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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KLK2-PVRL2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KLK2-PVRL2
	FusionPDB ID: 43067
	FusionGDB2.0 ID: 43067
		Hgene	Tgene
	Gene symbol	KLK2	PVRL2
	Gene ID	3817	5819
	Gene name	kallikrein related peptidase 2	nectin cell adhesion molecule 2
	Synonyms	KLK2A2\|hGK-1\|hK2	CD112\|HVEB\|PRR2\|PVRL2\|PVRR2
	Cytomap	19q13.33	19q13.32
	Type of gene	protein-coding	protein-coding
	Description	kallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2	nectin-2herpesvirus entry protein Bpoliovirus receptor-like 2poliovirus receptor-related 2 (herpesvirus entry mediator B)
	Modification date	20200313	20200313
	UniProtAcc	P20151	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000391810, ENST00000325321, ENST00000358049, ENST00000597509,	ENST00000252483, ENST00000252485,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 19 X 4=1596	8 X 6 X 7=336
	# samples	30	12
	** MAII score	log2(30/1596*10)=-2.41142624572647 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/336*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KLK2 [Title/Abstract] AND PVRL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KLK2(51376775)-PVRL2(45368527), # samples:2
Anticipated loss of major functional domain due to fusion event.	KLK2-PVRL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLK2-PVRL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLK2-PVRL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLK2-PVRL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PVRL2	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	9845526
Tgene	PVRL2	GO:0019064	fusion of virus membrane with host plasma membrane	12915581
Tgene	PVRL2	GO:0044406	adhesion of symbiont to host	12915581
Tgene	PVRL2	GO:0046596	regulation of viral entry into host cell	11602758
Tgene	PVRL2	GO:0046814	coreceptor-mediated virion attachment to host cell	12915581
Tgene	PVRL2	GO:0050862	positive regulation of T cell receptor signaling pathway	26755705
Tgene	PVRL2	GO:0060370	susceptibility to T cell mediated cytotoxicity	15039383

Fusion gene breakpoints across KLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PVRL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-G9-7509-01A	KLK2	chr19	51376774	+	PVRL2	chr19	45368527	+
ChimerDB4	PRAD	TCGA-G9-7509	KLK2	chr19	51376775	+	PVRL2	chr19	45368527	+
ChimerDB4	PRAD	TCGA-G9-7509	KLK2	chr19	51376775	+	PVRL2	chr19	45368528	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000325321	KLK2	chr19	51376775	+	ENST00000252485	PVRL2	chr19	45368527	+	1944	271	27	1622	531
ENST00000325321	KLK2	chr19	51376775	+	ENST00000252483	PVRL2	chr19	45368527	+	2649	271	27	1799	590
ENST00000358049	KLK2	chr19	51376775	+	ENST00000252485	PVRL2	chr19	45368527	+	1735	62	16	1413	465
ENST00000358049	KLK2	chr19	51376775	+	ENST00000252483	PVRL2	chr19	45368527	+	2440	62	16	1590	524
ENST00000325321	KLK2	chr19	51376775	+	ENST00000252485	PVRL2	chr19	45368528	+	1944	271	27	1622	531
ENST00000325321	KLK2	chr19	51376775	+	ENST00000252483	PVRL2	chr19	45368528	+	2649	271	27	1799	590
ENST00000358049	KLK2	chr19	51376775	+	ENST00000252485	PVRL2	chr19	45368528	+	1735	62	16	1413	465
ENST00000358049	KLK2	chr19	51376775	+	ENST00000252483	PVRL2	chr19	45368528	+	2440	62	16	1590	524
ENST00000325321	KLK2	chr19	51376774	+	ENST00000252485	PVRL2	chr19	45368527	+	1944	271	27	1622	531
ENST00000325321	KLK2	chr19	51376774	+	ENST00000252483	PVRL2	chr19	45368527	+	2649	271	27	1799	590
ENST00000358049	KLK2	chr19	51376774	+	ENST00000252485	PVRL2	chr19	45368527	+	1735	62	16	1413	465
ENST00000358049	KLK2	chr19	51376774	+	ENST00000252483	PVRL2	chr19	45368527	+	2440	62	16	1590	524

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000325321	ENST00000252485	KLK2	chr19	51376775	+	PVRL2	chr19	45368527	+	0.011878492	0.9881215
ENST00000325321	ENST00000252483	KLK2	chr19	51376775	+	PVRL2	chr19	45368527	+	0.005747922	0.9942521
ENST00000358049	ENST00000252485	KLK2	chr19	51376775	+	PVRL2	chr19	45368527	+	0.011811555	0.98818845
ENST00000358049	ENST00000252483	KLK2	chr19	51376775	+	PVRL2	chr19	45368527	+	0.005427793	0.9945722
ENST00000325321	ENST00000252485	KLK2	chr19	51376775	+	PVRL2	chr19	45368528	+	0.011878492	0.9881215
ENST00000325321	ENST00000252483	KLK2	chr19	51376775	+	PVRL2	chr19	45368528	+	0.005747922	0.9942521
ENST00000358049	ENST00000252485	KLK2	chr19	51376775	+	PVRL2	chr19	45368528	+	0.011811555	0.98818845
ENST00000358049	ENST00000252483	KLK2	chr19	51376775	+	PVRL2	chr19	45368528	+	0.005427793	0.9945722
ENST00000325321	ENST00000252485	KLK2	chr19	51376774	+	PVRL2	chr19	45368527	+	0.011878492	0.9881215
ENST00000325321	ENST00000252483	KLK2	chr19	51376774	+	PVRL2	chr19	45368527	+	0.005747922	0.9942521
ENST00000358049	ENST00000252485	KLK2	chr19	51376774	+	PVRL2	chr19	45368527	+	0.011811555	0.98818845
ENST00000358049	ENST00000252483	KLK2	chr19	51376774	+	PVRL2	chr19	45368527	+	0.005427793	0.9945722

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43067_43067_1_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000325321_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=590AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDE
DLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVE

--------------------------------------------------------------

>43067_43067_2_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000325321_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=531AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAG

--------------------------------------------------------------

>43067_43067_3_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000358049_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=524AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAV
AATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERS

--------------------------------------------------------------

>43067_43067_4_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000358049_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=465AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLL
LAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDME

--------------------------------------------------------------

>43067_43067_5_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=590AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDE
DLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVE

--------------------------------------------------------------

>43067_43067_6_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=531AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAG

--------------------------------------------------------------

>43067_43067_7_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368528_ENST00000252483_length(amino acids)=590AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDE
DLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVE

--------------------------------------------------------------

>43067_43067_8_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368528_ENST00000252485_length(amino acids)=531AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAG

--------------------------------------------------------------

>43067_43067_9_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=524AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAV
AATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERS

--------------------------------------------------------------

>43067_43067_10_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=465AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLL
LAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDME

--------------------------------------------------------------

>43067_43067_11_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368528_ENST00000252483_length(amino acids)=524AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAV
AATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERS

--------------------------------------------------------------

>43067_43067_12_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368528_ENST00000252485_length(amino acids)=465AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLL
LAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDME

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51376775/chr19:45368527)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLK2 P20151	.
FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252483

162_256

29.333333333333332

539.0

Domain

Note=Ig-like C2-type 1

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252483

261_345

29.333333333333332

539.0

Domain

Note=Ig-like C2-type 2

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252483

32_156

29.333333333333332

539.0

Domain

Note=Ig-like V-type

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252485

162_256

29.333333333333332

480.0

Domain

Note=Ig-like C2-type 1

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252485

261_345

29.333333333333332

480.0

Domain

Note=Ig-like C2-type 2

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252485

32_156

29.333333333333332

480.0

Domain

Note=Ig-like V-type

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252483

162_256

29.333333333333332

539.0

Domain

Note=Ig-like C2-type 1

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252483

261_345

29.333333333333332

539.0

Domain

Note=Ig-like C2-type 2

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252483

32_156

29.333333333333332

539.0

Domain

Note=Ig-like V-type

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252485

162_256

29.333333333333332

480.0

Domain

Note=Ig-like C2-type 1

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252485

261_345

29.333333333333332

480.0

Domain

Note=Ig-like C2-type 2

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252485

32_156

29.333333333333332

480.0

Domain

Note=Ig-like V-type

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252483

162_256

29.333333333333332

539.0

Domain

Note=Ig-like C2-type 1

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252483

261_345

29.333333333333332

539.0

Domain

Note=Ig-like C2-type 2

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252483

32_156

29.333333333333332

539.0

Domain

Note=Ig-like V-type

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252485

162_256

29.333333333333332

480.0

Domain

Note=Ig-like C2-type 1

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252485

261_345

29.333333333333332

480.0

Domain

Note=Ig-like C2-type 2

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252485

32_156

29.333333333333332

480.0

Domain

Note=Ig-like V-type

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252483

32_360

29.333333333333332

539.0

Topological domain

Extracellular

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252483

382_538

29.333333333333332

539.0

Topological domain

Cytoplasmic

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252485

32_360

29.333333333333332

480.0

Topological domain

Extracellular

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252485

382_538

29.333333333333332

480.0

Topological domain

Cytoplasmic

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252483

32_360

29.333333333333332

539.0

Topological domain

Extracellular

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252483

382_538

29.333333333333332

539.0

Topological domain

Cytoplasmic

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252485

32_360

29.333333333333332

480.0

Topological domain

Extracellular

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252485

382_538

29.333333333333332

480.0

Topological domain

Cytoplasmic

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252483

32_360

29.333333333333332

539.0

Topological domain

Extracellular

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252483

382_538

29.333333333333332

539.0

Topological domain

Cytoplasmic

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252485

32_360

29.333333333333332

480.0

Topological domain

Extracellular

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252485

382_538

29.333333333333332

480.0

Topological domain

Cytoplasmic

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252483

361_381

29.333333333333332

539.0

Transmembrane

Helical

Tgene

PVRL2

chr19:51376774

chr19:45368527

ENST00000252485

361_381

29.333333333333332

480.0

Transmembrane

Helical

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252483

361_381

29.333333333333332

539.0

Transmembrane

Helical

Tgene

PVRL2

chr19:51376775

chr19:45368527

ENST00000252485

361_381

29.333333333333332

480.0

Transmembrane

Helical

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252483

361_381

29.333333333333332

539.0

Transmembrane

Helical

Tgene

PVRL2

chr19:51376775

chr19:45368528

ENST00000252485

361_381

29.333333333333332

480.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLK2

chr19:51376774

chr19:45368527

ENST00000325321

25_258

15.333333333333334

262.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376774

chr19:45368527

ENST00000358049

25_258

15.333333333333334

224.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376774

chr19:45368527

ENST00000391810

25_258

160.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376775

chr19:45368527

ENST00000325321

25_258

15.333333333333334

262.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376775

chr19:45368527

ENST00000358049

25_258

15.333333333333334

224.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376775

chr19:45368527

ENST00000391810

25_258

160.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376775

chr19:45368528

ENST00000325321

25_258

15.333333333333334

262.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376775

chr19:45368528

ENST00000358049

25_258

15.333333333333334

224.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376775

chr19:45368528

ENST00000391810

25_258

160.0

Domain

Peptidase S1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
KLK2	SERPINF2, SERPINA3, SERPINA5, SERPINB6, APP, SUZ12, RNF2, ADAMTS1, SERPINE2, APLP2, GLG1, EXT2, BMP1, PIGT, FGFR4, MAN2B2, SUMF1, LRP6, JAG2, IL17RA, GALNT18, CERCAM, CHID1, PGAM2, ERGIC1, ROR2, PCSK9, B4GALT3, PCSK6, ARSK, MAN2A2, MANBA,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KLK2
PVRL2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to KLK2-PVRL2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to KLK2-PVRL2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KLK2	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	KLK2	C0376358	Malignant neoplasm of prostate	2	CTD_human