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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:JAZF1-TAX1BP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: JAZF1-TAX1BP1
FusionPDB ID: 40919
FusionGDB2.0 ID: 40919
HgeneTgene
Gene symbol

JAZF1

TAX1BP1

Gene ID

221895

8887

Gene nameJAZF zinc finger 1Tax1 binding protein 1
SynonymsTIP27|ZNF802CALCOCO3|T6BP|TXBP151
Cytomap

7p15.2-p15.1

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionjuxtaposed with another zinc finger protein 1TAK1-interacting protein 27juxtaposed with another zinc finger gene 1zinc finger protein 802tax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1
Modification date2020031320200327
UniProtAcc

Q86VZ6

.
Ensembl transtripts involved in fusion geneENST idsENST00000283928, ENST00000466516, 
ENST00000494033, ENST00000265393, 
ENST00000396319, ENST00000409980, 
ENST00000433216, ENST00000543117, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 19 X 11=438922 X 14 X 9=2772
# samples 2626
** MAII scorelog2(26/4389*10)=-4.07730874183119
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/2772*10)=-3.41434372910876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: JAZF1 [Title/Abstract] AND TAX1BP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)JAZF1(27880317)-TAX1BP1(27867357), # samples:5
TAX1BP1(27797752)-JAZF1(28031600), # samples:3
Anticipated loss of major functional domain due to fusion event.JAZF1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
JAZF1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
JAZF1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
JAZF1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TAX1BP1-JAZF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TAX1BP1-JAZF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJAZF1

GO:0000122

negative regulation of transcription by RNA polymerase II

15302918


check buttonFusion gene breakpoints across JAZF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TAX1BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5410-01AJAZF1chr7

27880317

-TAX1BP1chr7

27867357

+
ChimerDB4LUADTCGA-55-8096-01AJAZF1chr7

27880317

-TAX1BP1chr7

27867357

+
ChimerDB4OVTCGA-24-1470JAZF1chr7

28220081

-TAX1BP1chr7

27824781

+
ChimerDB4PCPGTCGA-SA-A6C2-01AJAZF1chr7

27880317

-TAX1BP1chr7

27867357

+
ChimerDB4SKCMTCGA-EB-A430-01AJAZF1chr7

27880317

-TAX1BP1chr7

27867357

+
ChimerDB4SKCMTCGA-EB-A5UN-06AJAZF1chr7

27880317

-TAX1BP1chr7

27867357

+
ChimerDB4THCATCGA-EL-A3H1-01AJAZF1chr7

28220082

-TAX1BP1chr7

27824782

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283928JAZF1chr728220081-ENST00000543117TAX1BP1chr727824781+21772813111912533
ENST00000283928JAZF1chr728220081-ENST00000265393TAX1BP1chr727824781+19652813111912533
ENST00000283928JAZF1chr728220081-ENST00000409980TAX1BP1chr727824781+21632813112110599
ENST00000283928JAZF1chr728220081-ENST00000433216TAX1BP1chr727824781+19482813111912533
ENST00000283928JAZF1chr728220081-ENST00000396319TAX1BP1chr727824781+24712813112038575
ENST00000283928JAZF1chr728220082-ENST00000543117TAX1BP1chr727824782+21772813111912533
ENST00000283928JAZF1chr728220082-ENST00000265393TAX1BP1chr727824782+19652813111912533
ENST00000283928JAZF1chr728220082-ENST00000409980TAX1BP1chr727824782+21632813112110599
ENST00000283928JAZF1chr728220082-ENST00000433216TAX1BP1chr727824782+19482813111912533
ENST00000283928JAZF1chr728220082-ENST00000396319TAX1BP1chr727824782+24712813112038575

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283928ENST00000543117JAZF1chr728220081-TAX1BP1chr727824781+0.0015668160.9984332
ENST00000283928ENST00000265393JAZF1chr728220081-TAX1BP1chr727824781+0.0023194190.99768054
ENST00000283928ENST00000409980JAZF1chr728220081-TAX1BP1chr727824781+0.0024033080.9975967
ENST00000283928ENST00000433216JAZF1chr728220081-TAX1BP1chr727824781+0.0022957570.9977042
ENST00000283928ENST00000396319JAZF1chr728220081-TAX1BP1chr727824781+0.0017556560.9982444
ENST00000283928ENST00000543117JAZF1chr728220082-TAX1BP1chr727824782+0.0015668160.9984332
ENST00000283928ENST00000265393JAZF1chr728220082-TAX1BP1chr727824782+0.0023194190.99768054
ENST00000283928ENST00000409980JAZF1chr728220082-TAX1BP1chr727824782+0.0024033080.9975967
ENST00000283928ENST00000433216JAZF1chr728220082-TAX1BP1chr727824782+0.0022957570.9977042
ENST00000283928ENST00000396319JAZF1chr728220082-TAX1BP1chr727824782+0.0017556560.9982444

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40919_40919_1_JAZF1-TAX1BP1_JAZF1_chr7_28220081_ENST00000283928_TAX1BP1_chr7_27824781_ENST00000265393_length(amino acids)=533AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDP

--------------------------------------------------------------

>40919_40919_2_JAZF1-TAX1BP1_JAZF1_chr7_28220081_ENST00000283928_TAX1BP1_chr7_27824781_ENST00000396319_length(amino acids)=575AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRV
PSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW

--------------------------------------------------------------

>40919_40919_3_JAZF1-TAX1BP1_JAZF1_chr7_28220081_ENST00000283928_TAX1BP1_chr7_27824781_ENST00000409980_length(amino acids)=599AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYA
SQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKC

--------------------------------------------------------------

>40919_40919_4_JAZF1-TAX1BP1_JAZF1_chr7_28220081_ENST00000283928_TAX1BP1_chr7_27824781_ENST00000433216_length(amino acids)=533AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDP

--------------------------------------------------------------

>40919_40919_5_JAZF1-TAX1BP1_JAZF1_chr7_28220081_ENST00000283928_TAX1BP1_chr7_27824781_ENST00000543117_length(amino acids)=533AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDP

--------------------------------------------------------------

>40919_40919_6_JAZF1-TAX1BP1_JAZF1_chr7_28220082_ENST00000283928_TAX1BP1_chr7_27824782_ENST00000265393_length(amino acids)=533AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDP

--------------------------------------------------------------

>40919_40919_7_JAZF1-TAX1BP1_JAZF1_chr7_28220082_ENST00000283928_TAX1BP1_chr7_27824782_ENST00000396319_length(amino acids)=575AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRV
PSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW

--------------------------------------------------------------

>40919_40919_8_JAZF1-TAX1BP1_JAZF1_chr7_28220082_ENST00000283928_TAX1BP1_chr7_27824782_ENST00000409980_length(amino acids)=599AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKLQLAEKDKEISGLISHLENLSREKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYA
SQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKC

--------------------------------------------------------------

>40919_40919_9_JAZF1-TAX1BP1_JAZF1_chr7_28220082_ENST00000283928_TAX1BP1_chr7_27824782_ENST00000433216_length(amino acids)=533AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDP

--------------------------------------------------------------

>40919_40919_10_JAZF1-TAX1BP1_JAZF1_chr7_28220082_ENST00000283928_TAX1BP1_chr7_27824782_ENST00000543117_length(amino acids)=533AA_BP=
MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL
KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA
RLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ
QKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE
NVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:27880317/chr7:27867357)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JAZF1

Q86VZ6

.
FUNCTION: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneJAZF1chr7:27880317chr7:27867357ENST00000283928-4512_37185.0244.0Zinc fingerNote=C2H2-type 1
HgeneJAZF1chr7:28220081chr7:27824781ENST00000283928-1512_3738.333333333333336244.0Zinc fingerNote=C2H2-type 1
HgeneJAZF1chr7:28220082chr7:27824782ENST00000283928-1512_3738.333333333333336244.0Zinc fingerNote=C2H2-type 1
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000433216316144_59947.0591.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000433216316144_59947.0591.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000265393417320_420204.0748.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000396319417320_420204.0790.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000433216316320_42047.0591.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000543117417320_420204.0748.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000265393417320_420204.0748.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000396319417320_420204.0790.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000433216316320_42047.0591.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000543117417320_420204.0748.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000002653931417727_753653.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000002653931417754_780653.0748.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000003963191417727_753695.0790.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000003963191417754_780695.0790.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000004332161316727_753496.0591.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000004332161316754_780496.0591.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000005431171417727_753653.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000005431171417754_780653.0748.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000265393417727_753204.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000265393417754_780204.0748.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000396319417727_753204.0790.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000396319417754_780204.0790.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000433216316727_75347.0591.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000433216316754_78047.0591.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000543117417727_753204.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000543117417754_780204.0748.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000265393417727_753204.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000265393417754_780204.0748.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000396319417727_753204.0790.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000396319417754_780204.0790.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000433216316727_75347.0591.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000433216316754_78047.0591.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000543117417727_753204.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000543117417754_780204.0748.0Zinc fingerUBZ1-type 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneJAZF1chr7:27880317chr7:27867357ENST00000283928-45173_198185.0244.0Zinc fingerNote=C2H2-type 2
HgeneJAZF1chr7:27880317chr7:27867357ENST00000283928-45208_230185.0244.0Zinc fingerNote=C2H2-type 3%3B degenerate
HgeneJAZF1chr7:28220081chr7:27824781ENST00000283928-15173_19838.333333333333336244.0Zinc fingerNote=C2H2-type 2
HgeneJAZF1chr7:28220081chr7:27824781ENST00000283928-15208_23038.333333333333336244.0Zinc fingerNote=C2H2-type 3%3B degenerate
HgeneJAZF1chr7:28220082chr7:27824782ENST00000283928-15173_19838.333333333333336244.0Zinc fingerNote=C2H2-type 2
HgeneJAZF1chr7:28220082chr7:27824782ENST00000283928-15208_23038.333333333333336244.0Zinc fingerNote=C2H2-type 3%3B degenerate
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000002653931417144_599653.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000003963191417144_599695.0790.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000004332161316144_599496.0591.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000005431171417144_599653.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000265393417144_599204.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000396319417144_599204.0790.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220081chr7:27824781ENST00000543117417144_599204.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000265393417144_599204.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000396319417144_599204.0790.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:28220082chr7:27824782ENST00000543117417144_599204.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000002653931417320_420653.0748.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000003963191417320_420695.0790.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000004332161316320_420496.0591.0RegionNote=Oligomerization
TgeneTAX1BP1chr7:27880317chr7:27867357ENST000005431171417320_420653.0748.0RegionNote=Oligomerization


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
JAZF1NR2C2, PPARG, RXRA, YEATS4, TRRAP, Ruvbl1, MEAF6, RUVBL1, MYCL, HIST1H2BA, MORF4L2, HIST1H4A, FAM9B, BRD8, SUZ12, KAT5, EP400, DMAP1, EPC1, EPC2, MBTD1, MRGBP, DDX39A, NR2C1, METAP2, CLTCL1, H2AFZ, VPS72, ACAD11, ING3, ING5,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
JAZF1all structure
TAX1BP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to JAZF1-TAX1BP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to JAZF1-TAX1BP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJAZF1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneJAZF1C0014170Endometrial Neoplasms1CTD_human
HgeneJAZF1C0024141Lupus Erythematosus, Systemic1CTD_human;ORPHANET
HgeneJAZF1C0033578Prostatic Neoplasms1CTD_human
HgeneJAZF1C0206630Endometrial Stromal Sarcoma1ORPHANET
HgeneJAZF1C0242380Libman-Sacks Disease1CTD_human
HgeneJAZF1C0376358Malignant neoplasm of prostate1CTD_human
HgeneJAZF1C0476089Endometrial Carcinoma1CTD_human