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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KCTD5-TSC2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KCTD5-TSC2
	FusionPDB ID: 41664
	FusionGDB2.0 ID: 41664
		Hgene	Tgene
	Gene symbol	KCTD5	TSC2
	Gene ID	54442	7249
	Gene name	potassium channel tetramerization domain containing 5	TSC complex subunit 2
	Synonyms	-	LAM\|PPP1R160\|TSC4
	Cytomap	16p13.3	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	BTB/POZ domain-containing protein KCTD5potassium channel tetramerisation domain containing 5	tuberinprotein phosphatase 1, regulatory subunit 160tuberous sclerosis 2 protein
	Modification date	20200313	20200313
	UniProtAcc	Q9NXV2	TSC22D4
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000301738, ENST00000564195, ENST00000569689,	ENST00000568366, ENST00000219476, ENST00000350773, ENST00000353929, ENST00000382538, ENST00000401874, ENST00000439673, ENST00000568454,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 3=48	6 X 9 X 4=216
	# samples	5	8
	** MAII score	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KCTD5 [Title/Abstract] AND TSC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KCTD5(2747998)-TSC2(2136194), # samples:3 TSC2(2112120)-KCTD5(2732706), # samples:1
Anticipated loss of major functional domain due to fusion event.	KCTD5-TSC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCTD5-TSC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCTD5-TSC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KCTD5-TSC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across KCTD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TSC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5J1-01A	KCTD5	chr16	2747998	-	TSC2	chr16	2136194	+
ChimerDB4	ACC	TCGA-OR-A5J1-01A	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+
ChimerDB4	ACC	TCGA-OR-A5J1	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000219476	TSC2	chr16	2136194	+	1391	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000382538	TSC2	chr16	2136194	+	1379	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000401874	TSC2	chr16	2136194	+	1381	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000353929	TSC2	chr16	2136194	+	1390	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000439673	TSC2	chr16	2136194	+	1380	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000350773	TSC2	chr16	2136194	+	1391	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000568454	TSC2	chr16	2136194	+	1394	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000219476	TSC2	chr16	2136193	+	1391	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000382538	TSC2	chr16	2136193	+	1379	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000401874	TSC2	chr16	2136193	+	1381	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000353929	TSC2	chr16	2136193	+	1390	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000439673	TSC2	chr16	2136193	+	1380	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000350773	TSC2	chr16	2136193	+	1391	527	74	1288	404
ENST00000301738	KCTD5	chr16	2747998	+	ENST00000568454	TSC2	chr16	2136193	+	1394	527	74	1288	404

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000301738	ENST00000219476	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+	0.007406252	0.9925937
ENST00000301738	ENST00000382538	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+	0.007647007	0.992353
ENST00000301738	ENST00000401874	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+	0.007579701	0.99242026
ENST00000301738	ENST00000353929	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+	0.007382163	0.9926178
ENST00000301738	ENST00000439673	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+	0.007496465	0.9925035
ENST00000301738	ENST00000350773	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+	0.007406252	0.9925937
ENST00000301738	ENST00000568454	KCTD5	chr16	2747998	+	TSC2	chr16	2136194	+	0.007292726	0.9927073
ENST00000301738	ENST00000219476	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+	0.007406252	0.9925937
ENST00000301738	ENST00000382538	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+	0.007647007	0.992353
ENST00000301738	ENST00000401874	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+	0.007579701	0.99242026
ENST00000301738	ENST00000353929	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+	0.007382163	0.9926178
ENST00000301738	ENST00000439673	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+	0.007496465	0.9925035
ENST00000301738	ENST00000350773	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+	0.007406252	0.9925937
ENST00000301738	ENST00000568454	KCTD5	chr16	2747998	+	TSC2	chr16	2136193	+	0.007292726	0.9927073

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41664_41664_1_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136193_ENST00000219476_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_2_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136193_ENST00000350773_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_3_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136193_ENST00000353929_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_4_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136193_ENST00000382538_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_5_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136193_ENST00000401874_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_6_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136193_ENST00000439673_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_7_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136193_ENST00000568454_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_8_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136194_ENST00000219476_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_9_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136194_ENST00000350773_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_10_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136194_ENST00000353929_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_11_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136194_ENST00000382538_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_12_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136194_ENST00000401874_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_13_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136194_ENST00000439673_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

>41664_41664_14_KCTD5-TSC2_KCTD5_chr16_2747998_ENST00000301738_TSC2_chr16_2136194_ENST00000568454_length(amino acids)=404AA_BP=8
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:2747998/chr16:2136194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KCTD5 Q9NXV2	TSC2 TSC22D4
FUNCTION: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449). {ECO:0000269\|PubMed:18573101, ECO:0000269\|PubMed:19361449}.	395

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCTD5

chr16:2747998

chr16:2136193

ENST00000301738

44_146

151.0

235.0

Domain

Note=BTB

Hgene

KCTD5

chr16:2747998

chr16:2136194

ENST00000301738

44_146

151.0

235.0

Domain

Note=BTB

Tgene

TSC2

chr16:2747998

chr16:2136193

ENST00000350773

1531_1758

1531.0

1785.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136193

ENST00000353929

1531_1758

1511.0

1765.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136193

ENST00000401874

1531_1758

1487.0

1741.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136193

ENST00000439673

1531_1758

1451.0

1705.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136194

ENST00000350773

1531_1758

1531.0

1785.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136194

ENST00000353929

1531_1758

1511.0

1765.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136194

ENST00000401874

1531_1758

1487.0

1741.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136194

ENST00000439673

1531_1758

1451.0

1705.0

Domain

Rap-GAP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TSC2

chr16:2747998

chr16:2136193

ENST00000219476

1531_1758

1554.0

1808.0

Domain

Rap-GAP

Tgene

TSC2

chr16:2747998

chr16:2136194

ENST00000219476

1531_1758

1554.0

1808.0

Domain

Rap-GAP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KCTD5
TSC2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to KCTD5-TSC2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to KCTD5-TSC2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source