SESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK -------------------------------------------------------------- >39565_39565_6_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000395762_RBBP6_chr16_24557483_ENST00000348022_length(amino acids)=1733AA_BP=1664 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLT KTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDP NMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHT CPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSIS SLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLL GQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLY PPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEESKSP YSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQ SPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLN IRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK SREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGER ERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKP LDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTK EPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQS KWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYS VLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLY ILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDT AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKK -------------------------------------------------------------- >39565_39565_7_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000395762_RBBP6_chr16_24557483_ENST00000381039_length(amino acids)=927AA_BP=858 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLT KTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDP NMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHT CPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSIS SLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQ VPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKD RDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELT RRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGN KLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKE SLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKH -------------------------------------------------------------- >39565_39565_8_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000395762_RBBP6_chr16_24557483_ENST00000452655_length(amino acids)=93AA_BP=18 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAVCKNTISHFFYTLL -------------------------------------------------------------- >39565_39565_9_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000449195_RBBP6_chr16_24557483_ENST00000319715_length(amino acids)=1767AA_BP=1698 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLT KTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDP NMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHT CPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSIS SLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLL GQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLY PPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKK SKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYR SRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYR EWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAP GDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK GDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPV KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTP EKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEK TDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQK FTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNK DFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPN EETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESD SESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK -------------------------------------------------------------- >39565_39565_10_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000449195_RBBP6_chr16_24557483_ENST00000348022_length(amino acids)=1733AA_BP=1664 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLT KTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDP NMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHT CPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSIS SLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLL GQSLLHGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLY PPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEESKSP YSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQ SPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLN IRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRK SREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGER ERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKP LDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTK EPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQS KWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYS VLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKD SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLY ILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDT AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKK -------------------------------------------------------------- >39565_39565_11_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000449195_RBBP6_chr16_24557483_ENST00000381039_length(amino acids)=927AA_BP=858 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLT KTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDP NMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHT CPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSIS SLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQ VPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKD RDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELT RRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGN KLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKE SLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKH -------------------------------------------------------------- >39565_39565_12_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000449195_RBBP6_chr16_24557483_ENST00000452655_length(amino acids)=93AA_BP=18 MVPWHLPMGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAVCKNTISHFFYTLL -------------------------------------------------------------- >39565_39565_13_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000543915_RBBP6_chr16_24557483_ENST00000319715_length(amino acids)=1760AA_BP=1691 MGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAE ANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAML TNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQN DVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQS SLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHG QLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTL PLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFT NDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHG YHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYY KGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNK HKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRK NDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKK DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISL SAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTV IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSH EIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRD KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVD KNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSV KEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHK -------------------------------------------------------------- >39565_39565_14_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000543915_RBBP6_chr16_24557483_ENST00000348022_length(amino acids)=1726AA_BP=1657 MGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAE ANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAML TNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQN DVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQS SLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLLHG QLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTL PLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEESKSPYSGSSYS RSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNV PQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFT RGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGV EENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSE PPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEK RKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLE STSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDF ESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENP EKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKD SASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPET QVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVG ISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDK -------------------------------------------------------------- >39565_39565_15_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000543915_RBBP6_chr16_24557483_ENST00000381039_length(amino acids)=920AA_BP=851 MGWLCSGLLFPVSCLVLLQVASSEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANLAE ANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAML TNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQN DVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSLTSNQS SLAPPVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWD KDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLE KENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPS RNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILN PPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAV VQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKK -------------------------------------------------------------- >39565_39565_16_IL4R-RBBP6_IL4R_chr16_27351594_ENST00000543915_RBBP6_chr16_24557483_ENST00000452655_length(amino acids)=90AA_BP=1 MLVDLTPPIGILLTITEEFLGIRALSSVYSELATCSRTRQLTGNRSPEQSHPIGRCQGTCAPLLHSPSGRPSGKWGTPGWPFPGPRRAGL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:27351594/chr16:24557483) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IL4R | . |
| FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000319715 | 0 | 18 | 560_565 | 55.333333333333336 | 1793.0 | Motif | PPxPxY | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000348022 | 0 | 17 | 560_565 | 55.333333333333336 | 1759.0 | Motif | PPxPxY | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000381039 | 0 | 11 | 560_565 | 55.333333333333336 | 953.0 | Motif | PPxPxY | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000452655 | 0 | 3 | 560_565 | 55.333333333333336 | 119.0 | Motif | PPxPxY | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000319715 | 0 | 18 | 159_176 | 55.333333333333336 | 1793.0 | Zinc finger | CCHC-type | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000319715 | 0 | 18 | 259_300 | 55.333333333333336 | 1793.0 | Zinc finger | RING-type%3B degenerate | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000348022 | 0 | 17 | 159_176 | 55.333333333333336 | 1759.0 | Zinc finger | CCHC-type | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000348022 | 0 | 17 | 259_300 | 55.333333333333336 | 1759.0 | Zinc finger | RING-type%3B degenerate | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000381039 | 0 | 11 | 159_176 | 55.333333333333336 | 953.0 | Zinc finger | CCHC-type | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000381039 | 0 | 11 | 259_300 | 55.333333333333336 | 953.0 | Zinc finger | RING-type%3B degenerate | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000452655 | 0 | 3 | 159_176 | 55.333333333333336 | 119.0 | Zinc finger | CCHC-type | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000452655 | 0 | 3 | 259_300 | 55.333333333333336 | 119.0 | Zinc finger | RING-type%3B degenerate |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 370_380 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Glu |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 563_566 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Ala |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 789_794 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Ser |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 370_380 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Glu |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 563_566 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Ala |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 789_794 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Ser |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 370_380 | 23.333333333333332 | 228.0 | Compositional bias | Note=Poly-Glu |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 563_566 | 23.333333333333332 | 228.0 | Compositional bias | Note=Poly-Ala |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 789_794 | 23.333333333333332 | 228.0 | Compositional bias | Note=Poly-Ser |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 370_380 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Glu |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 563_566 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Ala |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 789_794 | 23.333333333333332 | 826.0 | Compositional bias | Note=Poly-Ser |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 125_224 | 23.333333333333332 | 826.0 | Domain | Fibronectin type-III |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 125_224 | 23.333333333333332 | 826.0 | Domain | Fibronectin type-III |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 125_224 | 23.333333333333332 | 228.0 | Domain | Fibronectin type-III |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 125_224 | 23.333333333333332 | 826.0 | Domain | Fibronectin type-III |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 212_216 | 23.333333333333332 | 826.0 | Motif | Note=WSXWS motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 262_270 | 23.333333333333332 | 826.0 | Motif | Note=Box 1 motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 711_716 | 23.333333333333332 | 826.0 | Motif | Note=ITIM motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 212_216 | 23.333333333333332 | 826.0 | Motif | Note=WSXWS motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 262_270 | 23.333333333333332 | 826.0 | Motif | Note=Box 1 motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 711_716 | 23.333333333333332 | 826.0 | Motif | Note=ITIM motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 212_216 | 23.333333333333332 | 228.0 | Motif | Note=WSXWS motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 262_270 | 23.333333333333332 | 228.0 | Motif | Note=Box 1 motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 711_716 | 23.333333333333332 | 228.0 | Motif | Note=ITIM motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 212_216 | 23.333333333333332 | 826.0 | Motif | Note=WSXWS motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 262_270 | 23.333333333333332 | 826.0 | Motif | Note=Box 1 motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 711_716 | 23.333333333333332 | 826.0 | Motif | Note=ITIM motif |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 437_557 | 23.333333333333332 | 826.0 | Region | Note=Required for IRS1 activation and IL4-induced cell growth |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 558_657 | 23.333333333333332 | 826.0 | Region | Note=Required for IL4-induced gene expression |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 437_557 | 23.333333333333332 | 826.0 | Region | Note=Required for IRS1 activation and IL4-induced cell growth |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 558_657 | 23.333333333333332 | 826.0 | Region | Note=Required for IL4-induced gene expression |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 437_557 | 23.333333333333332 | 228.0 | Region | Note=Required for IRS1 activation and IL4-induced cell growth |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 558_657 | 23.333333333333332 | 228.0 | Region | Note=Required for IL4-induced gene expression |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 437_557 | 23.333333333333332 | 826.0 | Region | Note=Required for IRS1 activation and IL4-induced cell growth |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 558_657 | 23.333333333333332 | 826.0 | Region | Note=Required for IL4-induced gene expression |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 257_825 | 23.333333333333332 | 826.0 | Topological domain | Cytoplasmic |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 26_232 | 23.333333333333332 | 826.0 | Topological domain | Extracellular |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 257_825 | 23.333333333333332 | 826.0 | Topological domain | Cytoplasmic |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 26_232 | 23.333333333333332 | 826.0 | Topological domain | Extracellular |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 257_825 | 23.333333333333332 | 228.0 | Topological domain | Cytoplasmic |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 26_232 | 23.333333333333332 | 228.0 | Topological domain | Extracellular |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 257_825 | 23.333333333333332 | 826.0 | Topological domain | Cytoplasmic |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 26_232 | 23.333333333333332 | 826.0 | Topological domain | Extracellular |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000170630 | + | 1 | 9 | 233_256 | 23.333333333333332 | 826.0 | Transmembrane | Helical |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000395762 | + | 3 | 11 | 233_256 | 23.333333333333332 | 826.0 | Transmembrane | Helical |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000449195 | + | 3 | 8 | 233_256 | 23.333333333333332 | 228.0 | Transmembrane | Helical |
| Hgene | IL4R | chr16:27351594 | chr16:24557483 | ENST00000543915 | + | 2 | 10 | 233_256 | 23.333333333333332 | 826.0 | Transmembrane | Helical |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000319715 | 0 | 18 | 4_76 | 55.333333333333336 | 1793.0 | Domain | DWNN | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000348022 | 0 | 17 | 4_76 | 55.333333333333336 | 1759.0 | Domain | DWNN | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000381039 | 0 | 11 | 4_76 | 55.333333333333336 | 953.0 | Domain | DWNN | |
| Tgene | RBBP6 | chr16:27351594 | chr16:24557483 | ENST00000452655 | 0 | 3 | 4_76 | 55.333333333333336 | 119.0 | Domain | DWNN |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| IL4R | |
| RBBP6 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to IL4R-RBBP6 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to IL4R-RBBP6 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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