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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KCNN3-YEATS4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KCNN3-YEATS4
FusionPDB ID: 41530
FusionGDB2.0 ID: 41530
HgeneTgene
Gene symbol

KCNN3

YEATS4

Gene ID

3782

8089

Gene namepotassium calcium-activated channel subfamily N member 3YEATS domain containing 4
SynonymsKCa2.3|SK3|SKCA3|ZLS3|hSK34930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9
Cytomap

1q21.3

12q15

Type of geneprotein-codingprotein-coding
Descriptionsmall conductance calcium-activated potassium channel protein 3SKCa 3potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3potassium intermediate/small conductance calcium-activated channel, subfamily N, member YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1
Modification date2020032920200313
UniProtAcc

Q9UGI6

.
Ensembl transtripts involved in fusion geneENST idsENST00000358505, ENST00000271915, 
ENST00000361147, ENST00000515643, 
ENST00000247843, ENST00000548020, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 5=18010 X 4 X 4=160
# samples 810
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KCNN3 [Title/Abstract] AND YEATS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KCNN3(154705479)-YEATS4(69756568), # samples:3
Anticipated loss of major functional domain due to fusion event.KCNN3-YEATS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNN3-YEATS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNN3-YEATS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNN3-YEATS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KCNN3-YEATS4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KCNN3-YEATS4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KCNN3-YEATS4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYEATS4

GO:0043967

histone H4 acetylation

14966270

TgeneYEATS4

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across KCNN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YEATS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A2QS-01AKCNN3chr1

154705479

-YEATS4chr12

69756568

+
ChimerDB4SARCTCGA-FX-A2QSKCNN3chr1

154705478

-YEATS4chr12

69756567

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000271915KCNN3chr1154705479-ENST00000247843YEATS4chr1269756568+30191906582538826
ENST00000271915KCNN3chr1154705479-ENST00000548020YEATS4chr1269756568+26921906582376772
ENST00000361147KCNN3chr1154705479-ENST00000247843YEATS4chr1269756568+19198061311438435
ENST00000361147KCNN3chr1154705479-ENST00000548020YEATS4chr1269756568+15928061311276381
ENST00000271915KCNN3chr1154705478-ENST00000247843YEATS4chr1269756567+30191906582538826
ENST00000271915KCNN3chr1154705478-ENST00000548020YEATS4chr1269756567+26921906582376772
ENST00000361147KCNN3chr1154705478-ENST00000247843YEATS4chr1269756567+19198061311438435
ENST00000361147KCNN3chr1154705478-ENST00000548020YEATS4chr1269756567+15928061311276381

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000271915ENST00000247843KCNN3chr1154705479-YEATS4chr1269756568+0.0108946990.9891053
ENST00000271915ENST00000548020KCNN3chr1154705479-YEATS4chr1269756568+0.0301572550.96984273
ENST00000361147ENST00000247843KCNN3chr1154705479-YEATS4chr1269756568+0.0002046940.9997954
ENST00000361147ENST00000548020KCNN3chr1154705479-YEATS4chr1269756568+0.0003718860.99962807
ENST00000271915ENST00000247843KCNN3chr1154705478-YEATS4chr1269756567+0.0108946990.9891053
ENST00000271915ENST00000548020KCNN3chr1154705478-YEATS4chr1269756567+0.0301572550.96984273
ENST00000361147ENST00000247843KCNN3chr1154705478-YEATS4chr1269756567+0.0002046940.9997954
ENST00000361147ENST00000548020KCNN3chr1154705478-YEATS4chr1269756567+0.0003718860.99962807

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41530_41530_1_KCNN3-YEATS4_KCNN3_chr1_154705478_ENST00000271915_YEATS4_chr12_69756567_ENST00000247843_length(amino acids)=826AA_BP=616
MREFFHPLFFLQAPLLLSLPAQYNAFLSGSVWTPGSPREPKQAKERTGAKILVGEIGCLAFFEDIFGARVALGWGLVLQGIQPGPKMDTS
GHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQ
PVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGV
MKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRR
ALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERIL
YISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTL
MTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVA
RYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLF
QSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCL

--------------------------------------------------------------

>41530_41530_2_KCNN3-YEATS4_KCNN3_chr1_154705478_ENST00000271915_YEATS4_chr12_69756567_ENST00000548020_length(amino acids)=772AA_BP=616
MREFFHPLFFLQAPLLLSLPAQYNAFLSGSVWTPGSPREPKQAKERTGAKILVGEIGCLAFFEDIFGARVALGWGLVLQGIQPGPKMDTS
GHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQ
PVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGV
MKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRR
ALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERIL
YISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTL
MTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVA
RYFGKKREEDGHTHQWTVYVKPYRNEVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAEL

--------------------------------------------------------------

>41530_41530_3_KCNN3-YEATS4_KCNN3_chr1_154705478_ENST00000361147_YEATS4_chr12_69756567_ENST00000247843_length(amino acids)=435AA_BP=225
MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYT
PSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYH
DQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAY
VKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQ

--------------------------------------------------------------

>41530_41530_4_KCNN3-YEATS4_KCNN3_chr1_154705478_ENST00000361147_YEATS4_chr12_69756567_ENST00000548020_length(amino acids)=381AA_BP=225
MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYT
PSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYH
DQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEVTLYH
LLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRE

--------------------------------------------------------------

>41530_41530_5_KCNN3-YEATS4_KCNN3_chr1_154705479_ENST00000271915_YEATS4_chr12_69756568_ENST00000247843_length(amino acids)=826AA_BP=616
MREFFHPLFFLQAPLLLSLPAQYNAFLSGSVWTPGSPREPKQAKERTGAKILVGEIGCLAFFEDIFGARVALGWGLVLQGIQPGPKMDTS
GHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQ
PVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGV
MKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRR
ALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERIL
YISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTL
MTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVA
RYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLF
QSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCL

--------------------------------------------------------------

>41530_41530_6_KCNN3-YEATS4_KCNN3_chr1_154705479_ENST00000271915_YEATS4_chr12_69756568_ENST00000548020_length(amino acids)=772AA_BP=616
MREFFHPLFFLQAPLLLSLPAQYNAFLSGSVWTPGSPREPKQAKERTGAKILVGEIGCLAFFEDIFGARVALGWGLVLQGIQPGPKMDTS
GHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQ
PVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGV
MKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRR
ALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERIL
YISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTL
MTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVA
RYFGKKREEDGHTHQWTVYVKPYRNEVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAEL

--------------------------------------------------------------

>41530_41530_7_KCNN3-YEATS4_KCNN3_chr1_154705479_ENST00000361147_YEATS4_chr12_69756568_ENST00000247843_length(amino acids)=435AA_BP=225
MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYT
PSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYH
DQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAY
VKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQ

--------------------------------------------------------------

>41530_41530_8_KCNN3-YEATS4_KCNN3_chr1_154705479_ENST00000361147_YEATS4_chr12_69756568_ENST00000548020_length(amino acids)=381AA_BP=225
MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYT
PSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYH
DQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEVTLYH
LLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154705479/chr12:69756568)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNN3

Q9UGI6

.
FUNCTION: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:31155282). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. {ECO:0000269|PubMed:31155282}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-4830_94217.0419.0Compositional biasNote=Gln-rich
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-4842_64217.0419.0Compositional biasNote=Pro-rich
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-4830_94225.0427.0Compositional biasNote=Gln-rich
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-4842_64225.0427.0Compositional biasNote=Pro-rich
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-4830_94217.0419.0Compositional biasNote=Gln-rich
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-4842_64217.0419.0Compositional biasNote=Pro-rich
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-4830_94225.0427.0Compositional biasNote=Gln-rich
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-4842_64225.0427.0Compositional biasNote=Pro-rich
TgeneYEATS4chr1:154705478chr12:69756567ENST0000024784307178_22617.0228.0Coiled coilOntology_term=ECO:0000255
TgeneYEATS4chr1:154705479chr12:69756568ENST0000024784307178_22617.0228.0Coiled coilOntology_term=ECO:0000255
TgeneYEATS4chr1:154705478chr12:69756567ENST000002478430715_15817.0228.0DomainYEATS
TgeneYEATS4chr1:154705479chr12:69756568ENST000002478430715_15817.0228.0DomainYEATS
TgeneYEATS4chr1:154705478chr12:69756567ENST000002478430793_9717.0228.0RegionDiacetylated histone H3 binding
TgeneYEATS4chr1:154705479chr12:69756568ENST000002478430793_9717.0228.0RegionDiacetylated histone H3 binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48683_687217.0419.0Compositional biasNote=Poly-Gln
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48727_730217.0419.0Compositional biasNote=Poly-Ser
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48683_687225.0427.0Compositional biasNote=Poly-Gln
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48727_730225.0427.0Compositional biasNote=Poly-Ser
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48683_687217.0419.0Compositional biasNote=Poly-Gln
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48727_730217.0419.0Compositional biasNote=Poly-Ser
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48683_687225.0427.0Compositional biasNote=Poly-Gln
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48727_730225.0427.0Compositional biasNote=Poly-Ser
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48494_514217.0419.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48494_514225.0427.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48494_514217.0419.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48494_514225.0427.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48561_637217.0419.0RegionCalmodulin-binding
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48561_637225.0427.0RegionCalmodulin-binding
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48561_637217.0419.0RegionCalmodulin-binding
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48561_637225.0427.0RegionCalmodulin-binding
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48288_308217.0419.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48315_335217.0419.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48366_386217.0419.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48405_425217.0419.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48454_474217.0419.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN3chr1:154705478chr12:69756567ENST00000358505-48523_543217.0419.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48288_308225.0427.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48315_335225.0427.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48366_386225.0427.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48405_425225.0427.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48454_474225.0427.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN3chr1:154705478chr12:69756567ENST00000361147-48523_543225.0427.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48288_308217.0419.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48315_335217.0419.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48366_386217.0419.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48405_425217.0419.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48454_474217.0419.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN3chr1:154705479chr12:69756568ENST00000358505-48523_543217.0419.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48288_308225.0427.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48315_335225.0427.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48366_386225.0427.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48405_425225.0427.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48454_474225.0427.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN3chr1:154705479chr12:69756568ENST00000361147-48523_543225.0427.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KCNN3
YEATS4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KCNN3-YEATS4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KCNN3-YEATS4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource