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Fusion Protein:KDM1A-EPHB2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: KDM1A-EPHB2 | FusionPDB ID: 41698 | FusionGDB2.0 ID: 41698 | Hgene | Tgene | Gene symbol | KDM1A | EPHB2 | Gene ID | 23028 | 2048 |
| Gene name | lysine demethylase 1A | EPH receptor B2 | |
| Synonyms | AOF2|BHC110|CPRF|KDM1|LSD1 | BDPLT22|CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5 | |
| Cytomap | 1p36.12 | 1p36.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific histone demethylase 1ABRAF35-HDAC complex protein BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunitamine oxidase (flavin containing) domain 2flavin-containing amine oxidase domain-containing protein 2lysine (K)-specific d | ephrin type-B receptor 2EPH-like kinase 5developmentally-regulated Eph-related tyrosine kinaseelk-related tyrosine kinaseeph tyrosine kinase 3protein-tyrosine kinase HEK5renal carcinoma antigen NY-REN-47tyrosine-protein kinase TYRO5tyrosine-protei | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | O60341 | P29323 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000356634, ENST00000400181, ENST00000542151, | ENST00000465676, ENST00000374627, ENST00000374630, ENST00000374632, ENST00000400191, ENST00000544305, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 7 X 2=84 | 10 X 10 X 5=500 |
| # samples | 9 | 11 | |
| ** MAII score | log2(9/84*10)=0.0995356735509144 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/500*10)=-2.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: KDM1A [Title/Abstract] AND EPHB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KDM1A(23357127)-EPHB2(23208851), # samples:1 KDM1A(23357127)-EPHB2(23208852), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | KDM1A-EPHB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM1A-EPHB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM1A-EPHB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KDM1A-EPHB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KDM1A | GO:0033169 | histone H3-K9 demethylation | 16079795|20228790 |
| Hgene | KDM1A | GO:0034644 | cellular response to UV | 24217620 |
| Hgene | KDM1A | GO:0034720 | histone H3-K4 demethylation | 15620353|20228790|24217620 |
| Hgene | KDM1A | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 19497860 |
| Hgene | KDM1A | GO:0045892 | negative regulation of transcription, DNA-templated | 19497860 |
| Hgene | KDM1A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20833138 |
| Hgene | KDM1A | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 20833138 |
| Fusion gene breakpoints across KDM1A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across EPHB2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-4357-01A | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + |
| ChimerDB4 | STAD | TCGA-BR-4357 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000356634 | KDM1A | chr1 | 23357127 | + | ENST00000544305 | EPHB2 | chr1 | 23208851 | + | 928 | 666 | 149 | 811 | 220 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | + | ENST00000374630 | EPHB2 | chr1 | 23208851 | + | 2497 | 666 | 149 | 2323 | 724 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | + | ENST00000400191 | EPHB2 | chr1 | 23208851 | + | 3986 | 666 | 149 | 2530 | 793 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | + | ENST00000374632 | EPHB2 | chr1 | 23208851 | + | 3027 | 666 | 149 | 2326 | 725 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | + | ENST00000374627 | EPHB2 | chr1 | 23208851 | + | 3371 | 666 | 149 | 2221 | 690 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | + | ENST00000544305 | EPHB2 | chr1 | 23208851 | + | 883 | 621 | 104 | 766 | 220 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | + | ENST00000374630 | EPHB2 | chr1 | 23208851 | + | 2452 | 621 | 104 | 2278 | 724 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | + | ENST00000400191 | EPHB2 | chr1 | 23208851 | + | 3941 | 621 | 104 | 2485 | 793 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | + | ENST00000374632 | EPHB2 | chr1 | 23208851 | + | 2982 | 621 | 104 | 2281 | 725 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | + | ENST00000374627 | EPHB2 | chr1 | 23208851 | + | 3326 | 621 | 104 | 2176 | 690 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | + | ENST00000544305 | EPHB2 | chr1 | 23208851 | + | 881 | 619 | 102 | 764 | 220 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | + | ENST00000374630 | EPHB2 | chr1 | 23208851 | + | 2450 | 619 | 102 | 2276 | 724 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | + | ENST00000400191 | EPHB2 | chr1 | 23208851 | + | 3939 | 619 | 102 | 2483 | 793 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | + | ENST00000374632 | EPHB2 | chr1 | 23208851 | + | 2980 | 619 | 102 | 2279 | 725 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | + | ENST00000374627 | EPHB2 | chr1 | 23208851 | + | 3324 | 619 | 102 | 2174 | 690 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | - | ENST00000544305 | EPHB2 | chr1 | 23208852 | + | 928 | 666 | 149 | 811 | 220 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | - | ENST00000374630 | EPHB2 | chr1 | 23208852 | + | 2497 | 666 | 149 | 2323 | 724 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | - | ENST00000400191 | EPHB2 | chr1 | 23208852 | + | 3986 | 666 | 149 | 2530 | 793 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | - | ENST00000374632 | EPHB2 | chr1 | 23208852 | + | 3027 | 666 | 149 | 2326 | 725 |
| ENST00000356634 | KDM1A | chr1 | 23357127 | - | ENST00000374627 | EPHB2 | chr1 | 23208852 | + | 3371 | 666 | 149 | 2221 | 690 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | - | ENST00000544305 | EPHB2 | chr1 | 23208852 | + | 883 | 621 | 104 | 766 | 220 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | - | ENST00000374630 | EPHB2 | chr1 | 23208852 | + | 2452 | 621 | 104 | 2278 | 724 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | - | ENST00000400191 | EPHB2 | chr1 | 23208852 | + | 3941 | 621 | 104 | 2485 | 793 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | - | ENST00000374632 | EPHB2 | chr1 | 23208852 | + | 2982 | 621 | 104 | 2281 | 725 |
| ENST00000400181 | KDM1A | chr1 | 23357127 | - | ENST00000374627 | EPHB2 | chr1 | 23208852 | + | 3326 | 621 | 104 | 2176 | 690 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | - | ENST00000544305 | EPHB2 | chr1 | 23208852 | + | 881 | 619 | 102 | 764 | 220 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | - | ENST00000374630 | EPHB2 | chr1 | 23208852 | + | 2450 | 619 | 102 | 2276 | 724 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | - | ENST00000400191 | EPHB2 | chr1 | 23208852 | + | 3939 | 619 | 102 | 2483 | 793 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | - | ENST00000374632 | EPHB2 | chr1 | 23208852 | + | 2980 | 619 | 102 | 2279 | 725 |
| ENST00000542151 | KDM1A | chr1 | 23357127 | - | ENST00000374627 | EPHB2 | chr1 | 23208852 | + | 3324 | 619 | 102 | 2174 | 690 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000356634 | ENST00000544305 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.004926997 | 0.995073 |
| ENST00000356634 | ENST00000374630 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.006558819 | 0.9934411 |
| ENST00000356634 | ENST00000400191 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.001820675 | 0.9981793 |
| ENST00000356634 | ENST00000374632 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.004777174 | 0.99522287 |
| ENST00000356634 | ENST00000374627 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.005683788 | 0.99431616 |
| ENST00000400181 | ENST00000544305 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.004378739 | 0.99562126 |
| ENST00000400181 | ENST00000374630 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.006665471 | 0.99333453 |
| ENST00000400181 | ENST00000400191 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.001968963 | 0.9980311 |
| ENST00000400181 | ENST00000374632 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.005228939 | 0.99477106 |
| ENST00000400181 | ENST00000374627 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.006062916 | 0.993937 |
| ENST00000542151 | ENST00000544305 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.004519617 | 0.9954804 |
| ENST00000542151 | ENST00000374630 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.006643544 | 0.9933564 |
| ENST00000542151 | ENST00000400191 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.001968222 | 0.9980318 |
| ENST00000542151 | ENST00000374632 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.00522511 | 0.9947748 |
| ENST00000542151 | ENST00000374627 | KDM1A | chr1 | 23357127 | + | EPHB2 | chr1 | 23208851 | + | 0.006058384 | 0.99394166 |
| ENST00000356634 | ENST00000544305 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.004926997 | 0.995073 |
| ENST00000356634 | ENST00000374630 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.006558819 | 0.9934411 |
| ENST00000356634 | ENST00000400191 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.001820675 | 0.9981793 |
| ENST00000356634 | ENST00000374632 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.004777174 | 0.99522287 |
| ENST00000356634 | ENST00000374627 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.005683788 | 0.99431616 |
| ENST00000400181 | ENST00000544305 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.004378739 | 0.99562126 |
| ENST00000400181 | ENST00000374630 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.006665471 | 0.99333453 |
| ENST00000400181 | ENST00000400191 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.001968963 | 0.9980311 |
| ENST00000400181 | ENST00000374632 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.005228939 | 0.99477106 |
| ENST00000400181 | ENST00000374627 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.006062916 | 0.993937 |
| ENST00000542151 | ENST00000544305 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.004519617 | 0.9954804 |
| ENST00000542151 | ENST00000374630 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.006643544 | 0.9933564 |
| ENST00000542151 | ENST00000400191 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.001968222 | 0.9980318 |
| ENST00000542151 | ENST00000374632 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.00522511 | 0.9947748 |
| ENST00000542151 | ENST00000374627 | KDM1A | chr1 | 23357127 | - | EPHB2 | chr1 | 23208852 | + | 0.006058384 | 0.99394166 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >41698_41698_1_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208851_ENST00000374627_length(amino acids)=690AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEA EYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK -------------------------------------------------------------- >41698_41698_2_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208851_ENST00000374630_length(amino acids)=724AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_3_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208851_ENST00000374632_length(amino acids)=725AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK AMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQI -------------------------------------------------------------- >41698_41698_4_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208851_ENST00000400191_length(amino acids)=793AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_5_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208851_ENST00000544305_length(amino acids)=220AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM -------------------------------------------------------------- >41698_41698_6_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208852_ENST00000374627_length(amino acids)=690AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEA EYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK -------------------------------------------------------------- >41698_41698_7_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208852_ENST00000374630_length(amino acids)=724AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_8_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208852_ENST00000374632_length(amino acids)=725AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK AMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQI -------------------------------------------------------------- >41698_41698_9_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208852_ENST00000400191_length(amino acids)=793AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_10_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000356634_EPHB2_chr1_23208852_ENST00000544305_length(amino acids)=220AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM -------------------------------------------------------------- >41698_41698_11_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208851_ENST00000374627_length(amino acids)=690AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEA EYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK -------------------------------------------------------------- >41698_41698_12_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208851_ENST00000374630_length(amino acids)=724AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_13_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208851_ENST00000374632_length(amino acids)=725AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK AMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQI -------------------------------------------------------------- >41698_41698_14_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208851_ENST00000400191_length(amino acids)=793AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_15_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208851_ENST00000544305_length(amino acids)=220AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM -------------------------------------------------------------- >41698_41698_16_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208852_ENST00000374627_length(amino acids)=690AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEA EYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK -------------------------------------------------------------- >41698_41698_17_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208852_ENST00000374630_length(amino acids)=724AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_18_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208852_ENST00000374632_length(amino acids)=725AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK AMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQI -------------------------------------------------------------- >41698_41698_19_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208852_ENST00000400191_length(amino acids)=793AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_20_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000400181_EPHB2_chr1_23208852_ENST00000544305_length(amino acids)=220AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM -------------------------------------------------------------- >41698_41698_21_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208851_ENST00000374627_length(amino acids)=690AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEA EYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK -------------------------------------------------------------- >41698_41698_22_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208851_ENST00000374630_length(amino acids)=724AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_23_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208851_ENST00000374632_length(amino acids)=725AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK AMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQI -------------------------------------------------------------- >41698_41698_24_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208851_ENST00000400191_length(amino acids)=793AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_25_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208851_ENST00000544305_length(amino acids)=220AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM -------------------------------------------------------------- >41698_41698_26_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208852_ENST00000374627_length(amino acids)=690AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEA EYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK -------------------------------------------------------------- >41698_41698_27_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208852_ENST00000374630_length(amino acids)=724AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_28_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208852_ENST00000374632_length(amino acids)=725AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCV KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYR KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK AMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQI -------------------------------------------------------------- >41698_41698_29_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208852_ENST00000400191_length(amino acids)=793AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM HQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAE YQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVK IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQ -------------------------------------------------------------- >41698_41698_30_KDM1A-EPHB2_KDM1A_chr1_23357127_ENST00000542151_EPHB2_chr1_23208852_ENST00000544305_length(amino acids)=220AA_BP=172 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVV PGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSAPSAVSIM -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:23357127/chr1:23208851) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KDM1A | EPHB2 |
| FUNCTION: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16140033, PubMed:16079794, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412}. | FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 110_151 | 172.33333333333334 | 853.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 110_151 | 172.33333333333334 | 877.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 110_151 | 172.33333333333334 | 853.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 110_151 | 172.33333333333334 | 877.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 152_156 | 172.33333333333334 | 853.0 | Compositional bias | Note=Poly-Pro |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 7_42 | 172.33333333333334 | 853.0 | Compositional bias | Note=Ala-rich |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 152_156 | 172.33333333333334 | 877.0 | Compositional bias | Note=Poly-Pro |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 7_42 | 172.33333333333334 | 877.0 | Compositional bias | Note=Ala-rich |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 152_156 | 172.33333333333334 | 853.0 | Compositional bias | Note=Poly-Pro |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 7_42 | 172.33333333333334 | 853.0 | Compositional bias | Note=Ala-rich |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 152_156 | 172.33333333333334 | 877.0 | Compositional bias | Note=Poly-Pro |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 7_42 | 172.33333333333334 | 877.0 | Compositional bias | Note=Ala-rich |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 435_530 | 434.3333333333333 | 987.0 | Domain | Fibronectin type-III 2 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 621_884 | 434.3333333333333 | 987.0 | Domain | Protein kinase | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 913_977 | 434.3333333333333 | 987.0 | Domain | SAM | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 435_530 | 434.3333333333333 | 988.0 | Domain | Fibronectin type-III 2 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 621_884 | 434.3333333333333 | 988.0 | Domain | Protein kinase | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 913_977 | 434.3333333333333 | 988.0 | Domain | SAM | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 435_530 | 434.3333333333333 | 1056.0 | Domain | Fibronectin type-III 2 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 621_884 | 434.3333333333333 | 1056.0 | Domain | Protein kinase | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 913_977 | 434.3333333333333 | 1056.0 | Domain | SAM | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 435_530 | 434.3333333333333 | 987.0 | Domain | Fibronectin type-III 2 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 621_884 | 434.3333333333333 | 987.0 | Domain | Protein kinase | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 913_977 | 434.3333333333333 | 987.0 | Domain | SAM | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 435_530 | 434.3333333333333 | 988.0 | Domain | Fibronectin type-III 2 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 621_884 | 434.3333333333333 | 988.0 | Domain | Protein kinase | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 913_977 | 434.3333333333333 | 988.0 | Domain | SAM | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 435_530 | 434.3333333333333 | 1056.0 | Domain | Fibronectin type-III 2 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 621_884 | 434.3333333333333 | 1056.0 | Domain | Protein kinase | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 913_977 | 434.3333333333333 | 1056.0 | Domain | SAM | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 984_986 | 434.3333333333333 | 987.0 | Motif | PDZ-binding (in isoform 2) | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 984_986 | 434.3333333333333 | 988.0 | Motif | PDZ-binding (in isoform 2) | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 984_986 | 434.3333333333333 | 1056.0 | Motif | PDZ-binding (in isoform 2) | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 984_986 | 434.3333333333333 | 987.0 | Motif | PDZ-binding (in isoform 2) | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 984_986 | 434.3333333333333 | 988.0 | Motif | PDZ-binding (in isoform 2) | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 984_986 | 434.3333333333333 | 1056.0 | Motif | PDZ-binding (in isoform 2) | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 627_635 | 434.3333333333333 | 987.0 | Nucleotide binding | ATP | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 627_635 | 434.3333333333333 | 988.0 | Nucleotide binding | ATP | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 627_635 | 434.3333333333333 | 1056.0 | Nucleotide binding | ATP | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 627_635 | 434.3333333333333 | 987.0 | Nucleotide binding | ATP | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 627_635 | 434.3333333333333 | 988.0 | Nucleotide binding | ATP | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 627_635 | 434.3333333333333 | 1056.0 | Nucleotide binding | ATP | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 565_1055 | 434.3333333333333 | 987.0 | Topological domain | Cytoplasmic | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 565_1055 | 434.3333333333333 | 988.0 | Topological domain | Cytoplasmic | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 565_1055 | 434.3333333333333 | 1056.0 | Topological domain | Cytoplasmic | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 565_1055 | 434.3333333333333 | 987.0 | Topological domain | Cytoplasmic | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 565_1055 | 434.3333333333333 | 988.0 | Topological domain | Cytoplasmic | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 565_1055 | 434.3333333333333 | 1056.0 | Topological domain | Cytoplasmic | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 544_564 | 434.3333333333333 | 987.0 | Transmembrane | Helical | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 544_564 | 434.3333333333333 | 988.0 | Transmembrane | Helical | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 544_564 | 434.3333333333333 | 1056.0 | Transmembrane | Helical | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 544_564 | 434.3333333333333 | 987.0 | Transmembrane | Helical | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 544_564 | 434.3333333333333 | 988.0 | Transmembrane | Helical | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 544_564 | 434.3333333333333 | 1056.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 428_514 | 172.33333333333334 | 853.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 428_514 | 172.33333333333334 | 877.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 428_514 | 172.33333333333334 | 853.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 428_514 | 172.33333333333334 | 877.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 174_273 | 172.33333333333334 | 853.0 | Domain | SWIRM |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 174_273 | 172.33333333333334 | 877.0 | Domain | SWIRM |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 174_273 | 172.33333333333334 | 853.0 | Domain | SWIRM |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 174_273 | 172.33333333333334 | 877.0 | Domain | SWIRM |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 332_333 | 172.33333333333334 | 853.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 810_811 | 172.33333333333334 | 853.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 332_333 | 172.33333333333334 | 877.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 810_811 | 172.33333333333334 | 877.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 332_333 | 172.33333333333334 | 853.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 810_811 | 172.33333333333334 | 853.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 332_333 | 172.33333333333334 | 877.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 810_811 | 172.33333333333334 | 877.0 | Nucleotide binding | FAD |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000356634 | + | 2 | 19 | 300_852 | 172.33333333333334 | 853.0 | Region | Note=Demethylase activity |
| Hgene | KDM1A | chr1:23357127 | chr1:23208851 | ENST00000400181 | + | 2 | 21 | 300_852 | 172.33333333333334 | 877.0 | Region | Note=Demethylase activity |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000356634 | - | 2 | 19 | 300_852 | 172.33333333333334 | 853.0 | Region | Note=Demethylase activity |
| Hgene | KDM1A | chr1:23357127 | chr1:23208852 | ENST00000400181 | - | 2 | 21 | 300_852 | 172.33333333333334 | 877.0 | Region | Note=Demethylase activity |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 184_324 | 434.3333333333333 | 987.0 | Compositional bias | Note=Cys-rich | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 184_324 | 434.3333333333333 | 988.0 | Compositional bias | Note=Cys-rich | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 184_324 | 434.3333333333333 | 1056.0 | Compositional bias | Note=Cys-rich | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 184_324 | 434.3333333333333 | 987.0 | Compositional bias | Note=Cys-rich | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 184_324 | 434.3333333333333 | 988.0 | Compositional bias | Note=Cys-rich | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 184_324 | 434.3333333333333 | 1056.0 | Compositional bias | Note=Cys-rich | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 20_202 | 434.3333333333333 | 987.0 | Domain | Eph LBD | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 324_434 | 434.3333333333333 | 987.0 | Domain | Fibronectin type-III 1 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 20_202 | 434.3333333333333 | 988.0 | Domain | Eph LBD | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 324_434 | 434.3333333333333 | 988.0 | Domain | Fibronectin type-III 1 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 20_202 | 434.3333333333333 | 1056.0 | Domain | Eph LBD | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 324_434 | 434.3333333333333 | 1056.0 | Domain | Fibronectin type-III 1 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 20_202 | 434.3333333333333 | 987.0 | Domain | Eph LBD | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 324_434 | 434.3333333333333 | 987.0 | Domain | Fibronectin type-III 1 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 20_202 | 434.3333333333333 | 988.0 | Domain | Eph LBD | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 324_434 | 434.3333333333333 | 988.0 | Domain | Fibronectin type-III 1 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 20_202 | 434.3333333333333 | 1056.0 | Domain | Eph LBD | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 324_434 | 434.3333333333333 | 1056.0 | Domain | Fibronectin type-III 1 | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374630 | 4 | 16 | 19_543 | 434.3333333333333 | 987.0 | Topological domain | Extracellular | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000374632 | 4 | 16 | 19_543 | 434.3333333333333 | 988.0 | Topological domain | Extracellular | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208851 | ENST00000400191 | 4 | 17 | 19_543 | 434.3333333333333 | 1056.0 | Topological domain | Extracellular | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374630 | 4 | 16 | 19_543 | 434.3333333333333 | 987.0 | Topological domain | Extracellular | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000374632 | 4 | 16 | 19_543 | 434.3333333333333 | 988.0 | Topological domain | Extracellular | |
| Tgene | EPHB2 | chr1:23357127 | chr1:23208852 | ENST00000400191 | 4 | 17 | 19_543 | 434.3333333333333 | 1056.0 | Topological domain | Extracellular |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| KDM1A | |
| EPHB2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to KDM1A-EPHB2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to KDM1A-EPHB2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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