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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KMT2A-USP10

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KMT2A-USP10
	FusionPDB ID: 43222
	FusionGDB2.0 ID: 43222
		Hgene	Tgene
	Gene symbol	KMT2A	USP10
	Gene ID	4297	84669
	Gene name	lysine methyltransferase 2A	ubiquitin specific peptidase 32
	Synonyms	ALL-1\|CXXC7\|HRX\|HTRX1\|MLL\|MLL1\|MLL1A\|TRX1\|WDSTS	NY-REN-60\|USP10
	Cytomap	11q23.3	17q23.1-q23.2
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like	ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
	Modification date	20200319	20200313
	UniProtAcc	Q03164	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000354520, ENST00000389506, ENST00000534358, ENST00000420751,	ENST00000562743, ENST00000219473, ENST00000570191,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	79 X 196 X 13=201292	17 X 15 X 9=2295
	# samples	241	19
	** MAII score	log2(241/201292*10)=-6.38411287931608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2295*10)=-3.59442282997022 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KMT2A [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KMT2A(118359475)-USP10(84767039), # samples:1 KMT2A(118359932)-USP10(84758331), # samples:1
Anticipated loss of major functional domain due to fusion event.	KMT2A-USP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2A-USP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2A-USP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2A-USP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KMT2A	GO:0044648	histone H3-K4 dimethylation	25561738
Hgene	KMT2A	GO:0045944	positive regulation of transcription by RNA polymerase II	20861184
Hgene	KMT2A	GO:0051568	histone H3-K4 methylation	19556245
Hgene	KMT2A	GO:0065003	protein-containing complex assembly	15199122
Hgene	KMT2A	GO:0080182	histone H3-K4 trimethylation	20861184
Hgene	KMT2A	GO:0097692	histone H3-K4 monomethylation	25561738\|26324722

Fusion gene breakpoints across KMT2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	MH128093	KMT2A	chr11	118359475	+	USP10	chr16	84767039	+
ChiTaRS5.0	N/A	MH128094	KMT2A	chr11	118359932	+	USP10	chr16	84758331	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000534358	KMT2A	chr11	118359475	+	ENST00000219473	USP10	chr16	84767039	+	7377	4502	23	6877	2284
ENST00000534358	KMT2A	chr11	118359475	+	ENST00000570191	USP10	chr16	84767039	+	6990	4502	23	6877	2284
ENST00000389506	KMT2A	chr11	118359475	+	ENST00000219473	USP10	chr16	84767039	+	7354	4479	0	6854	2284
ENST00000389506	KMT2A	chr11	118359475	+	ENST00000570191	USP10	chr16	84767039	+	6967	4479	0	6854	2284
ENST00000354520	KMT2A	chr11	118359475	+	ENST00000219473	USP10	chr16	84767039	+	7240	4365	0	6740	2246
ENST00000354520	KMT2A	chr11	118359475	+	ENST00000570191	USP10	chr16	84767039	+	6853	4365	0	6740	2246

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000534358	ENST00000219473	KMT2A	chr11	118359475	+	USP10	chr16	84767039	+	0.00029093	0.99970907
ENST00000534358	ENST00000570191	KMT2A	chr11	118359475	+	USP10	chr16	84767039	+	0.000361274	0.9996387
ENST00000389506	ENST00000219473	KMT2A	chr11	118359475	+	USP10	chr16	84767039	+	0.000282733	0.9997173
ENST00000389506	ENST00000570191	KMT2A	chr11	118359475	+	USP10	chr16	84767039	+	0.000350073	0.9996499
ENST00000354520	ENST00000219473	KMT2A	chr11	118359475	+	USP10	chr16	84767039	+	0.000889025	0.999111
ENST00000354520	ENST00000570191	KMT2A	chr11	118359475	+	USP10	chr16	84767039	+	0.001009423	0.9989906

