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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:JAK2-PCM1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: JAK2-PCM1
	FusionPDB ID: 40858
	FusionGDB2.0 ID: 40858
		Hgene	Tgene
	Gene symbol	JAK2	PCM1
	Gene ID	3717	5108
	Gene name	Janus kinase 2	pericentriolar material 1
	Synonyms	JTK10\|THCYT3	PTC4\|RET/PCM-1
	Cytomap	9p24.1	8p22
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)	pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1
	Modification date	20200329	20200327
	UniProtAcc	O60674	Q15154
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000381652, ENST00000539801, ENST00000544510, ENST00000487310,	ENST00000327578, ENST00000518537, ENST00000518936, ENST00000524226, ENST00000325083, ENST00000519253,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 10 X 8=1040	10 X 14 X 6=840
	# samples	11	13
	** MAII score	log2(11/1040*10)=-3.24100809950379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/840*10)=-2.69187770463767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: JAK2 [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. JAK2-PCM1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. JAK2-PCM1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. JAK2-PCM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PCM1-JAK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PCM1-JAK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PCM1-JAK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	JAK2	GO:0010811	positive regulation of cell-substrate adhesion	10925297
Hgene	JAK2	GO:0019221	cytokine-mediated signaling pathway	8609418
Hgene	JAK2	GO:0033209	tumor necrosis factor-mediated signaling pathway	8609418
Hgene	JAK2	GO:0034612	response to tumor necrosis factor	8609418
Hgene	JAK2	GO:0035409	histone H3-Y41 phosphorylation	19783980
Hgene	JAK2	GO:0035722	interleukin-12-mediated signaling pathway	7528775
Hgene	JAK2	GO:0046677	response to antibiotic	16280321
Hgene	JAK2	GO:0050727	regulation of inflammatory response	10925297
Hgene	JAK2	GO:0060396	growth hormone receptor signaling pathway	10925297
Hgene	JAK2	GO:0070671	response to interleukin-12	7528775

Fusion gene breakpoints across JAK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	JAK2	chr9	5066789	+	PCM1	chr8	17829837	+
ChimerKB3	.	.	JAK2	chr9	5066789	+	PCM1	chr8	17882869	+
ChimerKB3	.	.	JAK2	chr9	5069208	+	PCM1	chr8	17842955	+
ChimerKB3	.	.	JAK2	chr9	5069208	+	PCM1	chr8	17871472	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000539801	JAK2	chr9	5066789	+	ENST00000325083	PCM1	chr8	17882869	+	1979	1439	113	1672	519
ENST00000539801	JAK2	chr9	5066789	+	ENST00000519253	PCM1	chr8	17882869	+	1814	1439	113	1672	519
ENST00000539801	JAK2	chr9	5066789	+	ENST00000524226	PCM1	chr8	17882869	+	1980	1439	113	1672	519
ENST00000381652	JAK2	chr9	5066789	+	ENST00000325083	PCM1	chr8	17882869	+	2360	1820	494	2053	519
ENST00000381652	JAK2	chr9	5066789	+	ENST00000519253	PCM1	chr8	17882869	+	2195	1820	494	2053	519
ENST00000381652	JAK2	chr9	5066789	+	ENST00000524226	PCM1	chr8	17882869	+	2361	1820	494	2053	519
ENST00000544510	JAK2	chr9	5066789	+	ENST00000325083	PCM1	chr8	17882869	+	1790	1250	260	1483	407
ENST00000544510	JAK2	chr9	5066789	+	ENST00000519253	PCM1	chr8	17882869	+	1625	1250	260	1483	407
ENST00000544510	JAK2	chr9	5066789	+	ENST00000524226	PCM1	chr8	17882869	+	1791	1250	260	1483	407
ENST00000539801	JAK2	chr9	5069208	+	ENST00000325083	PCM1	chr8	17842955	+	3899	1626	113	3592	1159
ENST00000539801	JAK2	chr9	5069208	+	ENST00000519253	PCM1	chr8	17842955	+	3710	1626	113	3568	1151
ENST00000539801	JAK2	chr9	5069208	+	ENST00000524226	PCM1	chr8	17842955	+	3570	1626	113	3262	1049
ENST00000381652	JAK2	chr9	5069208	+	ENST00000325083	PCM1	chr8	17842955	+	4280	2007	494	3973	1159
ENST00000381652	JAK2	chr9	5069208	+	ENST00000519253	PCM1	chr8	17842955	+	4091	2007	494	3949	1151
ENST00000381652	JAK2	chr9	5069208	+	ENST00000524226	PCM1	chr8	17842955	+	3951	2007	494	3643	1049
ENST00000544510	JAK2	chr9	5069208	+	ENST00000325083	PCM1	chr8	17842955	+	3710	1437	260	3403	1047
ENST00000544510	JAK2	chr9	5069208	+	ENST00000519253	PCM1	chr8	17842955	+	3521	1437	260	3379	1039
ENST00000544510	JAK2	chr9	5069208	+	ENST00000524226	PCM1	chr8	17842955	+	3381	1437	260	3073	937

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40858_40858_1_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000325083_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------

>40858_40858_2_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000519253_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------

>40858_40858_3_JAK2-PCM1_JAK2_chr9_5066789_ENST00000381652_PCM1_chr8_17882869_ENST00000524226_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------

>40858_40858_4_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000325083_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------

>40858_40858_5_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000519253_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------

>40858_40858_6_JAK2-PCM1_JAK2_chr9_5066789_ENST00000539801_PCM1_chr8_17882869_ENST00000524226_length(amino acids)=519AA_BP=442
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS

--------------------------------------------------------------

>40858_40858_7_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000325083_length(amino acids)=407AA_BP=330
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNISQKSDEEDFVKVEDLPLKLTIYS

--------------------------------------------------------------

>40858_40858_8_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000519253_length(amino acids)=407AA_BP=330
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNISQKSDEEDFVKVEDLPLKLTIYS

--------------------------------------------------------------

>40858_40858_9_JAK2-PCM1_JAK2_chr9_5066789_ENST00000544510_PCM1_chr8_17882869_ENST00000524226_length(amino acids)=407AA_BP=330
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNISQKSDEEDFVKVEDLPLKLTIYS

--------------------------------------------------------------

>40858_40858_10_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000325083_length(amino acids)=1159AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE
REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVN

--------------------------------------------------------------

>40858_40858_11_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000519253_length(amino acids)=1151AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQL
DRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNE
LAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED
EESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKND
QNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGN

--------------------------------------------------------------

>40858_40858_12_JAK2-PCM1_JAK2_chr9_5069208_ENST00000381652_PCM1_chr8_17842955_ENST00000524226_length(amino acids)=1049AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQEAESGNISQKSDEEDFVK

--------------------------------------------------------------

>40858_40858_13_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000325083_length(amino acids)=1159AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE
REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVN

--------------------------------------------------------------

>40858_40858_14_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000519253_length(amino acids)=1151AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQL
DRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNE
LAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED
EESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKND
QNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGN

--------------------------------------------------------------

>40858_40858_15_JAK2-PCM1_JAK2_chr9_5069208_ENST00000539801_PCM1_chr8_17842955_ENST00000524226_length(amino acids)=1049AA_BP=504
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSE
TERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKF
EVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIE
LFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASV
LSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPC
PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE
ISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS
DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQEAESGNISQKSDEEDFVK

--------------------------------------------------------------

>40858_40858_16_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000325083_length(amino acids)=1047AA_BP=392
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ
DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHL
DQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPF
LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNS
ITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK
AETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNIL
EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVE

--------------------------------------------------------------

>40858_40858_17_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000519253_length(amino acids)=1039AA_BP=392
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ
DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHL
DQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEV
CSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCK
RKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTN
YGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQPLNS
AAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTI

--------------------------------------------------------------

>40858_40858_18_JAK2-PCM1_JAK2_chr9_5069208_ENST00000544510_PCM1_chr8_17842955_ENST00000524226_length(amino acids)=937AA_BP=392
MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYN
SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITG
NGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHY
LCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFS
SLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ
DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHL
DQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPF
LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNS
ITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK
AETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr8:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
JAK2 O60674	PCM1 Q15154
FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). {ECO:0000269\|PubMed:12023369, ECO:0000269\|PubMed:19783980, ECO:0000269\|PubMed:20098430, ECO:0000269\|PubMed:21368206, ECO:0000269\|PubMed:21423214, ECO:0000269\|PubMed:7615558, ECO:0000269\|PubMed:9618263}.	FUNCTION: Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). {ECO:0000269\|PubMed:12403812, ECO:0000269\|PubMed:15659651, ECO:0000269\|PubMed:16943179, ECO:0000269\|PubMed:20551181, ECO:0000269\|PubMed:24121310, ECO:0000269\|PubMed:27979967}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (171) >>>171.pdbFusion protein BP residue: 330 CIF file (171) >>>171.cif	JAK2	chr9	5066789	+	PCM1	chr8	17882869	+	MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK LKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNISQKSDEEDFVKVE DLPLKLTIYSEADLRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPE	407
3D view using mol* of 171 (AA BP:330)


PDB file (335) >>>335.pdbFusion protein BP residue: 442 CIF file (335) >>>335.cif	JAK2	chr9	5066789	+	PCM1	chr8	17882869	+	MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVEEAESGNIS QKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEICEMQTEE	519
3D view using mol* of 335 (AA BP:442)


PDB file (719) >>>719.pdbFusion protein BP residue: 392 CIF file (719) >>>719.cif	JAK2	chr9	5069208	+	PCM1	chr8	17842955	+	MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSM FEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNF ERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREY ERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPV SEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRM VLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEIS EVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILED HGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESE GCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTE ATEENEHDEQEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVE	937
3D view using mol* of 719 (AA BP:392)


PDB file (767) >>>767.pdbFusion protein BP residue: 392 CIF file (767) >>>767.cif	JAK2	chr9	5069208	+	PCM1	chr8	17842955	+	MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSM FEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNF ERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREY ERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPC PRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQN DESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELA FFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEI DDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINL SKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHD EQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQPLNS AAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGS PDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKM	1039
3D view using mol* of 767 (AA BP:392)


PDB file (771) >>>771.pdbFusion protein BP residue: 392 CIF file (771) >>>771.cif	JAK2	chr9	5069208	+	PCM1	chr8	17842955	+	MQRWRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFV HGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPK CIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQ SAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQ DLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREA LSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISK LKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEY NLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKETGSDFSM FEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQ DIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNF ERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREY ERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPV SEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRM VLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEIS EVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILED HGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESE GCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTE ATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNIL EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQET PESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYS	1047
3D view using mol* of 771 (AA BP:392)


PDB file (774) >>>774.pdbFusion protein BP residue: 504 CIF file (774) >>>774.cif	JAK2	chr9	5069208	+	PCM1	chr8	17842955	+	MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP PKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNT DYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESL ATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVI HLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEET PVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEV CSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKL KDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQ SCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGP VDVQTSLQANTEATEENEHDEQEAESGNISQKSDEEDFVKVEDLPLKLTI	1049
3D view using mol* of 774 (AA BP:504)


PDB file (830) >>>830.pdbFusion protein BP residue: 504 CIF file (830) >>>830.cif	JAK2	chr9	5069208	+	PCM1	chr8	17842955	+	MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP PKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNT DYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESL ATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVI HLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSS QQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTS VRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLL VEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKR ILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED EESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQ ANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCY LNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKS AQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKL TIYSEADLRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPETVGAQS	1151
3D view using mol* of 830 (AA BP:504)


PDB file (835) >>>835.pdbFusion protein BP residue: 504 CIF file (835) >>>835.cif	JAK2	chr9	5069208	+	PCM1	chr8	17842955	+	MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP PKPKETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNT DYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESL ATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVI HLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEET PVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEV CSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKL KDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQ SCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRS DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGP VDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQN NCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLV PRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVK VEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKE	1159
3D view using mol* of 835 (AA BP:504)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

JAK2_pLDDT.png

PCM1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

JAK2_PCM1_171_PAE.png (AA BP:330)

JAK2_PCM1_171_pLDDT.png (AA BP:330)

JAK2_PCM1_171_pLDDT_and_active_sites.png (AA BP:330)

JAK2_PCM1_171_violinplot.png (AA BP:330)

JAK2_PCM1_335_pLDDT.png (AA BP:442)

JAK2_PCM1_335_pLDDT_and_active_sites.png (AA BP:442)

JAK2_PCM1_335_violinplot.png (AA BP:442)

JAK2_PCM1_719_pLDDT.png (AA BP:392)

JAK2_PCM1_719_pLDDT_and_active_sites.png (AA BP:392)

JAK2_PCM1_719_violinplot.png (AA BP:392)

JAK2_PCM1_767_pLDDT.png (AA BP:392)

JAK2_PCM1_767_pLDDT_and_active_sites.png (AA BP:392)

JAK2_PCM1_767_violinplot.png (AA BP:392)

JAK2_PCM1_771_pLDDT.png (AA BP:392)

JAK2_PCM1_771_pLDDT_and_active_sites.png (AA BP:392)

JAK2_PCM1_771_violinplot.png (AA BP:392)

JAK2_PCM1_774_pLDDT.png (AA BP:504)

JAK2_PCM1_774_pLDDT_and_active_sites.png (AA BP:504)

JAK2_PCM1_774_violinplot.png (AA BP:504)

JAK2_PCM1_830_pLDDT.png (AA BP:504)

JAK2_PCM1_830_pLDDT_and_active_sites.png (AA BP:504)

JAK2_PCM1_830_violinplot.png (AA BP:504)

JAK2_PCM1_835_pLDDT.png (AA BP:504)

JAK2_PCM1_835_pLDDT_and_active_sites.png (AA BP:504)

JAK2_PCM1_835_violinplot.png (AA BP:504)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

JAK2_PCM1_171.png

JAK2_PCM1_335.png

JAK2_PCM1_719.png

JAK2_PCM1_767.png

JAK2_PCM1_771.png

JAK2_PCM1_774.png

JAK2_PCM1_830.png

JAK2_PCM1_835.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
171	0.996	145	1.034	706.58	0.741	0.657	0.812	0.467	0.921	0.507	0.979	Chain A: 4,6,7,8,19,20,21,22,23,24,30,32,33,37,180 ,181,207,262,263,264,266,267,268,279,280,282,283,2 84,286,288,289,290,291,292,293,294,295,296,300,314 ,315,316,317,318,319,320,321,322,323,343
335	1.047	360	1.079	1057.469	0.576	0.736	0.932	0.676	0.93	0.727	1.019	Chain A: 10,11,12,13,64,65,68,69,79,80,81,82,83,84 ,85,86,87,96,97,98,117,118,120,130,131,132,133,134 ,135,136,137,142,144,292,293,367,371,374,375,376,3 77,378,379,380,389,390,391,392,394,395,396,399,400 ,401,402,403,404,405,407,408,411,412,415,427,428,4 32,433,435
719	1.1062	240	1.1646	507.983	0.501	0.7634	0.9375	1.6743	0.7159	2.3387	0.6931	Chain A: 60,63,64,67,68,71,105,106,108,109,110,113 ,116,117,119,120,121,123,124,127,613,614,617,618,6 20,701,704,879,880,881,882,883,884,885,886
767	1.018	374	1.054	1166.543	0.633	0.689	0.872	0.632	0.918	0.688	0.79	Chain A: 4,6,8,19,20,21,22,23,24,25,26,27,28,29,30 ,31,32,180,181,259,262,263,264,265,266,267,268,278 ,279,280,282,283,284,285,286,288,289,290,291,292,2 93,295,296,297,299,300,303,304,315,316,317,318,319 ,320,323,344,350,360,361,362,363,387,388,389,390,3 92,393,394,395,396,397,1006,1007
771	1.0775	469	1.1439	2048.739	0.5967	0.7108	0.895	1.3163	0.6829	1.9276	0.7298	Chain A: 10,11,12,13,14,15,16,18,19,20,29,30,31,32 ,33,60,63,64,65,67,68,69,71,72,75,106,109,113,116, 117,120,121,123,124,127,128,130,131,132,133,137,13 8,140,141,144,145,148,149,609,611,613,648,652,661, 663,664,666,667,668,669,670,671,673,674,675,701,70 4,705,706,708,709,710,712,713,714,716,717,724,989, 992,993,994,995,996,997,998
774	1.05	586	1.0604	1469.412	0.4539	0.7727	1.014	0.6711	1.0527	0.6375	0.9992	Chain A: 64,65,66,68,69,70,73,79,80,82,83,85,86,87 ,95,96,97,98,117,118,120,130,131,132,133,134,135,1 36,137,138,139,140,141,142,144,321,367,371,374,375 ,376,377,378,379,380,389,390,391,392,394,395,396,4 00,401,402,403,404,405,408,411,412,415,416,427,428 ,432,433,434,435,456,457,458,460,462,499,500,501,5 02,504,505,506,507,508,509
830	1.0645	605	1.084	1507.142	0.4495	0.7817	1.0206	0.9107	0.9971	0.9133	0.8445	Chain A: 64,65,66,68,69,73,79,80,81,82,83,84,85,86 ,87,95,96,97,98,117,118,120,130,131,132,133,134,13 5,136,137,138,139,140,141,142,143,144,292,293,321, 367,371,374,375,376,377,378,379,380,389,390,391,39 2,394,395,396,401,402,403,404,405,408,409,411,412, 415,416,427,428,431,432,433,434,435,456,457,458,46 2,474,499,500,501,502,504,505,506,507,508,509,510
835	1.0586	574	1.068	1513.659	0.466	0.7856	1.0359	0.8168	1.0534	0.7754	0.8472	Chain A: 63,64,65,66,68,69,79,80,81,82,83,84,85,86 ,87,95,96,97,98,117,118,120,131,132,133,134,135,13 6,137,138,139,140,142,144,367,371,374,375,376,377, 378,379,380,381,389,390,391,392,394,395,396,399,40 0,401,402,403,404,405,408,409,411,412,415,416,427, 428,431,432,433,434,435,456,457,458,460,474,497,49 9,500,501,502,503,504,505,506,507,508,509,510,511, 512,514,515

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
JAK2	PRMT5, SOCS1, PPIA, IL12RB2, EPOR, FYN, STAT5A, STAT5B, SH2B2, CXCR4, DNAJA3, HSPA8, TEC, PTPN12, PTK2, CSF2RB, GHR, VAV1, SIRPA, IRS1, BRCA1, GRB2, EGFR, PTK2B, PTPN11, TNFRSF1A, SOCS3, PTPN6, LYN, HTR2A, ERBB2, ELP2, KIT, RAF1, SH2B1, IL5RA, PPP2R1B, IFNGR1, IFNGR2, CCR5, PRLR, IL6ST, SHC1, GRB10, TUB, TSHR, STAT3, INSR, STAM, PTPN1, STAM2, IL2RB, CTLA4, ALK, IKBKG, FGFR1, STAT1, HSP90AA1, HSP90AB1, ASB2, SKP2, GTF2I, HIST3H3, HIST2H3C, CDKN1B, VHL, PIK3R1, MAP3K5, AGTR1, PTAFR, JAK2, IL4R, IL2RG, PPP1CC, ERBB3, CALM1, SRC, JAK3, PLCG1, HES1, HES5, Ifngr1, ASS1, RBMX, TRAF6, EZH2, DTX3L, EMD, KPNB1, NAP1L1, RCN1, SLC2A1, UBP1, ARL11, HSFY1, HDAC6, HNRNPL, CBL, RNF123, Lmo4, GOLPH3, IGF1R, PARP9, LNX1, LDOC1, CSK, MPL, CUL4A, CUL4B, M, JAK1, AMY1C, BPIFA2, ARHGAP18, BACH1, IGHA2, HMMR, MUC7, CST2, IGJ, PBK, MUC5B, SPRR3, ZG16B, VCP,
PCM1	BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, Haus4, Cep170, Haus1, Ndc80, Cep131, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, Cit, Nedd1, Prkacb, Prkar2a, Cetn2, Ppp2r1a, Uso1, Ccdc77, Dlg5, Lrrcc1, Cep55, Cep72, Fgfr1op, Immt, Sdccag8, Myh10, Cep152, Ccp110, Cep78, Bag2, Cdk5rap2, Cep290, Mib1, Cep120, Cenpe, Cep104, Ankrd26, Cep135, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168, HNRNPL, LNX1, EGLN3, GABARAP, PRC1, AKAP9, KLC4, PRKCI, FXR2, CDC42, KLC1, DDX23, RPA2, RBM5, USP9X, RNF31, ABI1, TFIP11, DDIT3, CCHCR1, RINT1, GOLGA2, KRT24, FAM188B, SPDL1, MYO6, ESR2, UBR7, TUBG1, EEA1, KIAA1429, ATG16L1, HOOK3, APEX1, SCARB2, VMP1, ETAA1, MTM1, TPTE2, CYLD, SPATA2, nsp2ab, RALBP1, CYTH4, FAM81A, PINK1, ACTB, nsp12, nsp16, nsp2, nsp7, ORF6, RQCD1, FAM120C, BRD1, SP110, SREBF2, nsp13ab, NDN, NUPR1, FAM184A, YBEY, DDX58, TRIM37, AR, ISG15, GOLGA1, LATS1, CAMSAP3, CCDC57, CDK5RAP2, CEP112, CEP295, CEP85L, CNTLN, CNTROB, DLG5, FAM184B, GAS8, GCC2, KIAA0586, KIAA1217, KIAA1671, KIF15, KIF1B, NYNRIN, PDZRN3, PLEKHG1, PPP1R13B, RGPD6, SRGAP1, TRIOBP, TRO, TTC3, WDR90, CEP170B, SPAG5, SEPT10, NAA40, VPS33B, KRT2, FAM9B, KRT86, KRT83, DISC1, DUSP16, FILIP1, NEBL, KRT73, SNAP91, KRT38, MAP7, KRT81, CCDC96, STX10, S100A2, KRT16, BFSP1, GOLGA6A, KRT14, C9orf16, USP28, KRT1, CETN1, REPIN1, TXNDC11, STRN, CCNB1IP1, ZNF24, LSM2, LARP4, ZNF830, PRPF6, DENND1A, INTS4, MORF4L1, PPIE, ALG13, GRN, NDUFA9, KAT5, Uba1, 2700060E02Rik, Bbs5, Fez2, Klc4, CDK1, TAX1BP1, GLI2, SPZ1, RB1CC1, MAGEL2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
JAK2
PCM1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to JAK2-PCM1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
JAK2	PCM1	Ruxolitinib	PubMed	32279331

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Related Diseases to JAK2-PCM1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
JAK2	PCM1	Myeloid Neoplasms	PubMed	32279331

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	JAK2	C0032463	Polycythemia Vera	12	CTD_human;ORPHANET;UNIPROT
Hgene	JAK2	C0040028	Thrombocythemia, Essential	10	CTD_human;ORPHANET
Hgene	JAK2	C0001815	Primary Myelofibrosis	9	CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	JAK2	C3489628	Thrombocytosis, Autosomal Dominant	8	CTD_human
Hgene	JAK2	C0019154	Hepatic Vein Thrombosis	3	CTD_human;ORPHANET
Hgene	JAK2	C0856761	Budd-Chiari Syndrome	3	CTD_human;ORPHANET
Hgene	JAK2	C0009324	Ulcerative Colitis	2	CTD_human
Hgene	JAK2	C0027022	Myeloproliferative disease	2	CTD_human
Hgene	JAK2	C0151744	Myocardial Ischemia	2	CTD_human
Hgene	JAK2	C0836924	Thrombocytosis	2	CTD_human
Hgene	JAK2	C3281125	THROMBOCYTHEMIA 3	2	UNIPROT
Hgene	JAK2	C0000786	Spontaneous abortion	1	CTD_human
Hgene	JAK2	C0000822	Abortion, Tubal	1	CTD_human
Hgene	JAK2	C0006663	Calcinosis	1	CTD_human
Hgene	JAK2	C0007873	Uterine Cervical Neoplasm	1	CTD_human
Hgene	JAK2	C0018824	Heart valve disease	1	CTD_human
Hgene	JAK2	C0019207	Hepatoma, Morris	1	CTD_human
Hgene	JAK2	C0019208	Hepatoma, Novikoff	1	CTD_human
Hgene	JAK2	C0021368	Inflammation	1	CTD_human
Hgene	JAK2	C0023418	leukemia	1	CTD_human
Hgene	JAK2	C0023467	Leukemia, Myelocytic, Acute	1	CGI;CTD_human;UNIPROT
Hgene	JAK2	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	JAK2	C0023904	Liver Neoplasms, Experimental	1	CTD_human
Hgene	JAK2	C0025472	Mesenteric Vascular Occlusion	1	CTD_human
Hgene	JAK2	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Hgene	JAK2	C0032461	Polycythemia	1	CTD_human
Hgene	JAK2	C0032962	Pregnancy Complications	1	CTD_human
Hgene	JAK2	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	JAK2	C0040038	Thromboembolism	1	CTD_human
Hgene	JAK2	C0042487	Venous Thrombosis	1	CTD_human
Hgene	JAK2	C0086404	Experimental Hepatoma	1	CTD_human
Hgene	JAK2	C0149871	Deep Vein Thrombosis	1	CTD_human
Hgene	JAK2	C0263628	Tumoral calcinosis	1	CTD_human
Hgene	JAK2	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	JAK2	C0400966	Non-alcoholic Fatty Liver Disease	1	CTD_human
Hgene	JAK2	C0521174	Microcalcification	1	CTD_human
Hgene	JAK2	C1527405	Erythrocytosis	1	CTD_human
Hgene	JAK2	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Hgene	JAK2	C3241937	Nonalcoholic Steatohepatitis	1	CTD_human
Hgene	JAK2	C3495676	Anorectal Malformations	1	GENOMICS_ENGLAND
Hgene	JAK2	C3830362	Early Pregnancy Loss	1	CTD_human
Hgene	JAK2	C4048328	cervical cancer	1	CTD_human
Hgene	JAK2	C4303761	Familial thrombocytosis	1	ORPHANET
Hgene	JAK2	C4552766	Miscarriage	1	CTD_human
Tgene	PCM1	C0036341	Schizophrenia	1	CTD_human
Tgene	PCM1	C0238463	Papillary thyroid carcinoma	1	ORPHANET