UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:IQGAP1-ABHD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: IQGAP1-ABHD2
FusionPDB ID: 40152
FusionGDB2.0 ID: 40152
HgeneTgene
Gene symbol

IQGAP1

ABHD2

Gene ID

8826

11057

Gene nameIQ motif containing GTPase activating protein 1abhydrolase domain containing 2, acylglycerol lipase
SynonymsHUMORFA01|SAR1|p195HS1-2|LABH2|PHPS1-2
Cytomap

15q26.1

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionras GTPase-activating-like protein IQGAP1RasGAP-like with IQ motifsmonoacylglycerol lipase ABHD22-arachidonoylglycerol hydrolaseabhydrolase domain containing 2abhydrolase domain-containing protein 2acetylesterasealpha/beta hydrolase domain containing protein 2lung alpha/beta hydrolase 2progesterone-sensitive lipas
Modification date2020032720200313
UniProtAcc

P46940

P08910

Ensembl transtripts involved in fusion geneENST idsENST00000268182, ENST00000560738, 
ENST00000560020, 		ENST00000562254, 
ENST00000352732, ENST00000355100, 
ENST00000565973, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 20 X 12=648011 X 11 X 4=484
# samples 3213
** MAII scorelog2(32/6480*10)=-4.33985000288463
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/484*10)=-1.89649542424614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: IQGAP1 [Title/Abstract] AND ABHD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IQGAP1(91017365)-ABHD2(89719043), # samples:1
IQGAP1(91017365)-ABHD2(89719042), # samples:1
Anticipated loss of major functional domain due to fusion event.IQGAP1-ABHD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IQGAP1-ABHD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IQGAP1-ABHD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IQGAP1-ABHD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIQGAP1

GO:0071277

cellular response to calcium ion

18567582

TgeneABHD2

GO:0032570

response to progesterone

26989199

TgeneABHD2

GO:0043401

steroid hormone mediated signaling pathway

26989199

TgeneABHD2

GO:0046464

acylglycerol catabolic process

26989199

TgeneABHD2

GO:0048240

sperm capacitation

26989199


check buttonFusion gene breakpoints across IQGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABHD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A92D-01AIQGAP1chr15

91017365

+ABHD2chr15

89719043

+
ChimerDB4STADTCGA-VQ-A92DIQGAP1chr15

91017365

+ABHD2chr15

89719042

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268182IQGAP1chr1591017365+ENST00000352732ABHD2chr1589719043+10376269912434381104
ENST00000268182IQGAP1chr1591017365+ENST00000565973ABHD2chr1589719043+3767269912434381104
ENST00000268182IQGAP1chr1591017365+ENST00000355100ABHD2chr1589719043+10376269912434381104
ENST00000560738IQGAP1chr1591017365+ENST00000352732ABHD2chr1589719043+8617940811679532
ENST00000560738IQGAP1chr1591017365+ENST00000565973ABHD2chr1589719043+2008940811679532
ENST00000560738IQGAP1chr1591017365+ENST00000355100ABHD2chr1589719043+8617940811679532
ENST00000268182IQGAP1chr1591017365+ENST00000352732ABHD2chr1589719042+10376269912434381104
ENST00000268182IQGAP1chr1591017365+ENST00000565973ABHD2chr1589719042+3767269912434381104
ENST00000268182IQGAP1chr1591017365+ENST00000355100ABHD2chr1589719042+10376269912434381104
ENST00000560738IQGAP1chr1591017365+ENST00000352732ABHD2chr1589719042+8617940811679532
ENST00000560738IQGAP1chr1591017365+ENST00000565973ABHD2chr1589719042+2008940811679532
ENST00000560738IQGAP1chr1591017365+ENST00000355100ABHD2chr1589719042+8617940811679532

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268182ENST00000352732IQGAP1chr1591017365+ABHD2chr1589719043+0.0003526190.9996474
ENST00000268182ENST00000565973IQGAP1chr1591017365+ABHD2chr1589719043+0.003045180.9969548
ENST00000268182ENST00000355100IQGAP1chr1591017365+ABHD2chr1589719043+0.0003526190.9996474
ENST00000560738ENST00000352732IQGAP1chr1591017365+ABHD2chr1589719043+0.0010016710.99899834
ENST00000560738ENST00000565973IQGAP1chr1591017365+ABHD2chr1589719043+0.0035482720.99645174
ENST00000560738ENST00000355100IQGAP1chr1591017365+ABHD2chr1589719043+0.0010016710.99899834
ENST00000268182ENST00000352732IQGAP1chr1591017365+ABHD2chr1589719042+0.0003526190.9996474
ENST00000268182ENST00000565973IQGAP1chr1591017365+ABHD2chr1589719042+0.003045180.9969548
ENST00000268182ENST00000355100IQGAP1chr1591017365+ABHD2chr1589719042+0.0003526190.9996474
ENST00000560738ENST00000352732IQGAP1chr1591017365+ABHD2chr1589719042+0.0010016710.99899834
ENST00000560738ENST00000565973IQGAP1chr1591017365+ABHD2chr1589719042+0.0035482720.99645174
ENST00000560738ENST00000355100IQGAP1chr1591017365+ABHD2chr1589719042+0.0010016710.99899834

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40152_40152_1_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000268182_ABHD2_chr15_89719042_ENST00000352732_length(amino acids)=1104AA_BP=859
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKM
TNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAI
NEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVV
KIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQ
ANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKF
HGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYA

--------------------------------------------------------------

>40152_40152_2_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000268182_ABHD2_chr15_89719042_ENST00000355100_length(amino acids)=1104AA_BP=859
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKM
TNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAI
NEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVV
KIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQ
ANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKF
HGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYA

--------------------------------------------------------------

>40152_40152_3_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000268182_ABHD2_chr15_89719042_ENST00000565973_length(amino acids)=1104AA_BP=859
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKM
TNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAI
NEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVV
KIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQ
ANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKF
HGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYA

--------------------------------------------------------------

>40152_40152_4_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000268182_ABHD2_chr15_89719043_ENST00000352732_length(amino acids)=1104AA_BP=859
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKM
TNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAI
NEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVV
KIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQ
ANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKF
HGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYA

--------------------------------------------------------------

>40152_40152_5_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000268182_ABHD2_chr15_89719043_ENST00000355100_length(amino acids)=1104AA_BP=859
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKM
TNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAI
NEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVV
KIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQ
ANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKF
HGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYA

--------------------------------------------------------------

>40152_40152_6_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000268182_ABHD2_chr15_89719043_ENST00000565973_length(amino acids)=1104AA_BP=859
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKM
TNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPEL
SVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAI
NEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVV
KIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQ
ANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKF
HGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYA

--------------------------------------------------------------

>40152_40152_7_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000560738_ABHD2_chr15_89719042_ENST00000352732_length(amino acids)=532AA_BP=287
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGE
TYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRL
QARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKI
QAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCR
RFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAA

--------------------------------------------------------------

>40152_40152_8_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000560738_ABHD2_chr15_89719042_ENST00000355100_length(amino acids)=532AA_BP=287
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGE
TYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRL
QARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKI
QAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCR
RFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAA

--------------------------------------------------------------

>40152_40152_9_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000560738_ABHD2_chr15_89719042_ENST00000565973_length(amino acids)=532AA_BP=287
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGE
TYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRL
QARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKI
QAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCR
RFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAA

--------------------------------------------------------------

>40152_40152_10_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000560738_ABHD2_chr15_89719043_ENST00000352732_length(amino acids)=532AA_BP=287
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGE
TYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRL
QARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKI
QAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCR
RFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAA

--------------------------------------------------------------

>40152_40152_11_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000560738_ABHD2_chr15_89719043_ENST00000355100_length(amino acids)=532AA_BP=287
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGE
TYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRL
QARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKI
QAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCR
RFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAA

--------------------------------------------------------------

>40152_40152_12_IQGAP1-ABHD2_IQGAP1_chr15_91017365_ENST00000560738_ABHD2_chr15_89719043_ENST00000565973_length(amino acids)=532AA_BP=287
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGE
TYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRL
QARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKI
QAFIRANKARDDYKTLSCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCR
RFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:91017365/chr15:89719043)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IQGAP1

P46940

ABHD2

P08910

FUNCTION: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.FUNCTION: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity). {ECO:0000250|UniProtKB:Q9QXM0, ECO:0000269|PubMed:26989199, ECO:0000269|PubMed:27247428}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+223844_159858.33333333333341658.0DomainCalponin-homology (CH)
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+2238679_712858.33333333333341658.0DomainWW
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+2238745_774858.33333333333341658.0DomainIQ 1
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+2238775_804858.33333333333341658.0DomainIQ 2
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+2238805_834858.33333333333341658.0DomainIQ 3
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+223844_159858.33333333333341658.0DomainCalponin-homology (CH)
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+2238679_712858.33333333333341658.0DomainWW
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+2238745_774858.33333333333341658.0DomainIQ 1
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+2238775_804858.33333333333341658.0DomainIQ 2
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+2238805_834858.33333333333341658.0DomainIQ 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+22381004_1237858.33333333333341658.0DomainRas-GAP
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+2238835_864858.33333333333341658.0DomainIQ 4
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+22381004_1237858.33333333333341658.0DomainRas-GAP
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+2238835_864858.33333333333341658.0DomainIQ 4
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+22381276_1657858.33333333333341658.0RegionNote=C2
HgeneIQGAP1chr15:91017365chr15:89719042ENST00000268182+2238956_1274858.33333333333341658.0RegionNote=C1
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+22381276_1657858.33333333333341658.0RegionNote=C2
HgeneIQGAP1chr15:91017365chr15:89719043ENST00000268182+2238956_1274858.33333333333341658.0RegionNote=C1
TgeneABHD2chr15:91017365chr15:89719042ENST00000352732411128_382179.33333333333334426.0DomainAB hydrolase-1
TgeneABHD2chr15:91017365chr15:89719042ENST00000355100613128_382179.33333333333334426.0DomainAB hydrolase-1
TgeneABHD2chr15:91017365chr15:89719042ENST00000565973815128_382179.33333333333334426.0DomainAB hydrolase-1
TgeneABHD2chr15:91017365chr15:89719043ENST00000352732411128_382179.33333333333334426.0DomainAB hydrolase-1
TgeneABHD2chr15:91017365chr15:89719043ENST00000355100613128_382179.33333333333334426.0DomainAB hydrolase-1
TgeneABHD2chr15:91017365chr15:89719043ENST00000565973815128_382179.33333333333334426.0DomainAB hydrolase-1
TgeneABHD2chr15:91017365chr15:89719042ENST000003527324111_9179.33333333333334426.0Topological domainCytoplasmic
TgeneABHD2chr15:91017365chr15:89719042ENST0000035273241131_425179.33333333333334426.0Topological domainExtracellular
TgeneABHD2chr15:91017365chr15:89719042ENST000003551006131_9179.33333333333334426.0Topological domainCytoplasmic
TgeneABHD2chr15:91017365chr15:89719042ENST0000035510061331_425179.33333333333334426.0Topological domainExtracellular
TgeneABHD2chr15:91017365chr15:89719042ENST000005659738151_9179.33333333333334426.0Topological domainCytoplasmic
TgeneABHD2chr15:91017365chr15:89719042ENST0000056597381531_425179.33333333333334426.0Topological domainExtracellular
TgeneABHD2chr15:91017365chr15:89719043ENST000003527324111_9179.33333333333334426.0Topological domainCytoplasmic
TgeneABHD2chr15:91017365chr15:89719043ENST0000035273241131_425179.33333333333334426.0Topological domainExtracellular
TgeneABHD2chr15:91017365chr15:89719043ENST000003551006131_9179.33333333333334426.0Topological domainCytoplasmic
TgeneABHD2chr15:91017365chr15:89719043ENST0000035510061331_425179.33333333333334426.0Topological domainExtracellular
TgeneABHD2chr15:91017365chr15:89719043ENST000005659738151_9179.33333333333334426.0Topological domainCytoplasmic
TgeneABHD2chr15:91017365chr15:89719043ENST0000056597381531_425179.33333333333334426.0Topological domainExtracellular
TgeneABHD2chr15:91017365chr15:89719042ENST0000035273241110_30179.33333333333334426.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABHD2chr15:91017365chr15:89719042ENST0000035510061310_30179.33333333333334426.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABHD2chr15:91017365chr15:89719042ENST0000056597381510_30179.33333333333334426.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABHD2chr15:91017365chr15:89719043ENST0000035273241110_30179.33333333333334426.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABHD2chr15:91017365chr15:89719043ENST0000035510061310_30179.33333333333334426.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABHD2chr15:91017365chr15:89719043ENST0000056597381510_30179.33333333333334426.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
IQGAP1
ABHD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to IQGAP1-ABHD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to IQGAP1-ABHD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource