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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KCNQ5-AMPH

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KCNQ5-AMPH
	FusionPDB ID: 41573
	FusionGDB2.0 ID: 41573
		Hgene	Tgene
	Gene symbol	KCNQ5	AMPH
	Gene ID	56479	273
	Gene name	potassium voltage-gated channel subfamily Q member 5	amphiphysin
	Synonyms	Kv7.5\|MRD46	AMPH1
	Cytomap	6q13	7p14.1
	Type of gene	protein-coding	protein-coding
	Description	potassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5	amphiphysinamphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen)amphiphysin I
	Modification date	20200313	20200313
	UniProtAcc	Q9NR82	AMIGO1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000342056, ENST00000355194, ENST00000355635, ENST00000370392, ENST00000370398, ENST00000402622, ENST00000403813, ENST00000414165,	ENST00000471913, ENST00000325590, ENST00000356264, ENST00000428293,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 7 X 4=224	5 X 3 X 5=75
	# samples	8	5
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KCNQ5 [Title/Abstract] AND AMPH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KCNQ5(73815090)-AMPH(38433814), # samples:3
Anticipated loss of major functional domain due to fusion event.	KCNQ5-AMPH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNQ5-AMPH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNQ5-AMPH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KCNQ5-AMPH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KCNQ5	GO:0071805	potassium ion transmembrane transport	10787416\|11159685

Fusion gene breakpoints across KCNQ5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AMPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8354-01A	KCNQ5	chr6	73815090	-	AMPH	chr7	38433814	-
ChimerDB4	LUSC	TCGA-85-8354-01A	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-
ChimerDB4	LUSC	TCGA-85-8354	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000342056	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	3231	1427	398	2116	572
ENST00000342056	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	3231	1427	398	2116	572
ENST00000342056	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	3229	1427	398	2116	572
ENST00000355194	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	3180	1376	347	2065	572
ENST00000355194	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	3180	1376	347	2065	572
ENST00000355194	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	3178	1376	347	2065	572
ENST00000370398	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	2942	1138	109	1827	572
ENST00000370398	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	2942	1138	109	1827	572
ENST00000370398	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	2940	1138	109	1827	572
ENST00000370392	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	2917	1113	84	1802	572
ENST00000370392	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	2917	1113	84	1802	572
ENST00000370392	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	2915	1113	84	1802	572
ENST00000355635	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000355635	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000355635	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	2831	1029	0	1718	572
ENST00000414165	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000414165	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000414165	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	2831	1029	0	1718	572
ENST00000402622	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000402622	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000402622	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	2831	1029	0	1718	572
ENST00000403813	KCNQ5	chr6	73815090	+	ENST00000325590	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000403813	KCNQ5	chr6	73815090	+	ENST00000356264	AMPH	chr7	38433814	-	2833	1029	0	1718	572
ENST00000403813	KCNQ5	chr6	73815090	+	ENST00000428293	AMPH	chr7	38433814	-	2831	1029	0	1718	572

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000342056	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.005101379	0.9948986
ENST00000342056	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.005101379	0.9948986
ENST00000342056	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.005108524	0.9948915
ENST00000355194	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.005030595	0.9949694
ENST00000355194	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.005030595	0.9949694
ENST00000355194	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.005050645	0.99494934
ENST00000370398	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.00420209	0.99579793
ENST00000370398	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.00420209	0.99579793
ENST00000370398	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004222408	0.9957776
ENST00000370392	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004262982	0.99573696
ENST00000370392	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004262982	0.99573696
ENST00000370392	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004280587	0.9957194
ENST00000355635	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000355635	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000355635	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004000607	0.99599946
ENST00000414165	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000414165	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000414165	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004000607	0.99599946
ENST00000402622	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000402622	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000402622	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004000607	0.99599946
ENST00000403813	ENST00000325590	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000403813	ENST00000356264	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.003983647	0.9960163
ENST00000403813	ENST00000428293	KCNQ5	chr6	73815090	+	AMPH	chr7	38433814	-	0.004000607	0.99599946

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41573_41573_1_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000342056_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_2_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000342056_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_3_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000342056_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_4_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000355194_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLPVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_5_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000355194_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLPVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_6_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000355194_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLPVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_7_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000355635_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_8_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000355635_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_9_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000355635_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_10_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000370392_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_11_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000370392_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_12_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000370392_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_13_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000370398_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_14_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000370398_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_15_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000370398_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_16_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000402622_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_17_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000402622_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_18_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000402622_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_19_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000403813_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_20_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000403813_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_21_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000403813_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_22_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000414165_AMPH_chr7_38433814_ENST00000325590_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_23_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000414165_AMPH_chr7_38433814_ENST00000356264_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

>41573_41573_24_KCNQ5-AMPH_KCNQ5_chr6_73815090_ENST00000414165_AMPH_chr7_38433814_ENST00000428293_length(amino acids)=572AA_BP=333
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL
GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW
YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA
AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA
PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:73815090/chr7:38433814)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KCNQ5 Q9NR82	AMPH AMIGO1
FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269\|PubMed:10787416, ECO:0000269\|PubMed:11159685, ECO:0000269\|PubMed:28669405}.	493

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

299_319

343.0

428.0

Intramembrane

Pore-forming%3B Name%3DSegment H5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

299_319

343.0

933.0

Intramembrane

Pore-forming%3B Name%3DSegment H5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

299_319

343.0

943.0

Intramembrane

Pore-forming%3B Name%3DSegment H5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

299_319

343.0

924.0

Intramembrane

Pore-forming%3B Name%3DSegment H5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

299_319

343.0

823.0

Intramembrane

Pore-forming%3B Name%3DSegment H5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

311_316

343.0

428.0

Motif

Selectivity filter

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

311_316

343.0

933.0

Motif

Selectivity filter

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

311_316

343.0

943.0

Motif

Selectivity filter

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

311_316

343.0

924.0

Motif

Selectivity filter

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

311_316

343.0

823.0

Motif

Selectivity filter

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

147_156

343.0

428.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

178_200

343.0

428.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

1_125

343.0

428.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

222_229

343.0

428.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

253_266

343.0

428.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

288_298

343.0

428.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

320_325

343.0

428.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

147_156

343.0

933.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

178_200

343.0

933.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

1_125

343.0

933.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

222_229

343.0

933.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

253_266

343.0

933.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

288_298

343.0

933.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

320_325

343.0

933.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

147_156

343.0

943.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

178_200

343.0

943.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

1_125

343.0

943.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

222_229

343.0

943.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

253_266

343.0

943.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

288_298

343.0

943.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

320_325

343.0

943.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

147_156

343.0

924.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

178_200

343.0

924.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

1_125

343.0

924.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

222_229

343.0

924.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

253_266

343.0

924.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

288_298

343.0

924.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

320_325

343.0

924.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

147_156

343.0

823.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

178_200

343.0

823.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

1_125

343.0

823.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

222_229

343.0

823.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

253_266

343.0

823.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

288_298

343.0

823.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

320_325

343.0

823.0

Topological domain

Extracellular

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

126_146

343.0

428.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

157_177

343.0

428.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

201_221

343.0

428.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

230_252

343.0

428.0

Transmembrane

Helical%3B Voltage-sensor%3B Name%3DSegment S4

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

267_287

343.0

428.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

326_346

343.0

428.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

126_146

343.0

933.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

157_177

343.0

933.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

201_221

343.0

933.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

230_252

343.0

933.0

Transmembrane

Helical%3B Voltage-sensor%3B Name%3DSegment S4

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

267_287

343.0

933.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

326_346

343.0

933.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

126_146

343.0

943.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

157_177

343.0

943.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

201_221

343.0

943.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

230_252

343.0

943.0

Transmembrane

Helical%3B Voltage-sensor%3B Name%3DSegment S4

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

267_287

343.0

943.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

326_346

343.0

943.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

126_146

343.0

924.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

157_177

343.0

924.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

201_221

343.0

924.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

230_252

343.0

924.0

Transmembrane

Helical%3B Voltage-sensor%3B Name%3DSegment S4

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

267_287

343.0

924.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

326_346

343.0

924.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

126_146

343.0

823.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

157_177

343.0

823.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

201_221

343.0

823.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

230_252

343.0

823.0

Transmembrane

Helical%3B Voltage-sensor%3B Name%3DSegment S4

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

267_287

343.0

823.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

326_346

343.0

823.0

Transmembrane

Helical%3B Name%3DSegment S6

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000325590

622_695

424.0

654.0

Domain

SH3

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000356264

622_695

466.0

696.0

Domain

SH3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370392

347_932

343.0

428.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000370398

347_932

343.0

933.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000402622

347_932

343.0

943.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000403813

347_932

343.0

924.0

Topological domain

Cytoplasmic

Hgene

KCNQ5

chr6:73815090

chr7:38433814

ENST00000414165

347_932

343.0

823.0

Topological domain

Cytoplasmic

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000325590

10_83

424.0

654.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000325590

144_191

424.0

654.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000356264

10_83

466.0

696.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000356264

144_191

466.0

696.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000325590

24_240

424.0

654.0

Domain

BAR

Tgene

AMPH

chr6:73815090

chr7:38433814

ENST00000356264

24_240

466.0

696.0

Domain

BAR

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1227_KCNQ5_73815090_AMPH_38433814_1227_KCNQ5_73815090_AMPH_38433814_ranked_0.pdb	KCNQ5	73815090	73815090	ENST00000428293	AMPH	chr7	38433814	-	MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLL GKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAW YIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAIIPGADADAAVGTLVSA AEGAPGEEAEAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEITIGAEPKETTEDAA PPGPTSETPELATEQKPIQDPQPTPSAPAMGAADQLASAREASQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAG	572

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

KCNQ5_pLDDT.png

AMPH_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KCNQ5
AMPH

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to KCNQ5-AMPH

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to KCNQ5-AMPH

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source