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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ITGB4-RBM39

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ITGB4-RBM39
FusionPDB ID: 40545
FusionGDB2.0 ID: 40545
HgeneTgene
Gene symbol

ITGB4

RBM39

Gene ID

3691

9584

Gene nameintegrin subunit beta 4RNA binding motif protein 39
SynonymsCD104|GP150CAPER|CAPERalpha|FSAP59|HCC1|RNPC2
Cytomap

17q25.1

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-4CD104 antigenRNA-binding protein 39CAPER alphaRNA-binding region (RNP1, RRM) containing 2coactivator of activating protein-1 and estrogen receptorsepididymis secretory sperm binding proteinfunctional spliceosome-associated protein 59hepatocellular carcinoma prot
Modification date2020032920200327
UniProtAcc

P16144

.
Ensembl transtripts involved in fusion geneENST idsENST00000584558, ENST00000200181, 
ENST00000339591, ENST00000449880, 
ENST00000450894, ENST00000579662, 
ENST00000253363, ENST00000361162, 
ENST00000407261, ENST00000528062, 
ENST00000397370, ENST00000463098, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 19 X 10=437024 X 16 X 12=4608
# samples 2927
** MAII scorelog2(29/4370*10)=-3.91350847437303
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4608*10)=-4.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ITGB4 [Title/Abstract] AND RBM39 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ITGB4(73720862)-RBM39(34301018), # samples:1
Anticipated loss of major functional domain due to fusion event.ITGB4-RBM39 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGB4-RBM39 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGB4-RBM39 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGB4-RBM39 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB4

GO:0009611

response to wounding

19403692

HgeneITGB4

GO:0031581

hemidesmosome assembly

12482924


check buttonFusion gene breakpoints across ITGB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBM39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-1076ITGB4chr17

73720862

+RBM39chr20

34301018

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000579662ITGB4chr1773720862+ENST00000253363RBM39chr2034301018-1693325246821191
ENST00000579662ITGB4chr1773720862+ENST00000361162RBM39chr2034301018-1675325246803185
ENST00000579662ITGB4chr1773720862+ENST00000528062RBM39chr2034301018-1405325246821191
ENST00000579662ITGB4chr1773720862+ENST00000407261RBM39chr2034301018-975325246821191
ENST00000339591ITGB4chr1773720862+ENST00000253363RBM39chr2034301018-1634266163762199
ENST00000339591ITGB4chr1773720862+ENST00000361162RBM39chr2034301018-1616266163744193
ENST00000339591ITGB4chr1773720862+ENST00000528062RBM39chr2034301018-1346266163762199
ENST00000339591ITGB4chr1773720862+ENST00000407261RBM39chr2034301018-916266163762199
ENST00000200181ITGB4chr1773720862+ENST00000253363RBM39chr2034301018-1634266163762199
ENST00000200181ITGB4chr1773720862+ENST00000361162RBM39chr2034301018-1616266163744193
ENST00000200181ITGB4chr1773720862+ENST00000528062RBM39chr2034301018-1346266163762199
ENST00000200181ITGB4chr1773720862+ENST00000407261RBM39chr2034301018-916266163762199
ENST00000450894ITGB4chr1773720862+ENST00000253363RBM39chr2034301018-1573205102701199
ENST00000450894ITGB4chr1773720862+ENST00000361162RBM39chr2034301018-1555205102683193
ENST00000450894ITGB4chr1773720862+ENST00000528062RBM39chr2034301018-1285205102701199
ENST00000450894ITGB4chr1773720862+ENST00000407261RBM39chr2034301018-855205102701199
ENST00000449880ITGB4chr1773720862+ENST00000253363RBM39chr2034301018-1455878583191
ENST00000449880ITGB4chr1773720862+ENST00000361162RBM39chr2034301018-1437878565185
ENST00000449880ITGB4chr1773720862+ENST00000528062RBM39chr2034301018-1167878583191
ENST00000449880ITGB4chr1773720862+ENST00000407261RBM39chr2034301018-737878583191

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000579662ENST00000253363ITGB4chr1773720862+RBM39chr2034301018-0.0014833280.9985166
ENST00000579662ENST00000361162ITGB4chr1773720862+RBM39chr2034301018-0.0009734530.99902654
ENST00000579662ENST00000528062ITGB4chr1773720862+RBM39chr2034301018-0.0021987940.99780124
ENST00000579662ENST00000407261ITGB4chr1773720862+RBM39chr2034301018-0.0054493230.99455065
ENST00000339591ENST00000253363ITGB4chr1773720862+RBM39chr2034301018-0.0022013640.9977986
ENST00000339591ENST00000361162ITGB4chr1773720862+RBM39chr2034301018-0.0010816560.9989184
ENST00000339591ENST00000528062ITGB4chr1773720862+RBM39chr2034301018-0.0027462610.9972537
ENST00000339591ENST00000407261ITGB4chr1773720862+RBM39chr2034301018-0.0062624820.99373746
ENST00000200181ENST00000253363ITGB4chr1773720862+RBM39chr2034301018-0.0022013640.9977986
ENST00000200181ENST00000361162ITGB4chr1773720862+RBM39chr2034301018-0.0010816560.9989184
ENST00000200181ENST00000528062ITGB4chr1773720862+RBM39chr2034301018-0.0027462610.9972537
ENST00000200181ENST00000407261ITGB4chr1773720862+RBM39chr2034301018-0.0062624820.99373746
ENST00000450894ENST00000253363ITGB4chr1773720862+RBM39chr2034301018-0.001809670.99819034
ENST00000450894ENST00000361162ITGB4chr1773720862+RBM39chr2034301018-0.0010303480.9989697
ENST00000450894ENST00000528062ITGB4chr1773720862+RBM39chr2034301018-0.0022752890.9977247
ENST00000450894ENST00000407261ITGB4chr1773720862+RBM39chr2034301018-0.004921170.9950788
ENST00000449880ENST00000253363ITGB4chr1773720862+RBM39chr2034301018-0.0017622350.9982377
ENST00000449880ENST00000361162ITGB4chr1773720862+RBM39chr2034301018-0.0010423680.99895763
ENST00000449880ENST00000528062ITGB4chr1773720862+RBM39chr2034301018-0.0018709470.99812907
ENST00000449880ENST00000407261ITGB4chr1773720862+RBM39chr2034301018-0.0030819480.9969181

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40545_40545_1_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000200181_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_2_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000200181_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=193AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQ
LSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPD

--------------------------------------------------------------

>40545_40545_3_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000200181_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_4_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000200181_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_5_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000339591_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_6_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000339591_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=193AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQ
LSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPD

--------------------------------------------------------------

>40545_40545_7_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000339591_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_8_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000339591_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_9_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000449880_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=191AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLS
NMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSM

--------------------------------------------------------------

>40545_40545_10_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000449880_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=185AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------

>40545_40545_11_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000449880_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=191AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLS
NMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSM

--------------------------------------------------------------

>40545_40545_12_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000449880_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=191AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLS
NMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSM

--------------------------------------------------------------

>40545_40545_13_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000450894_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_14_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000450894_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=193AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQ
LSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPD

--------------------------------------------------------------

>40545_40545_15_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000450894_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_16_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000450894_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=199AA_BP=34
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------

>40545_40545_17_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000579662_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=191AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLS
NMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSM

--------------------------------------------------------------

>40545_40545_18_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000579662_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=185AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------

>40545_40545_19_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000579662_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=191AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLS
NMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSM

--------------------------------------------------------------

>40545_40545_20_ITGB4-RBM39_ITGB4_chr17_73720862_ENST00000579662_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=191AA_BP=26
MAGPRPSPWARLLLAALISVSLSGTLGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLS
NMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSM

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73720862/chr20:34301018)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB4

P16144

.
FUNCTION: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBM39chr17:73720862chr20:34301018ENST000002533631017409_416365.3333333333333531.0Compositional biasNote=Poly-Ala
TgeneRBM39chr17:73720862chr20:34301018ENST000003611621017409_416365.3333333333333525.0Compositional biasNote=Poly-Ala
TgeneRBM39chr17:73720862chr20:34301018ENST00000528062916409_416343.3333333333333509.0Compositional biasNote=Poly-Ala
TgeneRBM39chr17:73720862chr20:34301018ENST000002533631017445_508365.3333333333333531.0DomainRRM 3
TgeneRBM39chr17:73720862chr20:34301018ENST000003611621017445_508365.3333333333333525.0DomainRRM 3
TgeneRBM39chr17:73720862chr20:34301018ENST00000528062916445_508343.3333333333333509.0DomainRRM 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+2401129_121826.3333333333333321823.0DomainFibronectin type-III 1
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+2401222_132126.3333333333333321823.0DomainFibronectin type-III 2
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240131_32926.3333333333333321823.0DomainNote=VWFA
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+2401530_162526.3333333333333321823.0DomainFibronectin type-III 3
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+2401643_173926.3333333333333321823.0DomainFibronectin type-III 4
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+24029_7326.3333333333333321823.0DomainNote=PSI
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240979_108426.3333333333333321823.0DomainNote=Calx-beta
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+2401129_121826.3333333333333321806.0DomainFibronectin type-III 1
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+2401222_132126.3333333333333321806.0DomainFibronectin type-III 2
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240131_32926.3333333333333321806.0DomainNote=VWFA
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+2401530_162526.3333333333333321806.0DomainFibronectin type-III 3
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+2401643_173926.3333333333333321806.0DomainFibronectin type-III 4
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+24029_7326.3333333333333321806.0DomainNote=PSI
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240979_108426.3333333333333321806.0DomainNote=Calx-beta
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+1391129_121826.3333333333333321806.0DomainFibronectin type-III 1
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+1391222_132126.3333333333333321806.0DomainFibronectin type-III 2
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139131_32926.3333333333333321806.0DomainNote=VWFA
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+1391530_162526.3333333333333321806.0DomainFibronectin type-III 3
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+1391643_173926.3333333333333321806.0DomainFibronectin type-III 4
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+13929_7326.3333333333333321806.0DomainNote=PSI
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139979_108426.3333333333333321806.0DomainNote=Calx-beta
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+2391129_121826.3333333333333321753.0DomainFibronectin type-III 1
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+2391222_132126.3333333333333321753.0DomainFibronectin type-III 2
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239131_32926.3333333333333321753.0DomainNote=VWFA
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+2391530_162526.3333333333333321753.0DomainFibronectin type-III 3
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+2391643_173926.3333333333333321753.0DomainFibronectin type-III 4
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+23929_7326.3333333333333321753.0DomainNote=PSI
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239979_108426.3333333333333321753.0DomainNote=Calx-beta
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+2391129_121826.3333333333333321753.0DomainFibronectin type-III 1
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+2391222_132126.3333333333333321753.0DomainFibronectin type-III 2
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239131_32926.3333333333333321753.0DomainNote=VWFA
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+2391530_162526.3333333333333321753.0DomainFibronectin type-III 3
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+2391643_173926.3333333333333321753.0DomainFibronectin type-III 4
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+23929_7326.3333333333333321753.0DomainNote=PSI
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239979_108426.3333333333333321753.0DomainNote=Calx-beta
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240194_19926.3333333333333321823.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240456_61926.3333333333333321823.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240732_74926.3333333333333321823.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240194_19926.3333333333333321806.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240456_61926.3333333333333321806.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240732_74926.3333333333333321806.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139194_19926.3333333333333321806.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139456_61926.3333333333333321806.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139732_74926.3333333333333321806.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239194_19926.3333333333333321753.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239456_61926.3333333333333321753.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239732_74926.3333333333333321753.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239194_19926.3333333333333321753.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239456_61926.3333333333333321753.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239732_74926.3333333333333321753.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240456_50226.3333333333333321823.0RepeatNote=I
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240503_54226.3333333333333321823.0RepeatNote=II
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240543_58126.3333333333333321823.0RepeatNote=III
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240582_61926.3333333333333321823.0RepeatNote=IV
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240456_50226.3333333333333321806.0RepeatNote=I
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240503_54226.3333333333333321806.0RepeatNote=II
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240543_58126.3333333333333321806.0RepeatNote=III
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240582_61926.3333333333333321806.0RepeatNote=IV
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139456_50226.3333333333333321806.0RepeatNote=I
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139503_54226.3333333333333321806.0RepeatNote=II
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139543_58126.3333333333333321806.0RepeatNote=III
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139582_61926.3333333333333321806.0RepeatNote=IV
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239456_50226.3333333333333321753.0RepeatNote=I
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239503_54226.3333333333333321753.0RepeatNote=II
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239543_58126.3333333333333321753.0RepeatNote=III
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239582_61926.3333333333333321753.0RepeatNote=IV
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239456_50226.3333333333333321753.0RepeatNote=I
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239503_54226.3333333333333321753.0RepeatNote=II
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239543_58126.3333333333333321753.0RepeatNote=III
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239582_61926.3333333333333321753.0RepeatNote=IV
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+24028_71026.3333333333333321823.0Topological domainExtracellular
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240734_182226.3333333333333321823.0Topological domainCytoplasmic
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+24028_71026.3333333333333321806.0Topological domainExtracellular
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240734_182226.3333333333333321806.0Topological domainCytoplasmic
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+13928_71026.3333333333333321806.0Topological domainExtracellular
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139734_182226.3333333333333321806.0Topological domainCytoplasmic
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+23928_71026.3333333333333321753.0Topological domainExtracellular
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239734_182226.3333333333333321753.0Topological domainCytoplasmic
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+23928_71026.3333333333333321753.0Topological domainExtracellular
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239734_182226.3333333333333321753.0Topological domainCytoplasmic
HgeneITGB4chr17:73720862chr20:34301018ENST00000200181+240711_73326.3333333333333321823.0TransmembraneHelical
HgeneITGB4chr17:73720862chr20:34301018ENST00000339591+240711_73326.3333333333333321806.0TransmembraneHelical
HgeneITGB4chr17:73720862chr20:34301018ENST00000449880+139711_73326.3333333333333321806.0TransmembraneHelical
HgeneITGB4chr17:73720862chr20:34301018ENST00000450894+239711_73326.3333333333333321753.0TransmembraneHelical
HgeneITGB4chr17:73720862chr20:34301018ENST00000579662+239711_73326.3333333333333321753.0TransmembraneHelical
TgeneRBM39chr17:73720862chr20:34301018ENST00000253363101741_90365.3333333333333531.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr17:73720862chr20:34301018ENST00000361162101741_90365.3333333333333525.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr17:73720862chr20:34301018ENST0000052806291641_90343.3333333333333509.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr17:73720862chr20:34301018ENST000002533631017153_230365.3333333333333531.0DomainRRM 1
TgeneRBM39chr17:73720862chr20:34301018ENST000002533631017250_328365.3333333333333531.0DomainRRM 2
TgeneRBM39chr17:73720862chr20:34301018ENST000003611621017153_230365.3333333333333525.0DomainRRM 1
TgeneRBM39chr17:73720862chr20:34301018ENST000003611621017250_328365.3333333333333525.0DomainRRM 2
TgeneRBM39chr17:73720862chr20:34301018ENST00000528062916153_230343.3333333333333509.0DomainRRM 1
TgeneRBM39chr17:73720862chr20:34301018ENST00000528062916250_328343.3333333333333509.0DomainRRM 2
TgeneRBM39chr17:73720862chr20:34301018ENST000002533631017291_355365.3333333333333531.0RegionActivating domain
TgeneRBM39chr17:73720862chr20:34301018ENST000003611621017291_355365.3333333333333525.0RegionActivating domain
TgeneRBM39chr17:73720862chr20:34301018ENST00000528062916291_355343.3333333333333509.0RegionActivating domain


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ITGB4
RBM39


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRBM39chr17:73720862chr20:34301018ENST000002533631017355_406365.3333333333333531.0ESR1 and ESR2
TgeneRBM39chr17:73720862chr20:34301018ENST000003611621017355_406365.3333333333333525.0ESR1 and ESR2
TgeneRBM39chr17:73720862chr20:34301018ENST000002533631017291_406365.3333333333333531.0JUN
TgeneRBM39chr17:73720862chr20:34301018ENST000003611621017291_406365.3333333333333525.0JUN
TgeneRBM39chr17:73720862chr20:34301018ENST00000528062916291_406343.3333333333333509.0JUN


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Related Drugs to ITGB4-RBM39


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ITGB4-RBM39


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource