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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KIF1B-UBE4B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIF1B-UBE4B
FusionPDB ID: 42612
FusionGDB2.0 ID: 42612
HgeneTgene
Gene symbol

KIF1B

UBE4B

Gene ID

23095

10277

Gene namekinesin family member 1Bubiquitination factor E4B
SynonymsCMT2|CMT2A|CMT2A1|HMSNII|KLP|NBLST1E4|HDNB1|UBOX3|UFD2|UFD2A
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF1Bkinesin superfamily protein KIF1Bubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, y
Modification date2020032820200313
UniProtAcc

O60333

.
Ensembl transtripts involved in fusion geneENST idsENST00000263934, ENST00000377081, 
ENST00000377083, ENST00000377086, 
ENST00000377093, ENST00000465635, 
ENST00000475795, ENST00000343090, 
ENST00000377157, ENST00000377153, 
ENST00000253251, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 19 X 14=47889 X 14 X 8=1008
# samples 2417
** MAII scorelog2(24/4788*10)=-4.31831684133498
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1008*10)=-2.56788898736222
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIF1B [Title/Abstract] AND UBE4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIF1B(10292492)-UBE4B(10238702), # samples:2
KIF1B(10292492)-UBE4B(10231196), # samples:2
KIF1B(10270936)-UBE4B(10238702), # samples:2
UBE4B(10155654)-KIF1B(10292308), # samples:1
Anticipated loss of major functional domain due to fusion event.KIF1B-UBE4B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF1B-UBE4B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF1B-UBE4B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF1B-UBE4B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF1B-UBE4B seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
KIF1B-UBE4B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE4B

GO:0008626

granzyme-mediated apoptotic signaling pathway

11802788

TgeneUBE4B

GO:0009411

response to UV

11802788

TgeneUBE4B

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

23509263


check buttonFusion gene breakpoints across KIF1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBE4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01AKIF1Bchr1

10292492

+UBE4Bchr1

10155519

+
ChimerDB4GBMTCGA-16-1045-01BKIF1Bchr1

10292492

-UBE4Bchr1

10238702

+
ChimerDB4GBMTCGA-16-1045-01BKIF1Bchr1

10292492

+UBE4Bchr1

10238702

+
ChimerDB4GBMTCGA-16-1045KIF1Bchr1

10292492

+UBE4Bchr1

10238701

+
ChimerDB4KIRCTCGA-BP-4338-01AKIF1Bchr1

10292492

-UBE4Bchr1

10231196

+
ChimerDB4KIRCTCGA-BP-4338-01AKIF1Bchr1

10292492

+UBE4Bchr1

10231196

+
ChimerDB4LIHCTCGA-G3-A25X-01AKIF1Bchr1

10270936

-UBE4Bchr1

10238702

+
ChimerDB4LIHCTCGA-G3-A25X-01AKIF1Bchr1

10270936

+UBE4Bchr1

10238702

+
ChimerDB4STADTCGA-HU-A4GH-01AKIF1Bchr1

10357304

+UBE4Bchr1

10189450

+
ChiTaRS5.0N/ACD655415KIF1Bchr1

10288422

-UBE4Bchr1

10216102

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377093KIF1Bchr110292492+ENST00000253251UBE4Bchr110155519+39812593335691178
ENST00000263934KIF1Bchr110292492+ENST00000253251UBE4Bchr110155519+39812593335691178
ENST00000377086KIF1Bchr110292492+ENST00000253251UBE4Bchr110155519+403030810336181171
ENST00000377083KIF1Bchr110292492+ENST00000253251UBE4Bchr110155519+414141922937291166
ENST00000377081KIF1Bchr110292492+ENST00000253251UBE4Bchr110155519+39071854334951150
ENST00000377093KIF1Bchr110357304+ENST00000253251UBE4Bchr110189450+481221303344001455
ENST00000377093KIF1Bchr110357304+ENST00000377157UBE4Bchr110189450+568821303344121459
ENST00000377093KIF1Bchr110357304+ENST00000343090UBE4Bchr110189450+568421303344001455
ENST00000263934KIF1Bchr110357304+ENST00000253251UBE4Bchr110189450+481221303344001455
ENST00000263934KIF1Bchr110357304+ENST00000377157UBE4Bchr110189450+568821303344121459
ENST00000263934KIF1Bchr110357304+ENST00000343090UBE4Bchr110189450+568421303344001455
ENST00000377086KIF1Bchr110357304+ENST00000253251UBE4Bchr110189450+4999231710345871494
ENST00000377086KIF1Bchr110357304+ENST00000377157UBE4Bchr110189450+5875231710345991498
ENST00000377086KIF1Bchr110357304+ENST00000343090UBE4Bchr110189450+5871231710345871494
ENST00000377083KIF1Bchr110357304+ENST00000253251UBE4Bchr110189450+4972229022945601443
ENST00000377083KIF1Bchr110357304+ENST00000377157UBE4Bchr110189450+5848229022945721447
ENST00000377083KIF1Bchr110357304+ENST00000343090UBE4Bchr110189450+5844229022945601443
ENST00000377081KIF1Bchr110357304+ENST00000253251UBE4Bchr110189450+487621944344641473
ENST00000377081KIF1Bchr110357304+ENST00000377157UBE4Bchr110189450+575221944344761477
ENST00000377081KIF1Bchr110357304+ENST00000343090UBE4Bchr110189450+574821944344641473

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377093ENST00000253251KIF1Bchr110292492+UBE4Bchr110155519+0.0009089950.999091
ENST00000263934ENST00000253251KIF1Bchr110292492+UBE4Bchr110155519+0.0009089950.999091
ENST00000377086ENST00000253251KIF1Bchr110292492+UBE4Bchr110155519+0.0010022740.99899775
ENST00000377083ENST00000253251KIF1Bchr110292492+UBE4Bchr110155519+0.0008742940.99912566
ENST00000377081ENST00000253251KIF1Bchr110292492+UBE4Bchr110155519+0.0008158990.9991841
ENST00000377093ENST00000253251KIF1Bchr110357304+UBE4Bchr110189450+0.0005368070.99946326
ENST00000377093ENST00000377157KIF1Bchr110357304+UBE4Bchr110189450+0.0004634030.99953663
ENST00000377093ENST00000343090KIF1Bchr110357304+UBE4Bchr110189450+0.0002438220.99975616
ENST00000263934ENST00000253251KIF1Bchr110357304+UBE4Bchr110189450+0.0005368070.99946326
ENST00000263934ENST00000377157KIF1Bchr110357304+UBE4Bchr110189450+0.0004634030.99953663
ENST00000263934ENST00000343090KIF1Bchr110357304+UBE4Bchr110189450+0.0002438220.99975616
ENST00000377086ENST00000253251KIF1Bchr110357304+UBE4Bchr110189450+0.0006490560.99935097
ENST00000377086ENST00000377157KIF1Bchr110357304+UBE4Bchr110189450+0.0005337550.99946624
ENST00000377086ENST00000343090KIF1Bchr110357304+UBE4Bchr110189450+0.0002900590.9997099
ENST00000377083ENST00000253251KIF1Bchr110357304+UBE4Bchr110189450+0.0005331580.99946684
ENST00000377083ENST00000377157KIF1Bchr110357304+UBE4Bchr110189450+0.0005030260.99949694
ENST00000377083ENST00000343090KIF1Bchr110357304+UBE4Bchr110189450+0.0002610010.999739
ENST00000377081ENST00000253251KIF1Bchr110357304+UBE4Bchr110189450+0.0005455450.99945444
ENST00000377081ENST00000377157KIF1Bchr110357304+UBE4Bchr110189450+0.0004438720.9995561
ENST00000377081ENST00000343090KIF1Bchr110357304+UBE4Bchr110189450+0.000239980.99976

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42612_42612_1_KIF1B-UBE4B_KIF1B_chr1_10292492_ENST00000263934_UBE4B_chr1_10155519_ENST00000253251_length(amino acids)=1178AA_BP=76
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTRVAHRSQSSEGVSSL
SSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDR
DVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGA
SSLSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQ
PSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLP
KSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAV
VNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFP
TECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCL
NFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKL
VEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFV
RYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELG
PRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKF
KLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWM

--------------------------------------------------------------

>42612_42612_2_KIF1B-UBE4B_KIF1B_chr1_10292492_ENST00000377081_UBE4B_chr1_10155519_ENST00000253251_length(amino acids)=1150AA_BP=48
MDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTRVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSC
EKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIG
QILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLGASGGASNWDSYSDHFTIETCK
ETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQD
EEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAE
DDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLW
VLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRA
IRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSD
VPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLS
TKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQ
EEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPE
KYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEF

--------------------------------------------------------------

>42612_42612_3_KIF1B-UBE4B_KIF1B_chr1_10292492_ENST00000377083_UBE4B_chr1_10155519_ENST00000253251_length(amino acids)=1166AA_BP=64
MRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTRVAHRSQSSEGVSSLSSSPSNSLETQS
QSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQF
KQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLGASGGA
SNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRN
LPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQ
RLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQT
DDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHH
LSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLR
ILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQ
PRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTF
LLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQ
QLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVA

--------------------------------------------------------------

>42612_42612_4_KIF1B-UBE4B_KIF1B_chr1_10292492_ENST00000377086_UBE4B_chr1_10155519_ENST00000253251_length(amino acids)=1171AA_BP=69
MLNELPRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTRVAHRSQSSEGVSSLSSSPSNS
LETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSS
LSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLG
ASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPY
MLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGC
GRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKK
AQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLT
LHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLI
QLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMT
NPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLI
NDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAML
NFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKV
EEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSD

--------------------------------------------------------------

>42612_42612_5_KIF1B-UBE4B_KIF1B_chr1_10292492_ENST00000377093_UBE4B_chr1_10155519_ENST00000253251_length(amino acids)=1178AA_BP=76
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTRVAHRSQSSEGVSSL
SSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDR
DVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGA
SSLSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQ
PSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLP
KSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAV
VNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFP
TECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCL
NFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKL
VEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFV
RYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELG
PRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKF
KLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWM

--------------------------------------------------------------

>42612_42612_6_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000263934_UBE4B_chr1_10189450_ENST00000253251_length(amino acids)=1455AA_BP=699
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSF
SFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSY
SVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKH
DNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTA
MVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS
VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
LLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNH
PEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVA
SLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAA
LSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPP
FSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDE
SFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRN
PYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF
NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKP
FLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKS
TIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELK

--------------------------------------------------------------

>42612_42612_7_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000263934_UBE4B_chr1_10189450_ENST00000343090_length(amino acids)=1455AA_BP=699
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSF
SFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSY
SVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKH
DNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTA
MVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS
VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
LLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNH
PEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVA
SLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAA
LSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPP
FSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDE
SFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRN
PYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF
NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKP
FLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKS
TIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELK

--------------------------------------------------------------

>42612_42612_8_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000263934_UBE4B_chr1_10189450_ENST00000377157_length(amino acids)=1459AA_BP=699
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSF
SFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSY
SVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKH
DNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTA
MVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS
VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
LLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNH
PEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVA
SLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAA
LSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPP
FSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDE
SFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRN
PYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF
NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKP
FLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKS
TIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRGKWTHPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPV

--------------------------------------------------------------

>42612_42612_9_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377081_UBE4B_chr1_10189450_ENST00000253251_length(amino acids)=1473AA_BP=717
MDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIG
KEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRV
REHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERADST
GAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYA
DRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGS
LTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSP
KKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQL
RSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALG
ELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQE
LFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNA
TMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQ
LKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQ
DIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTI
FKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLAL
ATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYS
KELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDP

--------------------------------------------------------------

>42612_42612_10_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377081_UBE4B_chr1_10189450_ENST00000343090_length(amino acids)=1473AA_BP=717
MDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIG
KEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRV
REHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERADST
GAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYA
DRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGS
LTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSP
KKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQL
RSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALG
ELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQE
LFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNA
TMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQ
LKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQ
DIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTI
FKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLAL
ATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYS
KELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDP

--------------------------------------------------------------

>42612_42612_11_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377081_UBE4B_chr1_10189450_ENST00000377157_length(amino acids)=1477AA_BP=717
MDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIG
KEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRV
REHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERADST
GAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYA
DRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGS
LTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSP
KKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQL
RSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALG
ELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQE
LFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNA
TMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQ
LKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQ
DIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTI
FKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLAL
ATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYS
KELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRGKWTHPLMDTLMTDPVRLPSGTIMDRSIILRHLLNS

--------------------------------------------------------------

>42612_42612_12_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377083_UBE4B_chr1_10189450_ENST00000253251_length(amino acids)=1443AA_BP=687
MRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSP
EDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCE
RVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVS
KISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINY
DETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTP
GGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRV
GQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTP
SAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVASLRLWLPKSLSP
GCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANM
KKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFF
LTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGL
LIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMF
MTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINM
LINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAA
MLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAE
KVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQN

--------------------------------------------------------------

>42612_42612_13_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377083_UBE4B_chr1_10189450_ENST00000343090_length(amino acids)=1443AA_BP=687
MRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSP
EDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCE
RVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVS
KISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINY
DETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTP
GGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRV
GQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTP
SAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVASLRLWLPKSLSP
GCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANM
KKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFF
LTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGL
LIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMF
MTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINM
LINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAA
MLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAE
KVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQN

--------------------------------------------------------------

>42612_42612_14_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377083_UBE4B_chr1_10189450_ENST00000377157_length(amino acids)=1447AA_BP=687
MRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSP
EDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCE
RVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVS
KISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINY
DETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTP
GGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRV
GQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTP
SAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVASLRLWLPKSLSP
GCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANM
KKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFF
LTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGL
LIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMF
MTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINM
LINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAA
MLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAE
KVEEIVAKNARAEIDYSDAPDEFRGKWTHPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMR

--------------------------------------------------------------

>42612_42612_15_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377086_UBE4B_chr1_10189450_ENST00000253251_length(amino acids)=1494AA_BP=738
MLNELPRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYW
SHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYM
EIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLS
TEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAM
VAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKH
RYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREA
LLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTL
EPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEI
LYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAIT
LENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDP
TYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNES
QWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDV
AEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVE
HTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQ
QQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDI
YLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLP

--------------------------------------------------------------

>42612_42612_16_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377086_UBE4B_chr1_10189450_ENST00000343090_length(amino acids)=1494AA_BP=738
MLNELPRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYW
SHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYM
EIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLS
TEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAM
VAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKH
RYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREA
LLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTL
EPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEI
LYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAIT
LENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDP
TYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNES
QWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDV
AEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVE
HTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQ
QQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDI
YLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLP

--------------------------------------------------------------

>42612_42612_17_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377086_UBE4B_chr1_10189450_ENST00000377157_length(amino acids)=1498AA_BP=738
MLNELPRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYW
SHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYM
EIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLS
TEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAM
VAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKH
RYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREA
LLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTL
EPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEI
LYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAIT
LENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDP
TYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNES
QWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDV
AEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVE
HTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQ
QQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDI
YLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRGKWTHPLMDTLMTDP

--------------------------------------------------------------

>42612_42612_18_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377093_UBE4B_chr1_10189450_ENST00000253251_length(amino acids)=1455AA_BP=699
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSF
SFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSY
SVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKH
DNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTA
MVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS
VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
LLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNH
PEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVA
SLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAA
LSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPP
FSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDE
SFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRN
PYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF
NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKP
FLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKS
TIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELK

--------------------------------------------------------------

>42612_42612_19_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377093_UBE4B_chr1_10189450_ENST00000343090_length(amino acids)=1455AA_BP=699
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSF
SFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSY
SVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKH
DNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTA
MVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS
VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
LLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNH
PEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVA
SLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAA
LSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPP
FSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDE
SFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRN
PYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF
NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKP
FLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKS
TIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELK

--------------------------------------------------------------

>42612_42612_20_KIF1B-UBE4B_KIF1B_chr1_10357304_ENST00000377093_UBE4B_chr1_10189450_ENST00000377157_length(amino acids)=1459AA_BP=699
MLTRSARRSAARLRKLGCNFKRRFDSLFLDCIYIYNKAIKMSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSF
SFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSY
SVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKH
DNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTA
MVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS
VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSEC
LLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNH
PEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLALGELCETKFGKTHPVCNLVA
SLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAA
LSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPP
FSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDE
SFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRN
PYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF
NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKP
FLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKS
TIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRGKWTHPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:10292492/chr1:10238702)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF1B

O60333

.
FUNCTION: Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. {ECO:0000269|PubMed:18334619}.; FUNCTION: Isoform 1 mediates the transport of synaptic vesicles in neuronal cells. {ECO:0000250|UniProtKB:O88658}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+2047365_386659.01771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+2047470_502659.01771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+2148365_386705.01824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+2148470_502705.01824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+2021365_386659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+2021470_502659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+2249365_386705.01817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+2249470_502705.01817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+2021365_386659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+2021470_502659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+2047556_612659.01771.0DomainFHA
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+20475_354659.01771.0DomainKinesin motor
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+2148556_612705.01824.0DomainFHA
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+21485_354705.01824.0DomainKinesin motor
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+2021556_612659.01154.0DomainFHA
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+20215_354659.01154.0DomainKinesin motor
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+2249556_612705.01817.0DomainFHA
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+22495_354705.01817.0DomainKinesin motor
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+2021556_612659.01154.0DomainFHA
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+20215_354659.01154.0DomainKinesin motor
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+204797_104659.01771.0Nucleotide bindingATP
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+214897_104705.01824.0Nucleotide bindingATP
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+202197_104659.01154.0Nucleotide bindingATP
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+224997_104705.01817.0Nucleotide bindingATP
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+202197_104659.01154.0Nucleotide bindingATP
TgeneUBE4Bchr1:10292492chr1:10155519ENST000002532511271227_130070.333333333333331174.0DomainNote=U-box
TgeneUBE4Bchr1:10292492chr1:10155519ENST000003430901281227_130070.333333333333331303.0DomainNote=U-box
TgeneUBE4Bchr1:10292492chr1:10155519ENST000003771571271227_130001062.0DomainNote=U-box
TgeneUBE4Bchr1:10357304chr1:10189450ENST000002532519271227_1300417.01174.0DomainNote=U-box
TgeneUBE4Bchr1:10357304chr1:10189450ENST0000034309010281227_1300546.01303.0DomainNote=U-box
TgeneUBE4Bchr1:10357304chr1:10189450ENST000003771579271227_1300301.01062.0DomainNote=U-box

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+247365_38635.3333333333333361771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+247470_50235.3333333333333361771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+247668_73735.3333333333333361771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+247841_86935.3333333333333361771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+148365_38635.3333333333333361824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+148470_50235.3333333333333361824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+148668_73735.3333333333333361824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+148841_86935.3333333333333361824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+221365_38635.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+221470_50235.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+221668_73735.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+221841_86935.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+249365_38635.3333333333333361817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+249470_50235.3333333333333361817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+249668_73735.3333333333333361817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+249841_86935.3333333333333361817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+221365_38635.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+221470_50235.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+221668_73735.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+221841_86935.3333333333333361154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+2047668_737659.01771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+2047841_869659.01771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+2148668_737705.01824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+2148841_869705.01824.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+2021668_737659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+2021841_869659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+2249668_737705.01817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+2249841_869705.01817.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+2021668_737659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+2021841_869659.01154.0Coiled coilOntology_term=ECO:0000255
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+2471702_179935.3333333333333361771.0DomainPH
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+247556_61235.3333333333333361771.0DomainFHA
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+2475_35435.3333333333333361771.0DomainKinesin motor
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+1481702_179935.3333333333333361824.0DomainPH
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+148556_61235.3333333333333361824.0DomainFHA
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+1485_35435.3333333333333361824.0DomainKinesin motor
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+2211702_179935.3333333333333361154.0DomainPH
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+221556_61235.3333333333333361154.0DomainFHA
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+2215_35435.3333333333333361154.0DomainKinesin motor
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+2491702_179935.3333333333333361817.0DomainPH
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+249556_61235.3333333333333361817.0DomainFHA
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+2495_35435.3333333333333361817.0DomainKinesin motor
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+2211702_179935.3333333333333361154.0DomainPH
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+221556_61235.3333333333333361154.0DomainFHA
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+2215_35435.3333333333333361154.0DomainKinesin motor
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000263934+20471702_1799659.01771.0DomainPH
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377081+21481702_1799705.01824.0DomainPH
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377083+20211702_1799659.01154.0DomainPH
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377086+22491702_1799705.01817.0DomainPH
HgeneKIF1Bchr1:10357304chr1:10189450ENST00000377093+20211702_1799659.01154.0DomainPH
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+24797_10435.3333333333333361771.0Nucleotide bindingATP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+14897_10435.3333333333333361824.0Nucleotide bindingATP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+22197_10435.3333333333333361154.0Nucleotide bindingATP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+24997_10435.3333333333333361817.0Nucleotide bindingATP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+22197_10435.3333333333333361154.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIF1B
UBE4B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000263934+247270_35035.3333333333333361771.0KBP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377081+148270_35035.3333333333333361824.0KBP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377083+221270_35035.3333333333333361154.0KBP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377086+249270_35035.3333333333333361817.0KBP
HgeneKIF1Bchr1:10292492chr1:10155519ENST00000377093+221270_35035.3333333333333361154.0KBP


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Related Drugs to KIF1B-UBE4B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KIF1B-UBE4B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource