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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KAT6A-ASXL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6A-ASXL2
FusionPDB ID: 41198
FusionGDB2.0 ID: 41198
HgeneTgene
Gene symbol

KAT6A

ASXL2

Gene ID

7994

55252

Gene namelysine acetyltransferase 6AASXL transcriptional regulator 2
SynonymsARTHS|MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220ASXH2|SHAPNS
Cytomap

8p11.21

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2
Modification date2020031320200313
UniProtAcc

Q92794

Q76L83

Ensembl transtripts involved in fusion geneENST idsENST00000265713, ENST00000396930, 
ENST00000406337, ENST00000485568, 
ENST00000272341, ENST00000336112, 
ENST00000404843, ENST00000497092, 
ENST00000435504, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 32 X 13=1081611 X 14 X 8=1232
# samples 4216
** MAII scorelog2(42/10816*10)=-4.68663391861606
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KAT6A [Title/Abstract] AND ASXL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6A(41909478)-ASXL2(25962260), # samples:1
KAT6A(41800309)-ASXL2(26068436), # samples:1
Anticipated loss of major functional domain due to fusion event.KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358

TgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

TgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

TgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783


check buttonFusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASXL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4myelodysplastic syndromeAB084281KAT6Achr8

41909478

ASXL2chr2

25962260
ChimerKB3..KAT6Achr8

41800310

ASXL2chr2

26068432

-
ChiTaRS5.0N/AAB084281KAT6Achr8

41800309

-ASXL2chr2

26068436

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265713KAT6Achr841800310ENST00000435504ASXL2chr226068432-15375284841270982228
ENST00000396930KAT6Achr841800310ENST00000435504ASXL2chr226068432-15507298054472302228
ENST00000265713KAT6Achr841800309-ENST00000435504ASXL2chr226068436-15375284841270982228
ENST00000396930KAT6Achr841800309-ENST00000435504ASXL2chr226068436-15507298054472302228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265713ENST00000435504KAT6Achr841800309-ASXL2chr226068436-0.0002058580.9997942
ENST00000396930ENST00000435504KAT6Achr841800309-ASXL2chr226068436-0.0002414460.99975854

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41198_41198_1_KAT6A-ASXL2_KAT6A_chr8_41800309_ENST00000265713_ASXL2_chr2_26068436_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

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>41198_41198_2_KAT6A-ASXL2_KAT6A_chr8_41800309_ENST00000396930_ASXL2_chr2_26068436_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

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>41198_41198_3_KAT6A-ASXL2_KAT6A_chr8_41800310_ENST00000265713_ASXL2_chr2_26068432_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

--------------------------------------------------------------

>41198_41198_4_KAT6A-ASXL2_KAT6A_chr8_41800310_ENST00000396930_ASXL2_chr2_26068432_ENST00000435504_length(amino acids)=2228AA_BP=812
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLK
TVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALI
NKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESY
YGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSS
ALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSIT
SPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSR
GGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSC
RQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPS
STLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQL
EDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTG
DEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAV
RGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41909478/chr2:25962260)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

ASXL2

Q76L83

FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417371_379812.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417788_801812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518371_379812.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518788_801812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518371_379812.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518788_801812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417504_778812.02005.0DomainMYST-type HAT
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-141795_171812.02005.0DomainH15
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518504_778812.02005.0DomainMYST-type HAT
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-151895_171812.02005.0DomainH15
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518504_778812.02005.0DomainMYST-type HAT
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-151895_171812.02005.0DomainH15
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171_144812.02005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417488_778812.02005.0RegionNote=Catalytic
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-141752_166812.02005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417645_649812.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417654_660812.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181_144812.02005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518488_778812.02005.0RegionNote=Catalytic
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-151852_166812.02005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518645_649812.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518654_660812.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181_144812.02005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518488_778812.02005.0RegionNote=Catalytic
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-151852_166812.02005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518645_649812.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518654_660812.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417206_265812.02005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417259_313812.02005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417537_562812.02005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518206_265812.02005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518259_313812.02005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518537_562812.02005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518206_265812.02005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518259_313812.02005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518537_562812.02005.0Zinc fingerC2HC MYST-type
TgeneASXL2chr8:41800309chr2:26068436ENST000002723410131173_11760919.0Compositional biasNote=Poly-Ser
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013303_3070919.0Compositional biasNote=Poly-Leu
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013654_6840919.0Compositional biasNote=Ala-rich
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013687_7390919.0Compositional biasNote=Gly-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000027234101395_2350919.0Compositional biasNote=Ser-rich
TgeneASXL2chr8:41800309chr2:26068436ENST000004048430101173_11760919.0Compositional biasNote=Poly-Ser
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010303_3070919.0Compositional biasNote=Poly-Leu
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010654_6840919.0Compositional biasNote=Ala-rich
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010687_7390919.0Compositional biasNote=Gly-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000040484301095_2350919.0Compositional biasNote=Ser-rich
TgeneASXL2chr8:41800309chr2:26068436ENST000004355040131173_117619.01436.0Compositional biasNote=Poly-Ser
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013303_30719.01436.0Compositional biasNote=Poly-Leu
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013654_68419.01436.0Compositional biasNote=Ala-rich
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013687_73919.01436.0Compositional biasNote=Gly-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000043550401395_23519.01436.0Compositional biasNote=Ser-rich
TgeneASXL2chr8:41800309chr2:26068436ENST0000027234101311_860919.0DomainHTH HARE-type
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013274_3830919.0DomainDEUBAD
TgeneASXL2chr8:41800309chr2:26068436ENST0000040484301011_860919.0DomainHTH HARE-type
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010274_3830919.0DomainDEUBAD
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013274_38319.01436.0DomainDEUBAD
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013174_1780919.0MotifNuclear localization signal
TgeneASXL2chr8:41800309chr2:26068436ENST00000272341013887_8910919.0MotifNote=LXXLL motif 2
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010174_1780919.0MotifNuclear localization signal
TgeneASXL2chr8:41800309chr2:26068436ENST00000404843010887_8910919.0MotifNote=LXXLL motif 2
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013174_17819.01436.0MotifNuclear localization signal
TgeneASXL2chr8:41800309chr2:26068436ENST00000435504013887_89119.01436.0MotifNote=LXXLL motif 2
TgeneASXL2chr8:41800309chr2:26068436ENST000002723410131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
TgeneASXL2chr8:41800309chr2:26068436ENST000004048430101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
TgeneASXL2chr8:41800309chr2:26068436ENST000004355040131397_143419.01436.0Zinc fingerNote=PHD-type%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171019_1026812.02005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171069_1078812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171147_1150812.02005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171221_1242812.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171267_1302812.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171411_1414812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171593_1597812.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171643_1704812.02005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171897_1977812.02005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-1417989_995812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181019_1026812.02005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181069_1078812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181147_1150812.02005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181221_1242812.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181267_1302812.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181411_1414812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181593_1597812.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181643_1704812.02005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181897_1977812.02005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-1518989_995812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181019_1026812.02005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181069_1078812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181147_1150812.02005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181221_1242812.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181267_1302812.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181411_1414812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181593_1597812.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181643_1704812.02005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181897_1977812.02005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-1518989_995812.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171913_1948812.02005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181913_1948812.02005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181913_1948812.02005.0RegionNote=Required for activation of RUNX1-2
TgeneASXL2chr8:41800309chr2:26068436ENST0000043550401311_8619.01436.0DomainHTH HARE-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1117)KAT6Achr841800310ASXL2chr226068432-
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQ
LELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWN
KLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLA
IKRAIGHGRLLKDGPLYRLNTKATNVDGKESCESLSCLPPVSLLPHEKDK
PVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTV
RVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM
PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSK
GPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSL
KFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTG
PPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSR
TILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF
LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMIL
PQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVIL
ECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRRE
KLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENE
EPQCQERELEISVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLN
AMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSD
SQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISP
SQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLKTVKAASDSVP
AKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLH
TRQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLL
PEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIR
QEIEKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTASPSDPKVKKTPAE
QPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNF
STSSEPLLSSALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLT
TASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLAT
LVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNR
GDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGARTL
ADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEG
QTARGGSPGSDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETK
TTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLN
PTRATATVASVSHPQGPSSCRQEKAPSPTGPALISGASPVHCAADGTVEL
KAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSAT
TAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLL
QGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEV
NERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEG
LSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQLEDISTSQRFM
LGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTE
ALKMGYTDCKNATGESSSSKEDDTDEESTGDEQESVTVKEEPQVSQSAGK
GDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFD
EKTLARDLIQAAQKQMAHAVRGKAIRSSPELFSSTVLPLPADSPTHQPLL
LPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDV
MSFSVTVTTIPASQAMNPSSHGQTIPVQAFSEENSIEGTPSKCYCRLKAM
2228


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KAT6A_pLDDT.png
all structure
all structure
ASXL2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KAT6A_ASXL2_1117_pLDDT_and_active_sites.png (AA BP:)
all structure
KAT6A_ASXL2_1117_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
11171.0751271.156518.9590.5840.680.9081.7680.592.9971.589Chain A: 1051,1054,1055,1057,1058,1059,1060,1061,1
062,1063,1070,1071,1074,1076,1079,1080,1084,1085,1
087,1088,1089,1096,1099,1100,1101,1104,1115,1120,1
124,1125,1128,1129,1132

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KAT6AING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, Myo1c, Rpl35, Tpx2, Srsf1, Tubgcp6, HEMGN, HNRNPL, KIAA1429, RANGAP1, BRD1, BRPF3, ING4, KAT7, JADE3, KAT6B, JADE2, JADE1, HIST1H2BO, HRG, CSNK2A2, APEX1, CENPA, DANCR, ZBTB2, CSNK2B, CSNK2A1, RFWD2, HSPD1, CMAS, HIST2H2BF, CASP2, TRIM65, HGH1, TTC4, PPP2R5C, OTUD3, DBNL, PIP4K2C, ATIC, NUDT12, B3GALTL, ATG4B, PABPN1, DEK, SF3A3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KAT6Aall structure
ASXL2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171517_1741812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181517_1741812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181517_1741812.02005.0PML
HgeneKAT6Achr8:41800309chr2:26068436ENST00000265713-14171517_1642812.02005.0RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000396930-15181517_1642812.02005.0RUNX1-2
HgeneKAT6Achr8:41800309chr2:26068436ENST00000406337-15181517_1642812.02005.0RUNX1-2


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Related Drugs to KAT6A-ASXL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6A-ASXL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6AC4225396MENTAL RETARDATION, AUTOSOMAL DOMINANT 323CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKAT6AC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
HgeneKAT6AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKAT6AC0025149Medulloblastoma1CTD_human
HgeneKAT6AC0033578Prostatic Neoplasms1CTD_human
HgeneKAT6AC0205833Medullomyoblastoma1CTD_human
HgeneKAT6AC0278510Childhood Medulloblastoma1CTD_human
HgeneKAT6AC0278876Adult Medulloblastoma1CTD_human
HgeneKAT6AC0376358Malignant neoplasm of prostate1CTD_human
HgeneKAT6AC0751291Desmoplastic Medulloblastoma1CTD_human
HgeneKAT6AC1275668Melanotic medulloblastoma1CTD_human
TgeneASXL2C0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneASXL2C0005695Bladder Neoplasm1CTD_human
TgeneASXL2C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneASXL2C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneASXL2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneASXL2C4310672SHASHI-PENA SYNDROME1GENOMICS_ENGLAND