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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM4C-GMPS

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM4C-GMPS
FusionPDB ID: 41830
FusionGDB2.0 ID: 41830
HgeneTgene
Gene symbol

KDM4C

GMPS

Gene ID

23081

8833

Gene namelysine demethylase 4Cguanine monophosphate synthase
SynonymsGASC1|JHDM3C|JMJD2C|TDRD14CGATD7
Cytomap

9p24.1

3q25.31

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14CGMP synthase [glutamine-hydrolyzing]GMP synthaseGMP synthetaseMLL/GMPS fusion proteinglutamine amidotransferaseguanine monophosphate synthetaseguanosine 5'-monophosphate synthasetesticular tissue protein Li 82
Modification date2020032920200313
UniProtAcc

Q9H3R0

P49915

Ensembl transtripts involved in fusion geneENST idsENST00000489243, ENST00000381306, 
ENST00000381309, ENST00000442236, 
ENST00000535193, ENST00000536108, 
ENST00000543771, ENST00000401787, 
ENST00000428870, 		ENST00000496455, 
ENST00000295920, ENST00000476145, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 15 X 12=39608 X 7 X 6=336
# samples 2211
** MAII scorelog2(22/3960*10)=-4.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM4C [Title/Abstract] AND GMPS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM4C(6893232)-GMPS(155611306), # samples:1
Anticipated loss of major functional domain due to fusion event.KDM4C-GMPS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4C-GMPS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4C-GMPS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4C-GMPS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

HgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

HgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792

TgeneGMPS

GO:0006177

GMP biosynthetic process

8089153


check buttonFusion gene breakpoints across KDM4C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GMPS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1403KDM4Cchr9

6893232

+GMPSchr3

155611306

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535193KDM4Cchr96893232+ENST00000496455GMPSchr3155611306+946210738331271014
ENST00000543771KDM4Cchr96893232+ENST00000496455GMPSchr3155611306+9890150144835551035
ENST00000381306KDM4Cchr96893232+ENST00000496455GMPSchr3155611306+9875148643335401035
ENST00000381309KDM4Cchr96893232+ENST00000496455GMPSchr3155611306+9875148643335401035
ENST00000442236KDM4Cchr96893232+ENST00000496455GMPSchr3155611306+92878982502952900
ENST00000536108KDM4Cchr96893232+ENST00000496455GMPSchr3155611306+92989094622963833

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535193ENST00000496455KDM4Cchr96893232+GMPSchr3155611306+7.46E-050.9999254
ENST00000543771ENST00000496455KDM4Cchr96893232+GMPSchr3155611306+0.0001200430.99987996
ENST00000381306ENST00000496455KDM4Cchr96893232+GMPSchr3155611306+0.0001186560.9998814
ENST00000381309ENST00000496455KDM4Cchr96893232+GMPSchr3155611306+0.0001186560.9998814
ENST00000442236ENST00000496455KDM4Cchr96893232+GMPSchr3155611306+0.0001241510.9998758
ENST00000536108ENST00000496455KDM4Cchr96893232+GMPSchr3155611306+0.000131980.99986804

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41830_41830_1_KDM4C-GMPS_KDM4C_chr9_6893232_ENST00000381306_GMPS_chr3_155611306_ENST00000496455_length(amino acids)=1035AA_BP=351
MSPSAEQVSQISQISLGRRPLSSLPPPPSRALAPTRAPDTALTIMEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGL
AKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGA
DINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQ
GFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLLENAGGDLK
DGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQ
MMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTEN
GKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALK
KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESAS
LVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKI
VADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVN
RVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTG

--------------------------------------------------------------

>41830_41830_2_KDM4C-GMPS_KDM4C_chr9_6893232_ENST00000381309_GMPS_chr3_155611306_ENST00000496455_length(amino acids)=1035AA_BP=351
MSPSAEQVSQISQISLGRRPLSSLPPPPSRALAPTRAPDTALTIMEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGL
AKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGA
DINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQ
GFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLLENAGGDLK
DGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQ
MMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTEN
GKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALK
KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESAS
LVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKI
VADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVN
RVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTG

--------------------------------------------------------------

>41830_41830_3_KDM4C-GMPS_KDM4C_chr9_6893232_ENST00000442236_GMPS_chr3_155611306_ENST00000496455_length(amino acids)=900AA_BP=216
MHTWSLKEPIVRVLQRYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFA
IKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTH
GDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLL
SGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSP
EEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILG
RELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLP
IKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESG
YAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

--------------------------------------------------------------

>41830_41830_4_KDM4C-GMPS_KDM4C_chr9_6893232_ENST00000535193_GMPS_chr3_155611306_ENST00000496455_length(amino acids)=1014AA_BP=330
MMKHYGLPWKRTEEAAADTALTIMEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNL
LIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNT
VLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLI
SPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLLENAGGDLKDGHHHYEGAVVILDAGAQYGK
VIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVF
NISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTV
QNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTT
LPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIR
KLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKAC
TTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTF
LTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEI

--------------------------------------------------------------

>41830_41830_5_KDM4C-GMPS_KDM4C_chr9_6893232_ENST00000536108_GMPS_chr3_155611306_ENST00000496455_length(amino acids)=833AA_BP=149
MDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLIS
PSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLLENAGGDLKDGHHHYEGAVVILDAGAQYGKV
IDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFN
ISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQ
NRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTL
PISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRK
LREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACT
TEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFL
TTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIK

--------------------------------------------------------------

>41830_41830_6_KDM4C-GMPS_KDM4C_chr9_6893232_ENST00000543771_GMPS_chr3_155611306_ENST00000496455_length(amino acids)=1035AA_BP=351
MSPSAEQVSQISQISLGRRPLSSLPPPPSRALAPTRAPDTALTIMEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGL
AKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGA
DINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQ
GFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLLENAGGDLK
DGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQ
MMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTEN
GKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALK
KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESAS
LVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKI
VADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVN
RVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:6893232/chr3:155611306)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4C

Q9H3R0

GMPS

P49915

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381306+821144_310307.01048.0DomainJmjC
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381306+82116_58307.01048.0DomainJmjN
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381309+822144_310307.01057.0DomainJmjC
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381309+82216_58307.01057.0DomainJmjN
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000535193+818144_310329.0836.0DomainJmjC
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000535193+81816_58329.0836.0DomainJmjN
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000543771+818144_310307.0814.0DomainJmjC
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000543771+81816_58307.0814.0DomainJmjN
TgeneGMPSchr9:6893232chr3:155611306ENST00000496455016217_4359.0694.0DomainGMPS ATP-PPase
TgeneGMPSchr9:6893232chr3:155611306ENST0000049645501627_2169.0694.0DomainGlutamine amidotransferase type-1
TgeneGMPSchr9:6893232chr3:155611306ENST00000496455016244_2509.0694.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381306+821877_934307.01048.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381306+821935_991307.01048.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381309+822877_934307.01057.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381309+822935_991307.01057.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000535193+818877_934329.0836.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000535193+818935_991329.0836.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000543771+818877_934307.0814.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000543771+818935_991307.0814.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381306+821689_747307.01048.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381306+821752_785307.01048.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381306+821808_865307.01048.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381309+822689_747307.01057.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381309+822752_785307.01057.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000381309+822808_865307.01057.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000535193+818689_747329.0836.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000535193+818752_785329.0836.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000535193+818808_865329.0836.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000543771+818689_747307.0814.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000543771+818752_785307.0814.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6893232chr3:155611306ENST00000543771+818808_865307.0814.0Zinc fingerPHD-type 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM4C
GMPSall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KDM4C-GMPS


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM4C-GMPS


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource