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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM5B-PPP1R12B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM5B-PPP1R12B
FusionPDB ID: 41865
FusionGDB2.0 ID: 41865
HgeneTgene
Gene symbol

KDM5B

PPP1R12B

Gene ID

10765

4660

Gene namelysine demethylase 5Bprotein phosphatase 1 regulatory subunit 12B
SynonymsCT31|JARID1B|MRT65|PLU-1|PLU1|PPP1R98|PUT1|RBBP2H1A|RBP2-H1MYPT2|PP1bp55
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 5Bcancer/testis antigen 31histone demethylase JARID1Bjumonji, AT rich interactive domain 1Bjumonji/ARID domain-containing protein 1Blysine (K)-specific demethylase 5Bprotein phosphatase 1, regulatory subunit 98putative Dprotein phosphatase 1 regulatory subunit 12Bmyosin phosphatase target subunit 2myosin phosphatase-targeting subunit 2protein phosphatase 1, regulatory (inhibitor) subunit 12B
Modification date2020032020200313
UniProtAcc

Q9UGL1

.
Ensembl transtripts involved in fusion geneENST idsENST00000367264, ENST00000367265, 
ENST00000456180, 		ENST00000290419, 
ENST00000367270, ENST00000391959, 
ENST00000356764, ENST00000480184, 
ENST00000336894, ENST00000608999, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 13 X 9=163814 X 15 X 6=1260
# samples 1716
** MAII scorelog2(17/1638*10)=-3.26832870550331
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM5B [Title/Abstract] AND PPP1R12B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM5B(202742246)-PPP1R12B(202536906), # samples:2
Anticipated loss of major functional domain due to fusion event.KDM5B-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM5B-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM5B-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM5B-PPP1R12B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM5B

GO:0034720

histone H3-K4 demethylation

20228790


check buttonFusion gene breakpoints across KDM5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP1R12B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-5965-02BKDM5Bchr1

202743741

-PPP1R12Bchr1

202385915

+
ChimerDB4LGGTCGA-FG-5965KDM5Bchr1

202743740

-PPP1R12Bchr1

202385914

+
ChimerDB4SARCTCGA-DX-A8BV-01AKDM5Bchr1

202742246

-PPP1R12Bchr1

202536906

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367265KDM5Bchr1202742246-ENST00000608999PPP1R12Bchr1202536906+1407917419341932332
ENST00000367265KDM5Bchr1202742246-ENST00000336894PPP1R12Bchr1202536906+994217419341932332
ENST00000367264KDM5Bchr1202742246-ENST00000608999PPP1R12Bchr1202536906+13027689113880255
ENST00000367264KDM5Bchr1202742246-ENST00000336894PPP1R12Bchr1202536906+8890689113880255
ENST00000367265KDM5Bchr1202743740-ENST00000608999PPP1R12Bchr1202385914+16374157093442271097
ENST00000367265KDM5Bchr1202743740-ENST00000336894PPP1R12Bchr1202385914+12237157093442271097
ENST00000367265KDM5Bchr1202743740-ENST00000480184PPP1R12Bchr1202385914+295515709342826630
ENST00000367265KDM5Bchr1202743740-ENST00000356764PPP1R12Bchr1202385914+284215709342439501
ENST00000367264KDM5Bchr1202743740-ENST00000608999PPP1R12Bchr1202385914+1532251811331751020
ENST00000367264KDM5Bchr1202743740-ENST00000336894PPP1R12Bchr1202385914+1118551811331751020
ENST00000367264KDM5Bchr1202743740-ENST00000480184PPP1R12Bchr1202385914+19035181131774553
ENST00000367264KDM5Bchr1202743740-ENST00000356764PPP1R12Bchr1202385914+17905181131387424
ENST00000367265KDM5Bchr1202743741-ENST00000608999PPP1R12Bchr1202385915+16374157093442271097
ENST00000367265KDM5Bchr1202743741-ENST00000336894PPP1R12Bchr1202385915+12237157093442271097
ENST00000367265KDM5Bchr1202743741-ENST00000480184PPP1R12Bchr1202385915+295515709342826630
ENST00000367265KDM5Bchr1202743741-ENST00000356764PPP1R12Bchr1202385915+284215709342439501
ENST00000367264KDM5Bchr1202743741-ENST00000608999PPP1R12Bchr1202385915+1532251811331751020
ENST00000367264KDM5Bchr1202743741-ENST00000336894PPP1R12Bchr1202385915+1118551811331751020
ENST00000367264KDM5Bchr1202743741-ENST00000480184PPP1R12Bchr1202385915+19035181131774553
ENST00000367264KDM5Bchr1202743741-ENST00000356764PPP1R12Bchr1202385915+17905181131387424

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367265ENST00000608999KDM5Bchr1202742246-PPP1R12Bchr1202536906+0.0258010140.97419894
ENST00000367265ENST00000336894KDM5Bchr1202742246-PPP1R12Bchr1202536906+0.0169863780.98301363
ENST00000367264ENST00000608999KDM5Bchr1202742246-PPP1R12Bchr1202536906+0.0029097060.9970902
ENST00000367264ENST00000336894KDM5Bchr1202742246-PPP1R12Bchr1202536906+0.0022515730.99774843
ENST00000367265ENST00000608999KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.0011916810.9988084
ENST00000367265ENST00000336894KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.0009931510.9990069
ENST00000367265ENST00000480184KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.0033930660.99660695
ENST00000367265ENST00000356764KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.002141050.99785894
ENST00000367264ENST00000608999KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.000533450.9994666
ENST00000367264ENST00000336894KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.0004430360.99955696
ENST00000367264ENST00000480184KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.0037251990.9962748
ENST00000367264ENST00000356764KDM5Bchr1202743740-PPP1R12Bchr1202385914+0.0014728180.99852717
ENST00000367265ENST00000608999KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.0011916810.9988084
ENST00000367265ENST00000336894KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.0009931510.9990069
ENST00000367265ENST00000480184KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.0033930660.99660695
ENST00000367265ENST00000356764KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.002141050.99785894
ENST00000367264ENST00000608999KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.000533450.9994666
ENST00000367264ENST00000336894KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.0004430360.99955696
ENST00000367264ENST00000480184KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.0037251990.9962748
ENST00000367264ENST00000356764KDM5Bchr1202743741-PPP1R12Bchr1202385915+0.0014728180.99852717

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41865_41865_1_KDM5B-PPP1R12B_KDM5B_chr1_202742246_ENST00000367264_PPP1R12B_chr1_202536906_ENST00000336894_length(amino acids)=255AA_BP=186
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN

--------------------------------------------------------------

>41865_41865_2_KDM5B-PPP1R12B_KDM5B_chr1_202742246_ENST00000367264_PPP1R12B_chr1_202536906_ENST00000608999_length(amino acids)=255AA_BP=186
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN

--------------------------------------------------------------

>41865_41865_3_KDM5B-PPP1R12B_KDM5B_chr1_202742246_ENST00000367265_PPP1R12B_chr1_202536906_ENST00000336894_length(amino acids)=332AA_BP=263
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRQ

--------------------------------------------------------------

>41865_41865_4_KDM5B-PPP1R12B_KDM5B_chr1_202742246_ENST00000367265_PPP1R12B_chr1_202536906_ENST00000608999_length(amino acids)=332AA_BP=263
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRQ

--------------------------------------------------------------

>41865_41865_5_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367264_PPP1R12B_chr1_202385914_ENST00000336894_length(amino acids)=1020AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD
LNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFS
ASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKL
NSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTA
NGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTE
GLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTA
KEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWAERLKRLESGGSNPTTSDSYGDRASARARREA
REARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEE

--------------------------------------------------------------

>41865_41865_6_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367264_PPP1R12B_chr1_202385914_ENST00000356764_length(amino acids)=424AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD

--------------------------------------------------------------

>41865_41865_7_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367264_PPP1R12B_chr1_202385914_ENST00000480184_length(amino acids)=553AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD
LNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFS
ASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKVQFGRVWGNSKAVFFF

--------------------------------------------------------------

>41865_41865_8_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367264_PPP1R12B_chr1_202385914_ENST00000608999_length(amino acids)=1020AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD
LNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFS
ASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKL
NSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTA
NGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTE
GLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTA
KEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREA
REARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEE

--------------------------------------------------------------

>41865_41865_9_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367265_PPP1R12B_chr1_202385914_ENST00000336894_length(amino acids)=1097AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK
EKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFN
KPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRE
SAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITG
TDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSA
VPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADL
DEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWAERLKRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVE
EDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQR

--------------------------------------------------------------

>41865_41865_10_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367265_PPP1R12B_chr1_202385914_ENST00000356764_length(amino acids)=501AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK

--------------------------------------------------------------

>41865_41865_11_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367265_PPP1R12B_chr1_202385914_ENST00000480184_length(amino acids)=630AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK
EKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFN
KPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKVQFGRVWGNSKAVFFFHENSILGTNENIF

--------------------------------------------------------------

>41865_41865_12_KDM5B-PPP1R12B_KDM5B_chr1_202743740_ENST00000367265_PPP1R12B_chr1_202385914_ENST00000608999_length(amino acids)=1097AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK
EKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFN
KPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRE
SAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITG
TDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSA
VPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADL
DEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVE
EDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQR

--------------------------------------------------------------

>41865_41865_13_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367264_PPP1R12B_chr1_202385915_ENST00000336894_length(amino acids)=1020AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD
LNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFS
ASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKL
NSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTA
NGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTE
GLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTA
KEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWAERLKRLESGGSNPTTSDSYGDRASARARREA
REARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEE

--------------------------------------------------------------

>41865_41865_14_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367264_PPP1R12B_chr1_202385915_ENST00000356764_length(amino acids)=424AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD

--------------------------------------------------------------

>41865_41865_15_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367264_PPP1R12B_chr1_202385915_ENST00000480184_length(amino acids)=553AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD
LNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFS
ASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKVQFGRVWGNSKAVFFF

--------------------------------------------------------------

>41865_41865_16_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367264_PPP1R12B_chr1_202385915_ENST00000608999_length(amino acids)=1020AA_BP=135
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY
FINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV
LRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESD
LNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFS
ASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKL
NSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTA
NGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTE
GLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTA
KEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREA
REARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEE

--------------------------------------------------------------

>41865_41865_17_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367265_PPP1R12B_chr1_202385915_ENST00000336894_length(amino acids)=1097AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK
EKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFN
KPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRE
SAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITG
TDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSA
VPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADL
DEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWAERLKRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVE
EDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQR

--------------------------------------------------------------

>41865_41865_18_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367265_PPP1R12B_chr1_202385915_ENST00000356764_length(amino acids)=501AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK

--------------------------------------------------------------

>41865_41865_19_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367265_PPP1R12B_chr1_202385915_ENST00000480184_length(amino acids)=630AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK
EKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFN
KPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKVQFGRVWGNSKAVFFFHENSILGTNENIF

--------------------------------------------------------------

>41865_41865_20_KDM5B-PPP1R12B_KDM5B_chr1_202743741_ENST00000367265_PPP1R12B_chr1_202385915_ENST00000608999_length(amino acids)=1097AA_BP=212
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNS
EGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV
QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNK
EKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFSSGLFN
KPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRE
SAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITG
TDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSA
VPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADL
DEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVE
EDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202742246/chr1:202536906)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM5B

Q9UGL1

.
FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-42832_73192.01581.0DomainJmjN
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-42897_187192.01581.0DomainARID
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-42732_73192.01545.0DomainJmjN
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-42797_187192.01545.0DomainARID
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-32832_73135.01581.0DomainJmjN
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-32732_73135.01545.0DomainJmjN
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-32832_73135.01581.0DomainJmjN
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-32732_73135.01545.0DomainJmjN
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000035676409336_3790387.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000367270813336_379145.02805.3333333333335Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000391959812336_379145.0209.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000480184010336_3790516.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000035676409336_37997.0387.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000367270013336_37902805.3333333333335Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000391959012336_3790209.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000480184010336_37997.0516.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000035676409336_37997.0387.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000367270013336_37902805.3333333333335Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000391959012336_3790209.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000480184010336_37997.0516.0Compositional biasNote=Glu-rich
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000035676409123_1520387.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000035676409216_2450387.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000035676409249_2780387.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202742246chr1:202536906ENST000003567640957_860387.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202742246chr1:202536906ENST000003567640990_1190387.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000367270813216_245145.02805.3333333333335RepeatNote=ANK 4
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000367270813249_278145.02805.3333333333335RepeatNote=ANK 5
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000391959812216_245145.0209.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000391959812249_278145.0209.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000480184010123_1520516.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000480184010216_2450516.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000480184010249_2780516.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000048018401057_860516.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000048018401090_1190516.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000035676409123_15297.0387.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000035676409216_24597.0387.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000035676409249_27897.0387.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000367270013123_15202805.3333333333335RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000367270013216_24502805.3333333333335RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000367270013249_27802805.3333333333335RepeatNote=ANK 5
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000036727001357_8602805.3333333333335RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000036727001390_11902805.3333333333335RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000391959012123_1520209.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000391959012216_2450209.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000391959012249_2780209.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000039195901257_860209.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000039195901290_1190209.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000480184010123_15297.0516.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000480184010216_24597.0516.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743740chr1:202385914ENST00000480184010249_27897.0516.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000035676409123_15297.0387.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000035676409216_24597.0387.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000035676409249_27897.0387.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000367270013123_15202805.3333333333335RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000367270013216_24502805.3333333333335RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000367270013249_27802805.3333333333335RepeatNote=ANK 5
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000036727001357_8602805.3333333333335RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000036727001390_11902805.3333333333335RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000391959012123_1520209.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000391959012216_2450209.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000391959012249_2780209.0RepeatNote=ANK 5
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000039195901257_860209.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000039195901290_1190209.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000480184010123_15297.0516.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000480184010216_24597.0516.0RepeatNote=ANK 4
TgenePPP1R12Bchr1:202743741chr1:202385915ENST00000480184010249_27897.0516.0RepeatNote=ANK 5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-4281434_1439192.01581.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-4271434_1439192.01545.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-3281434_1439135.01581.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-3271434_1439135.01545.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-3281434_1439135.01581.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-3271434_1439135.01545.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-428453_619192.01581.0DomainJmjC
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-427453_619192.01545.0DomainJmjC
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-328453_619135.01581.0DomainJmjC
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-32897_187135.01581.0DomainARID
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-327453_619135.01545.0DomainJmjC
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-32797_187135.01545.0DomainARID
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-328453_619135.01581.0DomainJmjC
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-32897_187135.01581.0DomainARID
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-327453_619135.01545.0DomainJmjC
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-32797_187135.01545.0DomainARID
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-4281176_1224192.01581.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-4281484_1538192.01581.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-428309_359192.01581.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367264-428692_744192.01581.0Zinc fingerC5HC2
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-4271176_1224192.01545.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-4271484_1538192.01545.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-427309_359192.01545.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202742246chr1:202536906ENST00000367265-427692_744192.01545.0Zinc fingerC5HC2
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-3281176_1224135.01581.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-3281484_1538135.01581.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-328309_359135.01581.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367264-328692_744135.01581.0Zinc fingerC5HC2
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-3271176_1224135.01545.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-3271484_1538135.01545.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-327309_359135.01545.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202743740chr1:202385914ENST00000367265-327692_744135.01545.0Zinc fingerC5HC2
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-3281176_1224135.01581.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-3281484_1538135.01581.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-328309_359135.01581.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367264-328692_744135.01581.0Zinc fingerC5HC2
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-3271176_1224135.01545.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-3271484_1538135.01545.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-327309_359135.01545.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202743741chr1:202385915ENST00000367265-327692_744135.01545.0Zinc fingerC5HC2
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000367270813123_152145.02805.3333333333335RepeatNote=ANK 3
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000036727081357_86145.02805.3333333333335RepeatNote=ANK 1
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000036727081390_119145.02805.3333333333335RepeatNote=ANK 2
TgenePPP1R12Bchr1:202742246chr1:202536906ENST00000391959812123_152145.0209.0RepeatNote=ANK 3
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000039195981257_86145.0209.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202742246chr1:202536906ENST0000039195981290_119145.0209.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743740chr1:202385914ENST000003567640957_8697.0387.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743740chr1:202385914ENST000003567640990_11997.0387.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000048018401057_8697.0516.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743740chr1:202385914ENST0000048018401090_11997.0516.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743741chr1:202385915ENST000003567640957_8697.0387.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743741chr1:202385915ENST000003567640990_11997.0387.0RepeatNote=ANK 2
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000048018401057_8697.0516.0RepeatNote=ANK 1
TgenePPP1R12Bchr1:202743741chr1:202385915ENST0000048018401090_11997.0516.0RepeatNote=ANK 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM5B
PPP1R12B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KDM5B-PPP1R12B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM5B-PPP1R12B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource