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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ITGAV-FAM171B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ITGAV-FAM171B
FusionPDB ID: 40489
FusionGDB2.0 ID: 40489
HgeneTgene
Gene symbol

ITGAV

FAM171B

Gene ID

3685

165215

Gene nameintegrin subunit alpha Vfamily with sequence similarity 171 member B
SynonymsCD51|MSK8|VNRA|VTNRKIAA1946
Cytomap

2q32.1

2q32.1

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-Vantigen identified by monoclonal antibody L230integrin alphaVbeta3integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)vitronectin receptor subunit alphaprotein FAM171B
Modification date2020031320200313
UniProtAcc

P06756

Q6P995

Ensembl transtripts involved in fusion geneENST idsENST00000261023, ENST00000374907, 
ENST00000433736, ENST00000474571, 
ENST00000304698, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 9 X 8=7924 X 5 X 4=80
# samples 137
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ITGAV [Title/Abstract] AND FAM171B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ITGAV(187498101)-FAM171B(187604955), # samples:1
ITGAV(187466878)-FAM171B(187604955), # samples:1
Anticipated loss of major functional domain due to fusion event.ITGAV-FAM171B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGAV-FAM171B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGAV

GO:0007155

cell adhesion

10218736

HgeneITGAV

GO:0008284

positive regulation of cell proliferation

19578119

HgeneITGAV

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

HgeneITGAV

GO:0034446

substrate adhesion-dependent cell spreading

24658351

HgeneITGAV

GO:0045785

positive regulation of cell adhesion

10708943

HgeneITGAV

GO:0050764

regulation of phagocytosis

10570297

HgeneITGAV

GO:0070588

calcium ion transmembrane transport

18395422

HgeneITGAV

GO:1901388

regulation of transforming growth factor beta activation

22278742

HgeneITGAV

GO:2000536

negative regulation of entry of bacterium into host cell

10570297


check buttonFusion gene breakpoints across ITGAV (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM171B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4438-01AITGAVchr2

187498101

+FAM171Bchr2

187604955

+
ChimerDB4STADTCGA-MX-A666-01AITGAVchr2

187466878

+FAM171Bchr2

187604955

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261023ITGAVchr2187498101+ENST00000304698FAM171Bchr2187604955+62839054931471032
ENST00000433736ITGAVchr2187498101+ENST00000304698FAM171Bchr2187604955+60016231302865911
ENST00000261023ITGAVchr2187466878+ENST00000304698FAM171Bchr2187604955+5968590492832927
ENST00000374907ITGAVchr2187466878+ENST00000304698FAM171Bchr2187604955+5953575342817927
ENST00000433736ITGAVchr2187466878+ENST00000304698FAM171Bchr2187604955+56863081302550806

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261023ENST00000304698ITGAVchr2187498101+FAM171Bchr2187604955+0.0001294780.99987054
ENST00000433736ENST00000304698ITGAVchr2187498101+FAM171Bchr2187604955+3.85E-050.9999615
ENST00000261023ENST00000304698ITGAVchr2187466878+FAM171Bchr2187604955+0.0003026510.9996973
ENST00000374907ENST00000304698ITGAVchr2187466878+FAM171Bchr2187604955+0.0003025770.99969745
ENST00000433736ENST00000304698ITGAVchr2187466878+FAM171Bchr2187604955+6.95E-050.9999305

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40489_40489_1_ITGAV-FAM171B_ITGAV_chr2_187466878_ENST00000261023_FAM171B_chr2_187604955_ENST00000304698_length(amino acids)=927AA_BP=1
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
VSVFMLKVQVNDIISRQYLSQAVVEVFVNYTKTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYSSVTLSLFPQ
SQANIWLFEDTVLITGKLADAKSQPSVQFSKALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNKPGFENIELTPLAAICVKIY
SGGKELKVNGSIQVSLPLLRLNDISAGDRIPAWTFDMNTGAWVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLPGTRGSGINEDSKDIT
AYHTVFLTAILGGTIVIVIGFFAVLLCYCRDKCGTPQKRERNITKLEVLKRDQTTSTTHINHISTVKVALKAEDKSQLFNAKNSSYSPQK
KEPSKAETEERVSMVKTRDDFKIYNEDVSFLSVNQNNYSRNPTQSLEPNVGSKQPKHINNNLSSSLGDAQDEKRYLTGNEEAYGRSHIPE
QLMHIYSQPIAILQTSDLFSTPEQLHTAKSATLPRKGQLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDAREEDIILEGQQSLPSQASD
WSRYSSSLLESVSVPGTLNEAVVMTPFSSELQGISEQTLLELSKGKPSPHPRAWFVSLDGKPVAQVRHSFIDLKKGKRTQSNDTSLDSGV
DMNELHSSRKLEREKTFIKSMHQPKILYLEDLDLSSSESGTTVCSPEDPALRHILDGGSGVIMEHPGEESPGRKSTVEDFEANTSPTKRR

--------------------------------------------------------------

>40489_40489_2_ITGAV-FAM171B_ITGAV_chr2_187466878_ENST00000374907_FAM171B_chr2_187604955_ENST00000304698_length(amino acids)=927AA_BP=1
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
VSVFMLKVQVNDIISRQYLSQAVVEVFVNYTKTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYSSVTLSLFPQ
SQANIWLFEDTVLITGKLADAKSQPSVQFSKALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNKPGFENIELTPLAAICVKIY
SGGKELKVNGSIQVSLPLLRLNDISAGDRIPAWTFDMNTGAWVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLPGTRGSGINEDSKDIT
AYHTVFLTAILGGTIVIVIGFFAVLLCYCRDKCGTPQKRERNITKLEVLKRDQTTSTTHINHISTVKVALKAEDKSQLFNAKNSSYSPQK
KEPSKAETEERVSMVKTRDDFKIYNEDVSFLSVNQNNYSRNPTQSLEPNVGSKQPKHINNNLSSSLGDAQDEKRYLTGNEEAYGRSHIPE
QLMHIYSQPIAILQTSDLFSTPEQLHTAKSATLPRKGQLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDAREEDIILEGQQSLPSQASD
WSRYSSSLLESVSVPGTLNEAVVMTPFSSELQGISEQTLLELSKGKPSPHPRAWFVSLDGKPVAQVRHSFIDLKKGKRTQSNDTSLDSGV
DMNELHSSRKLEREKTFIKSMHQPKILYLEDLDLSSSESGTTVCSPEDPALRHILDGGSGVIMEHPGEESPGRKSTVEDFEANTSPTKRR

--------------------------------------------------------------

>40489_40489_3_ITGAV-FAM171B_ITGAV_chr2_187466878_ENST00000433736_FAM171B_chr2_187604955_ENST00000304698_length(amino acids)=806AA_BP=0
MLLGTLLLILYILMLCRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATVSVFMLKVQVNDIISRQYLSQAVVEVFVNYT
KTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYSSVTLSLFPQSQANIWLFEDTVLITGKLADAKSQPSVQFSK
ALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNKPGFENIELTPLAAICVKIYSGGKELKVNGSIQVSLPLLRLNDISAGDRIP
AWTFDMNTGAWVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLPGTRGSGINEDSKDITAYHTVFLTAILGGTIVIVIGFFAVLLCYCRD
KCGTPQKRERNITKLEVLKRDQTTSTTHINHISTVKVALKAEDKSQLFNAKNSSYSPQKKEPSKAETEERVSMVKTRDDFKIYNEDVSFL
SVNQNNYSRNPTQSLEPNVGSKQPKHINNNLSSSLGDAQDEKRYLTGNEEAYGRSHIPEQLMHIYSQPIAILQTSDLFSTPEQLHTAKSA
TLPRKGQLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDAREEDIILEGQQSLPSQASDWSRYSSSLLESVSVPGTLNEAVVMTPFSSEL
QGISEQTLLELSKGKPSPHPRAWFVSLDGKPVAQVRHSFIDLKKGKRTQSNDTSLDSGVDMNELHSSRKLEREKTFIKSMHQPKILYLED

--------------------------------------------------------------

>40489_40489_4_ITGAV-FAM171B_ITGAV_chr2_187498101_ENST00000261023_FAM171B_chr2_187604955_ENST00000304698_length(amino acids)=1032AA_BP=1
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
GNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTK
ADRVLLGGPGSFYWQVSVFMLKVQVNDIISRQYLSQAVVEVFVNYTKTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTR
RMPIYSSVTLSLFPQSQANIWLFEDTVLITGKLADAKSQPSVQFSKALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNKPGFE
NIELTPLAAICVKIYSGGKELKVNGSIQVSLPLLRLNDISAGDRIPAWTFDMNTGAWVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLP
GTRGSGINEDSKDITAYHTVFLTAILGGTIVIVIGFFAVLLCYCRDKCGTPQKRERNITKLEVLKRDQTTSTTHINHISTVKVALKAEDK
SQLFNAKNSSYSPQKKEPSKAETEERVSMVKTRDDFKIYNEDVSFLSVNQNNYSRNPTQSLEPNVGSKQPKHINNNLSSSLGDAQDEKRY
LTGNEEAYGRSHIPEQLMHIYSQPIAILQTSDLFSTPEQLHTAKSATLPRKGQLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDAREED
IILEGQQSLPSQASDWSRYSSSLLESVSVPGTLNEAVVMTPFSSELQGISEQTLLELSKGKPSPHPRAWFVSLDGKPVAQVRHSFIDLKK
GKRTQSNDTSLDSGVDMNELHSSRKLEREKTFIKSMHQPKILYLEDLDLSSSESGTTVCSPEDPALRHILDGGSGVIMEHPGEESPGRKS

--------------------------------------------------------------

>40489_40489_5_ITGAV-FAM171B_ITGAV_chr2_187498101_ENST00000433736_FAM171B_chr2_187604955_ENST00000304698_length(amino acids)=911AA_BP=0
MLLGTLLLILYILMLCRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKIL
ACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQVSVFMLKVQVNDIISR
QYLSQAVVEVFVNYTKTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYSSVTLSLFPQSQANIWLFEDTVLITG
KLADAKSQPSVQFSKALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNKPGFENIELTPLAAICVKIYSGGKELKVNGSIQVSL
PLLRLNDISAGDRIPAWTFDMNTGAWVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLPGTRGSGINEDSKDITAYHTVFLTAILGGTIV
IVIGFFAVLLCYCRDKCGTPQKRERNITKLEVLKRDQTTSTTHINHISTVKVALKAEDKSQLFNAKNSSYSPQKKEPSKAETEERVSMVK
TRDDFKIYNEDVSFLSVNQNNYSRNPTQSLEPNVGSKQPKHINNNLSSSLGDAQDEKRYLTGNEEAYGRSHIPEQLMHIYSQPIAILQTS
DLFSTPEQLHTAKSATLPRKGQLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDAREEDIILEGQQSLPSQASDWSRYSSSLLESVSVPG
TLNEAVVMTPFSSELQGISEQTLLELSKGKPSPHPRAWFVSLDGKPVAQVRHSFIDLKKGKRTQSNDTSLDSGVDMNELHSSRKLEREKT
FIKSMHQPKILYLEDLDLSSSESGTTVCSPEDPALRHILDGGSGVIMEHPGEESPGRKSTVEDFEANTSPTKRRGRPPLAKRDSKTNIWK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:187498101/chr2:187604955)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGAV

P06756

FAM171B

Q6P995

FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+23032_98105.333333333333331049.0RepeatFG-GAP 1
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+22832_98105.333333333333331013.0RepeatFG-GAP 1
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630109_170210.333333333333341049.0RepeatFG-GAP 2
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+63032_98210.333333333333341049.0RepeatFG-GAP 1
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+63032_98164.333333333333341003.0RepeatFG-GAP 1
TgeneFAM171Bchr2:187466878chr2:187604955ENST0000030469808375_82679.33333333333333827.0Topological domainCytoplasmic
TgeneFAM171Bchr2:187498101chr2:187604955ENST0000030469808375_82679.33333333333333827.0Topological domainCytoplasmic
TgeneFAM171Bchr2:187466878chr2:187604955ENST0000030469808354_37479.33333333333333827.0TransmembraneHelical
TgeneFAM171Bchr2:187498101chr2:187604955ENST0000030469808354_37479.33333333333333827.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230260_268105.333333333333331049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230314_322105.333333333333331049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230379_387105.333333333333331049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230443_451105.333333333333331049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228260_268105.333333333333331013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228314_322105.333333333333331013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228379_387105.333333333333331013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228443_451105.333333333333331013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230260_26859.3333333333333361003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230314_32259.3333333333333361003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230379_38759.3333333333333361003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230443_45159.3333333333333361003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630260_268210.333333333333341049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630314_322210.333333333333341049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630379_387210.333333333333341049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630443_451210.333333333333341049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128260_26801013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128314_32201013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128379_38701013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128443_45101013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630260_268164.333333333333341003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630314_322164.333333333333341003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630379_387164.333333333333341003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630443_451164.333333333333341003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+2301019_1023105.333333333333331049.0MotifNote=GFFKR motif
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+2281019_1023105.333333333333331013.0MotifNote=GFFKR motif
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+2301019_102359.3333333333333361003.0MotifNote=GFFKR motif
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+6301019_1023210.333333333333341049.0MotifNote=GFFKR motif
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+1281019_102301013.0MotifNote=GFFKR motif
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+6301019_1023164.333333333333341003.0MotifNote=GFFKR motif
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230109_170105.333333333333331049.0RepeatFG-GAP 2
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230173_225105.333333333333331049.0RepeatFG-GAP 3
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230237_291105.333333333333331049.0RepeatFG-GAP 4
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230292_357105.333333333333331049.0RepeatFG-GAP 5
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230358_415105.333333333333331049.0RepeatFG-GAP 6
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230419_482105.333333333333331049.0RepeatFG-GAP 7
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228109_170105.333333333333331013.0RepeatFG-GAP 2
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228173_225105.333333333333331013.0RepeatFG-GAP 3
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228237_291105.333333333333331013.0RepeatFG-GAP 4
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228292_357105.333333333333331013.0RepeatFG-GAP 5
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228358_415105.333333333333331013.0RepeatFG-GAP 6
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228419_482105.333333333333331013.0RepeatFG-GAP 7
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230109_17059.3333333333333361003.0RepeatFG-GAP 2
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230173_22559.3333333333333361003.0RepeatFG-GAP 3
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230237_29159.3333333333333361003.0RepeatFG-GAP 4
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230292_35759.3333333333333361003.0RepeatFG-GAP 5
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+23032_9859.3333333333333361003.0RepeatFG-GAP 1
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230358_41559.3333333333333361003.0RepeatFG-GAP 6
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230419_48259.3333333333333361003.0RepeatFG-GAP 7
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630173_225210.333333333333341049.0RepeatFG-GAP 3
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630237_291210.333333333333341049.0RepeatFG-GAP 4
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630292_357210.333333333333341049.0RepeatFG-GAP 5
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630358_415210.333333333333341049.0RepeatFG-GAP 6
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630419_482210.333333333333341049.0RepeatFG-GAP 7
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128109_17001013.0RepeatFG-GAP 2
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128173_22501013.0RepeatFG-GAP 3
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128237_29101013.0RepeatFG-GAP 4
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128292_35701013.0RepeatFG-GAP 5
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+12832_9801013.0RepeatFG-GAP 1
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128358_41501013.0RepeatFG-GAP 6
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128419_48201013.0RepeatFG-GAP 7
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630109_170164.333333333333341003.0RepeatFG-GAP 2
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630173_225164.333333333333341003.0RepeatFG-GAP 3
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630237_291164.333333333333341003.0RepeatFG-GAP 4
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630292_357164.333333333333341003.0RepeatFG-GAP 5
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630358_415164.333333333333341003.0RepeatFG-GAP 6
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630419_482164.333333333333341003.0RepeatFG-GAP 7
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+2301017_1048105.333333333333331049.0Topological domainCytoplasmic
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+23031_992105.333333333333331049.0Topological domainExtracellular
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+2281017_1048105.333333333333331013.0Topological domainCytoplasmic
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+22831_992105.333333333333331013.0Topological domainExtracellular
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+2301017_104859.3333333333333361003.0Topological domainCytoplasmic
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+23031_99259.3333333333333361003.0Topological domainExtracellular
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+6301017_1048210.333333333333341049.0Topological domainCytoplasmic
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+63031_992210.333333333333341049.0Topological domainExtracellular
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+1281017_104801013.0Topological domainCytoplasmic
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+12831_99201013.0Topological domainExtracellular
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+6301017_1048164.333333333333341003.0Topological domainCytoplasmic
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+63031_992164.333333333333341003.0Topological domainExtracellular
HgeneITGAVchr2:187466878chr2:187604955ENST00000261023+230993_1016105.333333333333331049.0TransmembraneHelical
HgeneITGAVchr2:187466878chr2:187604955ENST00000374907+228993_1016105.333333333333331013.0TransmembraneHelical
HgeneITGAVchr2:187466878chr2:187604955ENST00000433736+230993_101659.3333333333333361003.0TransmembraneHelical
HgeneITGAVchr2:187498101chr2:187604955ENST00000261023+630993_1016210.333333333333341049.0TransmembraneHelical
HgeneITGAVchr2:187498101chr2:187604955ENST00000374907+128993_101601013.0TransmembraneHelical
HgeneITGAVchr2:187498101chr2:187604955ENST00000433736+630993_1016164.333333333333341003.0TransmembraneHelical
TgeneFAM171Bchr2:187466878chr2:187604955ENST000003046980843_5879.33333333333333827.0Compositional biasNote=Gln-rich
TgeneFAM171Bchr2:187498101chr2:187604955ENST000003046980843_5879.33333333333333827.0Compositional biasNote=Gln-rich
TgeneFAM171Bchr2:187466878chr2:187604955ENST000003046980833_35379.33333333333333827.0Topological domainExtracellular
TgeneFAM171Bchr2:187498101chr2:187604955ENST000003046980833_35379.33333333333333827.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ITGAV
FAM171B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ITGAV-FAM171B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ITGAV-FAM171B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource