| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:ING4-NCAPD2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ING4-NCAPD2 | FusionPDB ID: 39747 | FusionGDB2.0 ID: 39747 | Hgene | Tgene | Gene symbol | ING4 | NCAPD2 | Gene ID | 51147 | 9918 |
| Gene name | inhibitor of growth family member 4 | non-SMC condensin I complex subunit D2 | |
| Synonyms | my036|p29ING4 | CAP-D2|CNAP1|MCPH21|hCAP-D2 | |
| Cytomap | 12p13.31 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inhibitor of growth protein 4brain my036 proteincandidate tumor suppressor p33 ING1 homolog | condensin complex subunit 1XCAP-D2 homologchromosome condensation-related SMC-associated protein 1chromosome-associated protein D2 | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | Q9UNL4 | Q15021 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000341550, ENST00000396807, ENST00000412586, ENST00000423703, ENST00000446105, ENST00000486287, ENST00000444704, | ENST00000542492, ENST00000315579, ENST00000545962, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 3 X 3 X 3=27 | 6 X 6 X 5=180 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ING4 [Title/Abstract] AND NCAPD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ING4(6765892)-NCAPD2(6618882), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ING4-NCAPD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ING4-NCAPD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ING4-NCAPD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ING4-NCAPD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ING4-NCAPD2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. ING4-NCAPD2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. ING4-NCAPD2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ING4 | GO:0006260 | DNA replication | 16387653 |
| Hgene | ING4 | GO:0006473 | protein acetylation | 12750254 |
| Hgene | ING4 | GO:0006915 | apoptotic process | 15251430 |
| Hgene | ING4 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 16387653 |
| Hgene | ING4 | GO:0007050 | cell cycle arrest | 15251430 |
| Hgene | ING4 | GO:0008285 | negative regulation of cell proliferation | 12750254|15251430 |
| Hgene | ING4 | GO:0043065 | positive regulation of apoptotic process | 16387653 |
| Hgene | ING4 | GO:0043966 | histone H3 acetylation | 16387653 |
| Hgene | ING4 | GO:0043981 | histone H4-K5 acetylation | 16387653 |
| Hgene | ING4 | GO:0043982 | histone H4-K8 acetylation | 16387653 |
| Hgene | ING4 | GO:0043983 | histone H4-K12 acetylation | 16387653 |
| Hgene | ING4 | GO:0043984 | histone H4-K16 acetylation | 16387653 |
| Hgene | ING4 | GO:0045892 | negative regulation of transcription, DNA-templated | 15029197 |
| Hgene | ING4 | GO:0045926 | negative regulation of growth | 12750254 |
| Tgene | NCAPD2 | GO:0007076 | mitotic chromosome condensation | 11136719 |
| Fusion gene breakpoints across ING4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across NCAPD2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 43N | ING4 | chr12 | 6765892 | - | NCAPD2 | chr12 | 6618882 | + |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000341550 | ING4 | chr12 | 6765892 | - | ENST00000315579 | NCAPD2 | chr12 | 6618882 | + | 4778 | 156 | 32 | 4234 | 1400 |
| ENST00000396807 | ING4 | chr12 | 6765892 | - | ENST00000315579 | NCAPD2 | chr12 | 6618882 | + | 4770 | 148 | 24 | 4226 | 1400 |
| ENST00000446105 | ING4 | chr12 | 6765892 | - | ENST00000315579 | NCAPD2 | chr12 | 6618882 | + | 4772 | 150 | 26 | 4228 | 1400 |
| ENST00000423703 | ING4 | chr12 | 6765892 | - | ENST00000545962 | NCAPD2 | chr12 | 6618882 | + | 4193 | 109 | 118 | 4128 | 1336 |
| ENST00000412586 | ING4 | chr12 | 6765892 | - | ENST00000315579 | NCAPD2 | chr12 | 6618882 | + | 4731 | 109 | 0 | 4187 | 1395 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000341550 | ENST00000315579 | ING4 | chr12 | 6765892 | - | NCAPD2 | chr12 | 6618882 | + | 0.000704162 | 0.99929583 |
| ENST00000396807 | ENST00000315579 | ING4 | chr12 | 6765892 | - | NCAPD2 | chr12 | 6618882 | + | 0.000719991 | 0.99928004 |
| ENST00000446105 | ENST00000315579 | ING4 | chr12 | 6765892 | - | NCAPD2 | chr12 | 6618882 | + | 0.000717105 | 0.9992829 |
| ENST00000423703 | ENST00000545962 | ING4 | chr12 | 6765892 | - | NCAPD2 | chr12 | 6618882 | + | 0.00140587 | 0.9985941 |
| ENST00000412586 | ENST00000315579 | ING4 | chr12 | 6765892 | - | NCAPD2 | chr12 | 6618882 | + | 0.000688474 | 0.99931157 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >39747_39747_1_ING4-NCAPD2_ING4_chr12_6765892_ENST00000341550_NCAPD2_chr12_6618882_ENST00000315579_length(amino acids)=1400AA_BP=41 MFCFEMAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSR HSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDI RHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGM KSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDT RDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQ KETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATG HFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFS RKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLS LLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRL AQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKL EEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDT EAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGD LAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDII SRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFS AFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPN -------------------------------------------------------------- >39747_39747_2_ING4-NCAPD2_ING4_chr12_6765892_ENST00000396807_NCAPD2_chr12_6618882_ENST00000315579_length(amino acids)=1400AA_BP=41 MFCFEMAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSR HSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDI RHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGM KSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDT RDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQ KETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATG HFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFS RKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLS LLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRL AQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKL EEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDT EAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGD LAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDII SRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFS AFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPN -------------------------------------------------------------- >39747_39747_3_ING4-NCAPD2_ING4_chr12_6765892_ENST00000412586_NCAPD2_chr12_6618882_ENST00000315579_length(amino acids)=1395AA_BP=36 MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQEL PAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWN HSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVG EIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFL DTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQKETQK LQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATGHFQES EPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFSRKITE AIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVD ASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRLAQQVC HAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRT SQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDTEAELI RGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRF PNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSD PELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSV VGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPNTQQRA -------------------------------------------------------------- >39747_39747_4_ING4-NCAPD2_ING4_chr12_6765892_ENST00000423703_NCAPD2_chr12_6618882_ENST00000545962_length(amino acids)=1336AA_BP= MPFELRGPWLCCSTLILSTAFCMVSRHSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTK AAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKII QMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRN AVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAI QLLASFLANNPFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTED VKGRIYQLLAKASYKKAIILTREATGHFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDP EESRGNDELVKQEMLVQYLQDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLN AYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGK PEIVGSNLDTLVSIGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLI YQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKD PKEKNTSSETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQ LRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQI AALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPL TERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRY -------------------------------------------------------------- >39747_39747_5_ING4-NCAPD2_ING4_chr12_6765892_ENST00000446105_NCAPD2_chr12_6618882_ENST00000315579_length(amino acids)=1400AA_BP=41 MFCFEMAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSR HSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDI RHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGM KSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDT RDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQ KETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATG HFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFS RKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLS LLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRL AQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKL EEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDT EAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGD LAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDII SRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFS AFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPN -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6765892/chr12:6618882) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ING4 | NCAPD2 |
| FUNCTION: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}. | FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NCAPD2 | chr12:6765892 | chr12:6618882 | ENST00000315579 | 1 | 32 | 1342_1362 | 42.333333333333336 | 1402.0 | Motif | Note=Bipartite nuclear localization signal |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000341550 | - | 2 | 8 | 25_118 | 36.333333333333336 | 249.0 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000396807 | - | 2 | 8 | 25_118 | 36.333333333333336 | 250.0 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000412586 | - | 2 | 8 | 25_118 | 36.333333333333336 | 247.0 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000423703 | - | 2 | 7 | 25_118 | 36.333333333333336 | 177.66666666666666 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000444704 | - | 1 | 7 | 25_118 | 0.0 | 226.0 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000446105 | - | 2 | 8 | 25_118 | 36.333333333333336 | 246.0 | Coiled coil | Ontology_term=ECO:0000269 |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000341550 | - | 2 | 8 | 127_148 | 36.333333333333336 | 249.0 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000396807 | - | 2 | 8 | 127_148 | 36.333333333333336 | 250.0 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000412586 | - | 2 | 8 | 127_148 | 36.333333333333336 | 247.0 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000423703 | - | 2 | 7 | 127_148 | 36.333333333333336 | 177.66666666666666 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000444704 | - | 1 | 7 | 127_148 | 0.0 | 226.0 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000446105 | - | 2 | 8 | 127_148 | 36.333333333333336 | 246.0 | Motif | Note=Bipartite nuclear localization signal |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000341550 | - | 2 | 8 | 196_245 | 36.333333333333336 | 249.0 | Zinc finger | PHD-type |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000396807 | - | 2 | 8 | 196_245 | 36.333333333333336 | 250.0 | Zinc finger | PHD-type |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000412586 | - | 2 | 8 | 196_245 | 36.333333333333336 | 247.0 | Zinc finger | PHD-type |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000423703 | - | 2 | 7 | 196_245 | 36.333333333333336 | 177.66666666666666 | Zinc finger | PHD-type |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000444704 | - | 1 | 7 | 196_245 | 0.0 | 226.0 | Zinc finger | PHD-type |
| Hgene | ING4 | chr12:6765892 | chr12:6618882 | ENST00000446105 | - | 2 | 8 | 196_245 | 36.333333333333336 | 246.0 | Zinc finger | PHD-type |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ING4 | |
| NCAPD2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to ING4-NCAPD2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to ING4-NCAPD2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies