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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ALOX15-PSMD2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ALOX15-PSMD2
	FusionPDB ID: 4095
	FusionGDB2.0 ID: 4095
		Hgene	Tgene
	Gene symbol	ALOX15	PSMD2
	Gene ID	246	5708
	Gene name	arachidonate 15-lipoxygenase	proteasome 26S subunit, non-ATPase 2
	Synonyms	12-LOX\|15-LOX\|15-LOX-1\|LOG15	P97\|RPN1\|S2\|TRAP2
	Cytomap	17p13.2	3q27.1
	Type of gene	protein-coding	protein-coding
	Description	arachidonate 15-lipoxygenase12/15-lipoxygenase15-LOX type 115-lipooxygenase-115-lipoxygenase type 1arachidonate 12-lipoxygenase, leukocyte-typearachidonate omega-6 lipoxygenase	26S proteasome non-ATPase regulatory subunit 255.11 proteinTNFR-associated protein 2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2protein 55.11tumor necrosis factor type 1 receptor-associated protein 2
	Modification date	20200327	20200313
	UniProtAcc	O15296	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000293761, ENST00000545513, ENST00000570836, ENST00000574640,	ENST00000459910, ENST00000310118, ENST00000435761, ENST00000439383,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 2=8	7 X 8 X 3=168
	# samples	2	8
	** MAII score	log2(2/8*10)=1.32192809488736	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ALOX15 [Title/Abstract] AND PSMD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ALOX15(4539053)-PSMD2(184021734), # samples:1
Anticipated loss of major functional domain due to fusion event.	ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ALOX15	GO:0010811	positive regulation of cell-substrate adhesion	11278875
Hgene	ALOX15	GO:0019369	arachidonic acid metabolic process	1944593\|17052953
Hgene	ALOX15	GO:0019372	lipoxygenase pathway	1944593
Hgene	ALOX15	GO:0071277	cellular response to calcium ion	17052953

Fusion gene breakpoints across ALOX15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PSMD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-DJ-A2PZ	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000570836	ALOX15	chr17	4539053	-	ENST00000310118	PSMD2	chr3	184021734	+	2826	1258	31	2661	876
ENST00000570836	ALOX15	chr17	4539053	-	ENST00000435761	PSMD2	chr3	184021734	+	2772	1258	31	2661	876
ENST00000570836	ALOX15	chr17	4539053	-	ENST00000439383	PSMD2	chr3	184021734	+	2820	1258	31	2661	876
ENST00000293761	ALOX15	chr17	4539053	-	ENST00000310118	PSMD2	chr3	184021734	+	2743	1175	5	2578	857
ENST00000293761	ALOX15	chr17	4539053	-	ENST00000435761	PSMD2	chr3	184021734	+	2689	1175	5	2578	857
ENST00000293761	ALOX15	chr17	4539053	-	ENST00000439383	PSMD2	chr3	184021734	+	2737	1175	5	2578	857
ENST00000574640	ALOX15	chr17	4539053	-	ENST00000310118	PSMD2	chr3	184021734	+	2896	1328	164	2731	855
ENST00000574640	ALOX15	chr17	4539053	-	ENST00000435761	PSMD2	chr3	184021734	+	2842	1328	164	2731	855
ENST00000574640	ALOX15	chr17	4539053	-	ENST00000439383	PSMD2	chr3	184021734	+	2890	1328	164	2731	855
ENST00000545513	ALOX15	chr17	4539053	-	ENST00000310118	PSMD2	chr3	184021734	+	2826	1258	31	2661	876
ENST00000545513	ALOX15	chr17	4539053	-	ENST00000435761	PSMD2	chr3	184021734	+	2772	1258	31	2661	876
ENST00000545513	ALOX15	chr17	4539053	-	ENST00000439383	PSMD2	chr3	184021734	+	2820	1258	31	2661	876

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000570836	ENST00000310118	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.005765419	0.9942346
ENST00000570836	ENST00000435761	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.006771149	0.9932288
ENST00000570836	ENST00000439383	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.005797302	0.9942027
ENST00000293761	ENST00000310118	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.003301117	0.9966989
ENST00000293761	ENST00000435761	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.003914318	0.99608564
ENST00000293761	ENST00000439383	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.00331258	0.9966875
ENST00000574640	ENST00000310118	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.006864755	0.9931352
ENST00000574640	ENST00000435761	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.007618878	0.99238116
ENST00000574640	ENST00000439383	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.006872117	0.99312794
ENST00000545513	ENST00000310118	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.005765419	0.9942346
ENST00000545513	ENST00000435761	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.006771149	0.9932288
ENST00000545513	ENST00000439383	ALOX15	chr17	4539053	-	PSMD2	chr3	184021734	+	0.005797302	0.9942027

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4095_4095_1_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=857AA_BP=390
MSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPG
AGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVS
LAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKE
LEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHEL
QSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLL
LPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFA
NTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRY
GEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHL
GKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKT

--------------------------------------------------------------

>4095_4095_2_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=857AA_BP=390
MSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPG
AGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVS
LAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKE
LEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHEL
QSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLL
LPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFA
NTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRY
GEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHL
GKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKT

--------------------------------------------------------------

>4095_4095_3_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=857AA_BP=390
MSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPG
AGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVS
LAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKE
LEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHEL
QSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLL
LPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFA
NTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRY
GEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHL
GKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKT

--------------------------------------------------------------

>4095_4095_4_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV

--------------------------------------------------------------

>4095_4095_5_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV

--------------------------------------------------------------

>4095_4095_6_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV

--------------------------------------------------------------

>4095_4095_7_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV

--------------------------------------------------------------

>4095_4095_8_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV

--------------------------------------------------------------

>4095_4095_9_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV

--------------------------------------------------------------

>4095_4095_10_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=855AA_BP=388
METCHPHSDPKRPPRGRGLRLGYLARPPFSTRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKGPGAG
DEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLA
KGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELE
GGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQS
HLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLP
VMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANT
LVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGE
PTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGK
GTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTIT

--------------------------------------------------------------

>4095_4095_11_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=855AA_BP=388
METCHPHSDPKRPPRGRGLRLGYLARPPFSTRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKGPGAG
DEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLA
KGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELE
GGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQS
HLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLP
VMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANT
LVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGE
PTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGK
GTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTIT

--------------------------------------------------------------

>4095_4095_12_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=855AA_BP=388
METCHPHSDPKRPPRGRGLRLGYLARPPFSTRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKGPGAG
DEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLA
KGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELE
GGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQS
HLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLP
VMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANT
LVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGE
PTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGK
GTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTIT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:4539053/chr3:184021734)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ALOX15 O15296	.
FUNCTION: [Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644, PubMed:32404334) (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively downregulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809). {ECO:0000269\|PubMed:10542053, ECO:0000269\|PubMed:10625675, ECO:0000269\|PubMed:11839751, ECO:0000269\|PubMed:11956198, ECO:0000269\|PubMed:12704195, ECO:0000269\|PubMed:17493578, ECO:0000269\|PubMed:18067895, ECO:0000269\|PubMed:18311922, ECO:0000269\|PubMed:22912809, ECO:0000269\|PubMed:24282679, ECO:0000269\|PubMed:24497644, ECO:0000269\|PubMed:27145229, ECO:0000269\|PubMed:27435673, ECO:0000269\|PubMed:32404334, ECO:0000269\|PubMed:9177185, ECO:0000305\|PubMed:10542053, ECO:0000305\|PubMed:16112079, ECO:0000305\|PubMed:27145229, ECO:0000305\|PubMed:27435673}.; FUNCTION: [Isoform B]: Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. {ECO:0000269\|PubMed:12704195}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ALOX15

chr17:4539053

chr3:184021734

ENST00000293761

2_114

387.0

663.0

Domain

PLAT

Hgene

ALOX15

chr17:4539053

chr3:184021734

ENST00000570836

2_114

387.0

663.0

Domain

PLAT

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

623_641

441.0

909.0

Compositional bias

Note=Glu/Lys-rich

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

443_479

441.0

909.0

Repeat

Note=PC 2

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

480_514

441.0

909.0

Repeat

Note=PC 3

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

517_551

441.0

909.0

Repeat

Note=PC 4

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

560_589

441.0

909.0

Repeat

Note=PC 5

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

692_723

441.0

909.0

Repeat

Note=PC 6

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

742_757

441.0

909.0

Repeat

Note=PC 7

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ALOX15

chr17:4539053

chr3:184021734

ENST00000293761

115_662

387.0

663.0

Domain

Lipoxygenase

Hgene

ALOX15

chr17:4539053

chr3:184021734

ENST00000570836

115_662

387.0

663.0

Domain

Lipoxygenase

Tgene

PSMD2

chr17:4539053

chr3:184021734

ENST00000310118

409_442

441.0

909.0

Repeat

Note=PC 1

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ALOX15
PSMD2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ALOX15-PSMD2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ALOX15-PSMD2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source