UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:INPP4B-ARHGEF26

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: INPP4B-ARHGEF26
FusionPDB ID: 39781
FusionGDB2.0 ID: 39781
HgeneTgene
Gene symbol

INPP4B

ARHGEF26

Gene ID

8821

26084

Gene nameinositol polyphosphate-4-phosphatase type II BRho guanine nucleotide exchange factor 26
Synonyms-CSGEF|HMFN1864|SGEF
Cytomap

4q31.21

3q25.2

Type of geneprotein-codingprotein-coding
Descriptioninositol polyphosphate 4-phosphatase type IIinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDatype II inositol 3,4-bisphosphate 4-phosphataserho guanine nucleotide exchange factor 26Rho guanine nucleotide exchange factor (GEF) 26SH3 domain-containing guanine exchange factorSrc homology 3 domain-containing guanine nucleotide exchange factortesticular tissue protein Li 171
Modification date2020031320200313
UniProtAcc

O15327

Q96DR7

Ensembl transtripts involved in fusion geneENST idsENST00000262992, ENST00000308502, 
ENST00000506217, ENST00000508116, 
ENST00000509777, ENST00000513000, 
ENST00000507861, ENST00000508084, 
ENST00000465817, ENST00000483068, 
ENST00000356448, ENST00000465093, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 5=7806 X 5 X 4=120
# samples 146
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: INPP4B [Title/Abstract] AND ARHGEF26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)INPP4B(143324090)-ARHGEF26(153935657), # samples:1
Anticipated loss of major functional domain due to fusion event.INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
INPP4B-ARHGEF26 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across INPP4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGEF26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12OINPP4Bchr4

143324090

-ARHGEF26chr3

153935657

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000513000INPP4Bchr4143324090-ENST00000356448ARHGEF26chr3153935657+39318064281576382
ENST00000513000INPP4Bchr4143324090-ENST00000465093ARHGEF26chr3153935657+26798064281576382
ENST00000509777INPP4Bchr4143324090-ENST00000356448ARHGEF26chr3153935657+38427173391487382
ENST00000509777INPP4Bchr4143324090-ENST00000465093ARHGEF26chr3153935657+25907173391487382
ENST00000308502INPP4Bchr4143324090-ENST00000356448ARHGEF26chr3153935657+36174921141262382
ENST00000308502INPP4Bchr4143324090-ENST00000465093ARHGEF26chr3153935657+23654921141262382
ENST00000506217INPP4Bchr4143324090-ENST00000356448ARHGEF26chr3153935657+349737201142380
ENST00000506217INPP4Bchr4143324090-ENST00000465093ARHGEF26chr3153935657+224537201142380

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000513000ENST00000356448INPP4Bchr4143324090-ARHGEF26chr3153935657+0.0008083450.9991917
ENST00000513000ENST00000465093INPP4Bchr4143324090-ARHGEF26chr3153935657+0.0011913740.9988086
ENST00000509777ENST00000356448INPP4Bchr4143324090-ARHGEF26chr3153935657+0.000794870.9992052
ENST00000509777ENST00000465093INPP4Bchr4143324090-ARHGEF26chr3153935657+0.0011488730.99885106
ENST00000308502ENST00000356448INPP4Bchr4143324090-ARHGEF26chr3153935657+0.0006954760.99930453
ENST00000308502ENST00000465093INPP4Bchr4143324090-ARHGEF26chr3153935657+0.0009866650.9990133
ENST00000506217ENST00000356448INPP4Bchr4143324090-ARHGEF26chr3153935657+0.0006844290.9993156
ENST00000506217ENST00000465093INPP4Bchr4143324090-ARHGEF26chr3153935657+0.0009855190.9990145

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39781_39781_1_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000308502_ARHGEF26_chr3_153935657_ENST00000356448_length(amino acids)=382AA_BP=126
MIMEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTR
DPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDT
VLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVE
MLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT

--------------------------------------------------------------

>39781_39781_2_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000308502_ARHGEF26_chr3_153935657_ENST00000465093_length(amino acids)=382AA_BP=126
MIMEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTR
DPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDT
VLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVE
MLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT

--------------------------------------------------------------

>39781_39781_3_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000506217_ARHGEF26_chr3_153935657_ENST00000356448_length(amino acids)=380AA_BP=124
MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDP
LFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVL
FSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEML
LGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQ

--------------------------------------------------------------

>39781_39781_4_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000506217_ARHGEF26_chr3_153935657_ENST00000465093_length(amino acids)=380AA_BP=124
MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDP
LFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVL
FSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEML
LGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQ

--------------------------------------------------------------

>39781_39781_5_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000509777_ARHGEF26_chr3_153935657_ENST00000356448_length(amino acids)=382AA_BP=126
MIMEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTR
DPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDT
VLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVE
MLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT

--------------------------------------------------------------

>39781_39781_6_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000509777_ARHGEF26_chr3_153935657_ENST00000465093_length(amino acids)=382AA_BP=126
MIMEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTR
DPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDT
VLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVE
MLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT

--------------------------------------------------------------

>39781_39781_7_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000513000_ARHGEF26_chr3_153935657_ENST00000356448_length(amino acids)=382AA_BP=126
MIMEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTR
DPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDT
VLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVE
MLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT

--------------------------------------------------------------

>39781_39781_8_INPP4B-ARHGEF26_INPP4B_chr4_143324090_ENST00000513000_ARHGEF26_chr3_153935657_ENST00000465093_length(amino acids)=382AA_BP=126
MIMEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTR
DPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDT
VLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVE
MLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:143324090/chr3:153935657)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INPP4B

O15327

ARHGEF26

Q96DR7

FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}.FUNCTION: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGEF26chr4:143324090chr3:153935657ENST0000046581705106_1730447.0Compositional biasNote=Pro-rich
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000356448815655_782615.0872.0DomainPH
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000356448815789_850615.0872.0DomainSH3
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000465093815655_782615.0872.0DomainPH
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000465093815789_850615.0872.0DomainSH3
TgeneARHGEF26chr4:143324090chr3:153935657ENST0000046581705439_6230447.0DomainDH
TgeneARHGEF26chr4:143324090chr3:153935657ENST0000046581705655_7820447.0DomainPH
TgeneARHGEF26chr4:143324090chr3:153935657ENST0000046581705789_8500447.0DomainSH3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINPP4Bchr4:143324090chr3:153935657ENST00000262992-52423_165124.0925.0DomainC2
HgeneINPP4Bchr4:143324090chr3:153935657ENST00000308502-42323_165124.0925.0DomainC2
HgeneINPP4Bchr4:143324090chr3:153935657ENST00000506217-4523_165124.0132.0DomainC2
HgeneINPP4Bchr4:143324090chr3:153935657ENST00000508116-62523_165124.0925.0DomainC2
HgeneINPP4Bchr4:143324090chr3:153935657ENST00000513000-82723_165124.0925.0DomainC2
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000356448815106_173615.0872.0Compositional biasNote=Pro-rich
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000465093815106_173615.0872.0Compositional biasNote=Pro-rich
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000356448815439_623615.0872.0DomainDH
TgeneARHGEF26chr4:143324090chr3:153935657ENST00000465093815439_623615.0872.0DomainDH


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
INPP4B
ARHGEF26


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to INPP4B-ARHGEF26


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to INPP4B-ARHGEF26


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource