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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM2B-BCAS3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM2B-BCAS3
FusionPDB ID: 41744
FusionGDB2.0 ID: 41744
HgeneTgene
Gene symbol

KDM2B

BCAS3

Gene ID

84678

54828

Gene namelysine demethylase 2BBCAS3 microtubule associated cell migration factor
SynonymsCXXC2|FBXL10|Fbl10|JHDM1B|PCCX2GAOB1|MAAB
Cytomap

12q24.31

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethybreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2020031320200313
UniProtAcc

Q8NHM5

Q9H6U6

Ensembl transtripts involved in fusion geneENST idsENST00000377069, ENST00000377071, 
ENST00000542973, ENST00000536437, 
ENST00000538046, ENST00000543852, 
ENST00000585812, ENST00000390652, 
ENST00000407086, ENST00000408905, 
ENST00000588462, ENST00000589222, 
ENST00000585744, ENST00000588874, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 11 X 9=128745 X 32 X 19=27360
# samples 1553
** MAII scorelog2(15/1287*10)=-3.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(53/27360*10)=-5.6899320603227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM2B [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM2B(121883077)-BCAS3(59469337), # samples:1
Anticipated loss of major functional domain due to fusion event.KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KDM2B-BCAS3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM2B

GO:0035518

histone H2A monoubiquitination

16943429

HgeneKDM2B

GO:0070544

histone H3-K36 demethylation

26237645

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check buttonFusion gene breakpoints across KDM2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BCAS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1917KDM2Bchr12

121883077

-BCAS3chr17

59469337

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377069KDM2Bchr12121883077-ENST00000585744BCAS3chr1759469337+256624173862449687
ENST00000377069KDM2Bchr12121883077-ENST00000588874BCAS3chr1759469337+327124173862449687
ENST00000542973KDM2Bchr12121883077-ENST00000589222BCAS3chr1759469337+14515966642221
ENST00000542973KDM2Bchr12121883077-ENST00000390652BCAS3chr1759469337+14585966642221
ENST00000377071KDM2Bchr12121883077-ENST00000585744BCAS3chr1759469337+23252176732208711
ENST00000377071KDM2Bchr12121883077-ENST00000588874BCAS3chr1759469337+30302176732208711

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377069ENST00000585744KDM2Bchr12121883077-BCAS3chr1759469337+0.0046570680.99534297
ENST00000377069ENST00000588874KDM2Bchr12121883077-BCAS3chr1759469337+0.0026990320.99730104
ENST00000542973ENST00000589222KDM2Bchr12121883077-BCAS3chr1759469337+0.598933460.40106654
ENST00000542973ENST00000390652KDM2Bchr12121883077-BCAS3chr1759469337+0.59786320.40213674
ENST00000377071ENST00000585744KDM2Bchr12121883077-BCAS3chr1759469337+0.0045368850.9954631
ENST00000377071ENST00000588874KDM2Bchr12121883077-BCAS3chr1759469337+0.0024776670.9975223

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41744_41744_1_KDM2B-BCAS3_KDM2B_chr12_121883077_ENST00000377069_BCAS3_chr17_59469337_ENST00000585744_length(amino acids)=687AA_BP=
MVNSPKKMEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGL
GIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWP
QHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVER
CQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEY
QRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLS
NESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAI
TGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAP

--------------------------------------------------------------

>41744_41744_2_KDM2B-BCAS3_KDM2B_chr12_121883077_ENST00000377069_BCAS3_chr17_59469337_ENST00000588874_length(amino acids)=687AA_BP=
MVNSPKKMEAEKDSGRRLRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGL
GIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWP
QHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVER
CQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEY
QRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLS
NESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAI
TGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAP

--------------------------------------------------------------

>41744_41744_3_KDM2B-BCAS3_KDM2B_chr12_121883077_ENST00000377071_BCAS3_chr17_59469337_ENST00000585744_length(amino acids)=711AA_BP=
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGK
DFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHN
LALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTP
SEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFC

--------------------------------------------------------------

>41744_41744_4_KDM2B-BCAS3_KDM2B_chr12_121883077_ENST00000377071_BCAS3_chr17_59469337_ENST00000588874_length(amino acids)=711AA_BP=
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGK
DFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHN
LALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTP
SEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFC

--------------------------------------------------------------

>41744_41744_5_KDM2B-BCAS3_KDM2B_chr12_121883077_ENST00000542973_BCAS3_chr17_59469337_ENST00000390652_length(amino acids)=221AA_BP=1
MVCCRWWSLSCYSESRCFPLAEVLKASRVDDFIADGALHEHEVKLAFLLFHRVFLPRLATHKAHGGVGQHWRDALPHDAALLHAPGAPEL
LHVLAEVALSALGPQAGLALAASRPAPPSSCRCPVGGQLHRGGRAQLPLGPTHSPVLWSLLWPSHHRDPSDGQTRVIICVLLQDVLHTLQ

--------------------------------------------------------------

>41744_41744_6_KDM2B-BCAS3_KDM2B_chr12_121883077_ENST00000542973_BCAS3_chr17_59469337_ENST00000589222_length(amino acids)=221AA_BP=1
MVCCRWWSLSCYSESRCFPLAEVLKASRVDDFIADGALHEHEVKLAFLLFHRVFLPRLATHKAHGGVGQHWRDALPHDAALLHAPGAPEL
LHVLAEVALSALGPQAGLALAASRPAPPSSCRCPVGGQLHRGGRAQLPLGPTHSPVLWSLLWPSHHRDPSDGQTRVIICVLLQDVLHTLQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121883077/chr17:59469337)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2B

Q8NHM5

BCAS3

Q9H6U6

FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.FUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-1423409_430670.01266.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-1423409_430701.01337.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-1423178_346670.01266.0DomainJmjC
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-1423178_346701.01337.0DomainJmjC
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-1423606_652670.01266.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-1423606_652701.01337.0Zinc fingerCXXC-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-1423943_971670.01266.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-1423943_971701.01337.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-414943_97169.0912.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231014_1056670.01266.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231014_1056701.01337.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141014_105669.0912.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-414409_43069.0912.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231059_1105670.01266.0DomainNote=F-box
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231059_1105701.01337.0DomainNote=F-box
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141059_110569.0912.0DomainNote=F-box
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-414178_34669.0912.0DomainJmjC
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231093_1120670.01266.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231133_1154670.01266.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231156_1182670.01266.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231222_1247670.01266.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231248_1277670.01266.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231278_1302670.01266.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-14231303_1336670.01266.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231093_1120701.01337.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231133_1154701.01337.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231156_1182701.01337.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231222_1247701.01337.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231248_1277701.01337.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231278_1302701.01337.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-14231303_1336701.01337.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141093_112069.0912.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141133_115469.0912.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141156_118269.0912.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141222_124769.0912.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141248_127769.0912.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141278_130269.0912.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-4141303_133669.0912.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377069-1423659_725670.01266.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000377071-1423659_725701.01337.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-414606_65269.0912.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121883077chr17:59469337ENST00000542973-414659_72569.0912.0Zinc fingerPHD-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM2B
BCAS3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KDM2B-BCAS3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM2B-BCAS3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource