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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KAT6B-CCDC172

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6B-CCDC172
FusionPDB ID: 41226
FusionGDB2.0 ID: 41226
HgeneTgene
Gene symbol

KAT6B

CCDC172

Gene ID

23522

374355

Gene namelysine acetyltransferase 6Bcoiled-coil domain containing 172
SynonymsGTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopfC10orf96
Cytomap

10q22.2

10q25.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone acoiled-coil domain-containing protein 172UPF0628 protein C10orf96
Modification date2020031320200313
UniProtAcc

Q8WYB5

.
Ensembl transtripts involved in fusion geneENST idsENST00000490365, ENST00000287239, 
ENST00000372711, ENST00000372714, 
ENST00000372724, ENST00000372725, 
ENST00000333254, ENST00000497093, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 10=48301 X 3 X 1=3
# samples 321
** MAII scorelog2(32/4830*10)=-3.91587937883577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/3*10)=1.73696559416621
Context (manual curation of fusion genes in FusionPDB)

PubMed: KAT6B [Title/Abstract] AND CCDC172 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6B(76741686)-CCDC172(118100246), # samples:2
Anticipated loss of major functional domain due to fusion event.KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6B-CCDC172 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6B

GO:0016573

histone acetylation

11965546

HgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

HgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546


check buttonFusion gene breakpoints across KAT6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC172 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04L-01BKAT6Bchr10

76741685

+CCDC172chr10

118100245

+
ChimerDB4BRCATCGA-AQ-A04L-01BKAT6Bchr10

76741686

+CCDC172chr10

118100246

+
ChimerDB4BRCATCGA-AQ-A04L-01BKAT6Bchr10

76741686

+CCDC172chr10

118100282

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372725KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+313118483422459705
ENST00000372724KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+329420115052622705
ENST00000287239KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+414528624803473997
ENST00000372714KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+318218993932510705
ENST00000372711KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100246+341821353022746814
ENST00000372725KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+309418483421853503
ENST00000372724KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+325720115052016503
ENST00000287239KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+410828624802867795
ENST00000372714KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+314518993931904503
ENST00000372711KAT6Bchr1076741686+ENST00000333254CCDC172chr10118100282+338121353022140612
ENST00000372725KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+313118483422459705
ENST00000372724KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+329420115052622705
ENST00000287239KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+414528624803473997
ENST00000372714KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+318218993932510705
ENST00000372711KAT6Bchr1076741685+ENST00000333254CCDC172chr10118100245+341821353022746814

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372725ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0002239210.99977607
ENST00000372724ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0002297450.9997702
ENST00000287239ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0001620610.9998379
ENST00000372714ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0002320210.99976796
ENST00000372711ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100246+0.0001675460.9998324
ENST00000372725ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0003529820.999647
ENST00000372724ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0003430290.9996569
ENST00000287239ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0004627770.9995372
ENST00000372714ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0003588040.9996412
ENST00000372711ENST00000333254KAT6Bchr1076741686+CCDC172chr10118100282+0.0002185180.99978155
ENST00000372725ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0002239210.99977607
ENST00000372724ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0002297450.9997702
ENST00000287239ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0001620610.9998379
ENST00000372714ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0002320210.99976796
ENST00000372711ENST00000333254KAT6Bchr1076741685+CCDC172chr10118100245+0.0001675460.9998324

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41226_41226_1_KAT6B-CCDC172_KAT6B_chr10_76741685_ENST00000287239_CCDC172_chr10_118100245_ENST00000333254_length(amino acids)=997AA_BP=794
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPD
GRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVPSLSSLTTN
SQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLK
KHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCG
RYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKA
HENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQL
NELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQ

--------------------------------------------------------------

>41226_41226_2_KAT6B-CCDC172_KAT6B_chr10_76741685_ENST00000372711_CCDC172_chr10_118100245_ENST00000333254_length(amino acids)=814AA_BP=611
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPD
GRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYP
SVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHEN
ALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNEL
QKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKDL

--------------------------------------------------------------

>41226_41226_3_KAT6B-CCDC172_KAT6B_chr10_76741685_ENST00000372714_CCDC172_chr10_118100245_ENST00000333254_length(amino acids)=705AA_BP=502
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP
QEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQT
FEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLK

--------------------------------------------------------------

>41226_41226_4_KAT6B-CCDC172_KAT6B_chr10_76741685_ENST00000372724_CCDC172_chr10_118100245_ENST00000333254_length(amino acids)=705AA_BP=502
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP
QEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQT
FEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLK

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>41226_41226_5_KAT6B-CCDC172_KAT6B_chr10_76741685_ENST00000372725_CCDC172_chr10_118100245_ENST00000333254_length(amino acids)=705AA_BP=502
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP
QEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQT
FEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLK

--------------------------------------------------------------

>41226_41226_6_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000287239_CCDC172_chr10_118100246_ENST00000333254_length(amino acids)=997AA_BP=794
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPD
GRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVPSLSSLTTN
SQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLK
KHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCG
RYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKA
HENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQL
NELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQ

--------------------------------------------------------------

>41226_41226_7_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000287239_CCDC172_chr10_118100282_ENST00000333254_length(amino acids)=795AA_BP=
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPD
GRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVPSLSSLTTN
SQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLK
KHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCG

--------------------------------------------------------------

>41226_41226_8_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372711_CCDC172_chr10_118100246_ENST00000333254_length(amino acids)=814AA_BP=611
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPD
GRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYP
SVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHEN
ALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNEL
QKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKDL

--------------------------------------------------------------

>41226_41226_9_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372711_CCDC172_chr10_118100282_ENST00000333254_length(amino acids)=612AA_BP=
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPD
GRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYP

--------------------------------------------------------------

>41226_41226_10_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372714_CCDC172_chr10_118100246_ENST00000333254_length(amino acids)=705AA_BP=502
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP
QEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQT
FEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLK

--------------------------------------------------------------

>41226_41226_11_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372714_CCDC172_chr10_118100282_ENST00000333254_length(amino acids)=503AA_BP=
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP

--------------------------------------------------------------

>41226_41226_12_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372724_CCDC172_chr10_118100246_ENST00000333254_length(amino acids)=705AA_BP=502
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP
QEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQT
FEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLK

--------------------------------------------------------------

>41226_41226_13_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372724_CCDC172_chr10_118100282_ENST00000333254_length(amino acids)=503AA_BP=
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP

--------------------------------------------------------------

>41226_41226_14_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372725_CCDC172_chr10_118100246_ENST00000333254_length(amino acids)=705AA_BP=502
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP
QEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQT
FEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLK

--------------------------------------------------------------

>41226_41226_15_KAT6B-CCDC172_KAT6B_chr10_76741686_ENST00000372725_CCDC172_chr10_118100282_ENST00000333254_length(amino acids)=503AA_BP=
MSTMVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGT
FPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYG
SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCI
ECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT
SDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYP

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:76741686/chr10:118100246)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6B

Q8WYB5

.
FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118492_533791.02074.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118521_524791.02074.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118599_605791.02074.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017492_533608.01891.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017521_524608.01891.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017599_605608.01891.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118492_533791.02074.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118521_524791.02074.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118599_605791.02074.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017492_533608.01891.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017521_524608.01891.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017599_605608.01891.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118492_533791.02074.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118521_524791.02074.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118599_605791.02074.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017492_533608.01891.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017521_524608.01891.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017599_605608.01891.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118103_176791.02074.0DomainH15
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017103_176608.01891.0DomainH15
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118103_176791.02074.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017103_176608.01891.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118103_176791.02074.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017103_176608.01891.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017103_176499.01782.0DomainH15
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118361_717791.02074.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118361_717791.02074.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118361_717791.02074.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118213_272791.02074.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118269_320791.02074.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118748_773791.02074.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017213_272608.01891.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017269_320608.01891.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118213_272791.02074.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118269_320791.02074.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118748_773791.02074.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017213_272608.01891.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017269_320608.01891.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118213_272791.02074.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118269_320791.02074.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118748_773791.02074.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017213_272608.01891.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017269_320608.01891.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118269_320499.01782.0Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017213_272499.01782.0Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017269_320499.01782.0Zinc fingerPHD-type 2
TgeneCCDC172chr10:76741685chr10:118100245ENST0000033325429123_19155.0259.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC172chr10:76741685chr10:118100245ENST0000033325429226_25655.0259.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC172chr10:76741686chr10:118100246ENST0000033325429123_19155.0259.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC172chr10:76741686chr10:118100246ENST0000033325429226_25655.0259.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC172chr10:76741686chr10:118100282ENST0000033325409123_1910259.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC172chr10:76741686chr10:118100282ENST000003332540913_900259.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC172chr10:76741686chr10:118100282ENST0000033325409226_2560259.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+11181070_1104791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+11181204_1207791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+11181351_1373791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+11181409_1417791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+11181594_1763791.02074.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+11181961_2061791.02074.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+10171070_1104608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+10171204_1207608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+10171351_1373608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+10171409_1417608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+10171594_1763608.01891.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+10171961_2061608.01891.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+10171070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+10171204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+10171351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+10171409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+10171594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+10171961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+11181070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+11181204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+11181351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+11181409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+11181594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+11181961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+10171070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+10171204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+10171351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+10171409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+10171594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+10171961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+11181070_1104791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+11181204_1207791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+11181351_1373791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+11181409_1417791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+11181594_1763791.02074.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+11181961_2061791.02074.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+10171070_1104608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+10171204_1207608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+10171351_1373608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+10171409_1417608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+10171594_1763608.01891.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+10171961_2061608.01891.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+10171070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+10171204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+10171351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+10171409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+10171594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+10171961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+11181070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+11181204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+11181351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+11181409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+11181594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+11181961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+10171070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+10171204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+10171351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+10171409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+10171594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+10171961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+11181070_1104791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+11181204_1207791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+11181351_1373791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+11181409_1417791.02074.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+11181594_1763791.02074.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+11181961_2061791.02074.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+10171070_1104608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+10171204_1207608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+10171351_1373608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+10171409_1417608.01891.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+10171594_1763608.01891.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+10171961_2061608.01891.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+10171070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+10171204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+10171351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+10171409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+10171594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+10171961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+11181070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+11181204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+11181351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+11181409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+11181594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+11181961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+10171070_1104499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+10171204_1207499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+10171351_1373499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+10171409_1417499.01782.0Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+10171594_1763499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+10171961_2061499.01782.0Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017492_533499.01782.0Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017521_524499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017599_605499.01782.0Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118715_989791.02074.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017715_989608.01891.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118715_989791.02074.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017715_989608.01891.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118715_989791.02074.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017715_989608.01891.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017715_989499.01782.0DomainMYST-type HAT
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118718_1008791.02074.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118856_860791.02074.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118865_871791.02074.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017361_717608.01891.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017718_1008608.01891.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017856_860608.01891.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017865_871608.01891.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118718_1008791.02074.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118856_860791.02074.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118865_871791.02074.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017361_717608.01891.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017718_1008608.01891.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017856_860608.01891.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017865_871608.01891.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118718_1008791.02074.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118856_860791.02074.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118865_871791.02074.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017361_717608.01891.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017718_1008608.01891.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017856_860608.01891.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017865_871608.01891.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017361_717499.01782.0RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017718_1008499.01782.0RegionNote=Catalytic
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017856_860499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017865_871499.01782.0RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017748_773608.01891.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017748_773608.01891.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017748_773608.01891.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118748_773499.01782.0Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017748_773499.01782.0Zinc fingerC2HC MYST-type
TgeneCCDC172chr10:76741685chr10:118100245ENST000003332542913_9055.0259.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC172chr10:76741686chr10:118100246ENST000003332542913_9055.0259.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KAT6B
CCDC172


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+1118752_1008791.02074.0BRPF1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+1017752_1008608.01891.0BRPF1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+1017752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+1118752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+1017752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+1118752_1008791.02074.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+1017752_1008608.01891.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+1017752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+1118752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+1017752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+1118752_1008791.02074.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+1017752_1008608.01891.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+1017752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+1118752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+1017752_1008499.01782.0BRPF1
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000287239+11181560_2073791.02074.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372711+10171560_2073608.01891.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372714+10171560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372724+11181560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741685chr10:118100245ENST00000372725+10171560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000287239+11181560_2073791.02074.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372711+10171560_2073608.01891.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372714+10171560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372724+11181560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100246ENST00000372725+10171560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000287239+11181560_2073791.02074.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372711+10171560_2073608.01891.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372714+10171560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372724+11181560_2073499.01782.0RUNX1 and RUNX2
HgeneKAT6Bchr10:76741686chr10:118100282ENST00000372725+10171560_2073499.01782.0RUNX1 and RUNX2


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Related Drugs to KAT6B-CCDC172


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6B-CCDC172


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource