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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KDM5A-ANO2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KDM5A-ANO2
	FusionPDB ID: 41850
	FusionGDB2.0 ID: 41850
		Hgene	Tgene
	Gene symbol	KDM5A	ANO2
	Gene ID	5927	57101
	Gene name	lysine demethylase 5A	anoctamin 2
	Synonyms	RBBP-2\|RBBP2\|RBP2	C12orf3\|TMEM16B
	Cytomap	12p13.33	12p13.31
	Type of gene	protein-coding	protein-coding
	Description	lysine-specific demethylase 5AJumonji, AT rich interactive domain 1A (RBP2-like)histone demethylase JARID1Ajumonji/ARID domain-containing protein 1Alysine (K)-specific demethylase 5Aretinoblastoma binding protein 2	anoctamin-2anoctamin 2, calcium activated chloride channeltransmembrane protein 16B (eight membrane-spanning domains)
	Modification date	20200313	20200329
	UniProtAcc	P29375	Q9NQ90
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000382815, ENST00000399788, ENST00000540838,	ENST00000538154, ENST00000327087, ENST00000356134, ENST00000546188,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 15 X 6=990	12 X 11 X 8=1056
	# samples	18	15
	** MAII score	log2(18/990*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1056*10)=-2.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KDM5A [Title/Abstract] AND ANO2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KDM5A(427272)-ANO2(5708795), # samples:3
Anticipated loss of major functional domain due to fusion event.	KDM5A-ANO2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5A-ANO2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5A-ANO2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5A-ANO2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KDM5A	GO:0034720	histone H3-K4 demethylation	18270511
Hgene	KDM5A	GO:0045893	positive regulation of transcription, DNA-templated	11358960

Fusion gene breakpoints across KDM5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A1-A0SK-01A	KDM5A	chr12	427272	-	ANO2	chr12	5708795	-
ChimerDB4	BRCA	TCGA-A1-A0SK	KDM5A	chr12	427271	-	ANO2	chr12	5708795	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000399788	KDM5A	chr12	427272	-	ENST00000327087	ANO2	chr12	5708795	-	4818	3260	363	4169	1268
ENST00000399788	KDM5A	chr12	427272	-	ENST00000546188	ANO2	chr12	5708795	-	4815	3260	363	4169	1268
ENST00000399788	KDM5A	chr12	427272	-	ENST00000356134	ANO2	chr12	5708795	-	4815	3260	363	4169	1268
ENST00000382815	KDM5A	chr12	427272	-	ENST00000327087	ANO2	chr12	5708795	-	4818	3260	363	4169	1268
ENST00000382815	KDM5A	chr12	427272	-	ENST00000546188	ANO2	chr12	5708795	-	4815	3260	363	4169	1268
ENST00000382815	KDM5A	chr12	427272	-	ENST00000356134	ANO2	chr12	5708795	-	4815	3260	363	4169	1268
ENST00000399788	KDM5A	chr12	427271	-	ENST00000327087	ANO2	chr12	5708795	-	4818	3260	363	4169	1268
ENST00000399788	KDM5A	chr12	427271	-	ENST00000546188	ANO2	chr12	5708795	-	4815	3260	363	4169	1268
ENST00000399788	KDM5A	chr12	427271	-	ENST00000356134	ANO2	chr12	5708795	-	4815	3260	363	4169	1268
ENST00000382815	KDM5A	chr12	427271	-	ENST00000327087	ANO2	chr12	5708795	-	4818	3260	363	4169	1268
ENST00000382815	KDM5A	chr12	427271	-	ENST00000546188	ANO2	chr12	5708795	-	4815	3260	363	4169	1268
ENST00000382815	KDM5A	chr12	427271	-	ENST00000356134	ANO2	chr12	5708795	-	4815	3260	363	4169	1268

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399788	ENST00000327087	KDM5A	chr12	427272	-	ANO2	chr12	5708795	-	0.00064024	0.9993598
ENST00000399788	ENST00000546188	KDM5A	chr12	427272	-	ANO2	chr12	5708795	-	0.000634851	0.99936515
ENST00000399788	ENST00000356134	KDM5A	chr12	427272	-	ANO2	chr12	5708795	-	0.000634851	0.99936515
ENST00000382815	ENST00000327087	KDM5A	chr12	427272	-	ANO2	chr12	5708795	-	0.00064024	0.9993598
ENST00000382815	ENST00000546188	KDM5A	chr12	427272	-	ANO2	chr12	5708795	-	0.000634851	0.99936515
ENST00000382815	ENST00000356134	KDM5A	chr12	427272	-	ANO2	chr12	5708795	-	0.000634851	0.99936515
ENST00000399788	ENST00000327087	KDM5A	chr12	427271	-	ANO2	chr12	5708795	-	0.00064024	0.9993598
ENST00000399788	ENST00000546188	KDM5A	chr12	427271	-	ANO2	chr12	5708795	-	0.000634851	0.99936515
ENST00000399788	ENST00000356134	KDM5A	chr12	427271	-	ANO2	chr12	5708795	-	0.000634851	0.99936515
ENST00000382815	ENST00000327087	KDM5A	chr12	427271	-	ANO2	chr12	5708795	-	0.00064024	0.9993598
ENST00000382815	ENST00000546188	KDM5A	chr12	427271	-	ANO2	chr12	5708795	-	0.000634851	0.99936515
ENST00000382815	ENST00000356134	KDM5A	chr12	427271	-	ANO2	chr12	5708795	-	0.000634851	0.99936515

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41850_41850_1_KDM5A-ANO2_KDM5A_chr12_427271_ENST00000382815_ANO2_chr12_5708795_ENST00000327087_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_2_KDM5A-ANO2_KDM5A_chr12_427271_ENST00000382815_ANO2_chr12_5708795_ENST00000356134_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_3_KDM5A-ANO2_KDM5A_chr12_427271_ENST00000382815_ANO2_chr12_5708795_ENST00000546188_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_4_KDM5A-ANO2_KDM5A_chr12_427271_ENST00000399788_ANO2_chr12_5708795_ENST00000327087_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_5_KDM5A-ANO2_KDM5A_chr12_427271_ENST00000399788_ANO2_chr12_5708795_ENST00000356134_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_6_KDM5A-ANO2_KDM5A_chr12_427271_ENST00000399788_ANO2_chr12_5708795_ENST00000546188_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_7_KDM5A-ANO2_KDM5A_chr12_427272_ENST00000382815_ANO2_chr12_5708795_ENST00000327087_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_8_KDM5A-ANO2_KDM5A_chr12_427272_ENST00000382815_ANO2_chr12_5708795_ENST00000356134_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_9_KDM5A-ANO2_KDM5A_chr12_427272_ENST00000382815_ANO2_chr12_5708795_ENST00000546188_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_10_KDM5A-ANO2_KDM5A_chr12_427272_ENST00000399788_ANO2_chr12_5708795_ENST00000327087_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_11_KDM5A-ANO2_KDM5A_chr12_427272_ENST00000399788_ANO2_chr12_5708795_ENST00000356134_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

>41850_41850_12_KDM5A-ANO2_KDM5A_chr12_427272_ENST00000399788_ANO2_chr12_5708795_ENST00000546188_length(amino acids)=1268AA_BP=965
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDF
LDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTN
RSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQ
SPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARKLKKLFRKLKDETEAGETDSAHSK
HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSV
ISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:427272/chr12:5708795)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KDM5A P29375	ANO2 Q9NQ90
FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250\|UniProtKB:Q3UXZ9, ECO:0000269\|PubMed:11358960, ECO:0000269\|PubMed:15949438, ECO:0000269\|PubMed:17320160, ECO:0000269\|PubMed:17320161, ECO:0000269\|PubMed:17320163, ECO:0000269\|PubMed:18270511, ECO:0000269\|PubMed:19430464, ECO:0000269\|PubMed:27427228}.	FUNCTION: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269\|PubMed:19474308, ECO:0000269\|PubMed:20056604, ECO:0000269\|PubMed:21890523, ECO:0000269\|PubMed:21984732}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

19_60

965.6666666666666

1691.0

Domain

JmjN

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

437_603

965.6666666666666

1691.0

Domain

JmjC

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

84_174

965.6666666666666

1691.0

Domain

ARID

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

19_60

965.6666666666666

1691.0

Domain

JmjN

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

437_603

965.6666666666666

1691.0

Domain

JmjC

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

84_174

965.6666666666666

1691.0

Domain

ARID

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

419_423

965.6666666666666

1691.0

Motif

GSGFP motif

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

419_423

965.6666666666666

1691.0

Motif

GSGFP motif

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

293_343

965.6666666666666

1691.0

Zinc finger

PHD-type 1

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

676_728

965.6666666666666

1691.0

Zinc finger

C5HC2

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

293_343

965.6666666666666

1691.0

Zinc finger

PHD-type 1

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

676_728

965.6666666666666

1691.0

Zinc finger

C5HC2

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

1001_1003

695.6666666666666

999.0

Motif

Note=DLG4 binding (PDZ)

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

1001_1003

696.6666666666666

1000.0

Motif

Note=DLG4 binding (PDZ)

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

1001_1003

695.6666666666666

999.0

Motif

Note=DLG4 binding (PDZ)

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

1001_1003

696.6666666666666

1000.0

Motif

Note=DLG4 binding (PDZ)

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

770_801

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

823_907

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

929_1003

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

770_801

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

823_907

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

929_1003

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

770_801

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

823_907

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

929_1003

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

770_801

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

823_907

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

929_1003

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

749_769

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

802_822

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

908_928

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

749_769

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

802_822

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

908_928

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

749_769

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

802_822

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

908_928

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

749_769

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

802_822

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

908_928

696.6666666666666

1000.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

1492_1587

965.6666666666666

1691.0

Compositional bias

Note=Lys-rich

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

1492_1587

965.6666666666666

1691.0

Compositional bias

Note=Lys-rich

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

1161_1218

965.6666666666666

1691.0

Zinc finger

PHD-type 2

Hgene

KDM5A

chr12:427271

chr12:5708795

ENST00000399788

1607_1661

965.6666666666666

1691.0

Zinc finger

PHD-type 3

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

1161_1218

965.6666666666666

1691.0

Zinc finger

PHD-type 2

Hgene

KDM5A

chr12:427272

chr12:5708795

ENST00000399788

1607_1661

965.6666666666666

1691.0

Zinc finger

PHD-type 3

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

1_365

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

387_434

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

456_538

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

560_582

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

604_623

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

645_748

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

1_365

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

387_434

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

456_538

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

560_582

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

604_623

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

645_748

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

1_365

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

387_434

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

456_538

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

560_582

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

604_623

695.6666666666666

999.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

645_748

695.6666666666666

999.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

1_365

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

387_434

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

456_538

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

560_582

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

604_623

696.6666666666666

1000.0

Topological domain

Cytoplasmic

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

645_748

696.6666666666666

1000.0

Topological domain

Extracellular

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

366_386

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

435_455

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

539_559

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

583_603

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000327087

624_644

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

366_386

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

435_455

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

539_559

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

583_603

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427271

chr12:5708795

ENST00000356134

624_644

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

366_386

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

435_455

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

539_559

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

583_603

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000327087

624_644

695.6666666666666

999.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

366_386

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

435_455

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

539_559

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

583_603

696.6666666666666

1000.0

Transmembrane

Helical

Tgene

ANO2

chr12:427272

chr12:5708795

ENST00000356134

624_644

696.6666666666666

1000.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KDM5A
ANO2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to KDM5A-ANO2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to KDM5A-ANO2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source