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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KCTD15-MSI2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KCTD15-MSI2
	FusionPDB ID: 41621
	FusionGDB2.0 ID: 41621
		Hgene	Tgene
	Gene symbol	KCTD15	MSI2
	Gene ID	79047	124540
	Gene name	potassium channel tetramerization domain containing 15	musashi RNA binding protein 2
	Synonyms	-	MSI2H
	Cytomap	19q13.11	17q22
	Type of gene	protein-coding	protein-coding
	Description	BTB/POZ domain-containing protein KCTD15potassium channel tetramerisation domain containing 15potassium channel tetramerization domain-containing protein 15	RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2
	Modification date	20200320	20200313
	UniProtAcc	Q96SI1	Q96DH6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000284006, ENST00000430256, ENST00000588881, ENST00000589786, ENST00000592363,	ENST00000579505, ENST00000284073, ENST00000322684, ENST00000416426, ENST00000442934, ENST00000579180,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 3 X 2=12	26 X 18 X 10=4680
	# samples	3	30
	** MAII score	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(30/4680*10)=-3.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KCTD15 [Title/Abstract] AND MSI2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KCTD15(34302457)-MSI2(55693331), # samples:2
Anticipated loss of major functional domain due to fusion event.	KCTD15-MSI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCTD15-MSI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCTD15-MSI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KCTD15-MSI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across KCTD15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MSI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-FW-A3I3-06A	KCTD15	chr19	34302457	-	MSI2	chr17	55693331	+
ChimerDB4	SKCM	TCGA-FW-A3I3-06A	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000589786	KCTD15	chr19	34302457	+	ENST00000416426	MSI2	chr17	55693331	+	2050	942	249	1445	398
ENST00000589786	KCTD15	chr19	34302457	+	ENST00000284073	MSI2	chr17	55693331	+	6560	942	249	1391	380
ENST00000589786	KCTD15	chr19	34302457	+	ENST00000322684	MSI2	chr17	55693331	+	2242	942	1124	0	375
ENST00000589786	KCTD15	chr19	34302457	+	ENST00000442934	MSI2	chr17	55693331	+	2172	942	249	1391	380
ENST00000589786	KCTD15	chr19	34302457	+	ENST00000579180	MSI2	chr17	55693331	+	2247	942	1124	0	375
ENST00000284006	KCTD15	chr19	34302457	+	ENST00000416426	MSI2	chr17	55693331	+	2053	945	252	1448	398
ENST00000284006	KCTD15	chr19	34302457	+	ENST00000284073	MSI2	chr17	55693331	+	6563	945	252	1394	380
ENST00000284006	KCTD15	chr19	34302457	+	ENST00000322684	MSI2	chr17	55693331	+	2245	945	1127	0	376
ENST00000284006	KCTD15	chr19	34302457	+	ENST00000442934	MSI2	chr17	55693331	+	2175	945	252	1394	380
ENST00000284006	KCTD15	chr19	34302457	+	ENST00000579180	MSI2	chr17	55693331	+	2250	945	1127	0	376
ENST00000588881	KCTD15	chr19	34302457	+	ENST00000416426	MSI2	chr17	55693331	+	2138	1030	337	1533	398
ENST00000588881	KCTD15	chr19	34302457	+	ENST00000284073	MSI2	chr17	55693331	+	6648	1030	337	1479	380
ENST00000588881	KCTD15	chr19	34302457	+	ENST00000322684	MSI2	chr17	55693331	+	2330	1030	1212	151	353
ENST00000588881	KCTD15	chr19	34302457	+	ENST00000442934	MSI2	chr17	55693331	+	2260	1030	337	1479	380
ENST00000588881	KCTD15	chr19	34302457	+	ENST00000579180	MSI2	chr17	55693331	+	2335	1030	1212	151	353
ENST00000430256	KCTD15	chr19	34302457	+	ENST00000416426	MSI2	chr17	55693331	+	2209	1101	408	1604	398
ENST00000430256	KCTD15	chr19	34302457	+	ENST00000284073	MSI2	chr17	55693331	+	6719	1101	408	1550	380
ENST00000430256	KCTD15	chr19	34302457	+	ENST00000322684	MSI2	chr17	55693331	+	2401	1101	1283	249	344
ENST00000430256	KCTD15	chr19	34302457	+	ENST00000442934	MSI2	chr17	55693331	+	2331	1101	408	1550	380
ENST00000430256	KCTD15	chr19	34302457	+	ENST00000579180	MSI2	chr17	55693331	+	2406	1101	1283	249	344

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000589786	ENST00000416426	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.00592961	0.99407035
ENST00000589786	ENST00000284073	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.00035597	0.99964404
ENST00000589786	ENST00000322684	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.005909556	0.9940904
ENST00000589786	ENST00000442934	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.005791253	0.9942087
ENST00000589786	ENST00000579180	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.00547256	0.9945274
ENST00000284006	ENST00000416426	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.006181409	0.9938186
ENST00000284006	ENST00000284073	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.000357355	0.9996426
ENST00000284006	ENST00000322684	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.005916633	0.99408334
ENST00000284006	ENST00000442934	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.006004478	0.9939956
ENST00000284006	ENST00000579180	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.00554504	0.9944549
ENST00000588881	ENST00000416426	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.005310185	0.9946898
ENST00000588881	ENST00000284073	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.000346767	0.9996532
ENST00000588881	ENST00000322684	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.005295451	0.99470454
ENST00000588881	ENST00000442934	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.005134995	0.994865
ENST00000588881	ENST00000579180	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.005024687	0.9949753
ENST00000430256	ENST00000416426	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.003706816	0.9962931
ENST00000430256	ENST00000284073	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.000336609	0.99966335
ENST00000430256	ENST00000322684	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.003621358	0.9963786
ENST00000430256	ENST00000442934	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.00382553	0.99617445
ENST00000430256	ENST00000579180	KCTD15	chr19	34302457	+	MSI2	chr17	55693331	+	0.003338465	0.99666154

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41621_41621_1_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000284006_MSI2_chr17_55693331_ENST00000284073_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_2_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000284006_MSI2_chr17_55693331_ENST00000322684_length(amino acids)=376AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL
RGAGAAVCVKRGPARPLLAVRHLGFHPCPEYRWKPQALRLAVNLQGFSQQAHPCGTTTLFPRPLLGAGRSGSGAAPAPRSCRSRAPGAAS

--------------------------------------------------------------

>41621_41621_3_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000284006_MSI2_chr17_55693331_ENST00000416426_length(amino acids)=398AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPAS

--------------------------------------------------------------

>41621_41621_4_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000284006_MSI2_chr17_55693331_ENST00000442934_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_5_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000284006_MSI2_chr17_55693331_ENST00000579180_length(amino acids)=376AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL
RGAGAAVCVKRGPARPLLAVRHLGFHPCPEYRWKPQALRLAVNLQGFSQQAHPCGTTTLFPRPLLGAGRSGSGAAPAPRSCRSRAPGAAS

--------------------------------------------------------------

>41621_41621_6_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000430256_MSI2_chr17_55693331_ENST00000284073_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_7_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000430256_MSI2_chr17_55693331_ENST00000322684_length(amino acids)=344AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL

--------------------------------------------------------------

>41621_41621_8_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000430256_MSI2_chr17_55693331_ENST00000416426_length(amino acids)=398AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPAS

--------------------------------------------------------------

>41621_41621_9_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000430256_MSI2_chr17_55693331_ENST00000442934_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_10_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000430256_MSI2_chr17_55693331_ENST00000579180_length(amino acids)=344AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL

--------------------------------------------------------------

>41621_41621_11_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000588881_MSI2_chr17_55693331_ENST00000284073_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_12_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000588881_MSI2_chr17_55693331_ENST00000322684_length(amino acids)=353AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL

--------------------------------------------------------------

>41621_41621_13_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000588881_MSI2_chr17_55693331_ENST00000416426_length(amino acids)=398AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPAS

--------------------------------------------------------------

>41621_41621_14_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000588881_MSI2_chr17_55693331_ENST00000442934_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_15_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000588881_MSI2_chr17_55693331_ENST00000579180_length(amino acids)=353AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL

--------------------------------------------------------------

>41621_41621_16_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000589786_MSI2_chr17_55693331_ENST00000284073_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_17_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000589786_MSI2_chr17_55693331_ENST00000322684_length(amino acids)=375AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL
RGAGAAVCVKRGPARPLLAVRHLGFHPCPEYRWKPQALRLAVNLQGFSQQAHPCGTTTLFPRPLGAGRSGSGAAPAPRSCRSRAPGAASP

--------------------------------------------------------------

>41621_41621_18_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000589786_MSI2_chr17_55693331_ENST00000416426_length(amino acids)=398AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPAS

--------------------------------------------------------------

>41621_41621_19_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000589786_MSI2_chr17_55693331_ENST00000442934_length(amino acids)=380AA_BP=225
MPHRKERPSGSSLHTHGSTGTAEGGNMSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTE
PIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPMVRELERWQQEQEQRRRSRACDCLVVRVTPDLGER
IALSGEKALIEEVFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGS

--------------------------------------------------------------

>41621_41621_20_KCTD15-MSI2_KCTD15_chr19_34302457_ENST00000589786_MSI2_chr17_55693331_ENST00000579180_length(amino acids)=375AA_BP=1
MIAIAWSKSGVATAIGRHEVGISQHPHAKHERVHGVRQSPGPASCPRWEHDFFRLSFLTFYLYRVEPAVAIEREADDVRGVLVPAGVDGV
AHDVSGLGEDLLDEGLLAAECDPLAQVGRDAHHQAVTGPAAAPLLLLLLPALQLAHHGLELIVARLLVQQTEVLKVIRKQQLGRPQEAQD
VAENLPIPVNEIMLLQTVQDDGFSAIEEAAYPGVRVLGERGQAAGVHVAAHIDVHRCIGLGELGWQGDALGSQGRHRRPGERQPGHVSSL
RGAGAAVCVKRGPARPLLAVRHLGFHPCPEYRWKPQALRLAVNLQGFSQQAHPCGTTTLFPRPLGAGRSGSGAAPAPRSCRSRAPGAASP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34302457/chr17:55693331)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KCTD15 Q96SI1	MSI2 Q96DH6
FUNCTION: During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain. {ECO:0000250, ECO:0000269\|PubMed:23382213}.	FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCTD15

chr19:34302457

chr17:55693331

ENST00000284006

56_126

231.0

235.0

Domain

Note=BTB

Hgene

KCTD15

chr19:34302457

chr17:55693331

ENST00000430256

56_126

231.0

284.0

Domain

Note=BTB

Hgene

KCTD15

chr19:34302457

chr17:55693331

ENST00000588881

56_126

231.0

284.0

Domain

Note=BTB

Hgene

KCTD15

chr19:34302457

chr17:55693331

ENST00000589786

56_126

231.0

284.0

Domain

Note=BTB

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000284073

253_260

179.0

1951.0

Compositional bias

Note=Poly-Ala

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000322684

253_260

175.0

252.0

Compositional bias

Note=Poly-Ala

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000579180

253_260

75.0

152.0

Compositional bias

Note=Poly-Ala

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000579180

110_187

75.0

152.0

Domain

RRM 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000284073

110_187

179.0

1951.0

Domain

RRM 2

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000284073

21_111

179.0

1951.0

Domain

RRM 1

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000322684

110_187

175.0

252.0

Domain

RRM 2

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000322684

21_111

175.0

252.0

Domain

RRM 1

Tgene

MSI2

chr19:34302457

chr17:55693331

ENST00000579180

21_111

75.0

152.0

Domain

RRM 1

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KCTD15
MSI2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to KCTD15-MSI2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KCTD15-MSI2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source