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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:JAZF1-SNX13

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: JAZF1-SNX13
	FusionPDB ID: 40916
	FusionGDB2.0 ID: 40916
		Hgene	Tgene
	Gene symbol	JAZF1	SNX13
	Gene ID	221895	23161
	Gene name	JAZF zinc finger 1	sorting nexin 13
	Synonyms	TIP27\|ZNF802	RGS-PX1
	Cytomap	7p15.2-p15.1	7p21.1
	Type of gene	protein-coding	protein-coding
	Description	juxtaposed with another zinc finger protein 1TAK1-interacting protein 27juxtaposed with another zinc finger gene 1zinc finger protein 802	sorting nexin-13rgs domain- and phox domain-containing protein
	Modification date	20200313	20200313
	UniProtAcc	Q86VZ6	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000283928, ENST00000466516,	ENST00000496855, ENST00000409389, ENST00000409604, ENST00000428135,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 19 X 11=4389	5 X 5 X 4=100
	# samples	26	6
	** MAII score	log2(26/4389*10)=-4.07730874183119 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: JAZF1 [Title/Abstract] AND SNX13 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	JAZF1(28220082)-SNX13(17931258), # samples:3
Anticipated loss of major functional domain due to fusion event.	JAZF1-SNX13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. JAZF1-SNX13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. JAZF1-SNX13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. JAZF1-SNX13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	JAZF1	GO:0000122	negative regulation of transcription by RNA polymerase II	15302918
Tgene	SNX13	GO:0043547	positive regulation of GTPase activity	11729322

Fusion gene breakpoints across JAZF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SNX13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-A5TY-01A	JAZF1	chr7	28220082	-	SNX13	chr7	17931258	-
ChimerDB4	LGG	TCGA-DU-A5TY	JAZF1	chr7	28220081	-	SNX13	chr7	17931258	-
ChimerDB4	LGG	TCGA-DU-A5TY	JAZF1	chr7	28220082	-	SNX13	chr7	17931258	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000283928	JAZF1	chr7	28220082	-	ENST00000428135	SNX13	chr7	17931258	-	6211	281	293	2926	877
ENST00000283928	JAZF1	chr7	28220082	-	ENST00000409389	SNX13	chr7	17931258	-	6696	281	293	2719	808
ENST00000283928	JAZF1	chr7	28220082	-	ENST00000409604	SNX13	chr7	17931258	-	4010	281	293	622	109
ENST00000283928	JAZF1	chr7	28220081	-	ENST00000428135	SNX13	chr7	17931258	-	6211	281	293	2926	877
ENST00000283928	JAZF1	chr7	28220081	-	ENST00000409389	SNX13	chr7	17931258	-	6696	281	293	2719	808
ENST00000283928	JAZF1	chr7	28220081	-	ENST00000409604	SNX13	chr7	17931258	-	4010	281	293	622	109

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000283928	ENST00000428135	JAZF1	chr7	28220082	-	SNX13	chr7	17931258	-	0.000127211	0.9998728
ENST00000283928	ENST00000409389	JAZF1	chr7	28220082	-	SNX13	chr7	17931258	-	0.000146626	0.9998534
ENST00000283928	ENST00000409604	JAZF1	chr7	28220082	-	SNX13	chr7	17931258	-	0.018017298	0.9819827
ENST00000283928	ENST00000428135	JAZF1	chr7	28220081	-	SNX13	chr7	17931258	-	0.000127211	0.9998728
ENST00000283928	ENST00000409389	JAZF1	chr7	28220081	-	SNX13	chr7	17931258	-	0.000146626	0.9998534
ENST00000283928	ENST00000409604	JAZF1	chr7	28220081	-	SNX13	chr7	17931258	-	0.018017298	0.9819827

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40916_40916_1_JAZF1-SNX13_JAZF1_chr7_28220081_ENST00000283928_SNX13_chr7_17931258_ENST00000409389_length(amino acids)=808AA_BP=
MKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLR
VFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILL
PLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQR
LQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRA
AAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDG
DGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTVYADYDPYAVAGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFH
MRITEQFESLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNS
MRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKER

--------------------------------------------------------------

>40916_40916_2_JAZF1-SNX13_JAZF1_chr7_28220081_ENST00000283928_SNX13_chr7_17931258_ENST00000409604_length(amino acids)=109AA_BP=
MKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRVSPCRPGWSTMAQSRLTATSASW

--------------------------------------------------------------

>40916_40916_3_JAZF1-SNX13_JAZF1_chr7_28220081_ENST00000283928_SNX13_chr7_17931258_ENST00000428135_length(amino acids)=877AA_BP=
MKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLR
VFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILL
PLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQR
LQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRA
AAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDG
DGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESLS
SILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSL
PDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNL
LQQLIRATYGDTINRKIVDHVDWMTSPEQVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTRKG

--------------------------------------------------------------

>40916_40916_4_JAZF1-SNX13_JAZF1_chr7_28220082_ENST00000283928_SNX13_chr7_17931258_ENST00000409389_length(amino acids)=808AA_BP=
MKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLR
VFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILL
PLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQR
LQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRA
AAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDG
DGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTVYADYDPYAVAGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFH
MRITEQFESLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNS
MRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKER

--------------------------------------------------------------

>40916_40916_5_JAZF1-SNX13_JAZF1_chr7_28220082_ENST00000283928_SNX13_chr7_17931258_ENST00000409604_length(amino acids)=109AA_BP=
MKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRVSPCRPGWSTMAQSRLTATSASW

--------------------------------------------------------------

>40916_40916_6_JAZF1-SNX13_JAZF1_chr7_28220082_ENST00000283928_SNX13_chr7_17931258_ENST00000428135_length(amino acids)=877AA_BP=
MKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLR
VFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILL
PLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQR
LQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRA
AAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDG
DGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESLS
SILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSL
PDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNL
LQQLIRATYGDTINRKIVDHVDWMTSPEQVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTRKG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:28220082/chr7:17931258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
JAZF1 Q86VZ6	.
FUNCTION: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250\|UniProtKB:Q80ZQ5, ECO:0000269\|PubMed:15302918}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

JAZF1

chr7:28220081

chr7:17931258

ENST00000283928

12_37

38.333333333333336

244.0

Zinc finger

Note=C2H2-type 1

Hgene

JAZF1

chr7:28220082

chr7:17931258

ENST00000283928

12_37

38.333333333333336

244.0

Zinc finger

Note=C2H2-type 1

Tgene

SNX13

chr7:28220081

chr7:17931258

ENST00000428135

373_496

76.0

958.0

Domain

RGS

Tgene

SNX13

chr7:28220081

chr7:17931258

ENST00000428135

570_691

76.0

958.0

Domain

Tgene

SNX13

chr7:28220081

chr7:17931258

ENST00000428135

97_284

76.0

958.0

Domain

PXA

Tgene

SNX13

chr7:28220082

chr7:17931258

ENST00000428135

373_496

76.0

958.0

Domain

RGS

Tgene

SNX13

chr7:28220082

chr7:17931258

ENST00000428135

570_691

76.0

958.0

Domain

Tgene

SNX13

chr7:28220082

chr7:17931258

ENST00000428135

97_284

76.0

958.0

Domain

PXA

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

JAZF1

chr7:28220081

chr7:17931258

ENST00000283928

173_198

38.333333333333336

244.0

Zinc finger

Note=C2H2-type 2

Hgene

JAZF1

chr7:28220081

chr7:17931258

ENST00000283928

208_230

38.333333333333336

244.0

Zinc finger

Note=C2H2-type 3%3B degenerate

Hgene

JAZF1

chr7:28220082

chr7:17931258

ENST00000283928

173_198

38.333333333333336

244.0

Zinc finger

Note=C2H2-type 2

Hgene

JAZF1

chr7:28220082

chr7:17931258

ENST00000283928

208_230

38.333333333333336

244.0

Zinc finger

Note=C2H2-type 3%3B degenerate

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1665_JAZF1_28220082_SNX13_17931258_ranked_0.pdb	JAZF1	28220081	28220082	ENST00000409604	SNX13	chr7	17931258	-	MKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLR VFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILL PLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQR LQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRA AAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDG DGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTGVCNDHGKTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESLS SILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSL PDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNL LQQLIRATYGDTINRKIVDHVDWMTSPEQVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTRKG	877

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

JAZF1_pLDDT.png

SNX13_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
JAZF1	NR2C2, PPARG, RXRA, YEATS4, TRRAP, Ruvbl1, MEAF6, RUVBL1, MYCL, HIST1H2BA, MORF4L2, HIST1H4A, FAM9B, BRD8, SUZ12, KAT5, EP400, DMAP1, EPC1, EPC2, MBTD1, MRGBP, DDX39A, NR2C1, METAP2, CLTCL1, H2AFZ, VPS72, ACAD11, ING3, ING5,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
JAZF1
SNX13

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to JAZF1-SNX13

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to JAZF1-SNX13

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	JAZF1	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	JAZF1	C0014170	Endometrial Neoplasms	1	CTD_human
Hgene	JAZF1	C0024141	Lupus Erythematosus, Systemic	1	CTD_human;ORPHANET
Hgene	JAZF1	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	JAZF1	C0206630	Endometrial Stromal Sarcoma	1	ORPHANET
Hgene	JAZF1	C0242380	Libman-Sacks Disease	1	CTD_human
Hgene	JAZF1	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	JAZF1	C0476089	Endometrial Carcinoma	1	CTD_human