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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ITSN2-ESRP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ITSN2-ESRP1
FusionPDB ID: 40768
FusionGDB2.0 ID: 40768
HgeneTgene
Gene symbol

ITSN2

ESRP1

Gene ID

50618

54845

Gene nameintersectin 2epithelial splicing regulatory protein 1
SynonymsPRO2015|SH3D1B|SH3P18|SWA|SWAPDFNB109|RBM35A|RMB35A
Cytomap

2p23.3

8q22.1

Type of geneprotein-codingprotein-coding
Descriptionintersectin-2SH3 domain-containing protein 1BSH3P18-like WASP-associated proteinepithelial splicing regulatory protein 1RNA-binding motif protein 35ARNA-binding protein 35A
Modification date2020031320200313
UniProtAcc

Q9NZM3

Q6NXG1

Ensembl transtripts involved in fusion geneENST idsENST00000355123, ENST00000361999, 
ENST00000406921, ENST00000407704, 
ENST00000523347, ENST00000358397, 
ENST00000423620, ENST00000433389, 
ENST00000454170, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 16 X 6=124814 X 16 X 7=1568
# samples 1815
** MAII scorelog2(18/1248*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1568*10)=-3.38589115361933
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ITSN2 [Title/Abstract] AND ESRP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ITSN2(24550921)-ESRP1(95683681), # samples:1
Anticipated loss of major functional domain due to fusion event.ITSN2-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITSN2-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITSN2-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ITSN2-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITSN2

GO:1903861

positive regulation of dendrite extension

23999003

TgeneESRP1

GO:0043484

regulation of RNA splicing

19285943


check buttonFusion gene breakpoints across ITSN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ESRP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-C4-A0F7-01AITSN2chr2

24550921

-ESRP1chr8

95683681

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361999ITSN2chr224550921-ENST00000423620ESRP1chr895683681+23387067816249
ENST00000361999ITSN2chr224550921-ENST00000433389ESRP1chr895683681+24177067882271
ENST00000361999ITSN2chr224550921-ENST00000358397ESRP1chr895683681+24487067870267
ENST00000361999ITSN2chr224550921-ENST00000454170ESRP1chr895683681+21997067663198
ENST00000355123ITSN2chr224550921-ENST00000423620ESRP1chr895683681+27434754721221249
ENST00000355123ITSN2chr224550921-ENST00000433389ESRP1chr895683681+28224754721287271
ENST00000355123ITSN2chr224550921-ENST00000358397ESRP1chr895683681+28534754721275267
ENST00000355123ITSN2chr224550921-ENST00000454170ESRP1chr895683681+26044754721068198
ENST00000406921ITSN2chr224550921-ENST00000423620ESRP1chr895683681+25372692661015249
ENST00000406921ITSN2chr224550921-ENST00000433389ESRP1chr895683681+26162692661081271
ENST00000406921ITSN2chr224550921-ENST00000358397ESRP1chr895683681+26472692661069267
ENST00000406921ITSN2chr224550921-ENST00000454170ESRP1chr895683681+2398269266862198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361999ENST00000423620ITSN2chr224550921-ESRP1chr895683681+0.0005092950.99949074
ENST00000361999ENST00000433389ITSN2chr224550921-ESRP1chr895683681+0.0004303760.9995696
ENST00000361999ENST00000358397ITSN2chr224550921-ESRP1chr895683681+0.0003591950.9996408
ENST00000361999ENST00000454170ITSN2chr224550921-ESRP1chr895683681+0.0011623650.99883765
ENST00000355123ENST00000423620ITSN2chr224550921-ESRP1chr895683681+0.0007684750.9992316
ENST00000355123ENST00000433389ITSN2chr224550921-ESRP1chr895683681+0.0007816530.99921834
ENST00000355123ENST00000358397ITSN2chr224550921-ESRP1chr895683681+0.0005487930.9994512
ENST00000355123ENST00000454170ITSN2chr224550921-ESRP1chr895683681+0.0020057870.9979942
ENST00000406921ENST00000423620ITSN2chr224550921-ESRP1chr895683681+0.0005093630.9994906
ENST00000406921ENST00000433389ITSN2chr224550921-ESRP1chr895683681+0.0005926580.9994073
ENST00000406921ENST00000358397ITSN2chr224550921-ESRP1chr895683681+0.0003776710.99962234
ENST00000406921ENST00000454170ITSN2chr224550921-ESRP1chr895683681+0.0009140010.999086

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40768_40768_1_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000355123_ESRP1_chr8_95683681_ENST00000358397_length(amino acids)=267AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAG

--------------------------------------------------------------

>40768_40768_2_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000355123_ESRP1_chr8_95683681_ENST00000423620_length(amino acids)=249AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAG

--------------------------------------------------------------

>40768_40768_3_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000355123_ESRP1_chr8_95683681_ENST00000433389_length(amino acids)=271AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAY
YPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANLSGVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQYATEDGLIHTNDQARTLPKEWVC

--------------------------------------------------------------

>40768_40768_4_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000355123_ESRP1_chr8_95683681_ENST00000454170_length(amino acids)=198AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAY

--------------------------------------------------------------

>40768_40768_5_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000361999_ESRP1_chr8_95683681_ENST00000358397_length(amino acids)=267AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAG

--------------------------------------------------------------

>40768_40768_6_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000361999_ESRP1_chr8_95683681_ENST00000423620_length(amino acids)=249AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAG

--------------------------------------------------------------

>40768_40768_7_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000361999_ESRP1_chr8_95683681_ENST00000433389_length(amino acids)=271AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAY
YPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANLSGVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQYATEDGLIHTNDQARTLPKEWVC

--------------------------------------------------------------

>40768_40768_8_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000361999_ESRP1_chr8_95683681_ENST00000454170_length(amino acids)=198AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAY

--------------------------------------------------------------

>40768_40768_9_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000406921_ESRP1_chr8_95683681_ENST00000358397_length(amino acids)=267AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAG

--------------------------------------------------------------

>40768_40768_10_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000406921_ESRP1_chr8_95683681_ENST00000423620_length(amino acids)=249AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAYYPAG

--------------------------------------------------------------

>40768_40768_11_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000406921_ESRP1_chr8_95683681_ENST00000433389_length(amino acids)=271AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAY
YPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANLSGVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQYATEDGLIHTNDQARTLPKEWVC

--------------------------------------------------------------

>40768_40768_12_ITSN2-ESRP1_ITSN2_chr2_24550921_ENST00000406921_ESRP1_chr8_95683681_ENST00000454170_length(amino acids)=198AA_BP=1
MVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFATDIRTHGVHMVLNHQGRPSGDAFIQMKSADR
AFMAAQKCHKKNMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSVILNPRALQPSTAY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:24550921/chr8:95683681)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITSN2

Q9NZM3

ESRP1

Q6NXG1

FUNCTION: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}.FUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250|UniProtKB:Q3US41, ECO:0000269|PubMed:19285943}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneESRP1chr2:24550921chr8:95683681ENST00000358397916445_525411.01099.6666666666667DomainRRM 3
TgeneESRP1chr2:24550921chr8:95683681ENST00000423620915445_525411.0660.0DomainRRM 3
TgeneESRP1chr2:24550921chr8:95683681ENST00000433389916445_525411.01074.3333333333333DomainRRM 3
TgeneESRP1chr2:24550921chr8:95683681ENST00000454170914445_525411.0609.0DomainRRM 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-24067_7910.3333333333333341698.0Calcium bindingOntology_term=ECO:0000255
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-23967_7910.3333333333333341671.0Calcium bindingOntology_term=ECO:0000255
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-23067_7910.3333333333333341250.0Calcium bindingOntology_term=ECO:0000255
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-240361_75610.3333333333333341698.0Coiled coilOntology_term=ECO:0000255
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-239361_75610.3333333333333341671.0Coiled coilOntology_term=ECO:0000255
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-230361_75610.3333333333333341250.0Coiled coilOntology_term=ECO:0000255
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-2401053_111710.3333333333333341698.0DomainSH3 4
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-2401127_118610.3333333333333341698.0DomainSH3 5
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-2401209_139510.3333333333333341698.0DomainDH
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-2401434_154410.3333333333333341698.0DomainPH
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-2401552_166810.3333333333333341698.0DomainC2
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-24022_11010.3333333333333341698.0DomainEH 1
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-240244_33310.3333333333333341698.0DomainEH 2
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-24054_8910.3333333333333341698.0DomainEF-hand
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-240757_81810.3333333333333341698.0DomainSH3 1
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-240898_95610.3333333333333341698.0DomainSH3 2
HgeneITSN2chr2:24550921chr8:95683681ENST00000355123-240981_103910.3333333333333341698.0DomainSH3 3
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-2391053_111710.3333333333333341671.0DomainSH3 4
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-2391127_118610.3333333333333341671.0DomainSH3 5
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-2391209_139510.3333333333333341671.0DomainDH
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-2391434_154410.3333333333333341671.0DomainPH
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-2391552_166810.3333333333333341671.0DomainC2
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-23922_11010.3333333333333341671.0DomainEH 1
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-239244_33310.3333333333333341671.0DomainEH 2
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-23954_8910.3333333333333341671.0DomainEF-hand
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-239757_81810.3333333333333341671.0DomainSH3 1
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-239898_95610.3333333333333341671.0DomainSH3 2
HgeneITSN2chr2:24550921chr8:95683681ENST00000361999-239981_103910.3333333333333341671.0DomainSH3 3
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-2301053_111710.3333333333333341250.0DomainSH3 4
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-2301127_118610.3333333333333341250.0DomainSH3 5
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-2301209_139510.3333333333333341250.0DomainDH
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-2301434_154410.3333333333333341250.0DomainPH
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-2301552_166810.3333333333333341250.0DomainC2
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-23022_11010.3333333333333341250.0DomainEH 1
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-230244_33310.3333333333333341250.0DomainEH 2
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-23054_8910.3333333333333341250.0DomainEF-hand
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-230757_81810.3333333333333341250.0DomainSH3 1
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-230898_95610.3333333333333341250.0DomainSH3 2
HgeneITSN2chr2:24550921chr8:95683681ENST00000406921-230981_103910.3333333333333341250.0DomainSH3 3
TgeneESRP1chr2:24550921chr8:95683681ENST00000358397916225_302411.01099.6666666666667DomainRRM 1
TgeneESRP1chr2:24550921chr8:95683681ENST00000358397916326_406411.01099.6666666666667DomainRRM 2
TgeneESRP1chr2:24550921chr8:95683681ENST00000423620915225_302411.0660.0DomainRRM 1
TgeneESRP1chr2:24550921chr8:95683681ENST00000423620915326_406411.0660.0DomainRRM 2
TgeneESRP1chr2:24550921chr8:95683681ENST00000433389916225_302411.01074.3333333333333DomainRRM 1
TgeneESRP1chr2:24550921chr8:95683681ENST00000433389916326_406411.01074.3333333333333DomainRRM 2
TgeneESRP1chr2:24550921chr8:95683681ENST00000454170914225_302411.0609.0DomainRRM 1
TgeneESRP1chr2:24550921chr8:95683681ENST00000454170914326_406411.0609.0DomainRRM 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ESRP1ATXN1, RNF2, BMI1, RNF111, RGPD8, RGPD5, RBPMS, RGPD3, RBPMS2, ATXN2, THUMPD3, ZNF703, HELZ, ELAVL2, GPATCH8, BIRC6, ESR2, MED25, KLHDC7B, OXER1, DAZAP2, KRTAP19-5, ARID5A, PRR20B, PRR20A, PRR20D, PRR20C, PRR20E, ESR1, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR7-1, MIR9-1, MIR15B, MIR19B1, MIR19B2, MIR20B, MIR21, MIR25, MIR29C, MIR34A, MIR34B, MIR106A, MIR106B, MIR128-2, MIR138-1, MIR138-2, MIR141, MIR155, MIR200A, MIR200C, MIR222, MIR363, H1F0, CIT, KIF14, KIF20A, PRC1, PAK6, RANBP2, MRPS24, ZC3H10, ALG13, Rbm38, Rbm47,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ITSN2
ESRP1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ITSN2-ESRP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ITSN2-ESRP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneESRP1C4693935DEAFNESS, AUTOSOMAL RECESSIVE 1091GENOMICS_ENGLAND;UNIPROT