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43222_43222_1_KMT2A-USP10_KMT2A_chr11_118359475_ENST00000354520_USP10_chr16_84767039_ENST00000219473_length(amino acids)=2246AA_BP=16
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR
CKFCHVCGRQHQATKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISST
LNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSIS
TEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRD
TLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPS
SSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHL
MKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFIL
NGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKES
ATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEI

--------------------------------------------------------------

>43222_43222_2_KMT2A-USP10_KMT2A_chr11_118359475_ENST00000354520_USP10_chr16_84767039_ENST00000570191_length(amino acids)=2246AA_BP=16
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR
CKFCHVCGRQHQATKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISST
LNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSIS
TEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRD
TLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPS
SSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHL
MKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFIL
NGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKES
ATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEI

--------------------------------------------------------------

>43222_43222_3_KMT2A-USP10_KMT2A_chr11_118359475_ENST00000389506_USP10_chr16_84767039_ENST00000219473_length(amino acids)=2284AA_BP=16
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQA
VDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEV
LENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVP
DSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDP
TKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVT
LIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIR
PGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVG
PRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVT
LEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLR

--------------------------------------------------------------

>43222_43222_4_KMT2A-USP10_KMT2A_chr11_118359475_ENST00000389506_USP10_chr16_84767039_ENST00000570191_length(amino acids)=2284AA_BP=16
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQA
VDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEV
LENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVP
DSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDP
TKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVT
LIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIR
PGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVG
PRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVT
LEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLR

--------------------------------------------------------------

>43222_43222_5_KMT2A-USP10_KMT2A_chr11_118359475_ENST00000534358_USP10_chr16_84767039_ENST00000219473_length(amino acids)=2284AA_BP=16
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQA
VDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEV
LENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVP
DSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDP
TKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVT
LIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIR
PGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVG
PRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVT
LEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLR

--------------------------------------------------------------

>43222_43222_6_KMT2A-USP10_KMT2A_chr11_118359475_ENST00000534358_USP10_chr16_84767039_ENST00000570191_length(amino acids)=2284AA_BP=16
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQA
VDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEV
LENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVP
DSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDP
TKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVT
LIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIR
PGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVG
PRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVT
LEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLR

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:118359475/chr16:84767039)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KMT2A Q03164	.
FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

137_143

1455.0

3932.0

Compositional bias

Note=Poly-Gly

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

17_102

1455.0

3932.0

Compositional bias

Note=Ala/Gly/Ser-rich

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

561_564

1455.0

3932.0

Compositional bias

Note=Poly-Pro

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

568_571

1455.0

3932.0

Compositional bias

Note=Poly-Pro

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

137_143

1493.0

3970.0

Compositional bias

Note=Poly-Gly

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

17_102

1493.0

3970.0

Compositional bias

Note=Ala/Gly/Ser-rich

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

561_564

1493.0

3970.0

Compositional bias

Note=Poly-Pro

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

568_571

1493.0

3970.0

Compositional bias

Note=Poly-Pro

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

137_143

1493.0

3973.0

Compositional bias

Note=Poly-Gly

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

17_102

1493.0

3973.0

Compositional bias

Note=Ala/Gly/Ser-rich

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

561_564

1493.0

3973.0

Compositional bias

Note=Poly-Pro

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

568_571

1493.0

3973.0

Compositional bias

Note=Poly-Pro

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

169_180

1455.0

3932.0

DNA binding

Note=A.T hook 1

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

217_227

1455.0

3932.0

DNA binding

Note=A.T hook 2

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

301_309

1455.0

3932.0

DNA binding

Note=A.T hook 3

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

169_180

1493.0

3970.0

DNA binding

Note=A.T hook 1

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

217_227

1493.0

3970.0

DNA binding

Note=A.T hook 2

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

301_309

1493.0

3970.0

DNA binding

Note=A.T hook 3

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

169_180

1493.0

3973.0

DNA binding

Note=A.T hook 1

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

217_227

1493.0

3973.0

DNA binding

Note=A.T hook 2

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

301_309

1493.0

3973.0

DNA binding

Note=A.T hook 3

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

123_134

1455.0

3932.0

Motif

Integrase domain-binding motif 1 (IBM1)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

147_152

1455.0

3932.0

Motif

Integrase domain-binding motif 2 (IBM2)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

6_25

1455.0

3932.0

Motif

Menin-binding motif (MBM)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

123_134

1493.0

3970.0

Motif

Integrase domain-binding motif 1 (IBM1)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

147_152

1493.0

3970.0

Motif

Integrase domain-binding motif 2 (IBM2)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

6_25

1493.0

3970.0

Motif

Menin-binding motif (MBM)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

123_134

1493.0

3973.0

Motif

Integrase domain-binding motif 1 (IBM1)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

147_152

1493.0

3973.0

Motif

Integrase domain-binding motif 2 (IBM2)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

6_25

1493.0

3973.0

Motif

Menin-binding motif (MBM)

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

1147_1195

1455.0

3932.0

Zinc finger

CXXC-type

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

1147_1195

1493.0

3970.0

Zinc finger

CXXC-type

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

1431_1482

1493.0

3970.0

Zinc finger

PHD-type 1

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

1147_1195

1493.0

3973.0

Zinc finger

CXXC-type

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

1431_1482

1493.0

3973.0

Zinc finger

PHD-type 1

Tgene

USP10

chr11:118359475

chr16:84767039

ENST00000219473

415_795

7.0

799.0

Domain

Note=USP

Tgene

USP10

chr11:118359475

chr16:84767039

ENST00000570191

415_795

11.0

803.0

Domain

Note=USP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

1703_1748

1455.0

3932.0

Domain

Bromo%3B divergent

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

2018_2074

1455.0

3932.0

Domain

FYR N-terminal

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

3666_3747

1455.0

3932.0

Domain

FYR C-terminal

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

3829_3945

1455.0

3932.0

Domain

SET

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

3953_3969

1455.0

3932.0

Domain

Post-SET

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

1703_1748

1493.0

3970.0

Domain

Bromo%3B divergent

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

2018_2074

1493.0

3970.0

Domain

FYR N-terminal

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

3666_3747

1493.0

3970.0

Domain

FYR C-terminal

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

3829_3945

1493.0

3970.0

Domain

SET

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

3953_3969

1493.0

3970.0

Domain

Post-SET

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

1703_1748

1493.0

3973.0

Domain

Bromo%3B divergent

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

2018_2074

1493.0

3973.0

Domain

FYR N-terminal

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

3666_3747

1493.0

3973.0

Domain

FYR C-terminal

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

3829_3945

1493.0

3973.0

Domain

SET

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

3953_3969

1493.0

3973.0

Domain

Post-SET

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

3906_3907

1455.0

3932.0

Region

S-adenosyl-L-methionine binding

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

3906_3907

1493.0

3970.0

Region

S-adenosyl-L-methionine binding

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

3906_3907

1493.0

3973.0

Region

S-adenosyl-L-methionine binding

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

1431_1482

1455.0

3932.0

Zinc finger

PHD-type 1

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

1479_1533

1455.0

3932.0

Zinc finger

PHD-type 2

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

1566_1627

1455.0

3932.0

Zinc finger

PHD-type 3

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

1870_1910

1455.0

3932.0

Zinc finger

C2HC pre-PHD-type

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000354520

1931_1978

1455.0

3932.0

Zinc finger

PHD-type 4

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

1479_1533

1493.0

3970.0

Zinc finger

PHD-type 2

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

1566_1627

1493.0

3970.0

Zinc finger

PHD-type 3

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

1870_1910

1493.0

3970.0

Zinc finger

C2HC pre-PHD-type

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000389506

1931_1978

1493.0

3970.0

Zinc finger

PHD-type 4

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

1479_1533

1493.0

3973.0

Zinc finger

PHD-type 2

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

1566_1627

1493.0

3973.0

Zinc finger

PHD-type 3

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

1870_1910

1493.0

3973.0

Zinc finger

C2HC pre-PHD-type

Hgene

KMT2A

chr11:118359475

chr16:84767039

ENST00000534358

1931_1978

1493.0

3973.0

Zinc finger

PHD-type 4

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

KMT2A

PPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KMT2A
USP10

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	KMT2A	chr11:118359475	chr16:84767039	ENST00000354520	+	10	35	1584_1600	1455.0	3932.0	histone H3K4me3
Hgene	KMT2A	chr11:118359475	chr16:84767039	ENST00000389506	+	11	36	1584_1600	1493.0	3970.0	histone H3K4me3
Hgene	KMT2A	chr11:118359475	chr16:84767039	ENST00000534358	+	11	36	1584_1600	1493.0	3973.0	histone H3K4me3
Tgene	USP10	chr11:118359475	chr16:84767039	ENST00000219473		0	14	2_100	7.0	799.0	p53/TP53
Tgene	USP10	chr11:118359475	chr16:84767039	ENST00000570191		1	15	2_100	11.0	803.0	p53/TP53

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Related Drugs to KMT2A-USP10

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KMT2A-USP10

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KMT2A	C2826025	Mixed phenotype acute leukemia	3	ORPHANET
Hgene	KMT2A	C0023418	leukemia	2	CTD_human
Hgene	KMT2A	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Hgene	KMT2A	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Hgene	KMT2A	C0023466	Leukemia, Monocytic, Chronic	2	CTD_human
Hgene	KMT2A	C0023467	Leukemia, Myelocytic, Acute	2	CTD_human
Hgene	KMT2A	C0023470	Myeloid Leukemia	2	CTD_human
Hgene	KMT2A	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Hgene	KMT2A	C1854630	Growth Deficiency and Mental Retardation with Facial Dysmorphism	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	KMT2A	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Hgene	KMT2A	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CTD_human
Hgene	KMT2A	C0001418	Adenocarcinoma	1	CTD_human
Hgene	KMT2A	C0004403	Autosome Abnormalities	1	CTD_human
Hgene	KMT2A	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Hgene	KMT2A	C0005695	Bladder Neoplasm	1	CTD_human
Hgene	KMT2A	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Hgene	KMT2A	C0008625	Chromosome Aberrations	1	CTD_human
Hgene	KMT2A	C0023448	Lymphoid leukemia	1	CTD_human
Hgene	KMT2A	C0023465	Acute monocytic leukemia	1	CTD_human
Hgene	KMT2A	C0023479	Acute myelomonocytic leukemia	1	CTD_human
Hgene	KMT2A	C0024623	Malignant neoplasm of stomach	1	CTD_human
Hgene	KMT2A	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	KMT2A	C0036341	Schizophrenia	1	PSYGENET
Hgene	KMT2A	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	KMT2A	C0149925	Small cell carcinoma of lung	1	CTD_human
Hgene	KMT2A	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	KMT2A	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	KMT2A	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	KMT2A	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	KMT2A	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	KMT2A	C0270972	Cornelia De Lange Syndrome	1	ORPHANET
Hgene	KMT2A	C0280141	Acute Undifferentiated Leukemia	1	ORPHANET
Hgene	KMT2A	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	KMT2A	C0856823	Undifferentiated type acute leukemia	1	ORPHANET
Hgene	KMT2A	C1535926	Neurodevelopmental Disorders	1	CTD_human
Hgene	KMT2A	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Hgene	KMT2A	C2239176	Liver carcinoma	1	CTD_human
Hgene	KMT2A	C2930974	Acute erythroleukemia	1	CTD_human
Hgene	KMT2A	C2930975	Acute erythroleukemia - M6a subtype	1	CTD_human
Hgene	KMT2A	C2930976	Acute myeloid leukemia FAB-M6	1	CTD_human
Hgene	KMT2A	C2930977	Acute erythroleukemia - M6b subtype	1	CTD_human