UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ITGA6-MYO3B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ITGA6-MYO3B
	FusionPDB ID: 40444
	FusionGDB2.0 ID: 40444
		Hgene	Tgene
	Gene symbol	ITGA6	MYO3B
	Gene ID	3655	140469
	Gene name	integrin subunit alpha 6	myosin IIIB
	Synonyms	CD49f\|ITGA6B\|VLA-6	-
	Cytomap	2q31.1	2q31.1
	Type of gene	protein-coding	protein-coding
	Description	integrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6	myosin-IIIb
	Modification date	20200329	20200320
	UniProtAcc	P23229	Q8WXR4
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264106, ENST00000264107, ENST00000343713, ENST00000375221, ENST00000409080, ENST00000409532,	ENST00000602629, ENST00000334231, ENST00000408978, ENST00000409044,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 8 X 6=480	4 X 5 X 3=60
	# samples	12	5
	** MAII score	log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ITGA6 [Title/Abstract] AND MYO3B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ITGA6(173292698)-MYO3B(171191895), # samples:1
Anticipated loss of major functional domain due to fusion event.	ITGA6-MYO3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ITGA6-MYO3B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ITGA6-MYO3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ITGA6-MYO3B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ITGA6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A6E5-01A	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264107	ITGA6	chr2	173292698	-	ENST00000408978	MYO3B	chr2	171191895	+	5053	416	0	3692	1230
ENST00000264107	ITGA6	chr2	173292698	-	ENST00000409044	MYO3B	chr2	171191895	+	4972	416	0	3611	1203
ENST00000264107	ITGA6	chr2	173292698	-	ENST00000334231	MYO3B	chr2	171191895	+	5724	416	0	3692	1230
ENST00000343713	ITGA6	chr2	173292698	-	ENST00000408978	MYO3B	chr2	171191895	+	5022	385	167	3661	1164
ENST00000343713	ITGA6	chr2	173292698	-	ENST00000409044	MYO3B	chr2	171191895	+	4941	385	167	3580	1137
ENST00000343713	ITGA6	chr2	173292698	-	ENST00000334231	MYO3B	chr2	171191895	+	5693	385	167	3661	1164
ENST00000264106	ITGA6	chr2	173292698	-	ENST00000408978	MYO3B	chr2	171191895	+	5022	385	167	3661	1164
ENST00000264106	ITGA6	chr2	173292698	-	ENST00000409044	MYO3B	chr2	171191895	+	4941	385	167	3580	1137
ENST00000264106	ITGA6	chr2	173292698	-	ENST00000334231	MYO3B	chr2	171191895	+	5693	385	167	3661	1164
ENST00000375221	ITGA6	chr2	173292698	-	ENST00000408978	MYO3B	chr2	171191895	+	5022	385	167	3661	1164
ENST00000375221	ITGA6	chr2	173292698	-	ENST00000409044	MYO3B	chr2	171191895	+	4941	385	167	3580	1137
ENST00000375221	ITGA6	chr2	173292698	-	ENST00000334231	MYO3B	chr2	171191895	+	5693	385	167	3661	1164
ENST00000409080	ITGA6	chr2	173292698	-	ENST00000408978	MYO3B	chr2	171191895	+	4819	182	0	3458	1152
ENST00000409080	ITGA6	chr2	173292698	-	ENST00000409044	MYO3B	chr2	171191895	+	4738	182	0	3377	1125
ENST00000409080	ITGA6	chr2	173292698	-	ENST00000334231	MYO3B	chr2	171191895	+	5490	182	0	3458	1152

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264107	ENST00000408978	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.00059	0.99941003
ENST00000264107	ENST00000409044	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000790885	0.9992091
ENST00000264107	ENST00000334231	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000318759	0.99968123
ENST00000343713	ENST00000408978	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000564165	0.99943584
ENST00000343713	ENST00000409044	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000757902	0.99924207
ENST00000343713	ENST00000334231	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000304752	0.9996953
ENST00000264106	ENST00000408978	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000564165	0.99943584
ENST00000264106	ENST00000409044	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000757902	0.99924207
ENST00000264106	ENST00000334231	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000304752	0.9996953
ENST00000375221	ENST00000408978	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000564165	0.99943584
ENST00000375221	ENST00000409044	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000757902	0.99924207
ENST00000375221	ENST00000334231	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000304752	0.9996953
ENST00000409080	ENST00000408978	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000401332	0.9995987
ENST00000409080	ENST00000409044	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000540429	0.99945956
ENST00000409080	ENST00000334231	ITGA6	chr2	173292698	-	MYO3B	chr2	171191895	+	0.000221493	0.99977857

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40444_40444_1_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000264106_MYO3B_chr2_171191895_ENST00000334231_length(amino acids)=1164AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRS
HSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTP

--------------------------------------------------------------

>40444_40444_2_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000264106_MYO3B_chr2_171191895_ENST00000408978_length(amino acids)=1164AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRS
HSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTP

--------------------------------------------------------------

>40444_40444_3_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000264106_MYO3B_chr2_171191895_ENST00000409044_length(amino acids)=1137AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHS
QAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLE

--------------------------------------------------------------

>40444_40444_4_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000264107_MYO3B_chr2_171191895_ENST00000334231_length(amino acids)=1230AA_BP=139
LIKRLRVSREQRAHSAVASCPRGGAAGRRARPVPGVGPGAAARGGEGGCGSSSAAASDPARSAGRPLQVPAPLPVRPPMAAAGQLCLLYL
SAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHP
FIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILI
ALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLREKILQV
NSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPPRYI
ADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQNAASVLCISPEEL
QEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCINI
ANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELC
FGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPE
ETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAF
TAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREKGAIAIQSAWRGY
DARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKN
GHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNG

--------------------------------------------------------------

>40444_40444_5_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000264107_MYO3B_chr2_171191895_ENST00000408978_length(amino acids)=1230AA_BP=139
LIKRLRVSREQRAHSAVASCPRGGAAGRRARPVPGVGPGAAARGGEGGCGSSSAAASDPARSAGRPLQVPAPLPVRPPMAAAGQLCLLYL
SAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHP
FIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILI
ALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLREKILQV
NSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPPRYI
ADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQNAASVLCISPEEL
QEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCINI
ANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELC
FGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPE
ETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAF
TAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREKGAIAIQSAWRGY
DARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKN
GHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNG

--------------------------------------------------------------

>40444_40444_6_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000264107_MYO3B_chr2_171191895_ENST00000409044_length(amino acids)=1203AA_BP=139
LIKRLRVSREQRAHSAVASCPRGGAAGRRARPVPGVGPGAAARGGEGGCGSSSAAASDPARSAGRPLQVPAPLPVRPPMAAAGQLCLLYL
SAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHP
FIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILI
ALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLREKILQV
NSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPPRYI
ADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQNAASVLCISPEEL
QEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCINI
ANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELC
FGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPE
ETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAF
TAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREKGAIAIQSGDTSN
QSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGT
DLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYY

--------------------------------------------------------------

>40444_40444_7_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000343713_MYO3B_chr2_171191895_ENST00000334231_length(amino acids)=1164AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRS
HSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTP

--------------------------------------------------------------

>40444_40444_8_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000343713_MYO3B_chr2_171191895_ENST00000408978_length(amino acids)=1164AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRS
HSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTP

--------------------------------------------------------------

>40444_40444_9_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000343713_MYO3B_chr2_171191895_ENST00000409044_length(amino acids)=1137AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHS
QAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLE

--------------------------------------------------------------

>40444_40444_10_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000375221_MYO3B_chr2_171191895_ENST00000334231_length(amino acids)=1164AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRS
HSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTP

--------------------------------------------------------------

>40444_40444_11_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000375221_MYO3B_chr2_171191895_ENST00000408978_length(amino acids)=1164AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRS
HSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTP

--------------------------------------------------------------

>40444_40444_12_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000375221_MYO3B_chr2_171191895_ENST00000409044_length(amino acids)=1137AA_BP=73
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFN
HFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDED
TIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAH
LIVQHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYI
YAGLHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTD
KSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMN
VGILDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQ
TLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVAS
SSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVS
IRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGA
RRYKRVREKREKGAIAIQSGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHS
QAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLE

--------------------------------------------------------------

>40444_40444_13_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000409080_MYO3B_chr2_171191895_ENST00000334231_length(amino acids)=1152AA_BP=61
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFNHFISQCLIKDFE
RRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYAD
LLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKA
NNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSD
FRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQN
AASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENF
QRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRC
KYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKA
KVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILF
EEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREK
GAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQ
TSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSS

--------------------------------------------------------------

>40444_40444_14_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000409080_MYO3B_chr2_171191895_ENST00000408978_length(amino acids)=1152AA_BP=61
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFNHFISQCLIKDFE
RRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYAD
LLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKA
NNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSD
FRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQN
AASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENF
QRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRC
KYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKA
KVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILF
EEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREK
GAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQ
TSSNSPAVTEKNGHSQAQSSPKGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSS

--------------------------------------------------------------

>40444_40444_15_ITGA6-MYO3B_ITGA6_chr2_173292698_ENST00000409080_MYO3B_chr2_171191895_ENST00000409044_length(amino acids)=1125AA_BP=61
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLNPPPTLLHPEKWCEEFNHFISQCLIKDFE
RRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYAD
LLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKA
NNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSD
FRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQN
AASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENF
QRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRC
KYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKA
KVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILF
EEFVKRYYYLAFTAHQTPLASKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKREK
GAIAIQSGDTSNQSSGPHSPVAAGTRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCDIF
AGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:173292698/chr2:171191895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITGA6 P23229	MYO3B Q8WXR4
FUNCTION: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000250\|UniProtKB:Q61739, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:22351760, ECO:0000269\|PubMed:28873464}.	FUNCTION: Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. {ECO:0000250\|UniProtKB:Q1EG27}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000334231

1060_1089

258.6666666666667

1351.0

Domain

IQ 1

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000334231

1087_1116

258.6666666666667

1351.0

Domain

IQ 2

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000334231

343_1058

258.6666666666667

1351.0

Domain

Myosin motor

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000408978

1060_1089

249.66666666666666

1342.0

Domain

IQ 1

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000408978

1087_1116

249.66666666666666

1342.0

Domain

IQ 2

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000408978

343_1058

249.66666666666666

1342.0

Domain

Myosin motor

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000409044

1060_1089

249.66666666666666

1315.0

Domain

IQ 1

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000409044

1087_1116

249.66666666666666

1315.0

Domain

IQ 2

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000409044

343_1058

249.66666666666666

1315.0

Domain

Myosin motor

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000334231

939_961

258.6666666666667

1351.0

Region

Actin-binding

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000408978

939_961

249.66666666666666

1342.0

Region

Actin-binding

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000409044

939_961

249.66666666666666

1315.0

Region

Actin-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

363_371

60.666666666666664

1131.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

425_433

60.666666666666664

1131.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

480_488

60.666666666666664

1131.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

363_371

60.666666666666664

1648.6666666666667

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

425_433

60.666666666666664

1648.6666666666667

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

480_488

60.666666666666664

1648.6666666666667

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

363_371

60.666666666666664

1728.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

425_433

60.666666666666664

1728.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

480_488

60.666666666666664

1728.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

363_371

60.666666666666664

1772.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

425_433

60.666666666666664

1772.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

480_488

60.666666666666664

1772.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

363_371

60.666666666666664

1092.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

425_433

60.666666666666664

1092.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

480_488

60.666666666666664

1092.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

363_371

1085.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

425_433

1085.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

480_488

1085.3333333333333

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

1079_1083

60.666666666666664

1131.0

Motif

Note=GFFKR motif

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

1079_1083

60.666666666666664

1648.6666666666667

Motif

Note=GFFKR motif

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

1079_1083

60.666666666666664

1728.3333333333333

Motif

Note=GFFKR motif

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

1079_1083

60.666666666666664

1772.3333333333333

Motif

Note=GFFKR motif

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

1079_1083

60.666666666666664

1092.0

Motif

Note=GFFKR motif

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

1079_1083

1085.3333333333333

Motif

Note=GFFKR motif

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

101_166

60.666666666666664

1131.0

Repeat

FG-GAP 2

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

176_229

60.666666666666664

1131.0

Repeat

FG-GAP 3

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

283_339

60.666666666666664

1131.0

Repeat

FG-GAP 4

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

30_95

60.666666666666664

1131.0

Repeat

FG-GAP 1

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

340_402

60.666666666666664

1131.0

Repeat

FG-GAP 5

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

403_458

60.666666666666664

1131.0

Repeat

FG-GAP 6

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

459_518

60.666666666666664

1131.0

Repeat

FG-GAP 7

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

101_166

60.666666666666664

1648.6666666666667

Repeat

FG-GAP 2

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

176_229

60.666666666666664

1648.6666666666667

Repeat

FG-GAP 3

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

283_339

60.666666666666664

1648.6666666666667

Repeat

FG-GAP 4

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

30_95

60.666666666666664

1648.6666666666667

Repeat

FG-GAP 1

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

340_402

60.666666666666664

1648.6666666666667

Repeat

FG-GAP 5

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

403_458

60.666666666666664

1648.6666666666667

Repeat

FG-GAP 6

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

459_518

60.666666666666664

1648.6666666666667

Repeat

FG-GAP 7

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

101_166

60.666666666666664

1728.3333333333333

Repeat

FG-GAP 2

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

176_229

60.666666666666664

1728.3333333333333

Repeat

FG-GAP 3

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

283_339

60.666666666666664

1728.3333333333333

Repeat

FG-GAP 4

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

30_95

60.666666666666664

1728.3333333333333

Repeat

FG-GAP 1

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

340_402

60.666666666666664

1728.3333333333333

Repeat

FG-GAP 5

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

403_458

60.666666666666664

1728.3333333333333

Repeat

FG-GAP 6

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

459_518

60.666666666666664

1728.3333333333333

Repeat

FG-GAP 7

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

101_166

60.666666666666664

1772.3333333333333

Repeat

FG-GAP 2

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

176_229

60.666666666666664

1772.3333333333333

Repeat

FG-GAP 3

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

283_339

60.666666666666664

1772.3333333333333

Repeat

FG-GAP 4

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

30_95

60.666666666666664

1772.3333333333333

Repeat

FG-GAP 1

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

340_402

60.666666666666664

1772.3333333333333

Repeat

FG-GAP 5

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

403_458

60.666666666666664

1772.3333333333333

Repeat

FG-GAP 6

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

459_518

60.666666666666664

1772.3333333333333

Repeat

FG-GAP 7

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

101_166

60.666666666666664

1092.0

Repeat

FG-GAP 2

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

176_229

60.666666666666664

1092.0

Repeat

FG-GAP 3

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

283_339

60.666666666666664

1092.0

Repeat

FG-GAP 4

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

30_95

60.666666666666664

1092.0

Repeat

FG-GAP 1

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

340_402

60.666666666666664

1092.0

Repeat

FG-GAP 5

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

403_458

60.666666666666664

1092.0

Repeat

FG-GAP 6

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

459_518

60.666666666666664

1092.0

Repeat

FG-GAP 7

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

101_166

1085.3333333333333

Repeat

FG-GAP 2

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

176_229

1085.3333333333333

Repeat

FG-GAP 3

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

283_339

1085.3333333333333

Repeat

FG-GAP 4

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

30_95

1085.3333333333333

Repeat

FG-GAP 1

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

340_402

1085.3333333333333

Repeat

FG-GAP 5

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

403_458

1085.3333333333333

Repeat

FG-GAP 6

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

459_518

1085.3333333333333

Repeat

FG-GAP 7

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

1077_1130

60.666666666666664

1131.0

Topological domain

Cytoplasmic

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

24_1050

60.666666666666664

1131.0

Topological domain

Extracellular

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

1077_1130

60.666666666666664

1648.6666666666667

Topological domain

Cytoplasmic

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

24_1050

60.666666666666664

1648.6666666666667

Topological domain

Extracellular

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

1077_1130

60.666666666666664

1728.3333333333333

Topological domain

Cytoplasmic

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

24_1050

60.666666666666664

1728.3333333333333

Topological domain

Extracellular

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

1077_1130

60.666666666666664

1772.3333333333333

Topological domain

Cytoplasmic

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

24_1050

60.666666666666664

1772.3333333333333

Topological domain

Extracellular

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

1077_1130

60.666666666666664

1092.0

Topological domain

Cytoplasmic

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

24_1050

60.666666666666664

1092.0

Topological domain

Extracellular

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

1077_1130

1085.3333333333333

Topological domain

Cytoplasmic

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

24_1050

1085.3333333333333

Topological domain

Extracellular

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264106

1051_1076

60.666666666666664

1131.0

Transmembrane

Helical

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000264107

1051_1076

60.666666666666664

1648.6666666666667

Transmembrane

Helical

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000343713

1051_1076

60.666666666666664

1728.3333333333333

Transmembrane

Helical

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000375221

1051_1076

60.666666666666664

1772.3333333333333

Transmembrane

Helical

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409080

1051_1076

60.666666666666664

1092.0

Transmembrane

Helical

Hgene

ITGA6

chr2:173292698

chr2:171191895

ENST00000409532

1051_1076

1085.3333333333333

Transmembrane

Helical

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000334231

27_293

258.6666666666667

1351.0

Domain

Protein kinase

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000408978

27_293

249.66666666666666

1342.0

Domain

Protein kinase

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000409044

27_293

249.66666666666666

1315.0

Domain

Protein kinase

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000334231

33_41

258.6666666666667

1351.0

Nucleotide binding

ATP

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000408978

33_41

249.66666666666666

1342.0

Nucleotide binding

ATP

Tgene

MYO3B

chr2:173292698

chr2:171191895

ENST00000409044

33_41

249.66666666666666

1315.0

Nucleotide binding

ATP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ITGA6
MYO3B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ITGA6	chr2:173292698	chr2:171191895	ENST00000264106	-	1	26	1077_1083	60.666666666666664	1131.0	HPS5
Hgene	ITGA6	chr2:173292698	chr2:171191895	ENST00000264107	-	1	26	1077_1083	60.666666666666664	1648.6666666666667	HPS5
Hgene	ITGA6	chr2:173292698	chr2:171191895	ENST00000343713	-	1	26	1077_1083	60.666666666666664	1728.3333333333333	HPS5
Hgene	ITGA6	chr2:173292698	chr2:171191895	ENST00000375221	-	1	27	1077_1083	60.666666666666664	1772.3333333333333	HPS5
Hgene	ITGA6	chr2:173292698	chr2:171191895	ENST00000409080	-	1	25	1077_1083	60.666666666666664	1092.0	HPS5
Hgene	ITGA6	chr2:173292698	chr2:171191895	ENST00000409532	-	1	26	1077_1083	0	1085.3333333333333	HPS5

Top

Related Drugs to ITGA6-MYO3B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ITGA6-MYO3B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source