UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level3
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Potentially Interacting Small Molecules through Virtual Screening

leaf

Biochemical Features of Small Molecules with ADME

leaf

Drug Toxicity Information

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:JAK2-PAX5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: JAK2-PAX5
FusionPDB ID: 40857
FusionGDB2.0 ID: 40857
HgeneTgene
Gene symbol

JAK2

PAX5

Gene ID

3717

5079

Gene nameJanus kinase 2paired box 5
SynonymsJTK10|THCYT3ALL3|BSAP
Cytomap

9p24.1

9p13.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5
Modification date2020032920200313
UniProtAcc

O60674

Q02548

Ensembl transtripts involved in fusion geneENST idsENST00000381652, ENST00000539801, 
ENST00000544510, ENST00000487310, 
ENST00000358127, ENST00000377847, 
ENST00000377852, ENST00000377853, 
ENST00000414447, ENST00000446742, 
ENST00000520154, ENST00000520281, 
ENST00000522003, ENST00000523145, 
ENST00000523241, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 8=10408 X 7 X 6=336
# samples 119
** MAII scorelog2(11/1040*10)=-3.24100809950379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: JAK2 [Title/Abstract] AND PAX5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.PAX5-JAK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PAX5-JAK2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
PAX5-JAK2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJAK2

GO:0010811

positive regulation of cell-substrate adhesion

10925297

HgeneJAK2

GO:0019221

cytokine-mediated signaling pathway

8609418

HgeneJAK2

GO:0033209

tumor necrosis factor-mediated signaling pathway

8609418

HgeneJAK2

GO:0034612

response to tumor necrosis factor

8609418

HgeneJAK2

GO:0035409

histone H3-Y41 phosphorylation

19783980

HgeneJAK2

GO:0035722

interleukin-12-mediated signaling pathway

7528775

HgeneJAK2

GO:0046677

response to antibiotic

16280321

HgeneJAK2

GO:0050727

regulation of inflammatory response

10925297

HgeneJAK2

GO:0060396

growth hormone receptor signaling pathway

10925297

HgeneJAK2

GO:0070671

response to interleukin-12

7528775


check buttonFusion gene breakpoints across JAK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PAX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..JAK2chr9

5080683

+PAX5chr9

36966721

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539801JAK2chr95080683+ENST00000358127PAX5chr936966721-10404254711331181001
ENST00000539801JAK2chr95080683+ENST00000523241PAX5chr936966721-327525471132917934
ENST00000539801JAK2chr95080683+ENST00000520154PAX5chr936966721-318825471132830905
ENST00000539801JAK2chr95080683+ENST00000377852PAX5chr936966721-340525471133016967
ENST00000539801JAK2chr95080683+ENST00000377853PAX5chr936966721-342025471133031972
ENST00000539801JAK2chr95080683+ENST00000522003PAX5chr936966721-3128254711331181001
ENST00000539801JAK2chr95080683+ENST00000520281PAX5chr936966721-304125471133031972
ENST00000539801JAK2chr95080683+ENST00000414447PAX5chr936966721-3128254711331181001
ENST00000539801JAK2chr95080683+ENST00000523145PAX5chr936966721-293925471132929938
ENST00000539801JAK2chr95080683+ENST00000446742PAX5chr936966721-302625471133016967
ENST00000539801JAK2chr95080683+ENST00000377847PAX5chr936966721-293925471132929938
ENST00000381652JAK2chr95080683+ENST00000358127PAX5chr936966721-10785292849434991001
ENST00000381652JAK2chr95080683+ENST00000523241PAX5chr936966721-365629284943298934
ENST00000381652JAK2chr95080683+ENST00000520154PAX5chr936966721-356929284943211905
ENST00000381652JAK2chr95080683+ENST00000377852PAX5chr936966721-378629284943397967
ENST00000381652JAK2chr95080683+ENST00000377853PAX5chr936966721-380129284943412972
ENST00000381652JAK2chr95080683+ENST00000522003PAX5chr936966721-3509292849434991001
ENST00000381652JAK2chr95080683+ENST00000520281PAX5chr936966721-342229284943412972
ENST00000381652JAK2chr95080683+ENST00000414447PAX5chr936966721-3509292849434991001
ENST00000381652JAK2chr95080683+ENST00000523145PAX5chr936966721-332029284943310938
ENST00000381652JAK2chr95080683+ENST00000446742PAX5chr936966721-340729284943397967
ENST00000381652JAK2chr95080683+ENST00000377847PAX5chr936966721-332029284943310938
ENST00000544510JAK2chr95080683+ENST00000358127PAX5chr936966721-1021523582602929889
ENST00000544510JAK2chr95080683+ENST00000523241PAX5chr936966721-308623582602728822
ENST00000544510JAK2chr95080683+ENST00000520154PAX5chr936966721-299923582602641793
ENST00000544510JAK2chr95080683+ENST00000377852PAX5chr936966721-321623582602827855
ENST00000544510JAK2chr95080683+ENST00000377853PAX5chr936966721-323123582602842860
ENST00000544510JAK2chr95080683+ENST00000522003PAX5chr936966721-293923582602929889
ENST00000544510JAK2chr95080683+ENST00000520281PAX5chr936966721-285223582602842860
ENST00000544510JAK2chr95080683+ENST00000414447PAX5chr936966721-293923582602929889
ENST00000544510JAK2chr95080683+ENST00000523145PAX5chr936966721-275023582602740826
ENST00000544510JAK2chr95080683+ENST00000446742PAX5chr936966721-283723582602827855
ENST00000544510JAK2chr95080683+ENST00000377847PAX5chr936966721-275023582602740826

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40857_40857_1_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000358127_length(amino acids)=1001AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAA

--------------------------------------------------------------

>40857_40857_2_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000377847_length(amino acids)=938AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_3_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000377852_length(amino acids)=967AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_4_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000377853_length(amino acids)=972AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_5_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000414447_length(amino acids)=1001AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAA

--------------------------------------------------------------

>40857_40857_6_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000446742_length(amino acids)=967AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_7_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000520154_length(amino acids)=905AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQAPPTIIALPPEEPPHLQPPLPMTVTDPWSQ

--------------------------------------------------------------

>40857_40857_8_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000520281_length(amino acids)=972AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_9_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000522003_length(amino acids)=1001AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAA

--------------------------------------------------------------

>40857_40857_10_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000523145_length(amino acids)=938AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_11_JAK2-PAX5_JAK2_chr9_5080683_ENST00000381652_PAX5_chr9_36966721_ENST00000523241_length(amino acids)=934AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQGVSFPGVPTATLSIPRTTTPGGSPTRGCLA

--------------------------------------------------------------

>40857_40857_12_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000358127_length(amino acids)=1001AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAA

--------------------------------------------------------------

>40857_40857_13_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000377847_length(amino acids)=938AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_14_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000377852_length(amino acids)=967AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_15_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000377853_length(amino acids)=972AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_16_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000414447_length(amino acids)=1001AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAA

--------------------------------------------------------------

>40857_40857_17_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000446742_length(amino acids)=967AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_18_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000520154_length(amino acids)=905AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQAPPTIIALPPEEPPHLQPPLPMTVTDPWSQ

--------------------------------------------------------------

>40857_40857_19_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000520281_length(amino acids)=972AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_20_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000522003_length(amino acids)=1001AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAA

--------------------------------------------------------------

>40857_40857_21_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000523145_length(amino acids)=938AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG

--------------------------------------------------------------

>40857_40857_22_JAK2-PAX5_JAK2_chr9_5080683_ENST00000539801_PAX5_chr9_36966721_ENST00000523241_length(amino acids)=934AA_BP=811
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK
FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT
PGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQGVSFPGVPTATLSIPRTTTPGGSPTRGCLA

--------------------------------------------------------------

>40857_40857_23_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000358127_length(amino acids)=889AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTL

--------------------------------------------------------------

>40857_40857_24_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000377847_length(amino acids)=826AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSPYYYSAA

--------------------------------------------------------------

>40857_40857_25_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000377852_length(amino acids)=855AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPY

--------------------------------------------------------------

>40857_40857_26_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000377853_length(amino acids)=860AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTL

--------------------------------------------------------------

>40857_40857_27_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000414447_length(amino acids)=889AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTL

--------------------------------------------------------------

>40857_40857_28_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000446742_length(amino acids)=855AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSEFSGSPY

--------------------------------------------------------------

>40857_40857_29_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000520154_length(amino acids)=793AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK

--------------------------------------------------------------

>40857_40857_30_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000520281_length(amino acids)=860AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTL

--------------------------------------------------------------

>40857_40857_31_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000522003_length(amino acids)=889AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTL

--------------------------------------------------------------

>40857_40857_32_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000523145_length(amino acids)=826AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGSPYYYSAA

--------------------------------------------------------------

>40857_40857_33_JAK2-PAX5_JAK2_chr9_5080683_ENST00000544510_PAX5_chr9_36966721_ENST00000523241_length(amino acids)=822AA_BP=699
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLE
VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPGIQESPVPNGHSLPGRDFLRK
QMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQGVSFPGVPTATLSIPRTTTPGGSPTRGCLAPPTIIALPPEEPPHLQPPLPMT

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JAK2

O60674

PAX5

Q02548

FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263}.FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269|PubMed:10811620, ECO:0000269|PubMed:27181361, ECO:0000269|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269|PubMed:23678172, ECO:0000269|PubMed:31941781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (648) >>>648.pdbFusion protein BP residue: 699
CIF file (648) >>>648.cif		JAK2chr95080683+PAX5chr936966721-
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV
HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK
CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ
SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ
DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA
LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK
LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY
NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVF
RTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLN
YGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMH
FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDIL
QERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRK
LQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPG
IQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTT
793
3D view using mol* of 648 (AA BP:699)
PDB file (665) >>>665.pdbFusion protein BP residue: 699
CIF file (665) >>>665.cif		JAK2chr95080683+PAX5chr936966721-
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV
HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK
CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ
SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ
DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA
LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK
LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY
NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVF
RTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLN
YGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMH
FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDIL
QERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRK
LQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPG
IQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTT
TEPIKPEQGVSFPGVPTATLSIPRTTTPGGSPTRGCLAPPTIIALPPEEP
822
3D view using mol* of 665 (AA BP:699)
PDB file (668) >>>668.pdbFusion protein BP residue: 699
CIF file (668) >>>668.cif		JAK2chr95080683+PAX5chr936966721-
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV
HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK
CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ
SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ
DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA
LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK
LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY
NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVF
RTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLN
YGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMH
FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDIL
QERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRK
LQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPG
IQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTT
TEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIV
826
3D view using mol* of 668 (AA BP:699)
PDB file (680) >>>680.pdbFusion protein BP residue: 699
CIF file (680) >>>680.cif		JAK2chr95080683+PAX5chr936966721-
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV
HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK
CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ
SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ
DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA
LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK
LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY
NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVF
RTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLN
YGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMH
FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDIL
QERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRK
LQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPG
IQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTT
TEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIV
TGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAAT
855
3D view using mol* of 680 (AA BP:699)
PDB file (686) >>>686.pdbFusion protein BP residue: 699
CIF file (686) >>>686.cif		JAK2chr95080683+PAX5chr936966721-
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV
HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK
CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ
SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ
DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA
LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK
LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY
NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVF
RTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLN
YGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMH
FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDIL
QERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRK
LQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPG
IQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTT
TEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIV
TGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSPYYYSAAARGAAP
860
3D view using mol* of 686 (AA BP:699)
PDB file (700) >>>700.pdbFusion protein BP residue: 699
CIF file (700) >>>700.cif		JAK2chr95080683+PAX5chr936966721-
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV
HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK
CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ
SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ
DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA
LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK
LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY
NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVF
RTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG
VRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLN
YGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMH
FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDIL
QERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRK
LQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPG
IQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTT
TEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIV
TGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYS
889
3D view using mol* of 700 (AA BP:699)
PDB file (705) >>>705.pdbFusion protein BP residue: 811
CIF file (705) >>>705.cif		JAK2chr95080683+PAX5chr936966721-
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS
EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH
VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM
SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI
YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL
KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK
NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC
HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP
PKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNES
LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK
LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG
DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRA
IIRDLNSLFTPGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
FERQHYSDIFTTTEPIKPEQAPPTIIALPPEEPPHLQPPLPMTVTDPWSQ
905
3D view using mol* of 705 (AA BP:811)
PDB file (717) >>>717.pdbFusion protein BP residue: 811
CIF file (717) >>>717.cif		JAK2chr95080683+PAX5chr936966721-
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS
EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH
VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM
SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI
YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL
KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK
NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC
HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP
PKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNES
LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK
LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG
DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRA
IIRDLNSLFTPGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
FERQHYSDIFTTTEPIKPEQGVSFPGVPTATLSIPRTTTPGGSPTRGCLA
934
3D view using mol* of 717 (AA BP:811)
PDB file (721) >>>721.pdbFusion protein BP residue: 811
CIF file (721) >>>721.cif		JAK2chr95080683+PAX5chr936966721-
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS
EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH
VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM
SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI
YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL
KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK
NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC
HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP
PKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNES
LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK
LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG
DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRA
IIRDLNSLFTPGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
938
3D view using mol* of 721 (AA BP:811)
PDB file (738) >>>738.pdbFusion protein BP residue: 811
CIF file (738) >>>738.cif		JAK2chr95080683+PAX5chr936966721-
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS
EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH
VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM
SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI
YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL
KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK
NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC
HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP
PKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNES
LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK
LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG
DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRA
IIRDLNSLFTPGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSA
967
3D view using mol* of 738 (AA BP:811)
PDB file (739) >>>739.pdbFusion protein BP residue: 811
CIF file (739) >>>739.cif		JAK2chr95080683+PAX5chr936966721-
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS
EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH
VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM
SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI
YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL
KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK
NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC
HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP
PKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNES
LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK
LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG
DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRA
IIRDLNSLFTPGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSP
972
3D view using mol* of 739 (AA BP:811)
PDB file (754) >>>754.pdbFusion protein BP residue: 811
CIF file (754) >>>754.cif		JAK2chr95080683+PAX5chr936966721-
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS
EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH
VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM
SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI
YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL
KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK
NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC
HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP
PKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNES
LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK
LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG
DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRA
IIRDLNSLFTPGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRV
FERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIG
SSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSE
FSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR
1001
3D view using mol* of 754 (AA BP:811)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
JAK2_pLDDT.png
all structure
all structure
PAX5_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
JAK2_PAX5_648_pLDDT.png (AA BP:699)
all structure
JAK2_PAX5_648_pLDDT_and_active_sites.png (AA BP:699)
all structure
JAK2_PAX5_648_violinplot.png (AA BP:699)
all structure
JAK2_PAX5_665_pLDDT.png (AA BP:699)
all structure
JAK2_PAX5_665_pLDDT_and_active_sites.png (AA BP:699)
all structure
JAK2_PAX5_665_violinplot.png (AA BP:699)
all structure
JAK2_PAX5_668_pLDDT.png (AA BP:699)
all structure
JAK2_PAX5_668_pLDDT_and_active_sites.png (AA BP:699)
all structure
JAK2_PAX5_668_violinplot.png (AA BP:699)
all structure
JAK2_PAX5_680_pLDDT.png (AA BP:699)
all structure
JAK2_PAX5_680_pLDDT_and_active_sites.png (AA BP:699)
all structure
JAK2_PAX5_680_violinplot.png (AA BP:699)
all structure
JAK2_PAX5_686_pLDDT.png (AA BP:699)
all structure
JAK2_PAX5_686_pLDDT_and_active_sites.png (AA BP:699)
all structure
JAK2_PAX5_686_violinplot.png (AA BP:699)
all structure
JAK2_PAX5_700_pLDDT.png (AA BP:699)
all structure
JAK2_PAX5_700_pLDDT_and_active_sites.png (AA BP:699)
all structure
JAK2_PAX5_700_violinplot.png (AA BP:699)
all structure
JAK2_PAX5_705_pLDDT.png (AA BP:811)
all structure
JAK2_PAX5_705_pLDDT_and_active_sites.png (AA BP:811)
all structure
JAK2_PAX5_705_violinplot.png (AA BP:811)
all structure
JAK2_PAX5_717_pLDDT.png (AA BP:811)
all structure
JAK2_PAX5_717_pLDDT_and_active_sites.png (AA BP:811)
all structure
JAK2_PAX5_717_violinplot.png (AA BP:811)
all structure
JAK2_PAX5_721_pLDDT.png (AA BP:811)
all structure
JAK2_PAX5_721_pLDDT_and_active_sites.png (AA BP:811)
all structure
JAK2_PAX5_721_violinplot.png (AA BP:811)
all structure
JAK2_PAX5_738_pLDDT.png (AA BP:811)
all structure
JAK2_PAX5_738_pLDDT_and_active_sites.png (AA BP:811)
all structure
JAK2_PAX5_738_violinplot.png (AA BP:811)
all structure
JAK2_PAX5_739_pLDDT.png (AA BP:811)
all structure
JAK2_PAX5_739_pLDDT_and_active_sites.png (AA BP:811)
all structure
JAK2_PAX5_739_violinplot.png (AA BP:811)
all structure
JAK2_PAX5_754_pLDDT.png (AA BP:811)
all structure
JAK2_PAX5_754_pLDDT_and_active_sites.png (AA BP:811)
all structure
JAK2_PAX5_754_violinplot.png (AA BP:811)
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
JAK2_PAX5_648.png
all structure
JAK2_PAX5_665.png
all structure
JAK2_PAX5_680.png
all structure
JAK2_PAX5_686.png
all structure
JAK2_PAX5_700.png
all structure
JAK2_PAX5_705.png
all structure
JAK2_PAX5_717.png
all structure
JAK2_PAX5_721.png
all structure
JAK2_PAX5_738.png
all structure
JAK2_PAX5_739.png
all structure
JAK2_PAX5_754.png
all structure

Top

Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
6481.0662201.036533.0220.4330.7961.0430.6171.1710.5270.713Chain A: 439,440,441,442,443,444,445,447,467,469,4
82,512,516,517,520,521,523,524,527,560,561,563,564
,565,566,568,586,587,588,589,590,599,602,603,604,6
05,606,607,626,633,638,640,641,642,643,650
6651.11171.206392.7350.6510.6670.8221.550.4113.7731.224Chain A: 60,63,64,65,67,68,71,72,106,109,113,116,1
17,120,121,124,128,131,133,137,138,140,141,144,145

6681.0572251.031534.3940.4230.7831.030.551.1630.4730.732Chain A: 439,440,441,442,443,444,445,447,467,469,5
14,516,517,520,521,523,527,560,561,562,563,564,565
,566,568,586,587,588,589,590,592,599,602,603,606,6
07,626,633,638,640,641,643,650
6801.0652061.011552.5730.4490.7951.080.5031.2450.4040.719Chain A: 439,440,441,442,443,444,445,447,467,469,5
14,516,517,519,520,521,523,524,525,527,528,560,561
,563,564,565,566,568,586,587,588,589,590,592,599,6
02,603,606,607,633,638,640,641,643,650
6861.0522411.018549.8290.4320.7751.020.4831.1880.4070.794Chain A: 439,441,442,443,444,445,447,467,469,482,5
15,516,517,518,519,520,521,523,524,525,527,528,560
,561,563,564,565,566,568,586,587,588,589,590,592,5
99,602,603,604,605,606,607,633,638,640,641,642,643
,645,650
7001.0632071.036553.2590.4390.7921.0670.5941.1620.5110.814Chain A: 439,440,441,442,443,444,445,447,467,469,4
98,514,515,516,517,519,520,521,523,524,525,528,529
,560,561,562,563,564,565,566,568,586,587,588,589,5
90,599,602,603,606,607,622,623,626,633,640
7001.0165301.0311536.9830.5490.7220.9660.5491.0510.5220.869Chain A: 4,6,213,214,215,216,217,218,219,220,221,2
28,247,259,262,263,266,267,268,269,270,271,272,273
,274,279,280,281,282,283,284,285,286,287,288,290,2
91,311,315,316,317,319,320,323,344,350,363,366,367
,370,384,385,386,388,389,390,391,392,397,550,553,5
54,609,610,612,613,617,620,621,624,651,654,655,657
,665,667,670,671,673,674,677,678,679,680,681,682,6
83,684,685,687,688,689,691,692,694,695,696,697,698
,699,700,701,702,703
7051.0144921.0341595.6360.5720.7140.8990.4941.0280.4810.794Chain A: 271,272,273,274,275,276,277,278,279,280,2
82,283,284,285,286,288,296,298,300,304,317,327,328
,329,330,331,332,333,334,339,340,341,343,345,348,3
49,351,352,353,354,355,356,357,361,386,607,608,646
,647,648,649,652,655,656,659,685,687,690,692,693,6
94,806,807,809,810,811,812,813,814,838,839,843,846
,847,850,851,852,853,854,855,856,857,858,859,860,8
61
7171.0515271.0721570.940.5430.760.960.7340.9920.741.072Chain A: 57,62,63,64,65,66,67,68,69,70,73,79,80,82
,83,85,86,87,89,92,94,95,96,97,98,99,100,101,102,1
03,104,108,110,117,118,325,326,327,328,329,330,333
,358,359,360,363,364,367,371,374,375,379,380,382,3
83,384,385,386,389,390,391,392,393,394,395,396,397
,398,402,403,427,428,431,432,433,434,435,456,457,4
58,460,462,472,473,474,475,509,779,782,783,786,796
,800,803,804,806,807,808,809,810,811,812,813,814,8
26,827,829,830,833
7211.0791981.058507.640.4210.8171.0730.6751.140.5920.618Chain A: 551,552,553,554,555,556,557,559,579,581,5
94,628,629,632,633,635,639,672,673,674,675,676,677
,678,680,698,699,700,701,702,707,715,718,719,738,7
45,752
7381.10522691.1011551.2010.40880.85521.0990.94531.07990.87531.3231Chain A: 63,64,65,66,68,69,73,79,80,82,83,85,86,87
,96,97,98,114,117,118,133,367,370,371,374,375,379,
380,387,389,390,391,392,394,395,396,400,402,403,42
7,432,433,435,456,457,458,460,462,474,509
7391.10112631.1044574.1820.41810.84911.10451.00031.05840.94511.1874Chain A: 57,62,64,65,66,67,68,69,70,73,79,82,83,85
,86,87,96,97,98,117,118,133,367,370,371,374,375,37
9,380,387,389,390,391,392,394,395,396,400,402,403,
427,428,432,433,434,435,456,457,458,460,462,474,50
1,509
7541.04326781.0781769.1940.54920.72510.91570.76810.91110.84311.026Chain A: 57,61,62,63,64,65,66,67,68,69,70,73,79,80
,82,83,85,86,87,89,92,94,95,96,97,98,99,100,101,10
3,110,114,117,118,133,325,326,327,328,329,330,331,
333,338,340,358,359,360,363,364,367,370,371,374,37
5,379,380,381,382,383,384,385,386,387,388,389,390,
391,392,393,394,395,396,397,398,402,403,427,428,43
1,432,433,434,435,456,459,460,461,462,472,473,474,
475,476,509,777,779,800,803,804,806,807,808,810,81
1,812,813,814,825,826,827,828,829,830,831,832,833,
834,835,836,837,838,839

Top

Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
738ZINC000002599970DB00983Formoterol-9.88777-9.89997
738ZINC000049637509DB06636Isavuconazonium-7.24093-9.14563
738ZINC000000000856DB00983Formoterol-8.50146-8.51366
738ZINC000000601317DB01501Difenoxin-8.3365-8.352
738ZINC000003986735DB01254Dasatinib-7.70289-8.20119
738ZINC000084758479DB09128Brexpiprazole-7.79759-7.93289
738ZINC000035801098DB05039Indacaterol-6.12618-7.90738
738ZINC000001530571DB00490Buspirone-7.5521-7.8823
738ZINC000018043251DB00277Theophylline-7.82031-7.85281
738ZINC000000968326DB01132Pioglitazone-7.37901-7.81911
738ZINC000001843099DB00346Alfuzosin-7.8054-7.8054
738ZINC000030726187DB00305Mitomycin-5.6544-7.7923
738ZINC000001543916DB01610Valganciclovir-7.05517-7.76377
738ZINC000001997125DB08910Pomalidomide-7.70774-7.70774
738ZINC000013597823DB00900Didanosine-7.62258-7.70518
738ZINC000019796080DB00450Droperidol-6.58477-7.69697
738ZINC000003940470DB08910Pomalidomide-7.69058-7.69058
738ZINC000018516586DB00705Delavirdine-7.5147-7.6762
738ZINC000004099200DB00213Pantoprazole-7.33694-7.63864
738ZINC000000607986DB04861Nebivolol-7.57112-7.59092

Top

check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000049637509DB06636IsavuconazoniumSmall molecule[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1Approved|Investigational
ZINC000000601317DB01501DifenoxinSmall moleculeOC(=O)C1(CCN(CCC(C#N)(C2=CC=CC=C2)C2=CC=CC=C2)CC1)C1=CC=CC=C1Approved|Illicit
ZINC000003986735DB01254DasatinibSmall moleculeCC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1Approved|Investigational
ZINC000084758479DB09128BrexpiprazoleSmall moleculeO=C1NC2=CC(OCCCCN3CCN(CC3)C3=C4C=CSC4=CC=C3)=CC=C2C=C1Approved|Investigational
ZINC000035801098DB05039IndacaterolSmall moleculeCCC1=C(CC)C=C2CC(CC2=C1)NC[C@H](O)C1=C2C=CC(=O)NC2=C(O)C=C1Approved
ZINC000001530571DB00490BuspironeSmall moleculeO=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1Approved|Investigational
ZINC000018043251DB00277TheophyllineSmall moleculeCN1C2=C(NC=N2)C(=O)N(C)C1=OApproved
ZINC000001843099DB00346AlfuzosinSmall moleculeCOC1=CC2=C(C=C1OC)C(N)=NC(=N2)N(C)CCCNC(=O)C1CCCO1Approved|Investigational
ZINC000030726187DB00305MitomycinSmall molecule[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=OApproved
ZINC000001543916DB01610ValganciclovirSmall moleculeCC(C)[C@H](N)C(=O)OCC(CO)OCN1C=NC2=C1NC(N)=NC2=OApproved|Investigational
ZINC000013597823DB00900DidanosineSmall moleculeOC[C@@H]1CC[C@@H](O1)N1C=NC2=C1NC=NC2=OApproved
ZINC000019796080DB00450DroperidolSmall moleculeFC1=CC=C(C=C1)C(=O)CCCN1CCC(=CC1)N1C(=O)NC2=CC=CC=C12Approved|Vet_approved
ZINC000003940470DB08910PomalidomideSmall moleculeNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=OApproved
ZINC000018516586DB00705DelavirdineSmall moleculeCC(C)NC1=C(N=CC=C1)N1CCN(CC1)C(=O)C1=CC2=C(N1)C=CC(NS(C)(=O)=O)=C2Approved

Top

Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000002599970344.415.946630.817255.555164.209211.05301131.10747.28.775368.96100
ZINC000002599970344.416.639655.84259.44181.011215.38901154.47647.28.821266.12500
ZINC000000000856344.416.104642.08271.184183.213187.68201147.52647.28.665265.32800
ZINC000000000856344.414.876597.045248.042184.569164.43401098.95447.28.741263.46800
ZINC000000601317424.5416.02748.558133.395120.011495.15201377.44115.59.423177.07801
ZINC000000601317424.5417.316738.746129.449132.655476.64101371.87315.59.357174.10601
ZINC000000601317424.5417.434738.175130.95122.308484.91801364.68315.59.23176.06501
ZINC000003986735488.0062.542834.084388.576128.049221.67195.791474.937310.78.657383.52800
ZINC000003986735488.0062.892829.474386.166134.71206.668101.9311473.535310.78.79382.14100
ZINC000003986735488.0063.791836.959392.097138.831211.67494.3571479.736310.78.614381.32400
ZINC000084758479433.5677.182778.252256.64888.856381.54451.2031386.13916.258.208310001
ZINC000084758479433.5673.597780.417251.3787.519390.30851.221385.02916.258.207310001
ZINC000035801098392.4976.567723.38351.978176.028195.37401302.33846.458.773273.75101
ZINC000035801098392.4973.839725.07357.079176.515191.47501297.13446.458.801273.41201
ZINC000035801098392.4976.636719.071347.003176.457195.6101289.86946.458.766273.21401
ZINC000001530571385.5084.678729.103482.88999.207147.00701307.50907.58.719389.16700
ZINC000001530571385.5083.628723.903480.68493.105150.11301300.43507.58.564390.20100
ZINC000018043251180.1665.101367.499156.069142.57668.8550583.234159.081274.14900
ZINC000018043251180.1663.85368.83158.437132.21178.1820584.316159.211376.33200
ZINC000000968326356.4394.606651.231258.441124.988224.39643.4071141.92414.759.063310000
ZINC000000968326356.4393.454646.881263.838124.365223.67635.0031134.98814.759.205310000
ZINC000000968326356.4392.644650.951259.64127.388220.543.4231141.59314.759.146310000
ZINC000000968326356.4393.415646.869264.846124.171223.6934.1631135.11114.759.231310000
ZINC000001843099389.4535.901709.685530.17399.31480.19801256.02738.77.832391.07500
ZINC000030726187334.3312.852540.096256.014270.3913.6930959.0954.59.258.591238.61601
ZINC000030726187334.3312.798552.957260.241282.58210.1340973.0374.59.258.637236.4601
ZINC000001543916354.36510.833656.576282.226307.95566.39601129.771611.98.35910.46621
ZINC000001543916354.3658.84635.736259.299319.15557.28201114.93611.98.3181021
ZINC000001997125273.2486.886463.2689.305237.368136.5870796.928268.695259.94500
ZINC000013597823236.239.641435.158159.57170.601104.9870727.85628.48.967366.61800
ZINC000013597823236.238.965441.067165.063181.17394.8310736.52728.48.782364.56100
ZINC000019796080379.4335.336690.754177.289126.948339.68946.8281214.622168.72386.62500
ZINC000019796080379.4334.227703.161188.25122.749345.33746.8251231.012168.619387.34500
ZINC000019796080379.4336.26700.949186.412123.449344.26346.8251227.254168.598387.21500
ZINC000003940470273.2486.886463.25989.304237.367136.5870796.927268.695259.94500
ZINC000018516586456.56210.219808.132391.97158.605256.9040.6521430.9073108.134389.2101
ZINC000018516586456.56210.217791.378367.484166.108257.0530.7341414.4063108.031387.12301
ZINC000004099200383.3698.318623.128213.24477.412222.302110.171084.47189.124376.69200
ZINC000004099200383.3698.299620.121215.6578.983216.916108.5731082.558189.183376.22100
ZINC000004099200383.3698.355619.5212.86177.163219.295110.1821080.981189.019376.60300
ZINC000004099200383.3698.428625.396215.33578.49221.055110.5161084.724189.007376.45900
ZINC000000607986405.4415.004705.664273.42884.542253.93193.7631255.21236.49.141395.02900
ZINC000000607986405.4416.242723.401276.42185.145268.0793.7641269.44636.49.103395.44200


Top

Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000002599970COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc10.1338630780.246482573
ZINC000049637509CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000000000856COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc10.1338630780.246482573
ZINC000000601317N#CC(CCN1CCC(C(=O)O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc10.2273262230.209798219
ZINC000003986735Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n10.1920955290.112340477
ZINC000084758479O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]10.2500596280.126613838
ZINC000035801098CCc1cc2c(cc1CC)CC(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C20.1052921910.180827637
ZINC000001530571O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC10.1356846960.230451521
ZINC000018043251Cn1c(=O)c2[nH]cnc2n(C)c1=O0.2136154650.321876059
ZINC000000968326CCc1ccc(CCOc2ccc(C[C@@H]3SC(=O)NC3=O)cc2)nc10.1622557910.381863632
ZINC000001843099COc1cc2nc(N(C)CCCNC(=O)[C@H]3CCCO3)nc(N)c2cc1OC0.1359099950.310221167
ZINC000030726187CO[C@@]12[C@H](COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1C[C@@H]1N[C@@H]120.0273154510.442185166
ZINC000001543916CC(C)[C@H](N)C(=O)OC[C@@H](CO)OCn1cnc2c(=O)[nH]c(N)nc210.0662231610.39718523
ZINC000001997125Nc1cccc2c1C(=O)N([C@@H]1CCC(=O)NC1=O)C2=O0.1491246130.442164593
ZINC000013597823O=c1[nH]cnc2c1ncn2[C@H]1CC[C@@H](CO)O10.0734594820.448698447
ZINC000019796080O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc10.2197276360.259906112
ZINC000003940470Nc1cccc2c1C(=O)N([C@H]1CCC(=O)NC1=O)C2=O0.1491246130.442164593
ZINC000018516586CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC10.2168633390.103618764
ZINC000004099200COc1ccnc(C[S@](=O)c2nc3ccc(OC(F)F)cc3[nH]2)c1OC0.1146673540.321842622
ZINC000000607986O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O10.0555500820.198725964


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
JAK2PRMT5, SOCS1, PPIA, IL12RB2, EPOR, FYN, STAT5A, STAT5B, SH2B2, CXCR4, DNAJA3, HSPA8, TEC, PTPN12, PTK2, CSF2RB, GHR, VAV1, SIRPA, IRS1, BRCA1, GRB2, EGFR, PTK2B, PTPN11, TNFRSF1A, SOCS3, PTPN6, LYN, HTR2A, ERBB2, ELP2, KIT, RAF1, SH2B1, IL5RA, PPP2R1B, IFNGR1, IFNGR2, CCR5, PRLR, IL6ST, SHC1, GRB10, TUB, TSHR, STAT3, INSR, STAM, PTPN1, STAM2, IL2RB, CTLA4, ALK, IKBKG, FGFR1, STAT1, HSP90AA1, HSP90AB1, ASB2, SKP2, GTF2I, HIST3H3, HIST2H3C, CDKN1B, VHL, PIK3R1, MAP3K5, AGTR1, PTAFR, JAK2, IL4R, IL2RG, PPP1CC, ERBB3, CALM1, SRC, JAK3, PLCG1, HES1, HES5, Ifngr1, ASS1, RBMX, TRAF6, EZH2, DTX3L, EMD, KPNB1, NAP1L1, RCN1, SLC2A1, UBP1, ARL11, HSFY1, HDAC6, HNRNPL, CBL, RNF123, Lmo4, GOLPH3, IGF1R, PARP9, LNX1, LDOC1, CSK, MPL, CUL4A, CUL4B, M, JAK1, AMY1C, BPIFA2, ARHGAP18, BACH1, IGHA2, HMMR, MUC7, CST2, IGJ, PBK, MUC5B, SPRR3, ZG16B, VCP,
PAX5TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1, KAT2B, CDKN1B, UBE3A, RAD52, HMGB3, HOXC8, MAPK9, NFYC, FBLN1, GRHL2, DTX2, CSNK2A1, UBE2I, CCNC, BCAS2, C1orf109, GNG13, ZMYM5, SEC14L4, RNF144B, OSGIN1, CIB3, SAE1, STAC, TLK2, HMBOX1, NGLY1, NEIL2, LONRF1, LDLRAP1, LARP4, UBXN7, ACOT12, CKS1B, KLHL38, HGS, CXorf38, KRTAP10-8, PNMA5, KRTAP9-3, UBXN2B, CDK3, BKRF1, HIST1H3A, PAX8, KLHL14,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
JAK2all structure
PAX5all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to JAK2-PAX5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to JAK2-PAX5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJAK2C0032463Polycythemia Vera12CTD_human;ORPHANET;UNIPROT
HgeneJAK2C0040028Thrombocythemia, Essential10CTD_human;ORPHANET
HgeneJAK2C0001815Primary Myelofibrosis9CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneJAK2C3489628Thrombocytosis, Autosomal Dominant8CTD_human
HgeneJAK2C0019154Hepatic Vein Thrombosis3CTD_human;ORPHANET
HgeneJAK2C0856761Budd-Chiari Syndrome3CTD_human;ORPHANET
HgeneJAK2C0009324Ulcerative Colitis2CTD_human
HgeneJAK2C0027022Myeloproliferative disease2CTD_human
HgeneJAK2C0151744Myocardial Ischemia2CTD_human
HgeneJAK2C0836924Thrombocytosis2CTD_human
HgeneJAK2C3281125THROMBOCYTHEMIA 32UNIPROT
HgeneJAK2C0000786Spontaneous abortion1CTD_human
HgeneJAK2C0000822Abortion, Tubal1CTD_human
HgeneJAK2C0006663Calcinosis1CTD_human
HgeneJAK2C0007873Uterine Cervical Neoplasm1CTD_human
HgeneJAK2C0018824Heart valve disease1CTD_human
HgeneJAK2C0019207Hepatoma, Morris1CTD_human
HgeneJAK2C0019208Hepatoma, Novikoff1CTD_human
HgeneJAK2C0021368Inflammation1CTD_human
HgeneJAK2C0023418leukemia1CTD_human
HgeneJAK2C0023467Leukemia, Myelocytic, Acute1CGI;CTD_human;UNIPROT
HgeneJAK2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneJAK2C0023904Liver Neoplasms, Experimental1CTD_human
HgeneJAK2C0025472Mesenteric Vascular Occlusion1CTD_human
HgeneJAK2C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneJAK2C0032461Polycythemia1CTD_human
HgeneJAK2C0032962Pregnancy Complications1CTD_human
HgeneJAK2C0033578Prostatic Neoplasms1CTD_human
HgeneJAK2C0040038Thromboembolism1CTD_human
HgeneJAK2C0042487Venous Thrombosis1CTD_human
HgeneJAK2C0086404Experimental Hepatoma1CTD_human
HgeneJAK2C0149871Deep Vein Thrombosis1CTD_human
HgeneJAK2C0263628Tumoral calcinosis1CTD_human
HgeneJAK2C0376358Malignant neoplasm of prostate1CTD_human
HgeneJAK2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneJAK2C0521174Microcalcification1CTD_human
HgeneJAK2C1527405Erythrocytosis1CTD_human
HgeneJAK2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneJAK2C3241937Nonalcoholic Steatohepatitis1CTD_human
HgeneJAK2C3495676Anorectal Malformations1GENOMICS_ENGLAND
HgeneJAK2C3830362Early Pregnancy Loss1CTD_human
HgeneJAK2C4048328cervical cancer1CTD_human
HgeneJAK2C4303761Familial thrombocytosis1ORPHANET
HgeneJAK2C4552766Miscarriage1CTD_human
TgenePAX5C0006413Burkitt Lymphoma4ORPHANET
TgenePAX5C1292769Precursor B-cell lymphoblastic leukemia4ORPHANET
TgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CGI;CTD_human;UNIPROT
TgenePAX5C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgenePAX5C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgenePAX5C1535926Neurodevelopmental Disorders1CTD_human