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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KIAA0430-IQCK

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIAA0430-IQCK
FusionPDB ID: 42128
FusionGDB2.0 ID: 42128
HgeneTgene
Gene symbol

KIAA0430

IQCK

Gene ID

9665

124152

Gene namemeiosis regulator and mRNA stability factor 1IQ motif containing K
SynonymsKIAA0430|LKAP|LMKB|PPP1R34-
Cytomap

16p13.11

16p12.3

Type of geneprotein-codingprotein-coding
Descriptionmeiosis regulator and mRNA stability factor 1limkain-b1meiosis arrest female 1meiosis arrest female protein 1protein phosphatase 1, regulatory subunit 34IQ domain-containing protein K
Modification date2020031320200313
UniProtAcc.

Q8N0W5

Ensembl transtripts involved in fusion geneENST idsENST00000344181, ENST00000396368, 
ENST00000540441, ENST00000548025, 
ENST00000551742, ENST00000602337, 
ENST00000547936, 		ENST00000562762, 
ENST00000433597, ENST00000541926, 
ENST00000564186, ENST00000320394, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 7 X 4=1407 X 10 X 4=280
# samples 610
** MAII scorelog2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIAA0430 [Title/Abstract] AND IQCK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIAA0430(15724189)-IQCK(19867809), # samples:3
Anticipated loss of major functional domain due to fusion event.KIAA0430-IQCK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-IQCK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-IQCK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-IQCK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0430-IQCK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA0430

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across KIAA0430 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IQCK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A2LB-01AKIAA0430chr16

15724188

-IQCKchr16

19867808

+
ChimerDB4BLCATCGA-BT-A2LB-01AKIAA0430chr16

15724189

-IQCKchr16

19867809

+
ChimerDB4BLCATCGA-BT-A2LB-01AKIAA0430chr16

15725238

-IQCKchr16

19867809

+
ChimerDB4BLCATCGA-BT-A2LBKIAA0430chr16

15724188

-IQCKchr16

19867808

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344181KIAA0430chr1615724189-ENST00000320394IQCKchr1619867809+281617171811719512
ENST00000344181KIAA0430chr1615724188-ENST00000320394IQCKchr1619867808+281617171811719512
ENST00000396368KIAA0430chr1615725238-ENST00000320394IQCKchr1619867809+265715581951619474
ENST00000540441KIAA0430chr1615725238-ENST00000320394IQCKchr1619867809+25151416531477474
ENST00000551742KIAA0430chr1615725238-ENST00000320394IQCKchr1619867809+259915001371561474
ENST00000602337KIAA0430chr1615725238-ENST00000320394IQCKchr1619867809+259014911371552471
ENST00000548025KIAA0430chr1615725238-ENST00000320394IQCKchr1619867809+259014911371552471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344181ENST00000320394KIAA0430chr1615724189-IQCKchr1619867809+0.0054037780.9945963
ENST00000344181ENST00000320394KIAA0430chr1615724188-IQCKchr1619867808+0.0054037780.9945963
ENST00000396368ENST00000320394KIAA0430chr1615725238-IQCKchr1619867809+0.0031023580.9968977
ENST00000540441ENST00000320394KIAA0430chr1615725238-IQCKchr1619867809+0.003091730.99690825
ENST00000551742ENST00000320394KIAA0430chr1615725238-IQCKchr1619867809+0.0029800590.99701995
ENST00000602337ENST00000320394KIAA0430chr1615725238-IQCKchr1619867809+0.0026605680.9973394
ENST00000548025ENST00000320394KIAA0430chr1615725238-IQCKchr1619867809+0.0026605680.9973394

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42128_42128_1_KIAA0430-IQCK_KIAA0430_chr16_15724188_ENST00000344181_IQCK_chr16_19867808_ENST00000320394_length(amino acids)=512AA_BP=
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVF
WDIENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATV

--------------------------------------------------------------

>42128_42128_2_KIAA0430-IQCK_KIAA0430_chr16_15724189_ENST00000344181_IQCK_chr16_19867809_ENST00000320394_length(amino acids)=512AA_BP=
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVF
WDIENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATV

--------------------------------------------------------------

>42128_42128_3_KIAA0430-IQCK_KIAA0430_chr16_15725238_ENST00000396368_IQCK_chr16_19867809_ENST00000320394_length(amino acids)=474AA_BP=455
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVF
WDIENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATV

--------------------------------------------------------------

>42128_42128_4_KIAA0430-IQCK_KIAA0430_chr16_15725238_ENST00000540441_IQCK_chr16_19867809_ENST00000320394_length(amino acids)=474AA_BP=455
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVF
WDIENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATV

--------------------------------------------------------------

>42128_42128_5_KIAA0430-IQCK_KIAA0430_chr16_15725238_ENST00000548025_IQCK_chr16_19867809_ENST00000320394_length(amino acids)=471AA_BP=452
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFEVAVAGQVLENLPPIGVFWDI
ENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATVVLV

--------------------------------------------------------------

>42128_42128_6_KIAA0430-IQCK_KIAA0430_chr16_15725238_ENST00000551742_IQCK_chr16_19867809_ENST00000320394_length(amino acids)=474AA_BP=455
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVF
WDIENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATV

--------------------------------------------------------------

>42128_42128_7_KIAA0430-IQCK_KIAA0430_chr16_15725238_ENST00000602337_IQCK_chr16_19867809_ENST00000320394_length(amino acids)=471AA_BP=452
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFEVAVAGQVLENLPPIGVFWDI
ENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATVVLV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:15724189/chr16:19867809)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IQCK

Q8N0W5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-727117_125508.01743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-727117_125505.01740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-727117_125508.01743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-727117_125505.01740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-727117_125508.01743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-727117_125505.01740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-727117_125508.01743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-727117_125505.01740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-627117_125450.33333333333331743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-627117_125447.33333333333331740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-627117_125450.33333333333331743.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-627117_125447.33333333333331740.0Compositional biasNote=Poly-Gly
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-727353_490508.01743.0DomainNote=NYN
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-727353_490505.01740.0DomainNote=NYN
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-727353_490508.01743.0DomainNote=NYN
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-727353_490505.01740.0DomainNote=NYN
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-727353_490508.01743.0DomainNote=NYN
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-727353_490505.01740.0DomainNote=NYN
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-727353_490508.01743.0DomainNote=NYN
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-727353_490505.01740.0DomainNote=NYN

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271079_1082508.01743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271685_1690508.01743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271079_1082505.01740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271685_1690505.01740.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271079_1082508.01743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271685_1690508.01743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271079_1082505.01740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271685_1690505.01740.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271079_1082508.01743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271685_1690508.01743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271079_1082505.01740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271685_1690505.01740.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271079_1082508.01743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271685_1690508.01743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271079_1082505.01740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271685_1690505.01740.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271079_1082450.33333333333331743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271685_1690450.33333333333331743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271079_1082447.33333333333331740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271685_1690447.33333333333331740.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271079_1082450.33333333333331743.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271685_1690450.33333333333331743.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271079_1082447.33333333333331740.0Compositional biasNote=Poly-Pro
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271685_1690447.33333333333331740.0Compositional biasNote=Poly-Ser
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271003_1079508.01743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271099_1173508.01743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271175_1250508.01743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271259_1334508.01743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271335_1410508.01743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271411_1485508.01743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-7271486_1560508.01743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-727791_870508.01743.0DomainRRM
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000396368-727875_949508.01743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271003_1079505.01740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271099_1173505.01740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271175_1250505.01740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271259_1334505.01740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271335_1410505.01740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271411_1485505.01740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-7271486_1560505.01740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-727791_870505.01740.0DomainRRM
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000548025-727875_949505.01740.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271003_1079508.01743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271099_1173508.01743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271175_1250508.01743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271259_1334508.01743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271335_1410508.01743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271411_1485508.01743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-7271486_1560508.01743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-727791_870508.01743.0DomainRRM
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000551742-727875_949508.01743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271003_1079505.01740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271099_1173505.01740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271175_1250505.01740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271259_1334505.01740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271335_1410505.01740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271411_1485505.01740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-7271486_1560505.01740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-727791_870505.01740.0DomainRRM
HgeneKIAA0430chr16:15724188chr16:19867808ENST00000602337-727875_949505.01740.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271003_1079508.01743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271099_1173508.01743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271175_1250508.01743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271259_1334508.01743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271335_1410508.01743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271411_1485508.01743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-7271486_1560508.01743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-727791_870508.01743.0DomainRRM
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000396368-727875_949508.01743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271003_1079505.01740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271099_1173505.01740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271175_1250505.01740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271259_1334505.01740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271335_1410505.01740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271411_1485505.01740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-7271486_1560505.01740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-727791_870505.01740.0DomainRRM
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000548025-727875_949505.01740.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271003_1079508.01743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271099_1173508.01743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271175_1250508.01743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271259_1334508.01743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271335_1410508.01743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271411_1485508.01743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-7271486_1560508.01743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-727791_870508.01743.0DomainRRM
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000551742-727875_949508.01743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271003_1079505.01740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271099_1173505.01740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271175_1250505.01740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271259_1334505.01740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271335_1410505.01740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271411_1485505.01740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-7271486_1560505.01740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-727791_870505.01740.0DomainRRM
HgeneKIAA0430chr16:15724189chr16:19867809ENST00000602337-727875_949505.01740.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271003_1079450.33333333333331743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271099_1173450.33333333333331743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271175_1250450.33333333333331743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271259_1334450.33333333333331743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271335_1410450.33333333333331743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271411_1485450.33333333333331743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-6271486_1560450.33333333333331743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-627353_490450.33333333333331743.0DomainNote=NYN
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-627791_870450.33333333333331743.0DomainRRM
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000396368-627875_949450.33333333333331743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271003_1079447.33333333333331740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271099_1173447.33333333333331740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271175_1250447.33333333333331740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271259_1334447.33333333333331740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271335_1410447.33333333333331740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271411_1485447.33333333333331740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-6271486_1560447.33333333333331740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-627353_490447.33333333333331740.0DomainNote=NYN
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-627791_870447.33333333333331740.0DomainRRM
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000548025-627875_949447.33333333333331740.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271003_1079450.33333333333331743.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271099_1173450.33333333333331743.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271175_1250450.33333333333331743.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271259_1334450.33333333333331743.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271335_1410450.33333333333331743.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271411_1485450.33333333333331743.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-6271486_1560450.33333333333331743.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-627353_490450.33333333333331743.0DomainNote=NYN
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-627791_870450.33333333333331743.0DomainRRM
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000551742-627875_949450.33333333333331743.0DomainHTH OST-type 1
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271003_1079447.33333333333331740.0DomainHTH OST-type 2
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271099_1173447.33333333333331740.0DomainHTH OST-type 3
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271175_1250447.33333333333331740.0DomainHTH OST-type 4
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271259_1334447.33333333333331740.0DomainHTH OST-type 5
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271335_1410447.33333333333331740.0DomainHTH OST-type 6
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271411_1485447.33333333333331740.0DomainHTH OST-type 7
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-6271486_1560447.33333333333331740.0DomainHTH OST-type 8
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-627353_490447.33333333333331740.0DomainNote=NYN
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-627791_870447.33333333333331740.0DomainRRM
HgeneKIAA0430chr16:15725238chr16:19867809ENST00000602337-627875_949447.33333333333331740.0DomainHTH OST-type 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1088_KIAA0430_15724188_IQCK_19867808_1088_KIAA0430_15724188_IQCK_19867808_ranked_0.pdbKIAA04301572523815724188ENST00000320394IQCKchr1619867808+
MHGCMMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSL
QQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDF
PSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLK
GSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVF
WDIENCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATV
512


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
IQCK_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIAA0430
IQCK


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KIAA0430-IQCK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KIAA0430-IQCK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource