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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ITPKB-ZC3HAV1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ITPKB-ZC3HAV1
	FusionPDB ID: 40669
	FusionGDB2.0 ID: 40669
		Hgene	Tgene
	Gene symbol	ITPKB	ZC3HAV1
	Gene ID	3707	56829
	Gene name	inositol-trisphosphate 3-kinase B	zinc finger CCCH-type containing, antiviral 1
	Synonyms	IP3-3KB\|IP3K\|IP3K-B\|IP3KB\|PIG37	ARTD13\|FLB6421\|PARP13\|ZAP\|ZC3H2\|ZC3HDC2
	Cytomap	1q42.12	7q34
	Type of gene	protein-coding	protein-coding
	Description	inositol-trisphosphate 3-kinase BIP3 3-kinase BIP3K Binositol 1,4,5-trisphosphate 3-kinase BinsP 3-kinase Bproliferation-inducing protein 37	zinc finger CCCH-type antiviral protein 1ADP-ribosyltransferase diphtheria toxin-like 13inactive Poly [ADP-ribose] polymerase 13zinc finger CCCH domain-containing protein 2zinc finger CCCH-type, antiviral 1
	Modification date	20200313	20200313
	UniProtAcc	P27987	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000272117, ENST00000366784, ENST00000429204,	ENST00000242351, ENST00000464606, ENST00000471652,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 5 X 3=75	13 X 10 X 5=650
	# samples	6	16
	** MAII score	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/650*10)=-2.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ITPKB [Title/Abstract] AND ZC3HAV1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ITPKB(226923228)-ZC3HAV1(138749745), # samples:3 ZC3HAV1(138749625)-ITPKB(226836472), # samples:3
Anticipated loss of major functional domain due to fusion event.	ITPKB-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ITPKB-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ITPKB-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ITPKB-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZC3HAV1-ITPKB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ZC3HAV1-ITPKB seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ZC3HAV1-ITPKB seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ITPKB	GO:0032957	inositol trisphosphate metabolic process	1654894
Hgene	ITPKB	GO:0071277	cellular response to calcium ion	1654894
Tgene	ZC3HAV1	GO:0006471	protein ADP-ribosylation	25043379
Tgene	ZC3HAV1	GO:0009615	response to virus	21876179
Tgene	ZC3HAV1	GO:0045071	negative regulation of viral genome replication	21876179
Tgene	ZC3HAV1	GO:0061014	positive regulation of mRNA catabolic process	21876179

Fusion gene breakpoints across ITPKB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZC3HAV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A0J2-01A	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-
ChimerDB4	BRCA	TCGA-AO-A0J2	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000272117	ITPKB	chr1	226923228	-	ENST00000242351	ZC3HAV1	chr7	138749745	-	6843	1932	0	2768	922
ENST00000272117	ITPKB	chr1	226923228	-	ENST00000464606	ZC3HAV1	chr7	138749745	-	4447	1932	0	2768	922
ENST00000272117	ITPKB	chr1	226923228	-	ENST00000471652	ZC3HAV1	chr7	138749745	-	2854	1932	0	2159	719
ENST00000429204	ITPKB	chr1	226923228	-	ENST00000242351	ZC3HAV1	chr7	138749745	-	7171	2260	184	3096	970
ENST00000429204	ITPKB	chr1	226923228	-	ENST00000464606	ZC3HAV1	chr7	138749745	-	4775	2260	184	3096	970
ENST00000429204	ITPKB	chr1	226923228	-	ENST00000471652	ZC3HAV1	chr7	138749745	-	3182	2260	184	2487	767
ENST00000366784	ITPKB	chr1	226923228	-	ENST00000242351	ZC3HAV1	chr7	138749745	-	7331	2420	344	3256	970
ENST00000366784	ITPKB	chr1	226923228	-	ENST00000464606	ZC3HAV1	chr7	138749745	-	4935	2420	344	3256	970
ENST00000366784	ITPKB	chr1	226923228	-	ENST00000471652	ZC3HAV1	chr7	138749745	-	3342	2420	344	2647	767
ENST00000272117	ITPKB	chr1	226923227	-	ENST00000242351	ZC3HAV1	chr7	138749745	-	6843	1932	0	2768	922
ENST00000272117	ITPKB	chr1	226923227	-	ENST00000464606	ZC3HAV1	chr7	138749745	-	4447	1932	0	2768	922
ENST00000272117	ITPKB	chr1	226923227	-	ENST00000471652	ZC3HAV1	chr7	138749745	-	2854	1932	0	2159	719
ENST00000429204	ITPKB	chr1	226923227	-	ENST00000242351	ZC3HAV1	chr7	138749745	-	7171	2260	184	3096	970
ENST00000429204	ITPKB	chr1	226923227	-	ENST00000464606	ZC3HAV1	chr7	138749745	-	4775	2260	184	3096	970
ENST00000429204	ITPKB	chr1	226923227	-	ENST00000471652	ZC3HAV1	chr7	138749745	-	3182	2260	184	2487	767
ENST00000366784	ITPKB	chr1	226923227	-	ENST00000242351	ZC3HAV1	chr7	138749745	-	7331	2420	344	3256	970
ENST00000366784	ITPKB	chr1	226923227	-	ENST00000464606	ZC3HAV1	chr7	138749745	-	4935	2420	344	3256	970
ENST00000366784	ITPKB	chr1	226923227	-	ENST00000471652	ZC3HAV1	chr7	138749745	-	3342	2420	344	2647	767

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000272117	ENST00000242351	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.000681577	0.9993185
ENST00000272117	ENST00000464606	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.002068109	0.99793184
ENST00000272117	ENST00000471652	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.03710601	0.96289396
ENST00000429204	ENST00000242351	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.000706951	0.99929297
ENST00000429204	ENST00000464606	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.002062254	0.99793774
ENST00000429204	ENST00000471652	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.033840366	0.9661597
ENST00000366784	ENST00000242351	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.000764434	0.99923563
ENST00000366784	ENST00000464606	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.002184501	0.9978155
ENST00000366784	ENST00000471652	ITPKB	chr1	226923228	-	ZC3HAV1	chr7	138749745	-	0.035524618	0.96447545
ENST00000272117	ENST00000242351	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.000681577	0.9993185
ENST00000272117	ENST00000464606	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.002068109	0.99793184
ENST00000272117	ENST00000471652	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.03710601	0.96289396
ENST00000429204	ENST00000242351	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.000706951	0.99929297
ENST00000429204	ENST00000464606	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.002062254	0.99793774
ENST00000429204	ENST00000471652	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.033840366	0.9661597
ENST00000366784	ENST00000242351	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.000764434	0.99923563
ENST00000366784	ENST00000464606	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.002184501	0.9978155
ENST00000366784	ENST00000471652	ITPKB	chr1	226923227	-	ZC3HAV1	chr7	138749745	-	0.035524618	0.96447545

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40669_40669_1_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000272117_ZC3HAV1_chr7_138749745_ENST00000242351_length(amino acids)=922AA_BP=644
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGS
GSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSP
TAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTL
GLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPN
SAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDH
QPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATS
RAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIF

--------------------------------------------------------------

>40669_40669_2_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000272117_ZC3HAV1_chr7_138749745_ENST00000464606_length(amino acids)=922AA_BP=644
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGS
GSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSP
TAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTL
GLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPN
SAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDH
QPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATS
RAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIF

--------------------------------------------------------------

>40669_40669_3_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000272117_ZC3HAV1_chr7_138749745_ENST00000471652_length(amino acids)=719AA_BP=644
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGS
GSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSP
TAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTL
GLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPN

--------------------------------------------------------------

>40669_40669_4_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000366784_ZC3HAV1_chr7_138749745_ENST00000242351_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_5_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000366784_ZC3HAV1_chr7_138749745_ENST00000464606_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_6_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000366784_ZC3HAV1_chr7_138749745_ENST00000471652_length(amino acids)=767AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF

--------------------------------------------------------------

>40669_40669_7_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000429204_ZC3HAV1_chr7_138749745_ENST00000242351_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_8_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000429204_ZC3HAV1_chr7_138749745_ENST00000464606_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_9_ITPKB-ZC3HAV1_ITPKB_chr1_226923227_ENST00000429204_ZC3HAV1_chr7_138749745_ENST00000471652_length(amino acids)=767AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF

--------------------------------------------------------------

>40669_40669_10_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000272117_ZC3HAV1_chr7_138749745_ENST00000242351_length(amino acids)=922AA_BP=644
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGS
GSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSP
TAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTL
GLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPN
SAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDH
QPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATS
RAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIF

--------------------------------------------------------------

>40669_40669_11_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000272117_ZC3HAV1_chr7_138749745_ENST00000464606_length(amino acids)=922AA_BP=644
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGS
GSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSP
TAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTL
GLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPN
SAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDH
QPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATS
RAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIF

--------------------------------------------------------------

>40669_40669_12_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000272117_ZC3HAV1_chr7_138749745_ENST00000471652_length(amino acids)=719AA_BP=644
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGS
GSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSP
TAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTL
GLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPN

--------------------------------------------------------------

>40669_40669_13_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000366784_ZC3HAV1_chr7_138749745_ENST00000242351_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_14_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000366784_ZC3HAV1_chr7_138749745_ENST00000464606_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_15_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000366784_ZC3HAV1_chr7_138749745_ENST00000471652_length(amino acids)=767AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF

--------------------------------------------------------------

>40669_40669_16_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000429204_ZC3HAV1_chr7_138749745_ENST00000242351_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_17_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000429204_ZC3HAV1_chr7_138749745_ENST00000464606_length(amino acids)=970AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF
QAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVR
VSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCP

--------------------------------------------------------------

>40669_40669_18_ITPKB-ZC3HAV1_ITPKB_chr1_226923228_ENST00000429204_ZC3HAV1_chr7_138749745_ENST00000471652_length(amino acids)=767AA_BP=692
MPRPCRPICARSRGCRASGAEPGAPGGGGAGGGAGAGAAAAGSAGPSTMAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVL
SPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLR
ILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGG
PSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTS
TGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQS
AESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQ
CPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGAL
EETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVKDKRKNSNVDSSYLESLYQSCPRGVVPF

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:226923228/chr7:138749745)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITPKB P27987	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000272117

599_605

644.0

947.0

Compositional bias

Note=Poly-Ser

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000366784

599_605

644.0

645.0

Compositional bias

Note=Poly-Ser

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000429204

599_605

644.0

947.0

Compositional bias

Note=Poly-Ser

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000272117

599_605

644.0

947.0

Compositional bias

Note=Poly-Ser

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000366784

599_605

644.0

645.0

Compositional bias

Note=Poly-Ser

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000429204

599_605

644.0

947.0

Compositional bias

Note=Poly-Ser

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

716_902

624.0

903.0

Domain

PARP catalytic

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

716_902

624.0

700.0

Domain

PARP catalytic

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

716_902

624.0

903.0

Domain

PARP catalytic

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

716_902

624.0

700.0

Domain

PARP catalytic

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000272117

730_732

644.0

947.0

Nucleotide binding

ATP

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000366784

730_732

644.0

645.0

Nucleotide binding

ATP

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000429204

730_732

644.0

947.0

Nucleotide binding

ATP

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000272117

730_732

644.0

947.0

Nucleotide binding

ATP

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000366784

730_732

644.0

645.0

Nucleotide binding

ATP

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000429204

730_732

644.0

947.0

Nucleotide binding

ATP

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000272117

768_776

644.0

947.0

Region

Calmodulin-binding

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000272117

793_800

644.0

947.0

Region

Substrate binding

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000366784

768_776

644.0

645.0

Region

Calmodulin-binding

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000366784

793_800

644.0

645.0

Region

Substrate binding

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000429204

768_776

644.0

947.0

Region

Calmodulin-binding

Hgene

ITPKB

chr1:226923227

chr7:138749745

ENST00000429204

793_800

644.0

947.0

Region

Substrate binding

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000272117

768_776

644.0

947.0

Region

Calmodulin-binding

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000272117

793_800

644.0

947.0

Region

Substrate binding

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000366784

768_776

644.0

645.0

Region

Calmodulin-binding

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000366784

793_800

644.0

645.0

Region

Substrate binding

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000429204

768_776

644.0

947.0

Region

Calmodulin-binding

Hgene

ITPKB

chr1:226923228

chr7:138749745

ENST00000429204

793_800

644.0

947.0

Region

Substrate binding

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

594_681

624.0

903.0

Domain

WWE

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

594_681

624.0

700.0

Domain

WWE

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

594_681

624.0

903.0

Domain

WWE

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

594_681

624.0

700.0

Domain

WWE

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

285_292

624.0

903.0

Motif

Nuclear export signal

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

69_76

624.0

903.0

Motif

Nuclear localization signal

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

285_292

624.0

700.0

Motif

Nuclear export signal

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

69_76

624.0

700.0

Motif

Nuclear localization signal

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

285_292

624.0

903.0

Motif

Nuclear export signal

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

69_76

624.0

903.0

Motif

Nuclear localization signal

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

285_292

624.0

700.0

Motif

Nuclear export signal

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

69_76

624.0

700.0

Motif

Nuclear localization signal

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

224_254

624.0

903.0

Region

Binding to EXOSC5

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

2_254

624.0

903.0

Region

Note=N-terminal domain

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

224_254

624.0

700.0

Region

Binding to EXOSC5

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

2_254

624.0

700.0

Region

Note=N-terminal domain

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

224_254

624.0

903.0

Region

Binding to EXOSC5

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

2_254

624.0

903.0

Region

Note=N-terminal domain

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

224_254

624.0

700.0

Region

Binding to EXOSC5

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

2_254

624.0

700.0

Region

Note=N-terminal domain

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

150_172

624.0

903.0

Zinc finger

C3H1-type 3

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

169_193

624.0

903.0

Zinc finger

C3H1-type 4

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

73_86

624.0

903.0

Zinc finger

C3H1-type 1

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000242351

88_110

624.0

903.0

Zinc finger

C3H1-type 2

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

150_172

624.0

700.0

Zinc finger

C3H1-type 3

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

169_193

624.0

700.0

Zinc finger

C3H1-type 4

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

73_86

624.0

700.0

Zinc finger

C3H1-type 1

Tgene

ZC3HAV1

chr1:226923227

chr7:138749745

ENST00000471652

88_110

624.0

700.0

Zinc finger

C3H1-type 2

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

150_172

624.0

903.0

Zinc finger

C3H1-type 3

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

169_193

624.0

903.0

Zinc finger

C3H1-type 4

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

73_86

624.0

903.0

Zinc finger

C3H1-type 1

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000242351

88_110

624.0

903.0

Zinc finger

C3H1-type 2

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

150_172

624.0

700.0

Zinc finger

C3H1-type 3

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

169_193

624.0

700.0

Zinc finger

C3H1-type 4

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

73_86

624.0

700.0

Zinc finger

C3H1-type 1

Tgene

ZC3HAV1

chr1:226923228

chr7:138749745

ENST00000471652

88_110

624.0

700.0

Zinc finger

C3H1-type 2

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ITPKB
ZC3HAV1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ITPKB-ZC3HAV1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ITPKB-ZC3HAV1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source