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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:INCENP-CCS

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: INCENP-CCS
	FusionPDB ID: 39728
	FusionGDB2.0 ID: 39728
		Hgene	Tgene
	Gene symbol	INCENP	CCS
	Gene ID	3619	9973
	Gene name	inner centromere protein	copper chaperone for superoxide dismutase
	Synonyms	-	-
	Cytomap	11q12.3	11q13.2
	Type of gene	protein-coding	protein-coding
	Description	inner centromere proteinbinds and activates aurora-B and -C in vivo and in vitrochromosomal passenger proteininner centromere protein INCENPinner centromere protein antigens 135/155kDa	copper chaperone for superoxide dismutasesuperoxide dismutase copper chaperone
	Modification date	20200313	20200329
	UniProtAcc	Q9NQS7	Q9H7U1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000278849, ENST00000394818, ENST00000531099,	ENST00000310190, ENST00000533244,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 4 X 3=36	5 X 4 X 5=100
	# samples	4	6
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: INCENP [Title/Abstract] AND CCS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	INCENP(61908516)-CCS(66372810), # samples:2 INCENP(61908983)-CCS(66372810), # samples:2
Anticipated loss of major functional domain due to fusion event.	INCENP-CCS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. INCENP-CCS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. INCENP-CCS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. INCENP-CCS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across INCENP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-77-8153-01A	INCENP	chr11	61908516	+	CCS	chr11	66372810	+
ChimerDB4	LUSC	TCGA-77-8153-01A	INCENP	chr11	61908983	-	CCS	chr11	66372810	+
ChimerDB4	LUSC	TCGA-77-8153	INCENP	chr11	61908516	+	CCS	chr11	66372810	+
ChimerDB4	LUSC	TCGA-77-8153	INCENP	chr11	61908983	+	CCS	chr11	66372810	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394818	INCENP	chr11	61908516	+	ENST00000533244	CCS	chr11	66372810	+	2295	1795	67	2130	687
ENST00000394818	INCENP	chr11	61908516	+	ENST00000310190	CCS	chr11	66372810	+	2195	1795	67	2130	687
ENST00000278849	INCENP	chr11	61908516	+	ENST00000533244	CCS	chr11	66372810	+	2270	1770	42	2105	687
ENST00000278849	INCENP	chr11	61908516	+	ENST00000310190	CCS	chr11	66372810	+	2170	1770	42	2105	687
ENST00000394818	INCENP	chr11	61908983	+	ENST00000533244	CCS	chr11	66372810	+	2307	1807	67	2142	691
ENST00000394818	INCENP	chr11	61908983	+	ENST00000310190	CCS	chr11	66372810	+	2207	1807	67	2142	691

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394818	ENST00000533244	INCENP	chr11	61908516	+	CCS	chr11	66372810	+	0.027558919	0.972441
ENST00000394818	ENST00000310190	INCENP	chr11	61908516	+	CCS	chr11	66372810	+	0.035501953	0.96449804
ENST00000278849	ENST00000533244	INCENP	chr11	61908516	+	CCS	chr11	66372810	+	0.026426125	0.9735738
ENST00000278849	ENST00000310190	INCENP	chr11	61908516	+	CCS	chr11	66372810	+	0.034369737	0.9656303
ENST00000394818	ENST00000533244	INCENP	chr11	61908983	+	CCS	chr11	66372810	+	0.027701275	0.9722987
ENST00000394818	ENST00000310190	INCENP	chr11	61908983	+	CCS	chr11	66372810	+	0.03558689	0.9644131

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39728_39728_1_INCENP-CCS_INCENP_chr11_61908516_ENST00000278849_CCS_chr11_66372810_ENST00000310190_length(amino acids)=687AA_BP=576
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------

>39728_39728_2_INCENP-CCS_INCENP_chr11_61908516_ENST00000278849_CCS_chr11_66372810_ENST00000533244_length(amino acids)=687AA_BP=576
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------

>39728_39728_3_INCENP-CCS_INCENP_chr11_61908516_ENST00000394818_CCS_chr11_66372810_ENST00000310190_length(amino acids)=687AA_BP=576
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------

>39728_39728_4_INCENP-CCS_INCENP_chr11_61908516_ENST00000394818_CCS_chr11_66372810_ENST00000533244_length(amino acids)=687AA_BP=576
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------

>39728_39728_5_INCENP-CCS_INCENP_chr11_61908983_ENST00000394818_CCS_chr11_66372810_ENST00000310190_length(amino acids)=691AA_BP=577
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHP

--------------------------------------------------------------

>39728_39728_6_INCENP-CCS_INCENP_chr11_61908983_ENST00000394818_CCS_chr11_66372810_ENST00000533244_length(amino acids)=691AA_BP=577
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:61908516/chr11:66372810)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
INCENP Q9NQS7	CCS Q9H7U1
FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250\|UniProtKB:P53352, ECO:0000269\|PubMed:12925766, ECO:0000269\|PubMed:15316025, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:21346195, ECO:0000269\|PubMed:27332895}.	FUNCTION: Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250\|UniProtKB:Q3UHI0}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INCENP

chr11:61908516

chr11:66372810

ENST00000278849

167_171

531.0

915.0

Motif

PXVXL/I motif

Hgene

INCENP

chr11:61908516

chr11:66372810

ENST00000394818

167_171

531.0

919.0

Motif

PXVXL/I motif

Hgene

INCENP

chr11:61908983

chr11:66372810

ENST00000394818

167_171

535.0

919.0

Motif

PXVXL/I motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INCENP

chr11:61908983

chr11:66372810

ENST00000278849

167_171

915.0

Motif

PXVXL/I motif

Hgene

INCENP

chr11:61908516

chr11:66372810

ENST00000278849

531_765

531.0

915.0

Region

SAH

Hgene

INCENP

chr11:61908516

chr11:66372810

ENST00000278849

826_900

531.0

915.0

Region

IN box

Hgene

INCENP

chr11:61908516

chr11:66372810

ENST00000394818

531_765

531.0

919.0

Region

SAH

Hgene

INCENP

chr11:61908516

chr11:66372810

ENST00000394818

826_900

531.0

919.0

Region

IN box

Hgene

INCENP

chr11:61908983

chr11:66372810

ENST00000278849

531_765

915.0

Region

SAH

Hgene

INCENP

chr11:61908983

chr11:66372810

ENST00000278849

826_900

915.0

Region

IN box

Hgene

INCENP

chr11:61908983

chr11:66372810

ENST00000394818

531_765

535.0

919.0

Region

SAH

Hgene

INCENP

chr11:61908983

chr11:66372810

ENST00000394818

826_900

535.0

919.0

Region

IN box

Tgene

CCS

chr11:61908516

chr11:66372810

ENST00000533244

12_75

163.0

275.0

Domain

HMA

Tgene

CCS

chr11:61908983

chr11:66372810

ENST00000533244

12_75

163.0

275.0

Domain

HMA

Tgene

CCS

chr11:61908516

chr11:66372810

ENST00000533244

88_234

163.0

275.0

Region

Note=Superoxide dismutase-like

Tgene

CCS

chr11:61908983

chr11:66372810

ENST00000533244

88_234

163.0

275.0

Region

Note=Superoxide dismutase-like

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1417_INCENP_61908983_CCS_66372810_ranked_0.pdb	INCENP	61908983	61908983	ENST00000310190	CCS	chr11	66372810	+	MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHP	691

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

INCENP_pLDDT.png

CCS_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
INCENP
CCS

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	INCENP	chr11:61908516	chr11:66372810	ENST00000278849	+	10	18	822_897	531.0	915.0	AURKC
Hgene	INCENP	chr11:61908516	chr11:66372810	ENST00000394818	+	10	19	822_897	531.0	919.0	AURKC
Hgene	INCENP	chr11:61908983	chr11:66372810	ENST00000278849	+	1	18	822_897	0	915.0	AURKC
Hgene	INCENP	chr11:61908983	chr11:66372810	ENST00000394818	+	11	19	822_897	535.0	919.0	AURKC
Hgene	INCENP	chr11:61908983	chr11:66372810	ENST00000278849	+	1	18	124_248	0	915.0	CBX5

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Related Drugs to INCENP-CCS

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to INCENP-CCS

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source