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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KMT2C-AUTS2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KMT2C-AUTS2
FusionPDB ID: 43235
FusionGDB2.0 ID: 54197
HgeneTgene
Gene symbol

KMT2C

AUTS2

Gene ID

58508

26053

Gene namelysine methyltransferase 2Cactivator of transcription and developmental regulator AUTS2
SynonymsHALR|KLEFS2|MLL3FBRSL2|MRD26
Cytomap

7q36.1

7q11.22

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage leautism susceptibility gene 2 proteinAUTS2, activator of transcription and developmental regulatorautism susceptibility candidate 2autism-related protein 1
Modification date2020032020200313
UniProtAcc

Q8NEZ4

Q8WXX7

Ensembl transtripts involved in fusion geneENST idsENST00000262189, ENST00000355193, 
ENST00000485241, ENST00000485655, 
ENST00000403018, ENST00000489774, 
ENST00000342771, ENST00000406775, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 23 X 12=717625 X 24 X 10=6000
# samples 3227
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/6000*10)=-4.47393118833241
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KMT2C [Title/Abstract] AND AUTS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2C(152132711)-AUTS2(69900738), # samples:1
Anticipated loss of major functional domain due to fusion event.KMT2C-AUTS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-AUTS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-AUTS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-AUTS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722

TgeneAUTS2

GO:0045944

positive regulation of transcription by RNA polymerase II

25519132

TgeneAUTS2

GO:0051571

positive regulation of histone H3-K4 methylation

25519132

TgeneAUTS2

GO:2000620

positive regulation of histone H4-K16 acetylation

25519132


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AUTS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07C-01AKMT2Cchr7

152132711

-AUTS2chr7

69900738

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262189KMT2Cchr7152132711-ENST00000406775AUTS2chr769900738+49353806893427912
ENST00000262189KMT2Cchr7152132711-ENST00000342771AUTS2chr769900738+55723806893499936
ENST00000355193KMT2Cchr7152132711-ENST00000406775AUTS2chr769900738+49353806893427912
ENST00000355193KMT2Cchr7152132711-ENST00000342771AUTS2chr769900738+55723806893499936

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000406775KMT2Cchr7152132711-AUTS2chr769900738+0.0087032510.99129677
ENST00000262189ENST00000342771KMT2Cchr7152132711-AUTS2chr769900738+0.0063198780.9936801
ENST00000355193ENST00000406775KMT2Cchr7152132711-AUTS2chr769900738+0.0087032510.99129677
ENST00000355193ENST00000342771KMT2Cchr7152132711-AUTS2chr769900738+0.0063198780.9936801

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43235_43235_1_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000262189_AUTS2_chr7_69900738_ENST00000342771_length(amino acids)=936AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLK
PEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNS
MFGHKDGPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPV
NALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESAR
PNSTSSREAEPRKGEPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRT
RMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHH
PLSVDPRREHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPL

--------------------------------------------------------------

>43235_43235_2_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000262189_AUTS2_chr7_69900738_ENST00000406775_length(amino acids)=912AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLAR
PSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLH
RTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREK
DKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYENPKKS
SEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFH
WDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHM
LREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRER

--------------------------------------------------------------

>43235_43235_3_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000355193_AUTS2_chr7_69900738_ENST00000342771_length(amino acids)=936AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLK
PEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNS
MFGHKDGPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPV
NALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESAR
PNSTSSREAEPRKGEPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRT
RMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHH
PLSVDPRREHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPL

--------------------------------------------------------------

>43235_43235_4_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000355193_AUTS2_chr7_69900738_ENST00000406775_length(amino acids)=912AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLAR
PSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLH
RTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREK
DKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYENPKKS
SEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFH
WDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHM
LREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRER

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:152132711/chr7:69900738)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

AUTS2

Q8WXX7

FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-15934_4653.6666666666666644912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-16034_4653.6666666666666644969.0DNA bindingNote=A.T hook
TgeneAUTS2chr7:152132711chr7:69900738ENST000003427713191122_1181220.01260.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319288_471220.01260.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319525_548220.01260.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319545_646220.01260.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000403018051122_11810267.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805288_4710267.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805525_5480267.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805545_6460267.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST000004067753181122_1181220.01236.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318288_471220.01236.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318525_548220.01236.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318545_646220.01236.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319289_472220.01260.0RegionImportant for regulation of lamellipodia formation
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805289_4720267.0RegionImportant for regulation of lamellipodia formation
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318289_472220.01236.0RegionImportant for regulation of lamellipodia formation

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591338_136653.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591754_178753.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593054_308153.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593173_327253.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593391_343353.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159644_67253.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-15992_11253.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601338_136653.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601754_178753.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603054_308153.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603173_327253.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603391_343353.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160644_67253.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-16092_11253.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591719_179653.6666666666666644912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591834_228153.6666666666666644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1592412_263053.6666666666666644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1592690_278653.6666666666666644912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593012_350953.6666666666666644912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593277_338153.6666666666666644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601719_179653.6666666666666644969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601834_228153.6666666666666644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1602412_263053.6666666666666644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1602690_278653.6666666666666644969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603012_350953.6666666666666644969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603277_338153.6666666666666644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159436_48953.6666666666666644912.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594545_460553.6666666666666644912.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594606_469153.6666666666666644912.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594771_488753.6666666666666644912.0DomainSET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594895_491153.6666666666666644912.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160436_48953.6666666666666644969.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604545_460553.6666666666666644969.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604606_469153.6666666666666644969.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604771_488753.6666666666666644969.0DomainSET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604895_491153.6666666666666644969.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594848_484953.6666666666666644912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604848_484953.6666666666666644969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591007_105753.6666666666666644912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591084_113953.6666666666666644912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159227_26253.6666666666666644912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159283_33153.6666666666666644912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159341_39153.6666666666666644912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159344_38953.6666666666666644912.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159388_43853.6666666666666644912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594399_443953.6666666666666644912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594460_450753.6666666666666644912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159464_52053.6666666666666644912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159957_101053.6666666666666644912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601007_105753.6666666666666644969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601084_113953.6666666666666644969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160227_26253.6666666666666644969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160283_33153.6666666666666644969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160341_39153.6666666666666644969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160344_38953.6666666666666644969.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160388_43853.6666666666666644969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604399_443953.6666666666666644969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604460_450753.6666666666666644969.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160464_52053.6666666666666644969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160957_101053.6666666666666644969.0Zinc fingerPHD-type 5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KMT2C
AUTS2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KMT2C-AUTS2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KMT2C-AUTS2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource