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Fusion Protein:KLC1-BTK |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: KLC1-BTK | FusionPDB ID: 42824 | FusionGDB2.0 ID: 42824 | Hgene | Tgene | Gene symbol | KLC1 | BTK | Gene ID | 3831 | 695 |
| Gene name | kinesin light chain 1 | Bruton tyrosine kinase | |
| Synonyms | KLC|KNS2|KNS2A | AGMX1|AT|ATK|BPK|IGHD3|IMD1|PSCTK1|XLA | |
| Cytomap | 14q32.33 | Xq22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50 | tyrosine-protein kinase BTKB-cell progenitor kinaseBruton agammaglobulinemia tyrosine kinaseBruton's tyrosine kinaseagammaglobulinaemia tyrosine kinasedominant-negative kinase-deficient Brutons tyrosine kinasetruncated Bruton agammaglobulinemia tyro | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | Q07866 | Q06187 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000246489, ENST00000334553, ENST00000347839, ENST00000348520, ENST00000380038, ENST00000389744, ENST00000445352, ENST00000452929, ENST00000553286, ENST00000554280, ENST00000555836, ENST00000557450, ENST00000557575, | ENST00000464567, ENST00000308731, ENST00000372880, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 12 X 6=648 | 2 X 2 X 2=8 |
| # samples | 16 | 2 | |
| ** MAII score | log2(16/648*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: KLC1 [Title/Abstract] AND BTK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KLC1(104129264)-BTK(100604944), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | KLC1-BTK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLC1-BTK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. KLC1-BTK seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BTK | GO:0018108 | peptidyl-tyrosine phosphorylation | 11606584 |
| Fusion gene breakpoints across KLC1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across BTK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-KK-A59Z | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000348520 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1626 | 1116 | 319 | 1152 | 277 |
| ENST00000380038 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1600 | 1090 | 293 | 1126 | 277 |
| ENST00000389744 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1576 | 1066 | 269 | 1102 | 277 |
| ENST00000557575 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1566 | 1056 | 259 | 1092 | 277 |
| ENST00000553286 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1566 | 1056 | 259 | 1092 | 277 |
| ENST00000347839 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1566 | 1056 | 259 | 1092 | 277 |
| ENST00000555836 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1566 | 1056 | 259 | 1092 | 277 |
| ENST00000334553 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1566 | 1056 | 259 | 1092 | 277 |
| ENST00000246489 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1562 | 1052 | 255 | 1088 | 277 |
| ENST00000557450 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1562 | 1052 | 255 | 1088 | 277 |
| ENST00000554280 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1562 | 1052 | 255 | 1088 | 277 |
| ENST00000452929 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1562 | 1052 | 255 | 1088 | 277 |
| ENST00000445352 | KLC1 | chr14 | 104129264 | + | ENST00000372880 | BTK | chrX | 100604944 | - | 1500 | 990 | 199 | 1026 | 275 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000348520 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002563315 | 0.9974367 |
| ENST00000380038 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002434778 | 0.99756527 |
| ENST00000389744 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002591987 | 0.997408 |
| ENST00000557575 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002682817 | 0.99731714 |
| ENST00000553286 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002682817 | 0.99731714 |
| ENST00000347839 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002682817 | 0.99731714 |
| ENST00000555836 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002682817 | 0.99731714 |
| ENST00000334553 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002682817 | 0.99731714 |
| ENST00000246489 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.0026395 | 0.9973605 |
| ENST00000557450 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.0026395 | 0.9973605 |
| ENST00000554280 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.0026395 | 0.9973605 |
| ENST00000452929 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.0026395 | 0.9973605 |
| ENST00000445352 | ENST00000372880 | KLC1 | chr14 | 104129264 | + | BTK | chrX | 100604944 | - | 0.002420116 | 0.9975799 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >42824_42824_1_KLC1-BTK_KLC1_chr14_104129264_ENST00000246489_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_2_KLC1-BTK_KLC1_chr14_104129264_ENST00000334553_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_3_KLC1-BTK_KLC1_chr14_104129264_ENST00000347839_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_4_KLC1-BTK_KLC1_chr14_104129264_ENST00000348520_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_5_KLC1-BTK_KLC1_chr14_104129264_ENST00000380038_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_6_KLC1-BTK_KLC1_chr14_104129264_ENST00000389744_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_7_KLC1-BTK_KLC1_chr14_104129264_ENST00000445352_BTK_chrX_100604944_ENST00000372880_length(amino acids)=275AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVKQMSVP -------------------------------------------------------------- >42824_42824_8_KLC1-BTK_KLC1_chr14_104129264_ENST00000452929_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_9_KLC1-BTK_KLC1_chr14_104129264_ENST00000553286_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_10_KLC1-BTK_KLC1_chr14_104129264_ENST00000554280_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_11_KLC1-BTK_KLC1_chr14_104129264_ENST00000555836_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_12_KLC1-BTK_KLC1_chr14_104129264_ENST00000557450_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- >42824_42824_13_KLC1-BTK_KLC1_chr14_104129264_ENST00000557575_BTK_chrX_100604944_ENST00000372880_length(amino acids)=277AA_BP= MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMM ALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLF PNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRKQMS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104129264/chrX:100604944) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KLC1 | BTK |
| FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. | FUNCTION: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis. {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:9012831}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000246489 | + | 5 | 16 | 27_156 | 265.6666666666667 | 638.0 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000334553 | + | 5 | 17 | 27_156 | 265.6666666666667 | 668.6666666666666 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000347839 | + | 5 | 16 | 27_156 | 265.6666666666667 | 629.0 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000348520 | + | 5 | 15 | 27_156 | 265.6666666666667 | 585.0 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000389744 | + | 5 | 15 | 27_156 | 265.6666666666667 | 898.3333333333334 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000452929 | + | 5 | 16 | 27_156 | 265.6666666666667 | 619.0 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000553286 | + | 5 | 14 | 27_156 | 265.6666666666667 | 561.0 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000557450 | + | 5 | 15 | 27_156 | 265.6666666666667 | 585.0 | Coiled coil | . |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000246489 | + | 5 | 16 | 213_246 | 265.6666666666667 | 638.0 | Repeat | Note=TPR 1 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000334553 | + | 5 | 17 | 213_246 | 265.6666666666667 | 668.6666666666666 | Repeat | Note=TPR 1 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000347839 | + | 5 | 16 | 213_246 | 265.6666666666667 | 629.0 | Repeat | Note=TPR 1 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000348520 | + | 5 | 15 | 213_246 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 1 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000389744 | + | 5 | 15 | 213_246 | 265.6666666666667 | 898.3333333333334 | Repeat | Note=TPR 1 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000452929 | + | 5 | 16 | 213_246 | 265.6666666666667 | 619.0 | Repeat | Note=TPR 1 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000553286 | + | 5 | 14 | 213_246 | 265.6666666666667 | 561.0 | Repeat | Note=TPR 1 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000557450 | + | 5 | 15 | 213_246 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 1 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000246489 | + | 5 | 16 | 255_288 | 265.6666666666667 | 638.0 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000246489 | + | 5 | 16 | 297_330 | 265.6666666666667 | 638.0 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000246489 | + | 5 | 16 | 339_372 | 265.6666666666667 | 638.0 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000246489 | + | 5 | 16 | 381_414 | 265.6666666666667 | 638.0 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000246489 | + | 5 | 16 | 464_497 | 265.6666666666667 | 638.0 | Repeat | Note=TPR 6 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000334553 | + | 5 | 17 | 255_288 | 265.6666666666667 | 668.6666666666666 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000334553 | + | 5 | 17 | 297_330 | 265.6666666666667 | 668.6666666666666 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000334553 | + | 5 | 17 | 339_372 | 265.6666666666667 | 668.6666666666666 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000334553 | + | 5 | 17 | 381_414 | 265.6666666666667 | 668.6666666666666 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000334553 | + | 5 | 17 | 464_497 | 265.6666666666667 | 668.6666666666666 | Repeat | Note=TPR 6 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000347839 | + | 5 | 16 | 255_288 | 265.6666666666667 | 629.0 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000347839 | + | 5 | 16 | 297_330 | 265.6666666666667 | 629.0 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000347839 | + | 5 | 16 | 339_372 | 265.6666666666667 | 629.0 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000347839 | + | 5 | 16 | 381_414 | 265.6666666666667 | 629.0 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000347839 | + | 5 | 16 | 464_497 | 265.6666666666667 | 629.0 | Repeat | Note=TPR 6 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000348520 | + | 5 | 15 | 255_288 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000348520 | + | 5 | 15 | 297_330 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000348520 | + | 5 | 15 | 339_372 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000348520 | + | 5 | 15 | 381_414 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000348520 | + | 5 | 15 | 464_497 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 6 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000389744 | + | 5 | 15 | 255_288 | 265.6666666666667 | 898.3333333333334 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000389744 | + | 5 | 15 | 297_330 | 265.6666666666667 | 898.3333333333334 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000389744 | + | 5 | 15 | 339_372 | 265.6666666666667 | 898.3333333333334 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000389744 | + | 5 | 15 | 381_414 | 265.6666666666667 | 898.3333333333334 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000389744 | + | 5 | 15 | 464_497 | 265.6666666666667 | 898.3333333333334 | Repeat | Note=TPR 6 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000452929 | + | 5 | 16 | 255_288 | 265.6666666666667 | 619.0 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000452929 | + | 5 | 16 | 297_330 | 265.6666666666667 | 619.0 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000452929 | + | 5 | 16 | 339_372 | 265.6666666666667 | 619.0 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000452929 | + | 5 | 16 | 381_414 | 265.6666666666667 | 619.0 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000452929 | + | 5 | 16 | 464_497 | 265.6666666666667 | 619.0 | Repeat | Note=TPR 6 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000553286 | + | 5 | 14 | 255_288 | 265.6666666666667 | 561.0 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000553286 | + | 5 | 14 | 297_330 | 265.6666666666667 | 561.0 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000553286 | + | 5 | 14 | 339_372 | 265.6666666666667 | 561.0 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000553286 | + | 5 | 14 | 381_414 | 265.6666666666667 | 561.0 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000553286 | + | 5 | 14 | 464_497 | 265.6666666666667 | 561.0 | Repeat | Note=TPR 6 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000557450 | + | 5 | 15 | 255_288 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 2 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000557450 | + | 5 | 15 | 297_330 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 3 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000557450 | + | 5 | 15 | 339_372 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 4 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000557450 | + | 5 | 15 | 381_414 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 5 |
| Hgene | KLC1 | chr14:104129264 | chrX:100604944 | ENST00000557450 | + | 5 | 15 | 464_497 | 265.6666666666667 | 585.0 | Repeat | Note=TPR 6 |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 214_274 | 636.0 | 660.0 | Domain | SH3 | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 281_377 | 636.0 | 660.0 | Domain | SH2 | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 3_133 | 636.0 | 660.0 | Domain | PH | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 402_655 | 636.0 | 660.0 | Domain | Protein kinase | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 581_588 | 636.0 | 660.0 | Motif | Note=CAV1-binding | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 408_416 | 636.0 | 660.0 | Nucleotide binding | ATP | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 12_24 | 636.0 | 660.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate 1-binding | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 474_479 | 636.0 | 660.0 | Region | Note=Inhibitor-binding | |
| Tgene | BTK | chr14:104129264 | chrX:100604944 | ENST00000308731 | 17 | 19 | 135_171 | 636.0 | 660.0 | Zinc finger | Btk-type |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| KLC1 | MAPK8IP3, YWHAG, YWHAB, YWHAZ, SFN, LRSAM1, KIF5B, KIF5C, KIF5A, APP, MAPK6, SNCA, KLC2, KLC4, SKP1, BSDC1, FAM63B, LDLRAP1, PRKAG3, RASSF8, RIC3, YWHAE, ARCN1, COPB1, COPZ1, DIAPH1, TLE3, PTPN23, SMEK2, BNIP2, KRT31, CCDC114, EZH2, TRAK2, SYNE4, DTNBP1, KPTN, AZIN1, TRIP6, USP7, HSPB1, NTRK1, OFD1, FGFR1OP, CLK1, CSNK1D, RAP1B, SORT1, KLC3, POLR2C, PIAS1, NOLC1, RAB11FIP2, AVL9, ORC3, RBFOX1, RAB11FIP1, CEP44, DPY30, ZNF503, Kif5b, Klc2, Klc4, Klc3, COG6, KIF2B, MYCL, ARHGAP17, SNAPIN, EXOC3, TRPC4AP, RABEP2, USF1, CCDC83, CBY1, TRIM25, ZNF598, RIPK4, ARNT, HSPA8, KRAS, NIN, PCM1, UBE2M, KIAA1429, GBF1, RFFL, HOOK1, Clstn1, CLSTN1, APEX1, TRIM28, TACC3, AP1AR, ATCAY, ERBB2, MAP1LC3B, ADRB2, F2RL1, PTGER4, N, DNAJC16, DNAJC18, DDX58, ANAPC2, TSC1, NAA40, PRPS2, YWHAH, YWHAQ, S100A2, SPSB4, NPEPPS, EP300, MAPK8IP1, RAB10, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| KLC1 |  |
| BTK |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to KLC1-BTK |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to KLC1-BTK |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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