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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KCNMA1-MSMB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KCNMA1-MSMB
FusionPDB ID: 41495
FusionGDB2.0 ID: 41495
HgeneTgene
Gene symbol

KCNMA1

MSMB

Gene ID

3778

4477

Gene namepotassium calcium-activated channel subfamily M alpha 1microseminoprotein beta
SynonymsBKTM|CADEDS|IEG16|KCa1.1|LIWAS|MaxiK|PNKD3|SAKCA|SLO|SLO-ALPHA|SLO1|bA205K10.1|hSlo|mSLO1HPC13|IGBF|MSP|MSPB|PN44|PRPS|PSP|PSP-94|PSP57|PSP94
Cytomap

10q22.3

10q11.22

Type of geneprotein-codingprotein-coding
Descriptioncalcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpobeta-microseminoproteinimmunoglobulin binding factorprostate secreted seminal plasma proteinprostate secretory protein of 94 amino acidsseminal plasma beta-inhibin
Modification date2020031520200313
UniProtAcc

Q12791

P08118

Ensembl transtripts involved in fusion geneENST idsENST00000286627, ENST00000286628, 
ENST00000354353, ENST00000372440, 
ENST00000372443, ENST00000404771, 
ENST00000404857, ENST00000406533, 
ENST00000480683, ENST00000481070, 
ENST00000484507, 		ENST00000298239, 
ENST00000474170, ENST00000358559, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 17 X 10=340018 X 7 X 6=756
# samples 2521
** MAII scorelog2(25/3400*10)=-3.76553474636298
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/756*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KCNMA1 [Title/Abstract] AND MSMB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KCNMA1(78869931)-MSMB(51555731), # samples:3
Anticipated loss of major functional domain due to fusion event.KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNMA1-MSMB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNMA1

GO:0001666

response to hypoxia

15528406

HgeneKCNMA1

GO:0006813

potassium ion transport

7573516|7877450|11245614|12388065|17706472|18458941

HgeneKCNMA1

GO:0006970

response to osmotic stress

10840032|12388065

HgeneKCNMA1

GO:0030007

cellular potassium ion homeostasis

11245614

HgeneKCNMA1

GO:0034465

response to carbon monoxide

15528406

HgeneKCNMA1

GO:0042391

regulation of membrane potential

7877450|7993625

HgeneKCNMA1

GO:0045794

negative regulation of cell volume

12388065

HgeneKCNMA1

GO:0051592

response to calcium ion

12388065|18458941

HgeneKCNMA1

GO:0060073

micturition

11641143

HgeneKCNMA1

GO:0060083

smooth muscle contraction involved in micturition

11641143


check buttonFusion gene breakpoints across KCNMA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MSMB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A25D-01AKCNMA1chr10

78869931

-MSMBchr10

51555731

-
ChimerDB4BRCATCGA-A2-A25D-01AKCNMA1chr10

78869931

-MSMBchr10

51555731

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000404771KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-17061247621588508
ENST00000372440KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-194114822971823508
ENST00000372443KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-231718586732199508
ENST00000286628KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-1590113101472490
ENST00000286627KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-254320848992425508
ENST00000354353KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-1590113101472490
ENST00000404857KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-1590113101472490
ENST00000406533KCNMA1chr1078869931-ENST00000358559MSMBchr1051555731-1590113101472490

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000404771ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0028844770.9971155
ENST00000372440ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0035718440.9964282
ENST00000372443ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0051801550.9948198
ENST00000286628ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0021785710.99782145
ENST00000286627ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0057261240.99427384
ENST00000354353ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0021785710.99782145
ENST00000404857ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0021785710.99782145
ENST00000406533ENST00000358559KCNMA1chr1078869931-MSMBchr1051555731-0.0021785710.99782145

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41495_41495_1_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286627_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------

>41495_41495_2_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286628_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------

>41495_41495_3_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000354353_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------

>41495_41495_4_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372440_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------

>41495_41495_5_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372443_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------

>41495_41495_6_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404771_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------

>41495_41495_7_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404857_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------

>41495_41495_8_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000406533_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:78869931/chr10:51555731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNMA1

Q12791

MSMB

P08118

FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-82713_20377.01179.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-82739_60377.01179.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-8274_10377.01179.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-82813_20377.01237.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-82839_60377.01237.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-8284_10377.01237.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-82813_20377.01220.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-82839_60377.01220.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-8284_10377.01220.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827336_358377.01179.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828336_358377.01237.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828336_358377.01220.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827352_355377.01179.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828352_355377.01237.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828352_355377.01220.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827108_178377.01179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-8271_86377.01179.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827200_214377.01179.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827236_239377.01179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827261_264377.01179.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827286_300377.01179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827322_335377.01179.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827359_367377.01179.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828108_178377.01237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-8281_86377.01237.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828200_214377.01237.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828236_239377.01237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828261_264377.01237.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828286_300377.01237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828322_335377.01237.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828359_367377.01237.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828108_178377.01220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-8281_86377.01220.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828200_214377.01220.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828236_239377.01220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828261_264377.01220.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828286_300377.01220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828322_335377.01220.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828359_367377.01220.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827179_199377.01179.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827215_235377.01179.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827240_260377.01179.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827265_285377.01179.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827301_321377.01179.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-82787_107377.01179.0TransmembraneHelical%3B Name%3DSegment S0
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828179_199377.01237.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828215_235377.01237.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828240_260377.01237.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828265_285377.01237.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828301_321377.01237.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-82887_107377.01237.0TransmembraneHelical%3B Name%3DSegment S0
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828179_199377.01220.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828215_235377.01220.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828240_260377.01220.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828265_285377.01220.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828301_321377.01220.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-82887_107377.01220.0TransmembraneHelical%3B Name%3DSegment S0

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-1213_200169.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-1239_600169.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-124_100169.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827415_558377.01179.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828415_558377.01237.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828415_558377.01220.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12415_5580169.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12336_3580169.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-8271003_1025377.01179.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-8281003_1025377.01237.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-8281003_1025377.01220.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-121003_10250169.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12352_3550169.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-8271032_1052377.01179.0RegionNote=Segment S10
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827556_576377.01179.0RegionNote=Segment S7
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827613_633377.01179.0RegionNote=Segment S8
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827677_681377.01179.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827837_857377.01179.0RegionNote=Segment S9
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-8281032_1052377.01237.0RegionNote=Segment S10
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828556_576377.01237.0RegionNote=Segment S7
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828613_633377.01237.0RegionNote=Segment S8
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828677_681377.01237.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828837_857377.01237.0RegionNote=Segment S9
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-8281032_1052377.01220.0RegionNote=Segment S10
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828556_576377.01220.0RegionNote=Segment S7
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828613_633377.01220.0RegionNote=Segment S8
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828677_681377.01220.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828837_857377.01220.0RegionNote=Segment S9
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-121032_10520169.0RegionNote=Segment S10
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12556_5760169.0RegionNote=Segment S7
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12613_6330169.0RegionNote=Segment S8
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12677_6810169.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12837_8570169.0RegionNote=Segment S9
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827389_1236377.01179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828389_1236377.01237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828389_1236377.01220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12108_1780169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-121_860169.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12200_2140169.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12236_2390169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12261_2640169.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12286_3000169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12322_3350169.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12359_3670169.0Topological domainExtracellular
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12389_12360169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286627-827368_388377.01179.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000286628-828368_388377.01237.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000404857-828368_388377.01220.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12179_1990169.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12215_2350169.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12240_2600169.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12265_2850169.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12301_3210169.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-12368_3880169.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78869931chr10:51555731ENST00000480683-1287_1070169.0TransmembraneHelical%3B Name%3DSegment S0


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KCNMA1
MSMB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KCNMA1-MSMB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KCNMA1-MSMB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource