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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM4B-AKAP8L

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM4B-AKAP8L
FusionPDB ID: 41792
FusionGDB2.0 ID: 41792
HgeneTgene
Gene symbol

KDM4B

AKAP8L

Gene ID

23030

26993

Gene namelysine demethylase 4BA-kinase anchoring protein 8 like
SynonymsJMJD2B|TDRD14BHA95|HAP95|NAKAP|NAKAP95
Cytomap

19p13.3

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14BA-kinase anchor protein 8-likeA kinase (PRKA) anchor protein 8-likeAKAP8-like proteinhelicase A-binding protein 95 kDahomologous to AKAP95 proteinneighbor of A-kinase anchoring protein 95neighbor of AKAP95testis tissue sperm-binding protein Li 90mP
Modification date2020031320200313
UniProtAcc

O94953

Q9ULX6

Ensembl transtripts involved in fusion geneENST idsENST00000159111, ENST00000536461, 
ENST00000381759, ENST00000592175, 
ENST00000595879, ENST00000397410, 
ENST00000595465, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score30 X 16 X 14=67209 X 7 X 8=504
# samples 3811
** MAII scorelog2(38/6720*10)=-4.14438990933518
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM4B [Title/Abstract] AND AKAP8L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM4B(5144913)-AKAP8L(15491423), # samples:4
Anticipated loss of major functional domain due to fusion event.KDM4B-AKAP8L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4B-AKAP8L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4B-AKAP8L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4B-AKAP8L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4B

GO:0033169

histone H3-K9 demethylation

21914792

HgeneKDM4B

GO:0070544

histone H3-K36 demethylation

21914792

TgeneAKAP8L

GO:0006397

mRNA processing

17594903

TgeneAKAP8L

GO:0010793

regulation of mRNA export from nucleus

11402034

TgeneAKAP8L

GO:0045944

positive regulation of transcription by RNA polymerase II

11884601


check buttonFusion gene breakpoints across KDM4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKAP8L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-4486-01AKDM4Bchr19

5144912

+AKAP8Lchr19

15491422

-
ChimerDB4LUADTCGA-49-4486-01AKDM4Bchr19

5144913

-AKAP8Lchr19

15491423

-
ChimerDB4LUADTCGA-49-4486-01AKDM4Bchr19

5144913

+AKAP8Lchr19

15491423

-
ChimerDB4LUADTCGA-49-4486KDM4Bchr19

5144913

+AKAP8Lchr19

15491423

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000159111KDM4Bchr195144913+ENST00000397410AKAP8Lchr1915491423-3718323921836431141
ENST00000159111KDM4Bchr195144913+ENST00000595465AKAP8Lchr1915491423-3716323921836431141
ENST00000536461KDM4Bchr195144913+ENST00000397410AKAP8Lchr1915491423-364231634035671175
ENST00000536461KDM4Bchr195144913+ENST00000595465AKAP8Lchr1915491423-364031634035671175
ENST00000159111KDM4Bchr195144912+ENST00000397410AKAP8Lchr1915491422-3718323921836431141
ENST00000159111KDM4Bchr195144912+ENST00000595465AKAP8Lchr1915491422-3716323921836431141
ENST00000536461KDM4Bchr195144912+ENST00000397410AKAP8Lchr1915491422-364231634035671175
ENST00000536461KDM4Bchr195144912+ENST00000595465AKAP8Lchr1915491422-364031634035671175

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000159111ENST00000397410KDM4Bchr195144913+AKAP8Lchr1915491423-0.003474890.9965251
ENST00000159111ENST00000595465KDM4Bchr195144913+AKAP8Lchr1915491423-0.0034804430.99651957
ENST00000536461ENST00000397410KDM4Bchr195144913+AKAP8Lchr1915491423-0.0030772560.9969227
ENST00000536461ENST00000595465KDM4Bchr195144913+AKAP8Lchr1915491423-0.0030834470.99691653
ENST00000159111ENST00000397410KDM4Bchr195144912+AKAP8Lchr1915491422-0.003474890.9965251
ENST00000159111ENST00000595465KDM4Bchr195144912+AKAP8Lchr1915491422-0.0034804430.99651957
ENST00000536461ENST00000397410KDM4Bchr195144912+AKAP8Lchr1915491422-0.0030772560.9969227
ENST00000536461ENST00000595465KDM4Bchr195144912+AKAP8Lchr1915491422-0.0030834470.99691653

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41792_41792_1_KDM4B-AKAP8L_KDM4B_chr19_5144912_ENST00000159111_AKAP8L_chr19_15491422_ENST00000397410_length(amino acids)=1141AA_BP=1006
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKA
KSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQE
ASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMT
TDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDG
NLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGV

--------------------------------------------------------------

>41792_41792_2_KDM4B-AKAP8L_KDM4B_chr19_5144912_ENST00000159111_AKAP8L_chr19_15491422_ENST00000595465_length(amino acids)=1141AA_BP=1006
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKA
KSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQE
ASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMT
TDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDG
NLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGV

--------------------------------------------------------------

>41792_41792_3_KDM4B-AKAP8L_KDM4B_chr19_5144912_ENST00000536461_AKAP8L_chr19_15491422_ENST00000397410_length(amino acids)=1175AA_BP=1040
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEV
DPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL
NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQA
PSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI
CTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRP
ELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC
IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGS
YSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTD
SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEG

--------------------------------------------------------------

>41792_41792_4_KDM4B-AKAP8L_KDM4B_chr19_5144912_ENST00000536461_AKAP8L_chr19_15491422_ENST00000595465_length(amino acids)=1175AA_BP=1040
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEV
DPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL
NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQA
PSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI
CTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRP
ELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC
IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGS
YSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTD
SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEG

--------------------------------------------------------------

>41792_41792_5_KDM4B-AKAP8L_KDM4B_chr19_5144913_ENST00000159111_AKAP8L_chr19_15491423_ENST00000397410_length(amino acids)=1141AA_BP=1006
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKA
KSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQE
ASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMT
TDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDG
NLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGV

--------------------------------------------------------------

>41792_41792_6_KDM4B-AKAP8L_KDM4B_chr19_5144913_ENST00000159111_AKAP8L_chr19_15491423_ENST00000595465_length(amino acids)=1141AA_BP=1006
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKA
KSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQE
ASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMT
TDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDG
NLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGV

--------------------------------------------------------------

>41792_41792_7_KDM4B-AKAP8L_KDM4B_chr19_5144913_ENST00000536461_AKAP8L_chr19_15491423_ENST00000397410_length(amino acids)=1175AA_BP=1040
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEV
DPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL
NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQA
PSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI
CTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRP
ELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC
IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGS
YSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTD
SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEG

--------------------------------------------------------------

>41792_41792_8_KDM4B-AKAP8L_KDM4B_chr19_5144913_ENST00000536461_AKAP8L_chr19_15491423_ENST00000595465_length(amino acids)=1175AA_BP=1040
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEV
DPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL
NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQA
PSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI
CTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRP
ELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC
IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGS
YSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTD
SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5144913/chr19:15491423)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4B

O94953

AKAP8L

Q9ULX6

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:12538639, ECO:0000269|PubMed:16980585, ECO:0000305|PubMed:10761695}.; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. {ECO:0000269|PubMed:11884601}.; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269|PubMed:11402034}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. {ECO:0000269|PubMed:25034436}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+2123463_5351007.01097.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+2123463_5351007.01097.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+2123146_3091007.01097.0DomainJmjC
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+212315_571007.01097.0DomainJmjN
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+2123917_9741007.01097.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+2123146_3091007.01097.0DomainJmjC
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+212315_571007.01097.0DomainJmjN
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+2123917_9741007.01097.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+2123731_7891007.01097.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+2123794_8271007.01097.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+2123850_9071007.01097.0Zinc fingerPHD-type 2
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+2123731_7891007.01097.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+2123794_8271007.01097.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+2123850_9071007.01097.0Zinc fingerPHD-type 2
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000003974101114589_597512.0647.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000003974101114602_608512.0647.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000005954651114589_597451.0586.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000005954651114602_608451.0586.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000003974101114589_597512.0647.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000003974101114602_608512.0647.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000005954651114589_597451.0586.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000005954651114602_608451.0586.0Compositional biasNote=Pro-rich
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000005954651114484_507451.0586.0Zinc fingerC2H2 AKAP95-type 2
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000005954651114484_507451.0586.0Zinc fingerC2H2 AKAP95-type 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+112463_5350449.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+112463_5350449.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000159111+2123975_10311007.01097.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+112146_3090449.0DomainJmjC
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+11215_570449.0DomainJmjN
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+112917_9740449.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+112975_10310449.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000159111+2123975_10311007.01097.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+112146_3090449.0DomainJmjC
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+11215_570449.0DomainJmjN
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+112917_9740449.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+112975_10310449.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+112731_7890449.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+112794_8270449.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5144912chr19:15491422ENST00000381759+112850_9070449.0Zinc fingerPHD-type 2
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+112731_7890449.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+112794_8270449.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5144913chr19:15491423ENST00000381759+112850_9070449.0Zinc fingerPHD-type 2
TgeneAKAP8Lchr19:5144912chr19:15491422ENST00000397410111441_52512.0647.0Compositional biasNote=Gly/Tyr-rich
TgeneAKAP8Lchr19:5144912chr19:15491422ENST00000595465111441_52451.0586.0Compositional biasNote=Gly/Tyr-rich
TgeneAKAP8Lchr19:5144913chr19:15491423ENST00000397410111441_52512.0647.0Compositional biasNote=Gly/Tyr-rich
TgeneAKAP8Lchr19:5144913chr19:15491423ENST00000595465111441_52451.0586.0Compositional biasNote=Gly/Tyr-rich
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000003974101114274_279512.0647.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000003974101114280_296512.0647.0MotifNuclear export signal (NES)
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000003974101114362_364512.0647.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000005954651114274_279451.0586.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000005954651114280_296451.0586.0MotifNuclear export signal (NES)
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000005954651114362_364451.0586.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000003974101114274_279512.0647.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000003974101114280_296512.0647.0MotifNuclear export signal (NES)
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000003974101114362_364512.0647.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000005954651114274_279451.0586.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000005954651114280_296451.0586.0MotifNuclear export signal (NES)
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000005954651114362_364451.0586.0MotifNuclear localization signal
TgeneAKAP8Lchr19:5144912chr19:15491422ENST0000039741011141_268512.0647.0RegionSufficient for activation of CTE-mediated expression
TgeneAKAP8Lchr19:5144912chr19:15491422ENST0000059546511141_268451.0586.0RegionSufficient for activation of CTE-mediated expression
TgeneAKAP8Lchr19:5144913chr19:15491423ENST0000039741011141_268512.0647.0RegionSufficient for activation of CTE-mediated expression
TgeneAKAP8Lchr19:5144913chr19:15491423ENST0000059546511141_268451.0586.0RegionSufficient for activation of CTE-mediated expression
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000003974101114391_413512.0647.0Zinc fingerC2H2 AKAP95-type 1
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000003974101114484_507512.0647.0Zinc fingerC2H2 AKAP95-type 2
TgeneAKAP8Lchr19:5144912chr19:15491422ENST000005954651114391_413451.0586.0Zinc fingerC2H2 AKAP95-type 1
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000003974101114391_413512.0647.0Zinc fingerC2H2 AKAP95-type 1
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000003974101114484_507512.0647.0Zinc fingerC2H2 AKAP95-type 2
TgeneAKAP8Lchr19:5144913chr19:15491423ENST000005954651114391_413451.0586.0Zinc fingerC2H2 AKAP95-type 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1912_KDM4B_5144913_AKAP8L_15491423_ranked_0.pdbKDM4B51449125144913ENST00000595465AKAP8Lchr1915491423-
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEV
DPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL
NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQA
PSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI
CTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRP
ELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC
IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGS
YSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTD
SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEG
1175


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KDM4B_pLDDT.png
all structure
all structure
AKAP8L_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM4B
AKAP8L


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KDM4B-AKAP8L


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM4B-AKAP8L


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource