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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ITGA7-MYRFL

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ITGA7-MYRFL
	FusionPDB ID: 40453
	FusionGDB2.0 ID: 40453
		Hgene	Tgene
	Gene symbol	ITGA7	MYRFL
	Gene ID	3679	196446
	Gene name	integrin subunit alpha 7	myelin regulatory factor like
	Synonyms	-	C12orf15\|C12orf28\|bcm1377
	Cytomap	12q13.2	12q15
	Type of gene	protein-coding	protein-coding
	Description	integrin alpha-7integrin alpha 7 chain	myelin regulatory factor-like protein
	Modification date	20200328	20200322
	UniProtAcc	Q13683	Q96LU7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000257879, ENST00000257880, ENST00000347027, ENST00000394229, ENST00000394230, ENST00000452168, ENST00000553804, ENST00000555728,	ENST00000535034, ENST00000299350, ENST00000547771, ENST00000552032,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 8 X 5=280	29 X 16 X 7=3248
	# samples	8	26
	** MAII score	log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/3248*10)=-3.64296810415672 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ITGA7 [Title/Abstract] AND MYRFL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ITGA7(56089306)-MYRFL(70349143), # samples:2
Anticipated loss of major functional domain due to fusion event.	ITGA7-MYRFL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ITGA7-MYRFL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ITGA7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYRFL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A2IZ-01A	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000553804	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2584	2034	19	2391	790
ENST00000553804	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	2958	2034	19	2391	790
ENST00000553804	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2584	2034	19	2391	790
ENST00000257879	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2769	2219	78	2576	832
ENST00000257879	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	3143	2219	78	2576	832
ENST00000257879	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2769	2219	78	2576	832
ENST00000347027	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2737	2187	64	2544	826
ENST00000347027	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	3111	2187	64	2544	826
ENST00000347027	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2737	2187	64	2544	826
ENST00000452168	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2416	1866	31	2223	730
ENST00000452168	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	2790	1866	31	2223	730
ENST00000452168	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2416	1866	31	2223	730
ENST00000394229	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2773	2223	82	2580	832
ENST00000394229	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	3147	2223	82	2580	832
ENST00000394229	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2773	2223	82	2580	832
ENST00000257880	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2905	2355	82	2712	876
ENST00000257880	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	3279	2355	82	2712	876
ENST00000257880	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2905	2355	82	2712	876
ENST00000394230	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2785	2235	82	2592	836
ENST00000394230	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	3159	2235	82	2592	836
ENST00000394230	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2785	2235	82	2592	836
ENST00000555728	ITGA7	chr12	56089306	-	ENST00000552032	MYRFL	chr12	70349143	+	2714	2164	29	2521	830
ENST00000555728	ITGA7	chr12	56089306	-	ENST00000547771	MYRFL	chr12	70349143	+	3088	2164	29	2521	830
ENST00000555728	ITGA7	chr12	56089306	-	ENST00000299350	MYRFL	chr12	70349143	+	2714	2164	29	2521	830

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000553804	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.002221433	0.9977786
ENST00000553804	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001355118	0.9986449
ENST00000553804	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.002221433	0.9977786
ENST00000257879	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.003181865	0.99681807
ENST00000257879	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001995472	0.9980045
ENST00000257879	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.003181865	0.99681807
ENST00000347027	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.003867135	0.99613285
ENST00000347027	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.002468076	0.9975319
ENST00000347027	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.003867135	0.99613285
ENST00000452168	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001724193	0.99827576
ENST00000452168	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.000968772	0.9990312
ENST00000452168	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001724193	0.99827576
ENST00000394229	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.003151476	0.9968485
ENST00000394229	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001975857	0.9980241
ENST00000394229	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.003151476	0.9968485
ENST00000257880	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.00201828	0.99798167
ENST00000257880	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001235829	0.99876416
ENST00000257880	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.00201828	0.99798167
ENST00000394230	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.002442509	0.9975575
ENST00000394230	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001473711	0.9985262
ENST00000394230	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.002442509	0.9975575
ENST00000555728	ENST00000552032	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001927259	0.99807274
ENST00000555728	ENST00000547771	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001198336	0.9988017
ENST00000555728	ENST00000299350	ITGA7	chr12	56089306	-	MYRFL	chr12	70349143	+	0.001927259	0.99807274

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40453_40453_1_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000257879_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=832AA_BP=714
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKD
KLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNY
NIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCS

--------------------------------------------------------------

>40453_40453_2_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000257879_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=832AA_BP=714
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKD
KLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNY
NIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCS

--------------------------------------------------------------

>40453_40453_3_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000257879_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=832AA_BP=714
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKD
KLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNY
NIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCS

--------------------------------------------------------------

>40453_40453_4_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000257880_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=876AA_BP=758
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
TARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSG
KGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLN
QGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMD
GNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQV
PRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEI
HFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKG

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>40453_40453_5_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000257880_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=876AA_BP=758
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
TARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSG
KGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLN
QGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMD
GNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQV
PRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEI
HFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKG

--------------------------------------------------------------

>40453_40453_6_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000257880_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=876AA_BP=758
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
TARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSG
KGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLN
QGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMD
GNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQV
PRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEI
HFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKG

--------------------------------------------------------------

>40453_40453_7_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000347027_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=826AA_BP=708
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIV
VTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNK
HTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFA

--------------------------------------------------------------

>40453_40453_8_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000347027_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=826AA_BP=708
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIV
VTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNK
HTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFA

--------------------------------------------------------------

>40453_40453_9_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000347027_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=826AA_BP=708
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIV
VTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNK
HTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFA

--------------------------------------------------------------

>40453_40453_10_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000394229_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=832AA_BP=714
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKD
KLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNY
NIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCS

--------------------------------------------------------------

>40453_40453_11_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000394229_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=832AA_BP=714
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKD
KLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNY
NIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCS

--------------------------------------------------------------

>40453_40453_12_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000394229_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=832AA_BP=714
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
LLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGE
RLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAP
FDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPN
CAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKD
KLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNY
NIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCS

--------------------------------------------------------------

>40453_40453_13_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000394230_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=836AA_BP=718
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
TARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVM
LSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIA
VGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDL
EQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQE
NVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISG
NYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDL

--------------------------------------------------------------

>40453_40453_14_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000394230_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=836AA_BP=718
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
TARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVM
LSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIA
VGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDL
EQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQE
NVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISG
NYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDL

--------------------------------------------------------------

>40453_40453_15_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000394230_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=836AA_BP=718
MAGRTSGRRLKDQRDFGDQRRAWGDLGLGACEISLAFAGSSRRDRPMAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRK
EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPG
GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKG
TARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVM
LSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIA
VGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDL
EQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQE
NVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISG
NYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDL

--------------------------------------------------------------

>40453_40453_16_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000452168_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=730AA_BP=612
MGDLAGLQERGLVVVWLSSKCWPEASAQRKGALETVQMAPFATPMVQALTTTRIQRQAEGFQCWRECGTRRSPFEGKETCAHRYEARQRV
DQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAH
LDDGPYEAGGEKEQDPRLIPVPANSYFGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAV
ADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHG
SSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLR
VCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYS
LQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNV
KFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTD

--------------------------------------------------------------

>40453_40453_17_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000452168_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=730AA_BP=612
MGDLAGLQERGLVVVWLSSKCWPEASAQRKGALETVQMAPFATPMVQALTTTRIQRQAEGFQCWRECGTRRSPFEGKETCAHRYEARQRV
DQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAH
LDDGPYEAGGEKEQDPRLIPVPANSYFGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAV
ADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHG
SSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLR
VCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYS
LQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNV
KFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTD

--------------------------------------------------------------

>40453_40453_18_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000452168_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=730AA_BP=612
MGDLAGLQERGLVVVWLSSKCWPEASAQRKGALETVQMAPFATPMVQALTTTRIQRQAEGFQCWRECGTRRSPFEGKETCAHRYEARQRV
DQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAH
LDDGPYEAGGEKEQDPRLIPVPANSYFGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAV
ADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHG
SSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLR
VCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYS
LQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNV
KFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTD

--------------------------------------------------------------

>40453_40453_19_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000553804_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=790AA_BP=672
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGG
LFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGE
WKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGFS
IDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVY
VYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGS
LDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRL
RGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQ
RAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKR

--------------------------------------------------------------

>40453_40453_20_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000553804_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=790AA_BP=672
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGG
LFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGE
WKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGFS
IDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVY
VYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGS
LDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRL
RGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQ
RAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKR

--------------------------------------------------------------

>40453_40453_21_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000553804_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=790AA_BP=672
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGG
LFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGE
WKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGFS
IDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVY
VYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGS
LDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRL
RGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQ
RAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKR

--------------------------------------------------------------

>40453_40453_22_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000555728_MYRFL_chr12_70349143_ENST00000299350_length(amino acids)=830AA_BP=712
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGG
LFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGE
WKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLL
FVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERL
TSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFD
GDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCA
GGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKL
RAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNI
PVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTD

--------------------------------------------------------------

>40453_40453_23_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000555728_MYRFL_chr12_70349143_ENST00000547771_length(amino acids)=830AA_BP=712
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGG
LFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGE
WKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLL
FVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERL
TSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFD
GDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCA
GGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKL
RAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNI
PVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTD

--------------------------------------------------------------

>40453_40453_24_ITGA7-MYRFL_ITGA7_chr12_56089306_ENST00000555728_MYRFL_chr12_70349143_ENST00000552032_length(amino acids)=830AA_BP=712
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGG
LFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGE
WKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLL
FVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERL
TSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFD
GDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCA
GGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKL
RAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPISGNYNYNI
PVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTD

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56089306/chr12:70349143)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITGA7 Q13683	MYRFL Q96LU7
FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269\|PubMed:10694445, ECO:0000269\|PubMed:17641293, ECO:0000269\|PubMed:9307969}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

372_380

667.6666666666666

1138.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

434_442

667.6666666666666

1138.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

492_500

667.6666666666666

1138.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

372_380

711.6666666666666

1163.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

434_442

711.6666666666666

1163.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

492_500

711.6666666666666

1163.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

372_380

574.6666666666666

1045.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

434_442

574.6666666666666

1045.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

492_500

574.6666666666666

1045.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

372_380

671.6666666666666

1142.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

434_442

671.6666666666666

1142.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

492_500

671.6666666666666

1142.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

372_380

711.6666666666666

1182.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

434_442

711.6666666666666

1182.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

492_500

711.6666666666666

1182.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

110_175

667.6666666666666

1138.0

Repeat

FG-GAP 2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

185_238

667.6666666666666

1138.0

Repeat

FG-GAP 3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

292_349

667.6666666666666

1138.0

Repeat

FG-GAP 4

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

350_411

667.6666666666666

1138.0

Repeat

FG-GAP 5

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

35_103

667.6666666666666

1138.0

Repeat

FG-GAP 1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

412_467

667.6666666666666

1138.0

Repeat

FG-GAP 6

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

471_530

667.6666666666666

1138.0

Repeat

FG-GAP 7

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

110_175

711.6666666666666

1163.0

Repeat

FG-GAP 2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

185_238

711.6666666666666

1163.0

Repeat

FG-GAP 3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

292_349

711.6666666666666

1163.0

Repeat

FG-GAP 4

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

350_411

711.6666666666666

1163.0

Repeat

FG-GAP 5

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

35_103

711.6666666666666

1163.0

Repeat

FG-GAP 1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

412_467

711.6666666666666

1163.0

Repeat

FG-GAP 6

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

471_530

711.6666666666666

1163.0

Repeat

FG-GAP 7

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

110_175

574.6666666666666

1045.0

Repeat

FG-GAP 2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

185_238

574.6666666666666

1045.0

Repeat

FG-GAP 3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

292_349

574.6666666666666

1045.0

Repeat

FG-GAP 4

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

350_411

574.6666666666666

1045.0

Repeat

FG-GAP 5

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

35_103

574.6666666666666

1045.0

Repeat

FG-GAP 1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

412_467

574.6666666666666

1045.0

Repeat

FG-GAP 6

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

471_530

574.6666666666666

1045.0

Repeat

FG-GAP 7

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

110_175

671.6666666666666

1142.0

Repeat

FG-GAP 2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

185_238

671.6666666666666

1142.0

Repeat

FG-GAP 3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

292_349

671.6666666666666

1142.0

Repeat

FG-GAP 4

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

350_411

671.6666666666666

1142.0

Repeat

FG-GAP 5

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

35_103

671.6666666666666

1142.0

Repeat

FG-GAP 1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

412_467

671.6666666666666

1142.0

Repeat

FG-GAP 6

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

471_530

671.6666666666666

1142.0

Repeat

FG-GAP 7

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

110_175

711.6666666666666

1182.0

Repeat

FG-GAP 2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

185_238

711.6666666666666

1182.0

Repeat

FG-GAP 3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

292_349

711.6666666666666

1182.0

Repeat

FG-GAP 4

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

350_411

711.6666666666666

1182.0

Repeat

FG-GAP 5

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

35_103

711.6666666666666

1182.0

Repeat

FG-GAP 1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

412_467

711.6666666666666

1182.0

Repeat

FG-GAP 6

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

471_530

711.6666666666666

1182.0

Repeat

FG-GAP 7

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

953_958

667.6666666666666

1138.0

Compositional bias

Note=Poly-Arg

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

953_958

711.6666666666666

1163.0

Compositional bias

Note=Poly-Arg

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

953_958

574.6666666666666

1045.0

Compositional bias

Note=Poly-Arg

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

953_958

671.6666666666666

1142.0

Compositional bias

Note=Poly-Arg

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

953_958

711.6666666666666

1182.0

Compositional bias

Note=Poly-Arg

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

1107_1111

667.6666666666666

1138.0

Motif

Note=GFFKR motif

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

1107_1111

711.6666666666666

1163.0

Motif

Note=GFFKR motif

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

1107_1111

574.6666666666666

1045.0

Motif

Note=GFFKR motif

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

1107_1111

671.6666666666666

1142.0

Motif

Note=GFFKR motif

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

1107_1111

711.6666666666666

1182.0

Motif

Note=GFFKR motif

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

1157_1176

667.6666666666666

1138.0

Region

Note=3 X 4 AA repeats of D-X-H-P

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

1157_1176

711.6666666666666

1163.0

Region

Note=3 X 4 AA repeats of D-X-H-P

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

1157_1176

574.6666666666666

1045.0

Region

Note=3 X 4 AA repeats of D-X-H-P

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

1157_1176

671.6666666666666

1142.0

Region

Note=3 X 4 AA repeats of D-X-H-P

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

1157_1176

711.6666666666666

1182.0

Region

Note=3 X 4 AA repeats of D-X-H-P

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

1157_1160

667.6666666666666

1138.0

Repeat

Note=1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

1165_1168

667.6666666666666

1138.0

Repeat

Note=2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

1173_1176

667.6666666666666

1138.0

Repeat

Note=3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

1157_1160

711.6666666666666

1163.0

Repeat

Note=1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

1165_1168

711.6666666666666

1163.0

Repeat

Note=2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

1173_1176

711.6666666666666

1163.0

Repeat

Note=3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

1157_1160

574.6666666666666

1045.0

Repeat

Note=1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

1165_1168

574.6666666666666

1045.0

Repeat

Note=2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

1173_1176

574.6666666666666

1045.0

Repeat

Note=3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

1157_1160

671.6666666666666

1142.0

Repeat

Note=1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

1165_1168

671.6666666666666

1142.0

Repeat

Note=2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

1173_1176

671.6666666666666

1142.0

Repeat

Note=3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

1157_1160

711.6666666666666

1182.0

Repeat

Note=1

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

1165_1168

711.6666666666666

1182.0

Repeat

Note=2

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

1173_1176

711.6666666666666

1182.0

Repeat

Note=3

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

1104_1181

667.6666666666666

1138.0

Topological domain

Cytoplasmic

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

34_1082

667.6666666666666

1138.0

Topological domain

Extracellular

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

1104_1181

711.6666666666666

1163.0

Topological domain

Cytoplasmic

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

34_1082

711.6666666666666

1163.0

Topological domain

Extracellular

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

1104_1181

574.6666666666666

1045.0

Topological domain

Cytoplasmic

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

34_1082

574.6666666666666

1045.0

Topological domain

Extracellular

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

1104_1181

671.6666666666666

1142.0

Topological domain

Cytoplasmic

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

34_1082

671.6666666666666

1142.0

Topological domain

Extracellular

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

1104_1181

711.6666666666666

1182.0

Topological domain

Cytoplasmic

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

34_1082

711.6666666666666

1182.0

Topological domain

Extracellular

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257879

1083_1103

667.6666666666666

1138.0

Transmembrane

Helical

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000257880

1083_1103

711.6666666666666

1163.0

Transmembrane

Helical

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000452168

1083_1103

574.6666666666666

1045.0

Transmembrane

Helical

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000553804

1083_1103

671.6666666666666

1142.0

Transmembrane

Helical

Hgene

ITGA7

chr12:56089306

chr12:70349143

ENST00000555728

1083_1103

711.6666666666666

1182.0

Transmembrane

Helical

Tgene

MYRFL

chr12:56089306

chr12:70349143

ENST00000552032

543_575

791.6666666666666

911.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYRFL

chr12:56089306

chr12:70349143

ENST00000552032

142_405

791.6666666666666

911.0

DNA binding

NDT80

Tgene

MYRFL

chr12:56089306

chr12:70349143

ENST00000552032

451_559

791.6666666666666

911.0

Domain

Peptidase S74

Tgene

MYRFL

chr12:56089306

chr12:70349143

ENST00000552032

628_648

791.6666666666666

911.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ITGA7
MYRFL

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ITGA7-MYRFL

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ITGA7-MYRFL

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source